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Conserved domains on  [gi|45545437|ref|NP_996531|]
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citramalyl-CoA lyase, mitochondrial isoform 1 precursor [Homo sapiens]

Protein Classification

HpcH/HpaI aldolase/citrate lyase family protein( domain architecture ID 10006304)

HpcH/HpaI aldolase/citrate lyase family protein; similar to 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) aldolase (HpcH/HpaI) that catalyzes the reversible retro-aldol cleavage of HKHD to pyruvate and succinic semialdehyde, and to citrate lyase beta subunit CitE that is an enzymic subunit of citrate lyase, and cleaves citryl-CoA to oxaloacetate and acetyl CoA derivative

CATH:  3.20.20.60
Gene Ontology:  GO:0046872|GO:0016829
SCOP:  4003274

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
44-340 7.73e-99

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


:

Pssm-ID: 441876  Cd Length: 288  Bit Score: 293.60  E-value: 7.73e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437  44 PRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETL 123
Cdd:COG2301   5 LRRSLLFVPGDRPRRLAKALASGADAVILDLEDAVAPDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 124 LQSRvlPSSLMLPKVESPEEIQWFADKFSFHlkgRKLEQPMNLIPFVETAMGLLNfkavCEETLKVGPQVglflDAVVFG 203
Cdd:COG2301  85 VGAG--LDGIVLPKVESAEDVRALAALLTEL---EAEGGSIPLMALIETARGLLN----AAEIAAASPRV----EALVFG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 204 GEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQ 283
Cdd:COG2301 152 AEDLAADLGARRTRDGDELLYARSRIVLAARAAGLAAIDGVYTDFRDLEGLRAEARRARALGFDGKTAIHPSQIAVINEA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45545437 284 FSPSPEKIKWAEELIAAFKEHQqlGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK 340
Cdd:COG2301 232 FAPSEEEVAWARRILAAFEEAE--AKGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
 
Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
44-340 7.73e-99

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 293.60  E-value: 7.73e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437  44 PRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETL 123
Cdd:COG2301   5 LRRSLLFVPGDRPRRLAKALASGADAVILDLEDAVAPDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 124 LQSRvlPSSLMLPKVESPEEIQWFADKFSFHlkgRKLEQPMNLIPFVETAMGLLNfkavCEETLKVGPQVglflDAVVFG 203
Cdd:COG2301  85 VGAG--LDGIVLPKVESAEDVRALAALLTEL---EAEGGSIPLMALIETARGLLN----AAEIAAASPRV----EALVFG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 204 GEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQ 283
Cdd:COG2301 152 AEDLAADLGARRTRDGDELLYARSRIVLAARAAGLAAIDGVYTDFRDLEGLRAEARRARALGFDGKTAIHPSQIAVINEA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45545437 284 FSPSPEKIKWAEELIAAFKEHQqlGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK 340
Cdd:COG2301 232 FAPSEEEVAWARRILAAFEEAE--AKGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
46-274 1.99e-48

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 162.14  E-value: 1.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437    46 RAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDID---LGPTEKCVRVNSVSSGLAEEDLET 122
Cdd:pfam03328   1 RSGLFLPGANPAMAEIAAIAGADWVVIDLEDAVALAEKDAARVLVPTALQQLDalaAAPSEVVVRVNSLDSPFGKQDLAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437   123 LlqsRVLPSSLMLPKVESPEEIQWFADKFSFHLKG-RKLEQPMNLIPFVETAMGLLNfkavCEETLKVGPqvglfLDAVV 201
Cdd:pfam03328  81 L---DLGAQVVLVPKVETAEDARAAVSAIRYPPKGiRRANGNTCLLAQIESALGVLN----ADEIAAVEG-----VDGIF 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45545437   202 FGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHP 274
Cdd:pfam03328 149 LGAEDLSADLGTLRSPGGPEVLYARERIVTAARAAGIAAFDTVYSDENDAEGFLAEGALFVALGFDGKLLINP 221
 
Name Accession Description Interval E-value
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
44-340 7.73e-99

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 293.60  E-value: 7.73e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437  44 PRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETL 123
Cdd:COG2301   5 LRRSLLFVPGDRPRRLAKALASGADAVILDLEDAVAPDEKDAARENVAEALAELDFGGPEVFVRINALDTPWGLDDLAAL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 124 LQSRvlPSSLMLPKVESPEEIQWFADKFSFHlkgRKLEQPMNLIPFVETAMGLLNfkavCEETLKVGPQVglflDAVVFG 203
Cdd:COG2301  85 VGAG--LDGIVLPKVESAEDVRALAALLTEL---EAEGGSIPLMALIETARGLLN----AAEIAAASPRV----EALVFG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437 204 GEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQ 283
Cdd:COG2301 152 AEDLAADLGARRTRDGDELLYARSRIVLAARAAGLAAIDGVYTDFRDLEGLRAEARRARALGFDGKTAIHPSQIAVINEA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45545437 284 FSPSPEKIKWAEELIAAFKEHQqlGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK 340
Cdd:COG2301 232 FAPSEEEVAWARRILAAFEEAE--AKGVVSLDGKMVDRPHLRRARRILARARAIGVR 286
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
46-274 1.99e-48

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 162.14  E-value: 1.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437    46 RAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDID---LGPTEKCVRVNSVSSGLAEEDLET 122
Cdd:pfam03328   1 RSGLFLPGANPAMAEIAAIAGADWVVIDLEDAVALAEKDAARVLVPTALQQLDalaAAPSEVVVRVNSLDSPFGKQDLAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45545437   123 LlqsRVLPSSLMLPKVESPEEIQWFADKFSFHLKG-RKLEQPMNLIPFVETAMGLLNfkavCEETLKVGPqvglfLDAVV 201
Cdd:pfam03328  81 L---DLGAQVVLVPKVETAEDARAAVSAIRYPPKGiRRANGNTCLLAQIESALGVLN----ADEIAAVEG-----VDGIF 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45545437   202 FGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHP 274
Cdd:pfam03328 149 LGAEDLSADLGTLRSPGGPEVLYARERIVTAARAAGIAAFDTVYSDENDAEGFLAEGALFVALGFDGKLLINP 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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