|
Name |
Accession |
Description |
Interval |
E-value |
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
37-174 |
3.06e-22 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 89.69 E-value: 3.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 37 DTRSRTEEYKSWVLALLRKHGVQ--RVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYAlKERWERRKETafdnwvIE 114
Cdd:COG2227 2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA-RERAAELNVD------FV 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 115 EANWLTLPEdvkkPGDGFDAVICLgNSFAHLPdfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:COG2227 75 QGDLEDLPL----EDGSFDLVICS-EVLEHLP-------DPAALLRELARLLKPGGLLLL 122
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
61-170 |
1.25e-17 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 76.06 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 61 VLDVACGTGVDSIMLVEE-GFSVVSVDASDKMLKYAlKERWERRKEtafdNWVIEEANWLTLPEdvkkPGDGFDAVICLG 139
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-RERAAEAGL----NVEFVQGDAEDLPF----PDGSFDLVVSSG 71
|
90 100 110
....*....|....*....|....*....|.
gi 47086405 140 nSFAHLPDfkgdqSDQKLALQNIGSMVKPGG 170
Cdd:pfam13649 72 -VLHHLPD-----PDLEAALREIARVLKPGG 96
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
60-174 |
1.35e-13 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 65.53 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 60 RVLDVACGTGVDSIMLVE-EGFSVVSVDASDKMLKYAlKERWERRKEtafDNWVIEEANWLTLPEDvkkPGDGFDAVICl 138
Cdd:cd02440 1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELA-RKAAAALLA---DNVEVLKGDAEELPPE---ADESFDVIIS- 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 47086405 139 GNSFAHLPDfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:cd02440 73 DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
|
|
| PRK07580 |
PRK07580 |
Mg-protoporphyrin IX methyl transferase; Validated |
22-167 |
8.58e-09 |
|
Mg-protoporphyrin IX methyl transferase; Validated
Pssm-ID: 236059 [Multi-domain] Cd Length: 230 Bit Score: 54.84 E-value: 8.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 22 YADGKAAKVwQLYIGDTRSRT-EEYKSWVLALLRKHGvQRVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYALkerw 100
Cdd:PRK07580 29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTG-LRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEAR---- 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47086405 101 ERRKETAFDNWVIEEANWLtlpEDVKKPgdgFDAVICLgNSFAHLPdfkgdQSDQKLALQNIGSMVK 167
Cdd:PRK07580 103 ERAPEAGLAGNITFEVGDL---ESLLGR---FDTVVCL-DVLIHYP-----QEDAARMLAHLASLTR 157
|
|
| MenG_MenH_UbiE |
TIGR01934 |
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ... |
52-174 |
7.38e-06 |
|
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273884 [Multi-domain] Cd Length: 223 Bit Score: 46.10 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 52 LLRKHGVQRVLDVACGTGVDSIML---VEEGFSVVSVDASDKMLKYAlkerweRRKETAFDNWVIEEANWLTLP-EDvkk 127
Cdd:TIGR01934 34 LIGVFKGQKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVA------KKKSELPLNIEFIQADAEALPfED--- 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 47086405 128 pgDGFDAVIClgnSFAhLPDFkgdqSDQKLALQNIGSMVKPGGILII 174
Cdd:TIGR01934 105 --NSFDAVTI---AFG-LRNV----TDIQKALREMYRVLKPGGRLVI 141
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
37-174 |
3.06e-22 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 89.69 E-value: 3.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 37 DTRSRTEEYKSWVLALLRKHGVQ--RVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYAlKERWERRKETafdnwvIE 114
Cdd:COG2227 2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA-RERAAELNVD------FV 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 115 EANWLTLPEdvkkPGDGFDAVICLgNSFAHLPdfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:COG2227 75 QGDLEDLPL----EDGSFDLVICS-EVLEHLP-------DPAALLRELARLLKPGGLLLL 122
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
37-174 |
4.89e-20 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 84.28 E-value: 4.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 37 DTRSRTEEYKSWVLALLRKHGVQRVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYAlkerwERRKETAFDNWVIEEA 116
Cdd:COG2226 2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-----RERAAEAGLNVEFVVG 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 47086405 117 NWLTLPEdvkkPGDGFDAVICLgNSFAHLPdfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:COG2226 77 DAEDLPF----PDGSFDLVISS-FVLHHLP-------DPERALAEIARVLKPGGRLVV 122
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
61-170 |
1.25e-17 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 76.06 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 61 VLDVACGTGVDSIMLVEE-GFSVVSVDASDKMLKYAlKERWERRKEtafdNWVIEEANWLTLPEdvkkPGDGFDAVICLG 139
Cdd:pfam13649 1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-RERAAEAGL----NVEFVQGDAEDLPF----PDGSFDLVVSSG 71
|
90 100 110
....*....|....*....|....*....|.
