NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|741866079|ref|NP_989712|]
View 

thy-1 membrane glycoprotein precursor [Gallus gallus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-123 7.31e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 7.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079    30 LGQSLRVDCRYenktSNPLTYEFSLTKDNRKHIIqstisvsenvYRNRANVTMHKNLVCLYLHSFTTSDEGVYMCElkAT 109
Cdd:smart00410   8 EGESVTLSCEA----SGSPPPEVTWYKQGGKLLA----------ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA--AT 71

                           90
                   ....*....|....
gi 741866079   110 NDYtGNQIKNITVI 123
Cdd:smart00410  72 NSS-GSASSGTTLT 84
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-123 7.31e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 7.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079    30 LGQSLRVDCRYenktSNPLTYEFSLTKDNRKHIIqstisvsenvYRNRANVTMHKNLVCLYLHSFTTSDEGVYMCElkAT 109
Cdd:smart00410   8 EGESVTLSCEA----SGSPPPEVTWYKQGGKLLA----------ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA--AT 71

                           90
                   ....*....|....
gi 741866079   110 NDYtGNQIKNITVI 123
Cdd:smart00410  72 NSS-GSASSGTTLT 84
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 25-104 2.37e-04

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 37.86  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079  25 LSACLLGQSLRVDCRYENKTSNPLTYEFSLTKDNRKHIiqstisvsenvyrnranvtmhknlvcLYLHSFTTSDEGVYMC 104
Cdd:cd20948    4 DTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQE--------------------------LFLPAITENNEGTYTC 57
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-123 7.31e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 7.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079    30 LGQSLRVDCRYenktSNPLTYEFSLTKDNRKHIIqstisvsenvYRNRANVTMHKNLVCLYLHSFTTSDEGVYMCElkAT 109
Cdd:smart00410   8 EGESVTLSCEA----SGSPPPEVTWYKQGGKLLA----------ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCA--AT 71

                           90
                   ....*....|....
gi 741866079   110 NDYtGNQIKNITVI 123
Cdd:smart00410  72 NSS-GSASSGTTLT 84
IGv smart00406
Immunoglobulin V-Type;
33-105 1.52e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.21  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079    33 SLRVDCRYENKTsNPLTYEFSLTKDNRKH------IIQSTISVSENVYRNRANVT--MHKNLVCLYLHSFTTSDEGVYMC 104
Cdd:smart00406   1 SVTLSCKFSGST-FSSYYVSWVRQPPGKGlewlgyIGSNGSSYYQESYKGRFTISkdTSKNDVSLTISNLRVEDTGTYYC 79


                   .
gi 741866079   105 E 105
Cdd:smart00406  80 A 80
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 25-104 2.37e-04

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 37.86  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866079  25 LSACLLGQSLRVDCRYENKTSNPLTYEFSLTKDNRKHIiqstisvsenvyrnranvtmhknlvcLYLHSFTTSDEGVYMC 104
Cdd:cd20948    4 DTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQE--------------------------LFLPAITENNEGTYTC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH