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Conserved domains on  [gi|42573559|ref|NP_974876|]
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actin-related protein 9 [Arabidopsis thaliana]

Protein Classification

acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)

acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates

CATH:  3.30.420.40
Gene Ontology:  GO:0000166
PubMed:  8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
19-566 2.04e-155

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


:

Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 452.85  E-value: 2.04e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  19 NLVVINLGSANVRVGLAMDEKPFNVPNCIARYITQSGKPTVVDQ---MLNTEVTTNQHVDRERAYNSAASLLKIlfldes 95
Cdd:cd10206   1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPEDVppaVRNGEDSVESEEEREEALKEVERALKS------ 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  96 sssgsasRKMGRIDgynqastikkdsvftwtdvyedekisLASPAETSPDKGDASASEAVPDVTD--SKDTSESKRKYRK 173
Cdd:cd10206  75 -------RKKSNGR--------------------------RRIPNQVSAKQNKPSKPENVPEDLDasSGENWTDTSDYPD 121
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 174 MIFGEEALKISPKEPYCLYHPIRRGHFNVS-PHYSAQRVCEDLTAILDWILLEKLHITHKERFSFHAVIVVPETFDTREI 252
Cdd:cd10206 122 FLVGEEALRLPPSEEYNLHWPIRRGRLNVHsDGGSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHV 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 253 KEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWIQRHY 332
Cdd:cd10206 202 KELVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 333 QKWPQIntDVLAKPIDMLMLNQLKESFCEIRAGElETVATVHSYEE--GMPAVPHKTNLtslnvppmglfypnllvpeif 410
Cdd:cd10206 282 GFPYRE--CNLNSPLDFLLLERLKETYCTLDQDD-IGVQLHEFYVRepGQPTLKYQFKL--------------------- 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 411 pqpprqwfqdyenmledtwnmdfggggnmglpmwdsfafspskpkkeekIGLAEAITSSILSAGRIDLRRKLFSSIQLIG 490
Cdd:cd10206 338 -------------------------------------------------LPLDEAIVQSILSCASDELKRKMYSSILLVG 368
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42573559 491 GAGLTKGLVAAVEERVLHAIPPT-EAIDTVQVLPSRTE--PQFVTWKGGAILGILDFGREAWIERHQWMVNGVNKGGLK 566
Cdd:cd10206 369 GGAKIPGLAEALEDRLLIKIPSLfEAVETVEVLPPPKDmdPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
19-566 2.04e-155

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 452.85  E-value: 2.04e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  19 NLVVINLGSANVRVGLAMDEKPFNVPNCIARYITQSGKPTVVDQ---MLNTEVTTNQHVDRERAYNSAASLLKIlfldes 95
Cdd:cd10206   1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPEDVppaVRNGEDSVESEEEREEALKEVERALKS------ 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  96 sssgsasRKMGRIDgynqastikkdsvftwtdvyedekisLASPAETSPDKGDASASEAVPDVTD--SKDTSESKRKYRK 173
Cdd:cd10206  75 -------RKKSNGR--------------------------RRIPNQVSAKQNKPSKPENVPEDLDasSGENWTDTSDYPD 121
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 174 MIFGEEALKISPKEPYCLYHPIRRGHFNVS-PHYSAQRVCEDLTAILDWILLEKLHITHKERFSFHAVIVVPETFDTREI 252
Cdd:cd10206 122 FLVGEEALRLPPSEEYNLHWPIRRGRLNVHsDGGSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHV 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 253 KEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWIQRHY 332
Cdd:cd10206 202 KELVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 333 QKWPQIntDVLAKPIDMLMLNQLKESFCEIRAGElETVATVHSYEE--GMPAVPHKTNLtslnvppmglfypnllvpeif 410
Cdd:cd10206 282 GFPYRE--CNLNSPLDFLLLERLKETYCTLDQDD-IGVQLHEFYVRepGQPTLKYQFKL--------------------- 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 411 pqpprqwfqdyenmledtwnmdfggggnmglpmwdsfafspskpkkeekIGLAEAITSSILSAGRIDLRRKLFSSIQLIG 490
Cdd:cd10206 338 -------------------------------------------------LPLDEAIVQSILSCASDELKRKMYSSILLVG 368
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42573559 491 GAGLTKGLVAAVEERVLHAIPPT-EAIDTVQVLPSRTE--PQFVTWKGGAILGILDFGREAWIERHQWMVNGVNKGGLK 566
Cdd:cd10206 369 GGAKIPGLAEALEDRLLIKIPSLfEAVETVEVLPPPKDmdPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
213-561 3.65e-20

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 92.32  E-value: 3.65e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    213 EDLTAILDWILLEKLHITHKERfsfHAVIVVPETFDTREIKEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNIG 292
Cdd:smart00268  75 DDMEKIWDYTFFNELRVEPEEH---PVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSG 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    293 AQTSTVVCVEDGVSLPNTEKILPFGGEDICR--CLLWIQRHYQKwpqiNTDVlakpiDMLMLNQLKESFCeirageleTV 370
Cdd:smart00268 152 DGVTHVVPVVDGYVLPHAIKRIDIAGRDITDylKELLSERGYQF----NSSA-----EFEIVREIKEKLC--------YV 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    371 ATvhSYEEGMpaVPHKTNLTSLNVP-----PMGLFYP----NLLVPEIFpqpprqwfqdyenmledtwnmdfggggnmgl 441
Cdd:smart00268 215 AE--DFEKEM--KLARESSESSKLEktyelPDGNTIKvgneRFRIPEIL------------------------------- 259
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    442 pmwdsfaFSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEaidTVQV 521
Cdd:smart00268 260 -------FSPELIGLEQK-GIHELVYESIQKCD-IDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKL---KVKV 327
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 42573559    522 LPSrTEPQFVTWKGGAILGILDFGREAWIERHQWMVNGVN 561
Cdd:smart00268 328 IAP-PERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQ 366
Actin pfam00022
Actin;
161-561 5.28e-20

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 92.37  E-value: 5.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   161 SKDTSESKRKYrkmIFGEEAlkISPKEPYCLYHPIRRGHfnvsphysaqrVC--EDLTAILDWILLEKLHITHKErfsfH 238
Cdd:pfam00022  35 RGTKVEAANKY---YVGDEA--LTYRPGMEVRSPVEDGI-----------VVdwDAMEEIWEHVLKEELQVDPEE----H 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   239 AVIVVPETFDTREIKEMLTIVLGE------LYF-NSAVvhqegLSAvFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTE 311
Cdd:pfam00022  95 PLLLTEPPWNPPANREKAAEIMFEkfgvpaLYLaKNPV-----LSA-FASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   312 KILPFGGEDICRCL--------LWIQRHY---QKWPQINTDVLAKPI------------DMLMLNQLKESFCEI------ 362
Cdd:pfam00022 169 RRSDLGGDFLTDYLrellrsrnIEITPRYlikSKKPGDPAPAVTKRElpdttysyktyqERRVLEEIKESVCYVsddpfg 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   363 RAGELETVATVHsYEegmpaVPHKTNLTSLN---VPPMGLFYPNLLVPEIFPQPPRQwfqdyenmledtwnmdfggggnm 439
Cdd:pfam00022 249 DETTSSSIPTRV-YE-----LPDGSTIILGAerfRVPEILFNPSLIGSESELPPPQT----------------------- 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   440 glpmwdsfafspskpkkeeKIGLAEAITSSILsAGRIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIdTV 519
Cdd:pfam00022 300 -------------------AVGIPELIVDAIN-ACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKV-KI 358
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 42573559   520 QVLPSRTEPQFVTWKGGAILGILDFGREAWIERHQWMVNGVN 561
Cdd:pfam00022 359 IAPGNTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHGAS 400
PTZ00004 PTZ00004
actin-2; Provisional
238-552 2.57e-07

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 53.23  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  238 HAVIVVPETFDTREIKEMLTIVLGELyFNSAVVHQeGLSAV---FGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKIL 314
Cdd:PTZ00004 102 HPVLLTEAPLNPKANREKMTQIMFET-HNVPAMYV-AIQAVlslYASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAIHRL 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  315 PFGGEDIcrcllwiQRHYQKWPQINTDVLAKPIDMLMLNQLKESFCEIRAGELETVATVHSyEEGMPAVPHKtnLTSLNV 394
Cdd:PTZ00004 180 DVAGRDL-------TEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDFDEEMGNSAG-SSDKYEESYE--LPDGTI 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  395 PPMGlfypnllvPEIFpQPPRQWFQdyenmledtwnmdfggggnmglpmwdsfafsPSKPKKEEKIGLAEAITSSILSAG 474
Cdd:PTZ00004 250 ITVG--------SERF-RCPEALFQ-------------------------------PSLIGKEEPPGIHELTFQSINKCD 289
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573559  475 rIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIDTVqvlpSRTEPQFVTWKGGAILGILDFGREAWIER 552
Cdd:PTZ00004 290 -IDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVV----APPERKYSVWIGGSILSSLPTFQQMWVTK 362
COG5277 COG5277
Actin-related protein [Cytoskeleton];
405-555 3.89e-06

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 49.40  E-value: 3.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 405 LVPEIFPQPPRQWFQDYENM----LEDTWNMDFGGGGNMGLpmwdsfafspskpkkeekiglAEAITSSILSAGrIDLRR 480
Cdd:COG5277 282 LIGEILFNPNHEGFESYIQQgrlrIEDAVIGDVVLYGEMGL---------------------AEAIINSIMKCD-VEIQD 339
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 481 KLFSSIQLIGGA-------GLTKGLVAAVE--ERVLHAIPPTEAIDtvqvLPSRTEPQFVTWKGGAILGI-LDFGREA-W 549
Cdd:COG5277 340 ELYSNIILSGGAfnwsvppGLEDVAVDSVTrvQIELSELAPELKVN----VRLVSDPQYSVWKGAIIYGYaLPFSVKWsW 415

                ....*.
gi 42573559 550 IERHQW 555
Cdd:COG5277 416 ITKEGW 421
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
19-566 2.04e-155

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 452.85  E-value: 2.04e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  19 NLVVINLGSANVRVGLAMDEKPFNVPNCIARYITQSGKPTVVDQ---MLNTEVTTNQHVDRERAYNSAASLLKIlfldes 95
Cdd:cd10206   1 KTIVIHPGSRNLRIGRASDDLPVVIPHCIARRRKQTGSARPEDVppaVRNGEDSVESEEEREEALKEVERALKS------ 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  96 sssgsasRKMGRIDgynqastikkdsvftwtdvyedekisLASPAETSPDKGDASASEAVPDVTD--SKDTSESKRKYRK 173
Cdd:cd10206  75 -------RKKSNGR--------------------------RRIPNQVSAKQNKPSKPENVPEDLDasSGENWTDTSDYPD 121
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 174 MIFGEEALKISPKEPYCLYHPIRRGHFNVS-PHYSAQRVCEDLTAILDWILLEKLHITHKERFSFHAVIVVPETFDTREI 252
Cdd:cd10206 122 FLVGEEALRLPPSEEYNLHWPIRRGRLNVHsDGGSLTAVLDDLEDIWSHALEEKLEIPRKDLKNYRAVLVIPDLFDRRHV 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 253 KEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWIQRHY 332
Cdd:cd10206 202 KELVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPNSRIRLPYGGDDITRCFLWLLRRS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 333 QKWPQIntDVLAKPIDMLMLNQLKESFCEIRAGElETVATVHSYEE--GMPAVPHKTNLtslnvppmglfypnllvpeif 410
Cdd:cd10206 282 GFPYRE--CNLNSPLDFLLLERLKETYCTLDQDD-IGVQLHEFYVRepGQPTLKYQFKL--------------------- 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 411 pqpprqwfqdyenmledtwnmdfggggnmglpmwdsfafspskpkkeekIGLAEAITSSILSAGRIDLRRKLFSSIQLIG 490
Cdd:cd10206 338 -------------------------------------------------LPLDEAIVQSILSCASDELKRKMYSSILLVG 368
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42573559 491 GAGLTKGLVAAVEERVLHAIPPT-EAIDTVQVLPSRTE--PQFVTWKGGAILGILDFGREAWIERHQWMVNGVNKGGLK 566
Cdd:cd10206 369 GGAKIPGLAEALEDRLLIKIPSLfEAVETVEVLPPPKDmdPSLLAWKGGAVLACLDSAQELWITRKEWQRLGVRALRER 447
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
213-559 1.58e-21