gi 47086405 140 nSFAHLPDfkgdqSDQKLALQNIGSMVKPGG 170
Cdd:pfam13649 72 -VLHHLPD-----PDLEAALREIARVLKPGG 96
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
20-180 |
8.17e-17 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 76.58 E-value: 8.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 20 DQYADgkaakVWQLYIGDTR--SRTEEYKSWVLALLRKHGVQRVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYAlk 97
Cdd:COG4976 12 DQYAD-----SYDAALVEDLgyEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKA-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 98 erweRRKEtAFDNWVIEEANwltlpeDVKKPGDGFDAVICLGnSFAHLPdfkgdqsDQKLALQNIGSMVKPGGILIIDHR 177
Cdd:COG4976 85 ----REKG-VYDRLLVADLA------DLAEPDGRFDLIVAAD-VLTYLG-------DLAAVFAGVARALKPGGLFIFSVE 145
|
...
gi 47086405 178 NYD 180
Cdd:COG4976 146 DAD 148
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
52-174 |
4.89e-15 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 71.11 E-value: 4.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 52 LLRKHGV---QRVLDVACGTGVDSIMLVEE-GFSVVSVDASDKMLKYAlKERWERRKETafDNWVIEEANWLTLPEDvkk 127
Cdd:COG2230 43 ILRKLGLkpgMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYA-RERAAEAGLA--DRVEVRLADYRDLPAD--- 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 47086405 128 pgDGFDAVICLGnSFAHLPDfkgdqSDQKLALQNIGSMVKPGGILII 174
Cdd:COG2230 117 --GQFDAIVSIG-MFEHVGP-----ENYPAYFAKVARLLKPGGRLLL 155
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
60-174 |
1.35e-13 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 65.53 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 60 RVLDVACGTGVDSIMLVE-EGFSVVSVDASDKMLKYAlKERWERRKEtafDNWVIEEANWLTLPEDvkkPGDGFDAVICl 138
Cdd:cd02440 1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELA-RKAAAALLA---DNVEVLKGDAEELPPE---ADESFDVIIS- 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 47086405 139 GNSFAHLPDfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:cd02440 73 DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
60-176 |
2.59e-13 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 66.29 E-value: 2.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 60 RVLDVACGTGVDSIMLVEEGFS---VVSVDASDKMLKYALkerwERRKETAFDNWVIEEANWLTLPEDVKKpgDGFDAVI 136
Cdd:pfam13847 6 RVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKAR----ENAQKLGFDNVEFEQGDIEELPELLED--DKFDVVI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 47086405 137 CLGnSFAHLPdfkgdqsDQKLALQNIGSMVKPGGILIIDH 176
Cdd:pfam13847 80 SNC-VLNHIP-------DPDKVLQEILRVLKPGGRLIISD 111
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
60-176 |
6.03e-13 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 63.69 E-value: 6.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 60 RVLDVACGTGVDSIMLVEE--GFSVVSVDASDKMLKYAlkerweRRKetaFDNWVIEEANWLTLPedvkkPGDGFDAVIC 137
Cdd:COG4106 4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARA------RAR---LPNVRFVVADLRDLD-----PPEPFDLVVS 69
|
90 100 110
....*....|....*....|....*....|....*....
