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Conserved domains on  [gi|44662821|ref|NP_981967|]
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LRRN4 C-terminal-like protein precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 8.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 8.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44662821  83 PDPPRMGEVRiAAEEGRAVVHWCAP---FSPVLHYWLLLWD-GSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANE 158
Cdd:cd00063   1 PSPPTNLRVT-DVTSTSVTLSWTPPeddGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                ....
gi 44662821 159 AGAS 162
Cdd:cd00063  80 GGES 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 8.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 8.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44662821  83 PDPPRMGEVRiAAEEGRAVVHWCAP---FSPVLHYWLLLWD-GSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANE 158
Cdd:cd00063   1 PSPPTNLRVT-DVTSTSVTLSWTPPeddGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                ....
gi 44662821 159 AGAS 162
Cdd:cd00063  80 GGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-162 9.79e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 9.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44662821     83 PDPPRmgEVRI-AAEEGRAVVHWCAP-----FSPVLHYWLLLWDGSEAAQKgPPLNATVRRAELKGLKPGGIYVVCVVAA 156
Cdd:smart00060   1 PSPPS--NLRVtDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKE-VNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 44662821    157 NEAGAS 162
Cdd:smart00060  78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
100-163 3.26e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 3.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44662821   100 AVVHWCAPF---SPVLHYWLLLWD-GSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANEAGASR 163
Cdd:pfam00041  16 LTVSWTPPPdgnGPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 8.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 8.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44662821  83 PDPPRMGEVRiAAEEGRAVVHWCAP---FSPVLHYWLLLWD-GSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANE 158
Cdd:cd00063   1 PSPPTNLRVT-DVTSTSVTLSWTPPeddGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                ....
gi 44662821 159 AGAS 162
Cdd:cd00063  80 GGES 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-162 9.79e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 9.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44662821     83 PDPPRmgEVRI-AAEEGRAVVHWCAP-----FSPVLHYWLLLWDGSEAAQKgPPLNATVRRAELKGLKPGGIYVVCVVAA 156
Cdd:smart00060   1 PSPPS--NLRVtDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKE-VNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 44662821    157 NEAGAS 162
Cdd:smart00060  78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
100-163 3.26e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 3.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44662821   100 AVVHWCAPF---SPVLHYWLLLWD-GSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANEAGASR 163
Cdd:pfam00041  16 LTVSWTPPPdgnGPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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