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 94.10  E-value: 1.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 213 EDLTAILDWILLEKLHITHKErfsfHAVIVVPETFDTREIKE-MLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNI 291
Cdd:cd10169  27 DDMEKIWEHVFYNLLRVDPEE----HPVLLTEPPLNPKANREkLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDS 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 292 GAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWI--QRHYQkwpqintdvLAKPIDMLMLNQLKESFCeiragelet 369
Cdd:cd10169 103 GEGVTHIVPVYEGYVLPHAVRRLDIGGRDLTDYLAKLlrEKGYS---------FSTSAEREIVRDIKEKLC--------- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 370 vatvhsyeegmpavphktnltslnvppmglfypnllvpeifpqpprqwfqdyenmledtwnmdfggggnmglpmwdsfaf 449
Cdd:cd10169     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 450 spskpkkeekiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLvaavEERV---LHAIPPTEAIDTVQVLPSRt 526
Cdd:cd10169 165 -----------GLHELIYDSIMKCD-IDLRKELYSNIVLSGGTTLFPGF----AERLqkeLSKLAPSSVKVKVIAPPER- 227
                       330       340       350
                ....*....|....*....|....*....|...
gi 42573559 527 epQFVTWKGGAILGILDFGREAWIERHQWMVNG 559
Cdd:cd10169 228 --KYSAWIGGSILASLSTFQQMWITKEEYEEHG 258
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
213-561 3.65e-20

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 92.32  E-value: 3.65e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    213 EDLTAILDWILLEKLHITHKERfsfHAVIVVPETFDTREIKEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNIG 292
Cdd:smart00268  75 DDMEKIWDYTFFNELRVEPEEH---PVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSG 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    293 AQTSTVVCVEDGVSLPNTEKILPFGGEDICR--CLLWIQRHYQKwpqiNTDVlakpiDMLMLNQLKESFCeirageleTV 370
Cdd:smart00268 152 DGVTHVVPVVDGYVLPHAIKRIDIAGRDITDylKELLSERGYQF----NSSA-----EFEIVREIKEKLC--------YV 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    371 ATvhSYEEGMpaVPHKTNLTSLNVP-----PMGLFYP----NLLVPEIFpqpprqwfqdyenmledtwnmdfggggnmgl 441
Cdd:smart00268 215 AE--DFEKEM--KLARESSESSKLEktyelPDGNTIKvgneRFRIPEIL------------------------------- 259
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559    442 pmwdsfaFSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEaidTVQV 521
Cdd:smart00268 260 -------FSPELIGLEQK-GIHELVYESIQKCD-IDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKL---KVKV 327
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 42573559    522 LPSrTEPQFVTWKGGAILGILDFGREAWIERHQWMVNGVN 561
Cdd:smart00268 328 IAP-PERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQ 366
Actin pfam00022
Actin;
161-561 5.28e-20

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 92.37  E-value: 5.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   161 SKDTSESKRKYrkmIFGEEAlkISPKEPYCLYHPIRRGHfnvsphysaqrVC--EDLTAILDWILLEKLHITHKErfsfH 238
Cdd:pfam00022  35 RGTKVEAANKY---YVGDEA--LTYRPGMEVRSPVEDGI-----------VVdwDAMEEIWEHVLKEELQVDPEE----H 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   239 AVIVVPETFDTREIKEMLTIVLGE------LYF-NSAVvhqegLSAvFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTE 311
Cdd:pfam00022  95 PLLLTEPPWNPPANREKAAEIMFEkfgvpaLYLaKNPV-----LSA-FASGRTTGLVVDSGAGVTSVVPVHDGYVLQKAI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   312 KILPFGGEDICRCL--------LWIQRHY---QKWPQINTDVLAKPI------------DMLMLNQLKESFCEI------ 362
Cdd:pfam00022 169 RRSDLGGDFLTDYLrellrsrnIEITPRYlikSKKPGDPAPAVTKRElpdttysyktyqERRVLEEIKESVCYVsddpfg 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   363 RAGELETVATVHsYEegmpaVPHKTNLTSLN---VPPMGLFYPNLLVPEIFPQPPRQwfqdyenmledtwnmdfggggnm 439
Cdd:pfam00022 249 DETTSSSIPTRV-YE-----LPDGSTIILGAerfRVPEILFNPSLIGSESELPPPQT----------------------- 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559   440 glpmwdsfafspskpkkeeKIGLAEAITSSILsAGRIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIdTV 519
Cdd:pfam00022 300 -------------------AVGIPELIVDAIN-ACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKV-KI 358
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 42573559   520 QVLPSRTEPQFVTWKGGAILGILDFGREAWIERHQWMVNGVN 561
Cdd:pfam00022 359 IAPGNTVERRYSAWIGGSILASLGTFQQMWVSKQEYEEHGAS 400
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
215-560 1.81e-15

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 78.45  E-value: 1.81e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 215 LTAILDWILLEKLHITHKERfsfhAVIVVPETFDTREIKEMLTIVLGElYFN--SAVVHQEGLSAVFGNGLTTACIVNIG 292
Cdd:cd10207  54 LKEFLHELYFKHLLVNPKDR----RVVVVESVLCPTPFRETLAKVLFK-HFEvpSVLFAPSHLLSLLTLGIRTALVVDCG 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 293 AQTSTVVCVEDGVSLPNTEKILPFGGEDICRCL-LWIQRHYQKWPQINTDVLAKPIDMLmlnqLKESFCE---IRA---G 365
Cdd:cd10207 129 YRETRVLPVYEGVPLLSAWQSTPLGGKALHKRLkKLLLEHATVVTGDNKGQLLSSVDSL----LSEEVLEdikVRAcfvT 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 366 ELETVATVHSYEEGMPAVPhktnltSLNVPPMGlfYPnlLVPEIFPQPPRQWFQDYENMLEDtwnMDfggggnmglpmwd 445
Cdd:cd10207 205 SLERGKTLQSATEEGSTEE------PSPPPPVD--YP--LDGEKILIVPGSIRESAEELLFE---GD------------- 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 446 sfafspskpkkEEKIGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTE-------AIDT 518
Cdd:cd10207 259 -----------NEEKSLPTLILDSLLKCP-IDVRKQLAENIVVIGGTSMLPGFKHRLLEELRALLRKPKyfeelapKTFR 326
                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 42573559 519 VQVLPSRTEPQFVTWKGGAILGILDFGREAWIERHQWMVNGV 560
Cdd:cd10207 327 FHTPPSVFKPNYLAWLGGSIFGALESILGRSLSREAYLQTGR 368
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
157-542 1.38e-12

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 69.90  E-value: 1.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 157 DVTDSKDTSESKRKYRKMIFGEEALKIspkepyclyhpiRRGHFNVSPHYSAQRVC--EDLTAILDWILLEKLHITHKEr 234
Cdd:cd13395  40 DDDAEDYVGGSGEKKRKYYIGTNSIGV------------PRPNMEVISPLKDGLIEdwDAFEKLWDHALKNRLRVDPSE- 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 235 fsfHAVIVVPETFDTREIKEMLTivlgELYF-----------NSAVvhqegLSAvFGNGLTTACIVNIGAQTSTVVCVED 303
Cdd:cd13395 107 ---HPLLLTEPSWNTRANREKLT----ELMFekynvpafflaKNAV-----LSA-FANGRSTALVVDSGATSTSVVPVHD 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 304 GVSLPNTEKILPFGGEDICRCLLW--------------IQRHYQKWPQINTDVLAKPID-----------MLMLNQLKES 358
Cdd:cd13395 174 GYVLQKAIVRSPLGGDFLTDQLLKllesknieiiprymIKSKEPVEGGAPAKYTKKDLPnttssyhrymvRRVLQDFKES 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 359 FCEirageletVATVH---SYEEGMPAVPhktnltslnvppmglfypnllvpeifpqpprqwfqdYEnmLEDTWNMDFGG 435
Cdd:cd13395 254 VCQ--------VSDSPfdeSEAASIPTVS------------------------------------YE--LPDGYNIEFGA 287
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 436 ggnmglpmwDSFA-----FSPSKPKKEEK--------IGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAV 502
Cdd:cd13395 288 ---------ERFKipellFDPSLVKGIPAppsegnelLGLPQLVYTSIGSCD-VDIRPELYGNVVLTGGNSLLPGFTDRL 357
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 42573559 503 EERVLHAIPPTEAIDTVQVLPSrTEPQFVTWKGGAILGIL 542
Cdd:cd13395 358 NRELSEKAPGSLKLKILASGNT-VERRFSSWIGGSILASL 396
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
213-358 1.09e-11

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 66.56  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 213 EDLTAILDWILLEKLHItHKERFSFHAVIVVPETFdTREIKEMLT-IVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNI 291
Cdd:cd10208  48 DALEALWRHILFSLLSI-PRPTNNSPVLLSVPPSW-SKSDLELLTqLFFERLNVPAFAILEAPLAALYAAGATSGIVVDI 125
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573559 292 GAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWIQRhyQKWPQINT-DVLAKPIDMLMLNQLKES 358
Cdd:cd10208 126 GHEKTDITPIVDSQVVPHALVSIPIGGQDCTAHLAQLLK--SDEPELKSqAESGEEATLDLAEALKKS 191
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
449-552 5.94e-08

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 54.89  E-value: 5.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 449 FSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEaidTVQVL--PSRt 526
Cdd:cd13397 255 FRPSLIGREAP-GIHKLVYNSIMKCD-IDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSST---KVKVIapPER- 328
                        90       100
                ....*....|....*....|....*.
gi 42573559 527 epQFVTWKGGAILGILDFGREAWIER 552
Cdd:cd13397 329 --KYSVWIGGSILASLSTFKSMWITR 352
PTZ00004 PTZ00004
actin-2; Provisional
238-552 2.57e-07

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 53.23  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  238 HAVIVVPETFDTREIKEMLTIVLGELyFNSAVVHQeGLSAV---FGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKIL 314
Cdd:PTZ00004 102 HPVLLTEAPLNPKANREKMTQIMFET-HNVPAMYV-AIQAVlslYASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAIHRL 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  315 PFGGEDIcrcllwiQRHYQKWPQINTDVLAKPIDMLMLNQLKESFCEIRAGELETVATVHSyEEGMPAVPHKtnLTSLNV 394
Cdd:PTZ00004 180 DVAGRDL-------TEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDFDEEMGNSAG-SSDKYEESYE--LPDGTI 249
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  395 PPMGlfypnllvPEIFpQPPRQWFQdyenmledtwnmdfggggnmglpmwdsfafsPSKPKKEEKIGLAEAITSSILSAG 474
Cdd:PTZ00004 250 ITVG--------SERF-RCPEALFQ-------------------------------PSLIGKEEPPGIHELTFQSINKCD 289
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573559  475 rIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIDTVqvlpSRTEPQFVTWKGGAILGILDFGREAWIER 552
Cdd:PTZ00004 290 -IDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVV----APPERKYSVWIGGSILSSLPTFQQMWVTK 362
PTZ00466 PTZ00466
actin-like protein; Provisional
221-555 1.20e-06

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 51.10  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  221 WI-LLEKLHITHKErfsfHAVIVVPETFDTREIKEMLTIVLGELYFNSAV-VHQEGLSAVFGNGLTTACIVNIGAQTSTV 298
Cdd:PTZ00466  93 WIhVYNSMKINSEE----HPVLLTEAPLNPQKNKEKIAEVFFETFNVPALfISIQAILSLYSCGKTNGTVLDCGDGVCHC 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  299 VCVEDGVSLPNTEKILPFGGEDICRCLLWIQRHyqkwpqiNTDVLAKPIDMLMLNQLKESFCEIRAGELETVATVHSYEE 378
Cdd:PTZ00466 169 VSIYEGYSITNTITRTDVAGRDITTYLGYLLRK-------NGHLFNTSAEMEVVKNMKENCCYVSFNMNKEKNSSEKALT 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  379 GMP-AVPHKTNL---TSLNVPPMGLFYPNLLvpeifpqpprqwfqdyenmledtwnmdfggggnmGLpmwdsfafspskp 454
Cdd:PTZ00466 242 TLPyILPDGSQIligSERYRAPEVLFNPSIL----------------------------------GL------------- 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  455 kkeEKIGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLvaavEERVLHAIPPTEAIDTVQVLPSRTEPQFVTWK 534
Cdd:PTZ00466 275 ---EYLGLSELIVTSITRAD-MDLRRTLYSHIVLSGGTTMFHGF----GDRLLNEIRKFAPKDITIRISAPPERKFSTFI 346
                        330       340
                 ....*....|....*....|.
gi 42573559  535 GGAILGILDFGREAWIERHQW 555
Cdd:PTZ00466 347 GGSILASLATFKKIWISKQEF 367
PTZ00281 PTZ00281
actin; Provisional
213-559 1.95e-06