gi 47086405 138 lGNSFAHLPDFKGdqsdqklALQNIGSMVKPGGILIIDH 176
Cdd:COG4106 70 -NAALHWLPDHAA-------LLARLAAALAPGGVLAVQV 100
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
62-174 |
4.47e-12 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 61.14 E-value: 4.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 62 LDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYAlkerwERRKETAFDNWVIEEANWLTLPEDVkkpgdgFDAVICLgNS 141
Cdd:pfam08241 1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELA-----REKAPREGLTFVVGDAEDLPFPDNS------FDLVLSS-EV 68
|
90 100 110
....*....|....*....|....*....|...
gi 47086405 142 FAHLPdfkgdqsDQKLALQNIGSMVKPGGILII 174
Cdd:pfam08241 69 LHHVE-------DPERALREIARVLKPGGILII 94
|
|
| Methyltransf_23 |
pfam13489 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
41-202 |
6.53e-11 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 404385 [Multi-domain] Cd Length: 162 Bit Score: 59.75 E-value: 6.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 41 RTEEYKSWVLALLRKHGVQ-RVLDVACGTGVDSIMLVEEGFSVVSVDASDKMlkyalkerwerrKETAFDNWVIEEANwl 119
Cdd:pfam13489 5 RERLLADLLLRLLPKLPSPgRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA------------IERALLNVRFDQFD-- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 120 tlPEDVKKPGDGFDAVICLgNSFAHLPDFKGdqsdqklALQNIGSMVKPGG-ILIIDHRNYDYIIE-----TGQVPQGKN 193
Cdd:pfam13489 71 --EQEAAVPAGKFDVIVAR-EVLEHVPDPPA-------LLRQIAALLKPGGlLLLSTPLASDEADRlllewPYLRPRNGH 140
|
170
....*....|.
gi 47086405 194 IYYKS--DLKQ 202
Cdd:pfam13489 141 ISLFSarSLKR 151
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
50-180 |
1.73e-10 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 59.16 E-value: 1.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 50 LALLRKHGvqRVLDVACGTGVDSIMLVEE-GFSVVSVDASDKMLKYAlkeRwERRKETAFDNWVIEEANWLTLPEDvkkP 128
Cdd:COG0500 21 LERLPKGG--RVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALA---R-ARAAKAGLGNVEFLVADLAELDPL---P 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 47086405 129 GDGFDAVICLGnSFAHLPdfkgdQSDQKLALQNIGSMVKPGGILIIDHRNYD 180
Cdd:COG0500 92 AESFDLVVAFG-VLHHLP-----PEEREALLRELARALKPGGVLLLSASDAA 137
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
62-172 |
1.88e-10 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 56.61 E-value: 1.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 62 LDVACGTGVDSIMLVEE--GFSVVSVDASDKMLKYALkerwERRKETAFDNWVIEEanwLTLPEDVKKPGDGFDAVICLg 139
Cdd:pfam08242 1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAAR----ERLAALGLLNAVRVE---LFQLDLGELDPGSFDVVVAS- 72
|
90 100 110
....*....|....*....|....*....|...
