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Conserved domains on  [gi|45387859|ref|NP_991290|]
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zinc finger protein ZIC 5 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 16062894)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 243-286 5.31e-24

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


:

Pssm-ID: 436441  Cd Length: 45  Bit Score: 94.38  E-value: 5.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45387859   243 QPIKQELICKWIDQEQTA-KKPCSKTFSTMHELVNHVTVEHVGGP 286
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPApKKPCNKTFSTMHEIVTHLTVEHVGGP 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-489 8.81e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 297 ECPREGKAFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSH 376
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 377 VHTSdkpYFCKVRGCDKSYTHPSSLRKHMKVHCKSPPPPSANTGSSYHPSSTTIGdaLSPNLDPHRNRSSNLSPQVTNLN 456
Cdd:COG5048 115 SNSN---DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS--LHPPLPANSLSKDPSSNLSLLIS 189

                       170       180       190
                ....*....|....*....|....*....|...
gi 45387859 457 EWYVCQGSAGPNNLHTPSSDVPTSESDDEDSFR 489
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 243-286 5.31e-24

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 94.38  E-value: 5.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45387859   243 QPIKQELICKWIDQEQTA-KKPCSKTFSTMHELVNHVTVEHVGGP 286
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPApKKPCNKTFSTMHEIVTHLTVEHVGGP 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-489 8.81e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 297 ECPREGKAFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSH 376
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 377 VHTSdkpYFCKVRGCDKSYTHPSSLRKHMKVHCKSPPPPSANTGSSYHPSSTTIGdaLSPNLDPHRNRSSNLSPQVTNLN 456
Cdd:COG5048 115 SNSN---DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS--LHPPLPANSLSKDPSSNLSLLIS 189

                       170       180       190
                ....*....|....*....|....*....|...
gi 45387859 457 EWYVCQGSAGPNNLHTPSSDVPTSESDDEDSFR 489
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 325-414 9.94e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 41.25  E-value: 9.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859   325 PCPFPGCGKVFARSENLKIHKRTHTGE------KPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYFcKVRGCDKSYTHP 398
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYF-KCENCLLRFRTH 79

                          90
                  ....*....|....*....
gi 45387859   399 SSLRKHMKV---HCKSPPP 414
Cdd:pfam15909  80 RSLFKHLHVcaeHAQSPAP 98
 
Name Accession Description Interval E-value
zf_ZIC pfam18366
Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family ...
 243-286 5.31e-24

Zic proteins zinc finger domain; This is the ZF1 (Zinc Finger 1) domain found in Zic family proteins found in Eukaryotes. In humans, there are five members of the Zic family that are involved in human congenital anomalies. One of them, ZIC3, causes X-linked heterotaxy (HTX1), which is a left-right axis disturbance that manifests as variable combinations of heart malformation, altered lung lobation, splenic abnormality and gastrointestinal malrotation. Zic faily proteins contain multiple zinc finger domains (ZFD), which are generally composed of five tandemly repeated C2H2 zinc finger (ZF) motifs. Sequence comparison analysis reveal that this N-terminal ZF (ZF1) domain of the Zic zinc finger domains is unique in that it possesses more amino acid residues (6-38 amino acids) between the two cysteine residues of the C2H2 motif compared to Gli and Glis ZF1s or any of the other ZFs (ZF2-5) in the Gli/Glis/Zic superfamily of proteins. Mutations in cysteine 253 (C253S) or histidine 286 (H286R) in ZIC3 ZF1, which are found in heterotaxy patients, result in extranuclear localization of the mutant ZIC3 protein. Furthermore, mutations in the evolutionarily conserved amino acid residues (C253, W255, C268, H281 and H286) of ZF1 generally impair nuclear localization.


Pssm-ID: 436441  Cd Length: 45  Bit Score: 94.38  E-value: 5.31e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45387859   243 QPIKQELICKWIDQEQTA-KKPCSKTFSTMHELVNHVTVEHVGGP 286
Cdd:pfam18366   1 QPIKQELSCKWIDPEQPApKKPCNKTFSTMHEIVTHLTVEHVGGP 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-489 8.81e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 297 ECPREGKAFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSH 376
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 377 VHTSdkpYFCKVRGCDKSYTHPSSLRKHMKVHCKSPPPPSANTGSSYHPSSTTIGdaLSPNLDPHRNRSSNLSPQVTNLN 456
Cdd:COG5048 115 SNSN---DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS--LHPPLPANSLSKDPSSNLSLLIS 189

                       170       180       190
                ....*....|....*....|....*....|...
gi 45387859 457 EWYVCQGSAGPNNLHTPSSDVPTSESDDEDSFR 489
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 320-406 1.82e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 320 GEKPFPCPFPGCGKVFARSENLKIHKRT-HtgekpfkcefdgCDRKFANSSDRKKHSHVHTSDKPYFCKVrgCDKSYTHP 398
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHgH------------QNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNL 411


                ....*...
gi 45387859 399 SSLRKHMK 406
Cdd:COG5189 412 NGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-422 6.22e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 211 SSSLHSYNSMNLNVNLATAPHGATGAFLRYMRQPIKQELICKWidqeqtakKPCSKTFSTMHELVNHVTVEHVGGPEQST 290
Cdd:COG5048 250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKS--------KQCNISFSRSSPLTRHLRSVNHSGESLKP 321

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 291 HVCFWEECPREGKAFKAKYkliNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTH-----TGEKPFKCEFDGCDRKF 365
Cdd:COG5048 322 FSCPYSLCGKLFSRNDALK---RHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNF 398

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45387859 366 ANSSDRKKHSHVHTSDKPYFCKVRGCDKSYTHPSSLRKHMKVHCKSPPPPSANTGSS 422
Cdd:COG5048 399 KRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-454 1.18e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 321 EKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYfckvRGCDKSYTHPSS 400
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSD----LNSKSLPLSNSK 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45387859 401 LRKHMKVHCKSppPPSANTGSSYHPSSTTIGDALSPNLDPHRNRSSNLSPQVTN 454
Cdd:COG5048 105 ASSSSLSSSSS--NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNS 156
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 325-414 9.94e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 41.25  E-value: 9.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859   325 PCPFPGCGKVFARSENLKIHKRTHTGE------KPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYFcKVRGCDKSYTHP 398
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYF-KCENCLLRFRTH 79

                          90
                  ....*....|....*....
gi 45387859   399 SSLRKHMKV---HCKSPPP 414
Cdd:pfam15909  80 RSLFKHLHVcaeHAQSPAP 98
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
318-454 1.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387859 318 HTGE--KPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTS-----DKPYFCKVRG 390
Cdd:COG5048 314 HSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLSNS 393

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45387859 391 CDKSYTHPSSLRKHMKVHCKSPPPPSANTGSSyhpssttIGDALSPNLDPHRNRSSNLSPQVTN 454
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS-------KSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-367 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|....*...
gi 45387859   340 NLKIHKRTHTGEKPFKCEFdgCDRKFAN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-337 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*..
gi 45387859   311 LINHIRVHTGEKPFPCPFpgCGKVFAR 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 324-348 8.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.56e-03
                          10        20
                  ....*....|....*....|....*
gi 45387859   324 FPCPfpGCGKVFARSENLKIHKRTH 348
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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