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 50.47  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  213 EDLTAILDWILLEKLHITHKErfsfHAVIVVPETFDTREIKEMLTIVLGELYFNSAV-VHQEGLSAVFGNGLTTACIVNI 291
Cdd:PTZ00281  81 DDMEKIWHHTFYNELRVAPEE----HPVLLTEAPLNPKANREKMTQIMFETFNTPAMyVAIQAVLSLYASGRTTGIVMDS 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  292 GAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCLLWI--QRHYQkwpqintdvLAKPIDMLMLNQLKESFCEIR---AGE 366
Cdd:PTZ00281 157 GDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKIltERGYS---------FTTTAEREIVRDIKEKLAYVAldfEAE 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  367 LETVATVHSYEEGMpAVPHKTNLTSLNVP---PMGLFYPNLLvpeifpqpprqwfqdyenmledtwnmdfggggnmGLpm 443
Cdd:PTZ00281 228 MQTAASSSALEKSY-ELPDGQVITIGNERfrcPEALFQPSFL----------------------------------GM-- 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559  444 wdsfafspskpkkeEKIGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIDTVqvlp 523
Cdd:PTZ00281 271 --------------ESAGIHETTYNSIMKCD-VDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKII---- 331
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 42573559  524 SRTEPQFVTWKGGAILGILDFGREAWIERHQWMVNG 559
Cdd:PTZ00281 332 APPERKYSVWIGGSILASLSTFQQMWISKEEYDESG 367
COG5277 COG5277
Actin-related protein [Cytoskeleton];
405-555 3.89e-06

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 49.40  E-value: 3.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 405 LVPEIFPQPPRQWFQDYENM----LEDTWNMDFGGGGNMGLpmwdsfafspskpkkeekiglAEAITSSILSAGrIDLRR 480
Cdd:COG5277 282 LIGEILFNPNHEGFESYIQQgrlrIEDAVIGDVVLYGEMGL---------------------AEAIINSIMKCD-VEIQD 339
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 481 KLFSSIQLIGGA-------GLTKGLVAAVE--ERVLHAIPPTEAIDtvqvLPSRTEPQFVTWKGGAILGI-LDFGREA-W 549
Cdd:COG5277 340 ELYSNIILSGGAfnwsvppGLEDVAVDSVTrvQIELSELAPELKVN----VRLVSDPQYSVWKGAIIYGYaLPFSVKWsW 415

                ....*.
gi 42573559 550 IERHQW 555
Cdd:COG5277 416 ITKEGW 421
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
449-555 9.66e-06

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 9.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 449 FSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLvaavEERVLHAIPPTEAIDTVQVLPSRTEP 528
Cdd:cd10216 258 FNPELIGLEYP-GVHEVLVDSIQKSD-LDLRKTLYSNIVLSGGSTLFKGF----GDRLLSEVKKLAPKDVKIRISAPPER 331
                        90       100
                ....*....|....*....|....*..
gi 42573559 529 QFVTWKGGAILGILDFGREAWIERHQW 555
Cdd:cd10216 332 LYSTWIGGSILASLSTFKKMWVSKKEY 358
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
172-555 1.88e-05

