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Conserved domains on  [gi|45552579|ref|NP_995813|]
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schnurri, isoform D [Drosophila melanogaster]

Protein Classification

zf-H2C2_2 and zf-C2H2 domain-containing protein( domain architecture ID 12143109)

protein containing domains zf-H2C2_2, zf-C2H2, and zf-C2H2_8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1830-1855 3.48e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 3.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 45552579   1830 MLKKHIRTHTDVRPFTCSHCNFSFKT 1855
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1816-1838 1.37e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 45552579   1816 YVCSECGIRCKKPSMLKKHIRTH 1838
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1844-1868 2.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.09e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579   1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHL--RTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-523 4.25e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 4.25e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579    499 LEKHIRAHTNERPYPCDTCGIAFKT 523
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
1185-1269 9.10e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 44.71  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552579  1185 SLVLSRLSA--------AQTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVdy 1256
Cdd:PRK14951  355 TMVLLRLLAfkpaaaaeAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-- 432

                          90
                  ....*....|...
gi 45552579  1257 AQQSTPRKAQDSV 1269
Cdd:PRK14951  433 APAAAPAAAPAAV 445
zf-C2H2_8 super family cl25789
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 2305-2352 4.10e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


The actual alignment was detected with superfamily member pfam15909:

Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 4.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 45552579   2305 RPTCTMCSKTFQRQHQLTLHMNIHYM-ERKFKCEPCSISFRTQGHLQKH 2352
Cdd:pfam15909   37 RCSALSCTETFPSMQELVAHSKLHYKpNRYFKCENCLLRFRTHRSLFKH 85
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1830-1855 3.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 3.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 45552579   1830 MLKKHIRTHTDVRPFTCSHCNFSFKT 1855
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1816-1838 1.37e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 45552579   1816 YVCSECGIRCKKPSMLKKHIRTH 1838
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1844-1868 2.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.09e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579   1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHL--RTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-523 4.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 4.25e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579    499 LEKHIRAHTNERPYPCDTCGIAFKT 523
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1185-1269 9.10e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.71  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552579  1185 SLVLSRLSA--------AQTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVdy 1256
Cdd:PRK14951  355 TMVLLRLLAfkpaaaaeAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-- 432

                          90
                  ....*....|...
gi 45552579  1257 AQQSTPRKAQDSV 1269
Cdd:PRK14951  433 APAAAPAAAPAAV 445
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 2305-2352 4.10e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 4.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 45552579   2305 RPTCTMCSKTFQRQHQLTLHMNIHYM-ERKFKCEPCSISFRTQGHLQKH 2352
Cdd:pfam15909   37 RCSALSCTETFPSMQELVAHSKLHYKpNRYFKCENCLLRFRTHRSLFKH 85
ZnF_C2H2 smart00355
zinc finger;
1844-1868 4.38e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 4.38e-03
                            10        20
                    ....*....|....*....|....*
gi 45552579    1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:smart00355    1 YRCPECGKVFKSKSALREHM--RTH 23
ZnF_C2H2 smart00355
zinc finger;
1816-1838 5.88e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 5.88e-03
                            10        20
                    ....*....|....*....|...
gi 45552579    1816 YVCSECGIRCKKPSMLKKHIRTH 1838
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1830-1855 3.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 3.48e-05
                           10        20
                   ....*....|....*....|....*.
gi 45552579   1830 MLKKHIRTHTDVRPFTCSHCNFSFKT 1855
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1816-1838 1.37e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|...
gi 45552579   1816 YVCSECGIRCKKPSMLKKHIRTH 1838
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1844-1868 2.09e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 2.09e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579   1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHL--RTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-523 4.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 4.25e-04
                           10        20
                   ....*....|....*....|....*
gi 45552579    499 LEKHIRAHTNERPYPCDTCGIAFKT 523
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1185-1269 9.10e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.71  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552579  1185 SLVLSRLSA--------AQTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTPLVdy 1256
Cdd:PRK14951  355 TMVLLRLLAfkpaaaaeAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-- 432

                          90
                  ....*....|...
gi 45552579  1257 AQQSTPRKAQDSV 1269
Cdd:PRK14951  433 APAAAPAAAPAAV 445
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
1844-1868 2.56e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 2.56e-03
                           10        20
                   ....*....|....*....|....*
gi 45552579   1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHL--RKH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 2305-2352 4.10e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 4.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 45552579   2305 RPTCTMCSKTFQRQHQLTLHMNIHYM-ERKFKCEPCSISFRTQGHLQKH 2352
Cdd:pfam15909   37 RCSALSCTETFPSMQELVAHSKLHYKpNRYFKCENCLLRFRTHRSLFKH 85
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 2333-2359 4.13e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.76  E-value: 4.13e-03
                           10        20
                   ....*....|....*....|....*..
gi 45552579   2333 KFKCEPCSISFRTQGHLQKHERSEAHK 2359
Cdd:pfam12171    1 QFYCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_C2H2 smart00355
zinc finger;
1844-1868 4.38e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.67  E-value: 4.38e-03
                            10        20
                    ....*....|....*....|....*
gi 45552579    1844 FTCSHCNFSFKTKGNLTKHMqsKTH 1868
Cdd:smart00355    1 YRCPECGKVFKSKSALREHM--RTH 23
ZnF_C2H2 smart00355
zinc finger;
1816-1838 5.88e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 5.88e-03
                            10        20
                    ....*....|....*....|...
gi 45552579    1816 YVCSECGIRCKKPSMLKKHIRTH 1838
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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