gi 47086405 140 NSFAHLPDFKGdqsdqklALQNIGSMVKPGGIL 172
Cdd:pfam08242 73 NVLHHLADPRA-------VLRNIRRLLKPGGVL 98
|
|
| PRK07580 |
PRK07580 |
Mg-protoporphyrin IX methyl transferase; Validated |
22-167 |
8.58e-09 |
|
Mg-protoporphyrin IX methyl transferase; Validated
Pssm-ID: 236059 [Multi-domain] Cd Length: 230 Bit Score: 54.84 E-value: 8.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 22 YADGKAAKVwQLYIGDTRSRT-EEYKSWVLALLRKHGvQRVLDVACGTGVDSIMLVEEGFSVVSVDASDKMLKYALkerw 100
Cdd:PRK07580 29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTG-LRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEAR---- 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47086405 101 ERRKETAFDNWVIEEANWLtlpEDVKKPgdgFDAVICLgNSFAHLPdfkgdQSDQKLALQNIGSMVK 167
Cdd:PRK07580 103 ERAPEAGLAGNITFEVGDL---ESLLGR---FDTVVCL-DVLIHYP-----QEDAARMLAHLASLTR 157
|
|
| ubiE |
PRK00216 |
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ... |
59-174 |
2.66e-08 |
|
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;
Pssm-ID: 234689 [Multi-domain] Cd Length: 239 Bit Score: 53.62 E-value: 2.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 59 QRVLDVACGTGVDSIMLVEEG---FSVVSVDASDKMLKYAlKERWERRKETAFDNWVIEEANWLTLPEDVkkpgdgFDAV 135
Cdd:PRK00216 53 DKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVG-REKLRDLGLSGNVEFVQGDAEALPFPDNS------FDAV 125
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 47086405 136 -ICLG--NsfahLPDFkgdqsdqKLALQNIGSMVKPGGILII 174
Cdd:PRK00216 126 tIAFGlrN----VPDI-------DKALREMYRVLKPGGRLVI 156
|
|
| PRK08317 |
PRK08317 |
hypothetical protein; Provisional |
43-183 |
2.72e-08 |
|
hypothetical protein; Provisional
Pssm-ID: 181382 [Multi-domain] Cd Length: 241 Bit Score: 53.40 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 43 EEYKSWVLALLRKHGVQRVLDVACGTGVDSIML---VEEGFSVVSVDASDKMLKYAlKERWErrKETAFDNWVIEEANWL 119
Cdd:PRK08317 5 RRYRARTFELLAVQPGDRVLDVGCGPGNDARELarrVGPEGRVVGIDRSEAMLALA-KERAA--GLGPNVEFVRGDADGL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086405 120 TLPEDVkkpgdgFDAVICLgNSFAHLPDFKGdqsdqklALQNIGSMVKPGGILIIDHRNYDYII 183
Cdd:PRK08317 82 PFPDGS------FDAVRSD-RVLQHLEDPAR-------ALAEIARVLRPGGRVVVLDTDWDTLV 131
|
|
| MenG_MenH_UbiE |
TIGR01934 |
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ... |
52-174 |
7.38e-06 |
|
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273884 [Multi-domain] Cd Length: 223 Bit Score: 46.10 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 52 LLRKHGVQRVLDVACGTGVDSIML---VEEGFSVVSVDASDKMLKYAlkerweRRKETAFDNWVIEEANWLTLP-EDvkk 127
Cdd:TIGR01934 34 LIGVFKGQKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVA------KKKSELPLNIEFIQADAEALPfED--- 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 47086405 128 pgDGFDAVIClgnSFAhLPDFkgdqSDQKLALQNIGSMVKPGGILII 174
Cdd:TIGR01934 105 --NSFDAVTI---AFG-LRNV----TDIQKALREMYRVLKPGGRLVI 141
|
|
| Ubie_methyltran |
pfam01209 |
ubiE/COQ5 methyltransferase family; |
59-188 |
3.65e-05 |
|
ubiE/COQ5 methyltransferase family;
Pssm-ID: 395966 [Multi-domain] Cd Length: 228 Bit Score: 43.97 E-value: 3.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 59 QRVLDVACGTGVDSIML---VEEGFSVVSVDASDKMLKYALKerweRRKETAFDNWVIEEANWLTLPEdvkkPGDGFDAV 135
Cdd:pfam01209 44 NKFLDVAGGTGDWTFGLsdsAGSSGKVVGLDINENMLKEGEK----KAKEEGKYNIEFLQGNAEELPF----EDDSFDIV 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 47086405 136 IClgnSFAhLPDFkgdqSDQKLALQNIGSMVKPGGILiidhrnydYIIETGQV 188