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 47.03  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 172 RKMIF-GEEALKISPkePYCLYHPIRRGHfnVSPHYSAQrvcedltAILDWILLEKLHITHKErfsfHAVIVVPETFDTR 250
Cdd:cd10214  47 RKETFvGKELANVEP--PLKLVNPLRHGI--VVDWDCVQ-------DIWEYIFEKEMKILPEE----HAVLVSDPPLSPT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 251 EIKEMLTIVLGElYFNSAVVH---QEGLSaVFGNGLTTACIVNIGAQTSTVVCVEDGVSLPNTEKILPFGGEDIcrcllw 327
Cdd:cd10214 112 TNREKYAELMFE-TFSIPAMHiayQSRLS-LYSYGRTSGLVVESGHGVSYVVPIHEGYNLPHITGRADYAGSDL------ 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 328 iqrhyqkwpqinTDVLAKpidmlMLNQLKESFCEirageletvatvhsyeEGMPAV---PHKTNLTSLNVP-PMGLfypn 403
Cdd:cd10214 184 ------------TAYLMK-----LLNEAGNKFTD----------------DQLHIVediKKKCCYVALDFEeEMGL---- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 404 llvpeifpqPPRQWFQDYEnmLEDTWNMDFGGggnmglpmwDSFA-----FSPSKPKKEEkIGLAEAITSSiLSAGRIDL 478
Cdd:cd10214 227 ---------PPQEYTVDYE--LPDGHLITIGK---------ERFRcpemlFNPSLIGSKQ-PGLHTLTMNS-LNKCDANL 284
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42573559 479 RRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIdtVQVLPSRtepQFVTWKGGAILGILDFGREAWIERHQW 555
Cdd:cd10214 285 KKDLAKNILLCGGSTMFDGFPDRFQKELSKLCPNDNPI--VAASPER---KYSVWTGGSILASLKSFQQLWVRRREY 356
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
449-559 5.70e-05

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 45.62  E-value: 5.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 449 FSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVaaveERV---LHAIPPTEAidTVQV-LPS 524
Cdd:cd10210 285 FHPSDIGIQQA-GIAEAIVQSINACP-EELQPLLYANIVLTGGNALFPGFR----ERLeaeLRSLAPDDY--DVNVtLPE 356
                        90       100       110
                ....*....|....*....|....*....|....*
gi 42573559 525 rtEPQFVTWKGGAILGILDFGREAWIERHQWMVNG 559
Cdd:cd10210 357 --DPITYAWEGGSLLAQSPEFEELAVTRAEYEEHG 389
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
21-65 2.79e-03

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 40.23  E-value: 2.79e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 42573559  21 VVINLGSANVRVGLAMDEKPFNVPNCIARYITQSGKPTVVDQMLN 65
Cdd:cd10210   2 LVLDNGAYTIKAGFASDDPPRVIPNCIAKPKSERRRLFGDDQLDE 46
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
449-555 5.59e-03

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 39.27  E-value: 5.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 449 FSPSKPKKEEKiGLAEAITSSILSAGrIDLRRKLFSSIQLIGGAGLTKGLVAAVEERVLHAIPPTEAIDTVqVLPSRtep 528
Cdd:cd10224 257 FQPSFLGMEAA-GIHETTYNSIMKCD-VDIRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTMKIKIV-APPER--- 330
                        90       100
                ....*....|....*....|....*..
gi 42573559 529 QFVTWKGGAILGILDFGREAWIERHQW 555
Cdd:cd10224 331 KYSVWIGGSILASLSTFQQMWISKQEY 357
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
213-377 6.93e-03

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 39.08  E-value: 6.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 213 EDLTAILDWILLEKLHITHKErfsfHAVIVV-PETFDTREIKEMLTIVLGELYFNSAVVHQEGLSAVFGNGLTTACIVNI 291
Cdd:cd10220  77 DDMEHLWDYTFGEKLKIDPRE----CKILLTePPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDS 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 292 GAQTSTVVCVEDGVSLPNTEKILPFGGEDICRCL--LWIQRHYqkwpqintdVLAKPIDMLMLNQLKESFC--------E 361
Cdd:cd10220 153 GDGVTHIVPVYEGFSLPHLTRRLDVAGRDITRYLikLLLLRGY---------AFNRTADFETVREIKEKLCyvaydielE 223
                       170
                ....*....|....*.
gi 42573559 362 IRAGeLETVATVHSYE 377
Cdd:cd10220 224 QKLA-LETTVLVESYT 238
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
460-556 7.78e-03

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 38.71  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573559 460 IGLAEAItSSILSAGRIDLRRKLFSSIQLIGGAGLTKGLvaavEERV---LHAIPPTEAidTVQVLPSRtEPQFVTWKGG 536
Cdd:cd10211 244 FGLVETI-EFVLKRYPAEQQDRLVQNVFLTGGNALFPGL----KERLekeLRAIRPFGS--PFNVVRAK-DPVLDAWRGA 315
                        90       100
                ....*....|....*....|
gi 42573559 537 AILGILDFGREAWIERHQWM 556
Cdd:cd10211 316 AKWALDSTFEKVWITKQEYE 335
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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