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Conserved domains on  [gi|47086391|ref|NP_997986|]
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cysteine-rich motor neuron 1 protein precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIM1_C super family cl44859
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1026 1.54e-66

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


The actual alignment was detected with superfamily member pfam19442:

Pssm-ID: 437274  Cd Length: 130  Bit Score: 219.34  E-value: 1.54e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086391    898 ENDVMPQFRGeFGSLQMPYLDGKTPLPSEDAGLH-WAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQ 976
Cdd:pfam19442    1 ENDIVHQPRD-MGHLQVDYREGSRPHPSEDSSLHsVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47086391    977 LVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQT 1026
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQT 129
IGFBP pfam00219
Insulin-like growth factor binding protein;
33-84 3.53e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 3.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 47086391     33 PCDKSKC-EEPKPCTGSVVLGICGCCSVCAKQKNESCGgvyGLYGTCDRGLRC 84
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCG---VYTPPCGKGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 812-866 7.87e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 44.34  E-value: 7.87e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    812 CHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTV--EGSCCPMC 866
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 678-729 2.79e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 42.41  E-value: 2.79e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    678 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQ--DSCCPHC 729
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
330-384 2.87e-05

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.87e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     330 CTLNGVEYHDGDMFRMDACRFCRCQGGVSV-CFTAQCG-VLHCERYY--VPDGECCPVC 384
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPpPPDCPNPErvKPPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 751-803 6.63e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 41.64  E-value: 6.63e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 47086391    751 EDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNC--ARPVLRKGQCCPYC 803
Cdd:pfam00093    3 QNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 607-657 2.99e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    607 DGRRHENGQSWH-DGCRDCYCHAGREMCALISCPVPPCDNPT--IRPGHCCPTC 657
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 561-586 1.33e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    561 CPELPCDKACPMGFQHDELGCLICQC 586
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 397-450 2.28e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member smart00214:

Pssm-ID: 450195  Cd Length: 59  Bit Score: 37.11  E-value: 2.28e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     397 CYVNGQILAHGDHWREDDCTFCQCVSGD-ARCVAAAC--GHSCLNPVT--VPGECCPVC 450
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECppPPDCPNPERvkPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 506-526 4.90e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 4.90e-03
                           10        20
                   ....*....|....*....|.
gi 47086391    506 CTLKCPFGFQTDIHGCDVCQC 526
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 533-558 6.20e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


:

Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 6.20e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    533 CKAVACAKDCPFGYIKNKHGCDTCRC 558
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1026 1.54e-66