Cdd:pfam01209 116 TI---SFG-LRNF----PDYLKVLKEAFRVLKPGGRV--------VCLEFSKP 152
|
|
| TrmR |
COG4122 |
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ... |
52-176 |
1.41e-04 |
|
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443298 Cd Length: 173 Bit Score: 41.71 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 52 LLRKHGVQRVLDVACGTGVDSIMLVE---EGFSVVSVDASDKMLKYAlKERWERRKETafDNWVIEEANWL-TLPEDVKK 127
Cdd:COG4122 11 LARLLGAKRILEIGTGTGYSTLWLARalpDDGRLTTIEIDPERAAIA-RENFARAGLA--DRIRLILGDALeVLPRLADG 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 47086405 128 PgdgFDAVIClgnsfahlpDfkGDQSDQKLALQNIGSMVKPGGILIIDH 176
Cdd:COG4122 88 P---FDLVFI---------D--ADKSNYPDYLELALPLLRPGGLIVADN 122
|
|
| HemK |
COG2890 |
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ... |
39-137 |
1.64e-04 |
|
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442135 [Multi-domain] Cd Length: 282 Bit Score: 42.44 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 39 RSRTEEYKSWVLALLRKHGVQRVLDVACGTGVDSIMLVEE--GFSVVSVDASDKMLKYAlkerweRR--KETAFDNWV-I 113
Cdd:COG2890 94 RPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVA------RRnaERLGLEDRVrF 167
|
90 100
....*....|....*....|....*
gi 47086405 114 EEANWLT-LPEDVKkpgdgFDAVIC 137
Cdd:COG2890 168 LQGDLFEpLPGDGR-----FDLIVS 187
|
|
| Trm11 |
COG1041 |
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ... |
60-186 |
2.48e-04 |
|
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 440663 [Multi-domain] Cd Length: 172 Bit Score: 41.09 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 60 RVLDVACGTGVdsiMLVEE---GFSVVSVDASDKMLKYAlkerweRR--KETAFDNWVIEEANWLTLPEdvkkPGDGFDA 134
Cdd:COG1041 29 TVLDPFCGTGT---ILIEAgllGRRVIGSDIDPKMVEGA------REnlEHYGYEDADVIRGDARDLPL----ADESVDA 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47086405 135 VIC----------LGNSFAHLpdFKGdqsdqklALQNIGSMVKPGGILII--DHRNYDYIIETG 186
Cdd:COG1041 96 IVTdppygrsskiSGEELLEL--YEK-------ALEEAARVLKPGGRVVIvtPRDIDELLEEAG 150
|
|
| PRK09328 |
PRK09328 |
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional |
39-137 |
2.77e-04 |
|
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
Pssm-ID: 236467 [Multi-domain] Cd Length: 275 Bit Score: 41.69 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 39 RSRTEEYKSWVLALLRKHGVQRVLDVACGTGVDSIMLVEE--GFSVVSVDASDKMLKYAlkerweRR--KETAFDNWVIE 114
Cdd:PRK09328 90 RPETEELVEWALEALLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALAVA------RRnaKHGLGARVEFL 163
|
90 100
....*....|....*....|...
gi 47086405 115 EANWLTlpedvKKPGDGFDAVIC 137
Cdd:PRK09328 164 QGDWFE-----PLPGGRFDLIVS 181
|
|
| BioC |
TIGR02072 |
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ... |
50-226 |
8.67e-04 |
|
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Pssm-ID: 273953 [Multi-domain] Cd Length: 240 Bit Score: 39.96 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 50 LALLRKHGV---QRVLDVACGTGVDSIMLVEEgFSVVSVDA---SDKMLKYAlkerweRRKETAFDNWVIEEANWLTLPE 123
Cdd:TIGR02072 24 LALLKEKGIfipASVLDIGCGTGYLTRALLKR-FPQAEFIAldiSAGMLAQA------KTKLSENVQFICGDAEKLPLED 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 124 DVkkpgdgFDAVIClgNS-FAHLPDFKGdqsdqklALQNIGSMVKPGGILIIDHRNYDYIIETGQVPQGKNIYYKS--DL 200
Cdd:TIGR02072 97 SS------FDLIVS--NLaLQWCDDLSQ-------ALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQHGLRYLSldEL 161
|
170 180
....*....|....*....|....*...
