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Conserved domains on  [gi|78486586|ref|NP_997717|]
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bolA-like protein 3 isoform 1 [Homo sapiens]

Protein Classification

BolA family protein( domain architecture ID 1825)

BolA family protein may be a stress-responsive transcriptional regulator and may also participate in iron metabolism; similar to mammalian BolA-like protein 3 that acts as an iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins, and to Vibrio cholerae DNA-binding transcriptional regulator BolA

CATH:  3.30.300.90
Gene Ontology:  GO:0016226|GO:0106035
PubMed:  32910989
SCOP:  4003220

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BolA super family cl00386
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 40-106 5.06e-10

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


The actual alignment was detected with superfamily member pfam01722:

Pssm-ID: 469753  Cd Length: 75  Bit Score: 51.30  E-value: 5.06e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78486586    40 LKEKFPrATAIKVTDIS-------GGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIK-EMHGLRIFTSVPK 106
Cdd:pfam01722   1 LTEALA-PTHLEVEDEShkhaghaGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAgGIHALSIKTYTPE 74
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 40-106 5.06e-10

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 51.30  E-value: 5.06e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78486586    40 LKEKFPrATAIKVTDIS-------GGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIK-EMHGLRIFTSVPK 106
Cdd:pfam01722   1 LTEALA-PTHLEVEDEShkhaghaGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAgGIHALSIKTYTPE 74
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
36-106 8.09e-09

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 48.22  E-value: 8.09e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78486586  36 VTQILKEKFPRATaIKVTdisgGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIK--EMHGLRIFTSVPK 106
Cdd:COG5007   6 IKQLIEAGLPCAE-VEVE----GDGSHFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIAsgEIHALSIKTYTPE 73
 
Name Accession Description Interval E-value
BolA pfam01722
BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various ...
 40-106 5.06e-10

BolA-like protein; This family consist of the morphoprotein BolA from E. coli and its various homologs. In E. coli over expression of this protein causes round morphology and may be involved in switching the cell between elongation and septation systems during cell division. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase. BolA is also induced by stress during early stages of growth and may have a general role in stress response. It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5.


Pssm-ID: 460305  Cd Length: 75  Bit Score: 51.30  E-value: 5.06e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78486586    40 LKEKFPrATAIKVTDIS-------GGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIK-EMHGLRIFTSVPK 106
Cdd:pfam01722   1 LTEALA-PTHLEVEDEShkhaghaGGGETHFKVVIVSDAFEGKSLVARHRLVYDALADELAgGIHALSIKTYTPE 74
IbaG COG5007
Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];
36-106 8.09e-09

Acid stress protein IbaG/YrbA, BolA-like family [Signal transduction mechanisms];


Pssm-ID: 444031  Cd Length: 81  Bit Score: 48.22  E-value: 8.09e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78486586  36 VTQILKEKFPRATaIKVTdisgGCGAMYEIKIESEEFKEKRTVQQHQMVNQALKEEIK--EMHGLRIFTSVPK 106
Cdd:COG5007   6 IKQLIEAGLPCAE-VEVE----GDGSHFEAIVVSDAFEGLSRVKRQQLVYAPLGDYIAsgEIHALSIKTYTPE 73
BolA COG0271
DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and ...
 35-106 3.77e-08

DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation [Transcription, Signal transduction mechanisms];


Pssm-ID: 440041  Cd Length: 90  Bit Score: 46.72  E-value: 3.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78486586  35 RVTQILKEKFPrATAIKVTDIS-------GGCGAM-YEIKIESEEFKEKRTVQQHQMVNQALKEEIK-EMHGLRIFTSVP 105
Cdd:COG0271   6 RIEEKLTAALA-PEHLEVIDEShlhaghaGAGGEShFKVVIVSDAFAGKSRVARHRLVYAALADELAgGIHALAIHAYTP 84


                .
gi 78486586 106 K 106
Cdd:COG0271  85 E 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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