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 219.34  E-value: 1.54e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086391    898 ENDVMPQFRGeFGSLQMPYLDGKTPLPSEDAGLH-WAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQ 976
Cdd:pfam19442    1 ENDIVHQPRD-MGHLQVDYREGSRPHPSEDSSLHsVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47086391    977 LVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQT 1026
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQT 129
IGFBP pfam00219
Insulin-like growth factor binding protein;
33-84 3.53e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 3.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 47086391     33 PCDKSKC-EEPKPCTGSVVLGICGCCSVCAKQKNESCGgvyGLYGTCDRGLRC 84
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCG---VYTPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 812-866 7.87e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 7.87e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    812 CHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTV--EGSCCPMC 866
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 31-89 2.78e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.22  E-value: 2.78e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086391      31 CLPCDKSKC-EEPKPCTGSVVLGICGCCSVCAKQKNESCgGVYGLYgtCDRGLRCVIRPP 89
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPC-GVYTPR--CAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 678-729 2.79e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.79e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    678 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQ--DSCCPHC 729
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
330-384 2.87e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.87e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     330 CTLNGVEYHDGDMFRMDACRFCRCQGGVSV-CFTAQCG-VLHCERYY--VPDGECCPVC 384
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPpPPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 751-803 6.63e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 6.63e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 47086391    751 EDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNC--ARPVLRKGQCCPYC 803
Cdd:pfam00093    3 QNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-803 1.38e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.38e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 47086391     752 DGDIFLAAESWKPNVCSSCVCLDGA-ISCFSESCPPV-NCARPVLRK--GQCCPYC 803
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 330-384 1.76e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    330 CTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCE--RYYVPDGECCPVC 384
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 607-657 2.99e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    607 DGRRHENGQSWH-DGCRDCYCHAGREMCALISCPVPPCDNPT--IRPGHCCPTC 657
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
812-866 3.49e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.49e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     812 CHFNGKTYMDEERWDIDSCTHCYCLQGQT-LCSTVSCP-ALPCHQP--LTVEGSCCPMC 866
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPpPPDCPNPerVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
678-729 1.04e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 1.04e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 47086391     678 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCHSPIRTQ--DSCCPHC 729
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 561-586 1.33e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    561 CPELPCDKACPMGFQHDELGCLICQC 586
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
VWC smart00214
von Willebrand factor (vWF) type C domain;
397-450 2.28e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.28e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     397 CYVNGQILAHGDHWREDDCTFCQCVSGD-ARCVAAAC--GHSCLNPVT--VPGECCPVC 450
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECppPPDCPNPERvkPPGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 506-526 4.90e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 4.90e-03
                           10        20
                   ....*....|....*....|.
gi 47086391    506 CTLKCPFGFQTDIHGCDVCQC 526
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 397-450 5.79e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 5.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    397 CYVNGQILAHGDHWREDDCTFCQCVSGDARCVAAACGH-SCLNP--VTVPGECCPVC 450
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 533-558 6.20e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 6.20e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    533 CKAVACAKDCPFGYIKNKHGCDTCRC 558
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Name Accession Description Interval E-value
CRIM1_C pfam19442
Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) ...
 898-1026 1.54e-66

Cysteine-rich motor neuron 1 protein C-terminal; Cysteine-rich motor neuron 1 protein (CRIM1) interacts with growth factors implicated in motor neuron differentiation and survival, playing a role in central nervous system development. It is upregulated in endothelial cells during tube formation. CRIM1 also modulates BMP activity, which affects its processing and delivery to the cell surface. This is CRIM1 C-terminal domain containing the transmembrane region.


Pssm-ID: 437274  Cd Length: 130  Bit Score: 219.34  E-value: 1.54e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086391    898 ENDVMPQFRGeFGSLQMPYLDGKTPLPSEDAGLH-WAWVALPVLMMMLTLAALLLVNQRKQWIPVPCYRTPNKSTCLNNQ 976
Cdd:pfam19442    1 ENDIVHQPRD-MGHLQVDYREGSRPHPSEDSSLHsVAWVTVPIMIALVLIIALLLINQKKQWIPVPCYRTPTKPSCLNNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 47086391    977 LVYVDCQKGTKVQVDSSQRMLRIADPDSRYSGYYSMQKHNNLQADNFYQT 1026
Cdd:pfam19442   80 LVYVDCKKGTMVQVDSSQRMLRIADPDSRYSGFYSMQKQNNLQADNFYQT 129
IGFBP pfam00219
Insulin-like growth factor binding protein;
33-84 3.53e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 47.70  E-value: 3.53e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 47086391     33 PCDKSKC-EEPKPCTGSVVLGICGCCSVCAKQKNESCGgvyGLYGTCDRGLRC 84
Cdd:pfam00219    4 PCDPERCpPPPPGCPAGVVLDGCGCCKVCARQEGEPCG---VYTPPCGKGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 812-866 7.87e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 7.87e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    812 CHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCHQPLTV--EGSCCPMC 866
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 31-89 2.78e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 43.22  E-value: 2.78e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086391      31 CLPCDKSKC-EEPKPCTGSVVLGICGCCSVCAKQKNESCgGVYGLYgtCDRGLRCVIRPP 89
Cdd:smart00121    3 CPPCDPARCpPCPPGCAELVRLDGCGCCPVCARQEGEPC-GVYTPR--CAPGLRCQPPPG 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 678-729 2.79e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.79e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    678 GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCHSPIRTQ--DSCCPHC 729
Cdd:pfam00093    4 NGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLEIppGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
330-384 2.87e-05

