SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
117-344
3.27e-43
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.
The actual alignment was detected with superfamily member cd19179:
Pssm-ID: 394802 Cd Length: 237 Bit Score: 153.24 E-value: 3.27e-43
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an ...
360-483
4.68e-29
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex.
:
Pssm-ID: 462737 Cd Length: 130 Bit Score: 111.35 E-value: 4.68e-29
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
117-344
3.27e-43
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.
Pssm-ID: 380956 Cd Length: 237 Bit Score: 153.24 E-value: 3.27e-43
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an ...
360-483
4.68e-29
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex.
Pssm-ID: 462737 Cd Length: 130 Bit Score: 111.35 E-value: 4.68e-29
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ...
117-344
3.27e-43
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO.
Pssm-ID: 380956 Cd Length: 237 Bit Score: 153.24 E-value: 3.27e-43
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
115-344
4.82e-42
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.
Pssm-ID: 380925 [Multi-domain] Cd Length: 236 Bit Score: 150.29 E-value: 4.82e-42
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an ...
360-483
4.68e-29
Rubisco LSMT substrate-binding; Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex.
Pssm-ID: 462737 Cd Length: 130 Bit Score: 111.35 E-value: 4.68e-29
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
115-344
1.53e-24
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.
Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 102.38 E-value: 1.53e-24
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ...
115-344
2.96e-22
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1.
Pssm-ID: 380953 Cd Length: 251 Bit Score: 95.78 E-value: 2.96e-22
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
115-346
6.05e-20
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).
Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 89.29 E-value: 6.05e-20
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ...
115-344
1.43e-17
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b).
Pssm-ID: 380957 Cd Length: 252 Bit Score: 82.39 E-value: 1.43e-17
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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