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Conserved domains on  [gi|269847499|ref|NP_998891|]
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protein INCA1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
INCA1 super family cl21009
INCA1; This family of proteins inhibits cyclin-dependent kinase activity.
12-175 2.51e-97

INCA1; This family of proteins inhibits cyclin-dependent kinase activity.


The actual alignment was detected with superfamily member pfam15142:

Pssm-ID: 464527  Cd Length: 178  Bit Score: 280.93  E-value: 2.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   12 PFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVFWKNLNQRPTPTWLEEQHIPPMLLPPPEML---------------WRR 76
Cdd:pfam15142   1 PFAKCSRVVSRSPPPSLPSQSLRLMPQRYGDIFWENLSQRPSPTWMEEQYIPPLLRATGCSQpglyppeglpppemlCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   77 KKRRPCLEGMQQqGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPSTNEYPDLEEERA 156
Cdd:pfam15142  81 KRRRPHLAGMQQ-GPGGIPARVRAVTYHLEDLRRRQRIINELKKAQWGSSGAASEPLVLAEEGCGFPSTTEYPDLEEERA 159
                         170
                  ....*....|....*....
gi 269847499  157 TYPQEEDRFLTPGRAQLLW 175
Cdd:pfam15142 160 TYPQEEDHFLTPGRAQLLW 178
 
Name Accession Description Interval E-value
INCA1 pfam15142
INCA1; This family of proteins inhibits cyclin-dependent kinase activity.
12-175 2.51e-97

INCA1; This family of proteins inhibits cyclin-dependent kinase activity.


Pssm-ID: 464527  Cd Length: 178  Bit Score: 280.93  E-value: 2.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   12 PFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVFWKNLNQRPTPTWLEEQHIPPMLLPPPEML---------------WRR 76
Cdd:pfam15142   1 PFAKCSRVVSRSPPPSLPSQSLRLMPQRYGDIFWENLSQRPSPTWMEEQYIPPLLRATGCSQpglyppeglpppemlCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   77 KKRRPCLEGMQQqGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPSTNEYPDLEEERA 156
Cdd:pfam15142  81 KRRRPHLAGMQQ-GPGGIPARVRAVTYHLEDLRRRQRIINELKKAQWGSSGAASEPLVLAEEGCGFPSTTEYPDLEEERA 159
                         170
                  ....*....|....*....
gi 269847499  157 TYPQEEDRFLTPGRAQLLW 175
Cdd:pfam15142 160 TYPQEEDHFLTPGRAQLLW 178
 
Name Accession Description Interval E-value
INCA1 pfam15142
INCA1; This family of proteins inhibits cyclin-dependent kinase activity.
12-175 2.51e-97

INCA1; This family of proteins inhibits cyclin-dependent kinase activity.


Pssm-ID: 464527  Cd Length: 178  Bit Score: 280.93  E-value: 2.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   12 PFAKCSRVVSRSPPPRLPSQSLRPMPQRYGDVFWKNLNQRPTPTWLEEQHIPPMLLPPPEML---------------WRR 76
Cdd:pfam15142   1 PFAKCSRVVSRSPPPSLPSQSLRLMPQRYGDIFWENLSQRPSPTWMEEQYIPPLLRATGCSQpglyppeglpppemlCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269847499   77 KKRRPCLEGMQQqGLGGVPARVRAVTYHLEDLRRRQSIINELKKAQWGSSGAASEPVVLGEEGCGFPSTNEYPDLEEERA 156
Cdd:pfam15142  81 KRRRPHLAGMQQ-GPGGIPARVRAVTYHLEDLRRRQRIINELKKAQWGSSGAASEPLVLAEEGCGFPSTTEYPDLEEERA 159
                         170
                  ....*....|....*....
gi 269847499  157 TYPQEEDRFLTPGRAQLLW 175
Cdd:pfam15142 160 TYPQEEDHFLTPGRAQLLW 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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