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 42.50  E-value: 2.87e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     330 CTLNGVEYHDGDMFRMDACRFCRCQGGVSV-CFTAQCG-VLHCERYY--VPDGECCPVC 384
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPpPPDCPNPErvKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 751-803 6.63e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.64  E-value: 6.63e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 47086391    751 EDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNC--ARPVLRKGQCCPYC 803
Cdd:pfam00093    3 QNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCpnPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-803 1.38e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.38e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 47086391     752 DGDIFLAAESWKPNVCSSCVCLDGA-ISCFSESCPPV-NCARPVLRK--GQCCPYC 803
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKppGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 330-384 1.76e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 40.49  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    330 CTLNGVEYHDGDMFRMDACRFCRCQGGVSVCFTAQCGVLHCE--RYYVPDGECCPVC 384
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 607-657 2.99e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 47086391    607 DGRRHENGQSWH-DGCRDCYCHAGREMCALISCPVPPCDNPT--IRPGHCCPTC 657
Cdd:pfam00093    4 NGVVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
812-866 3.49e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.49e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     812 CHFNGKTYMDEERWDIDSCTHCYCLQGQT-LCSTVSCP-ALPCHQP--LTVEGSCCPMC 866
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECPpPPDCPNPerVKPPGECCPRC 59
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 830-866 9.18e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.76  E-value: 9.18e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 47086391    830 CTHCYC---LQGQTLCSTVS--CPALPCHQPLTVEGSCCPMC 866
Cdd:pfam14828  194 PSGCGCgndENLERICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC smart00214
von Willebrand factor (vWF) type C domain;
678-729 1.04e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 1.04e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 47086391     678 GGEYFVEGETWNIDSCTQCTCHSGR-VLCETEVCPP-LLCHSPIRTQ--DSCCPHC 729
Cdd:smart00214    4 NGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKppGECCPRC 59
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 561-586 1.33e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 37.15  E-value: 1.33e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    561 CPELPCDKACPMGFQHDELGCLICQC 586
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 669-729 1.91e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.99  E-value: 1.91e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47086391    669 SEASVCLAPGGEYFVEGETWNIDsCTQCTCHSGRVL---C--ETEVCPPLLCHSPIRTQDSCCPHC 729
Cdd:pfam14828  171 SRLGQLQFHGAGALRVGPEACSD-PSGCGCGNDENLeriCanVLQRCPPPHCLSPLRPEGHCCDVC 235
VWC smart00214
von Willebrand factor (vWF) type C domain;
397-450 2.28e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 2.28e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 47086391     397 CYVNGQILAHGDHWREDDCTFCQCVSGD-ARCVAAAC--GHSCLNPVT--VPGECCPVC 450
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECppPPDCPNPERvkPPGECCPRC 59
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 621-657 3.31e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 41.22  E-value: 3.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 47086391    621 CRD---CYCH---AGREMCA--LISCPVPPCDNPtIRP-GHCCPTC 657
Cdd:pfam14828  191 CSDpsgCGCGndeNLERICAnvLQRCPPPHCLSP-LRPeGHCCDVC 235
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 506-526 4.90e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 4.90e-03
                           10        20
                   ....*....|....*....|.
gi 47086391    506 CTLKCPFGFQTDIHGCDVCQC 526
Cdd:pfam02822    6 CRLKCPYGFQTDENGCPTCEC 26
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 397-450 5.79e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 5.79e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 47086391    397 CYVNGQILAHGDHWREDDCTFCQCVSGDARCVAAACGH-SCLNP--VTVPGECCPVC 450
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPlDCPNPrlEIPPGECCPVC 57
Antistasin pfam02822
Antistasin family; Members of this family are inhibitors of trypsin family proteases. This ...
 533-558 6.20e-03

Antistasin family; Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.


Pssm-ID: 460713  Cd Length: 26  Bit Score: 35.23  E-value: 6.20e-03
                           10        20
                   ....*....|....*....|....*.
gi 47086391    533 CKAVACAKDCPFGYIKNKHGCDTCRC 558
Cdd:pfam02822    1 CPPLNCRLKCPYGFQTDENGCPTCEC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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