gi 47086405 201 KQ--DISTSVLWVNSKPhmITLDYTLVL 226
Cdd:TIGR02072 162 KAllKNSFELLTLEEEL--ITLSFDDPL 187
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
51-136 |
1.81e-03 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 38.73 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 51 ALLRKHGvQRVLDVACGTGVDSIMLVEEGFSVVSVDASDkmlkYALKERWERRKETAFDNWVIE--EANwltLPEDVKkp 128
Cdd:PRK14968 18 NAVDKKG-DRVLEVGTGSGIVAIVAAKNGKKVVGVDINP----YAVECAKCNAKLNNIRNNGVEviRSD---LFEPFR-- 87
|
....*...
gi 47086405 129 GDGFDAVI 136
Cdd:PRK14968 88 GDKFDVIL 95
|
|
| Rsm22 |
COG5459 |
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ... |
47-174 |
3.92e-03 |
|
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins
Pssm-ID: 444210 [Multi-domain] Cd Length: 306 Bit Score: 38.40 E-value: 3.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 47 SWVLALLRKHGV----QRVLDVACGTGVDSI---MLVEEGFSVVSVDASDKMLkyalkeRWERRKETAFDNWVIEEANWl 119
Cdd:COG5459 66 RAALAELAEAGPdfapLTVLDVGAGPGTAAWaaaDAWPSLLDATLLERSAAAL------ALGRRLARAAANPALETAEW- 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 47086405 120 tLPEDVKK--PGDGFDAVIClGNSFAHLPDfkgdqsDQKLALqnIGSM-VKPGGILII 174
Cdd:COG5459 139 -RLADLAAalPAPPADLVVA-SYVLNELAD------AARAAL--VDRLwLAPDGALLI 186
|
|
| PRK06922 |
PRK06922 |
class I SAM-dependent methyltransferase; |
34-174 |
4.82e-03 |
|
class I SAM-dependent methyltransferase;
Pssm-ID: 180751 [Multi-domain] Cd Length: 677 Bit Score: 38.31 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 34 YIGDTRSrTEEYKSWVLALLRKhgvQRVLDVACGTGVDSIMLVEE--GFSVVSVDASDKMLkyalkERWERRKETAFDNW 111
Cdd:PRK06922 399 YLEHMNS-SADDKRIILDYIKG---DTIVDVGAGGGVMLDMIEEEteDKRIYGIDISENVI-----DTLKKKKQNEGRSW 469
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47086405 112 VIEEANWLTLPEDVKKpgDGFDAVI---CLGNSFAHLPdFKGDQSDQ---KLALQNIGSMVKPGGILII 174
Cdd:PRK06922 470 NVIKGDAINLSSSFEK--ESVDTIVyssILHELFSYIE-YEGKKFNHeviKKGLQSAYEVLKPGGRIII 535
|
|
| RlmK |
COG1092 |
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ... |
59-173 |
7.18e-03 |
|
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 440709 [Multi-domain] Cd Length: 392 Bit Score: 37.47 E-value: 7.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086405 59 QRVLDVACGTGvdsimlveeGFS----------VVSVDASDKMLKYA--------LKERWERRKETAFDnwvieeanWLt 120
Cdd:COG1092 218 KRVLNLFSYTG---------GFSvhaaaggaksVTSVDLSATALEWAkenaalngLDDRHEFVQADAFD--------WL- 279
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 47086405 121 lpEDVKKPGDGFDAVIC----LGNSFAHLPDFKGDQSD-QKLALQnigsMVKPGGILI 173
Cdd:COG1092 280 --RELAREGERFDLIILdppaFAKSKKDLFDAQRDYKDlNRLALK----LLAPGGILV 331
|
|
|