NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1396658786|ref|NP_999851|]
View 

sulfotransferase 6B1 [Danio rerio]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
48-283 8.81e-70

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 216.44  E-value: 8.81e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786  48 EDDLILVAYPKCGFNWMVAVLRKIIN-ASTGKDEKPP-----ERPPLVEFLPPTVQ-------EEMAQMPPPRLLGTHLH 114
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrGDFEKSEEPHlfnnhNRSPFLEWYPGDTYfdvaegpVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 115 PDNMPATFFTKKPKILVVFRNPKDTVVSYYHFMNKNPVLPNAESWDKFFSDFMTGDVSWGSYFDHALAWEKRIDDPNVMI 194
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 195 VMYEDLKQNLPEGVKKISEFFSLPLTDEQVSSIAGQSTFSAMVENSQKSHGN---FGSIFFRKGEVGDWKNHFSEAQSKQ 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKlpkEVSPFFRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 1396658786 272 MDELYHSKLAGT 283
Cdd:pfam00685 241 FDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
48-283 8.81e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 216.44  E-value: 8.81e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786  48 EDDLILVAYPKCGFNWMVAVLRKIIN-ASTGKDEKPP-----ERPPLVEFLPPTVQ-------EEMAQMPPPRLLGTHLH 114
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrGDFEKSEEPHlfnnhNRSPFLEWYPGDTYfdvaegpVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 115 PDNMPATFFTKKPKILVVFRNPKDTVVSYYHFMNKNPVLPNAESWDKFFSDFMTGDVSWGSYFDHALAWEKRIDDPNVMI 194
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 195 VMYEDLKQNLPEGVKKISEFFSLPLTDEQVSSIAGQSTFSAMVENSQKSHGN---FGSIFFRKGEVGDWKNHFSEAQSKQ 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKlpkEVSPFFRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 1396658786 272 MDELYHSKLAGT 283
Cdd:pfam00685 241 FDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 44-285 1.16e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 98.84  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786  44 LQAREDDLILVAYPKCGFNWMVAVLRKIINASTGKDEKPP--ERPPLvEFLP---------PTVqeEMAQMPPPRLLGTH 112
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPllKRNPH-EFVPyieidfpffPSV--DVLKDKGNTLFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 113 LHPDNMPATFFTKKPKILVVFRNPKDTVVSYYHFMNKN-----PVLPNAESWDKFfsdfMTGDVSWGSYFDHALA-WEKR 186
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKErsqqgPLNSLEESFDMF----CRGLSVYGPYLDHVLGyWKAY 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 187 IDDPN-VMIVMYEDLKQNLPEGVKKISEFFSLPLTDEQ-----VSSIAGQSTFSAMvENSQKSHGN----------FGSI 250
Cdd:PLN02164  228 QENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETL-KNLEANKGEkdredrpavyANSA 306

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1396658786 251 FFRKGEVGDWKNHFSEAQSKQMDELYHSKLAGTKL 285
Cdd:PLN02164  307 YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
48-283 8.81e-70

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 216.44  E-value: 8.81e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786  48 EDDLILVAYPKCGFNWMVAVLRKIIN-ASTGKDEKPP-----ERPPLVEFLPPTVQ-------EEMAQMPPPRLLGTHLH 114
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNrGDFEKSEEPHlfnnhNRSPFLEWYPGDTYfdvaegpVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 115 PDNMPATFFTKKPKILVVFRNPKDTVVSYYHFMNKNPVLPNAESWDKFFSDFMTGDVSWGSYFDHALAWEKRIDDPNVMI 194
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 195 VMYEDLKQNLPEGVKKISEFFSLPLTDEQVSSIAGQSTFSAMVENSQKSHGN---FGSIFFRKGEVGDWKNHFSEAQSKQ 271
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKlpkEVSPFFRKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|..
gi 1396658786 272 MDELYHSKLAGT 283
Cdd:pfam00685 241 FDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 44-285 1.16e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 98.84  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786  44 LQAREDDLILVAYPKCGFNWMVAVLRKIINASTGKDEKPP--ERPPLvEFLP---------PTVqeEMAQMPPPRLLGTH 112
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPllKRNPH-EFVPyieidfpffPSV--DVLKDKGNTLFSTH 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 113 LHPDNMPATFFTKKPKILVVFRNPKDTVVSYYHFMNKN-----PVLPNAESWDKFfsdfMTGDVSWGSYFDHALA-WEKR 186
Cdd:PLN02164  152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKErsqqgPLNSLEESFDMF----CRGLSVYGPYLDHVLGyWKAY 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658786 187 IDDPN-VMIVMYEDLKQNLPEGVKKISEFFSLPLTDEQ-----VSSIAGQSTFSAMvENSQKSHGN----------FGSI 250
Cdd:PLN02164  228 QENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETL-KNLEANKGEkdredrpavyANSA 306

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1396658786 251 FFRKGEVGDWKNHFSEAQSKQMDELYHSKLAGTKL 285
Cdd:PLN02164  307 YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH