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Conserved domains on  [gi|42573099|ref|NP_974646|]
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alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 49-260 2.72e-38

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 135.43  E-value: 2.72e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  49 LTTKSGNKVVATFWR---HPFARFTLLYSHGNAADLGQMVeLFIELRAHLRVNIMSYDYSGYGASTGKPSEFNTY--YDI 123
Cdd:COG1073  15 FKSRDGIKLAGDLYLpagASKKYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGESEGEPREEGSPerRDA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 124 EAVYSCLRSDYGIKQEEIILYGQSVGSGPTLHMASRLKRLRGVVL------------------HSAILSGIRVLYPVKMT 185
Cdd:COG1073  94 RAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILdspftsledlaaqrakeaRGAYLPGVPYLPNVRLA 173

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573099 186 LWF-DIFKNIDKIRHVNSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDPLWVKGGGHCNL--ETYPEYIKHLKKFVNA 260
Cdd:COG1073 174 SLLnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKK 251
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 49-260 2.72e-38

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 135.43  E-value: 2.72e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  49 LTTKSGNKVVATFWR---HPFARFTLLYSHGNAADLGQMVeLFIELRAHLRVNIMSYDYSGYGASTGKPSEFNTY--YDI 123
Cdd:COG1073  15 FKSRDGIKLAGDLYLpagASKKYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGESEGEPREEGSPerRDA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 124 EAVYSCLRSDYGIKQEEIILYGQSVGSGPTLHMASRLKRLRGVVL------------------HSAILSGIRVLYPVKMT 185
Cdd:COG1073  94 RAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILdspftsledlaaqrakeaRGAYLPGVPYLPNVRLA 173

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573099 186 LWF-DIFKNIDKIRHVNSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDPLWVKGGGHCNL--ETYPEYIKHLKKFVNA 260
Cdd:COG1073 174 SLLnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKK 251
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 70-176 1.96e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 42.11  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099    70 TLLYSHGNAADLGQMVELFIEL-RAHLRVnIMsYDYSGYGASTGKPSEFN-TYYDIEAVYSCLRSDYGIKQeeIILYGQS 147
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALaRDGFRV-IA-LDLRGFGKSSRPKAQDDyRTDDLAEDLEYILEALGLEK--VNLVGHS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 42573099   148 VGSGPTLHMASRL-KRLRGVVLHSAILSGI 176
Cdd:pfam00561  78 MGGLIALAYAAKYpDRVKALVLLGALDPPH 107
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 49-260 2.72e-38

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 135.43  E-value: 2.72e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  49 LTTKSGNKVVATFWR---HPFARFTLLYSHGNAADLGQMVeLFIELRAHLRVNIMSYDYSGYGASTGKPSEFNTY--YDI 123
Cdd:COG1073  15 FKSRDGIKLAGDLYLpagASKKYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGESEGEPREEGSPerRDA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 124 EAVYSCLRSDYGIKQEEIILYGQSVGSGPTLHMASRLKRLRGVVL------------------HSAILSGIRVLYPVKMT 185
Cdd:COG1073  94 RAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILdspftsledlaaqrakeaRGAYLPGVPYLPNVRLA 173

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42573099 186 LWF-DIFKNIDKIRHVNSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDPLWVKGGGHCNL--ETYPEYIKHLKKFVNA 260
Cdd:COG1073 174 SLLnDEFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKK 251
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
43-260 3.09e-20

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 86.59  E-value: 3.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  43 NVEVHQLTTKSGNKVVATFWR-HPFARFTLLYSHGNAADLGQMVELFIELRAHlRVNIMSYDYSGYGASTGKPSEFNTY- 120
Cdd:COG2267   2 TRRLVTLPTRDGLRLRGRRWRpAGSPRGTVVLVHGLGEHSGRYAELAEALAAA-GYAVLAFDLRGHGRSDGPRGHVDSFd 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 121 ---YDIEAVYSCLRSDYGIKqeeIILYGQSVGSGPTLHMASRL-KRLRGVVLHS-AILSGIRVLYPVKMTLWFDIFKNID 195
Cdd:COG2267  81 dyvDDLRAALDALRARPGLP---VVLLGHSMGGLIALLYAARYpDRVAGLVLLApAYRADPLLGPSARWLRALRLAEALA 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42573099 196 KIRhvnSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDPLWVKGGGHCNL-ETY-PEYIKHLKKFVNA 260
Cdd:COG2267 158 RID---VPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELLnEPArEEVLAAILAWLER 221
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
48-259 3.21e-18

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 81.60  E-value: 3.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  48 QLTTKSGNKVVATFWR------HPfarfTLLYSHGNAADLGQMVELFIELRAHLRVNIMSYDYSGYGASTGKPSEFNtYY 121
Cdd:COG1506   1 TFKSADGTTLPGWLYLpadgkkYP----VVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDE-VD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 122 DIEAVYSCLRSDYGIKQEEIILYGQSVGSGPTLHMASRLKRL-RGVVLHSAI------------LSGIRVLYPVKMTLWF 188
Cdd:COG1506  76 DVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRfKAAVALAGVsdlrsyygttreYTERLMGGPWEDPEAY 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42573099 189 DIFKNIDKIRHVNSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDP---LWVKGGGHCNLETY-PEYIKHLKKFVN 259
Cdd:COG1506 156 AARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAGKPvelLVYPGEGHGFSGAGaPDYLERILDFLD 230
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 70-260 2.33e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 73.50  E-value: 2.33e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  70 TLLYSHGNAADLGQMVELFIELRAHLRVnImSYDYSGYGASTgKPSEFNTYYDIEAVYSCLRSDYGIKQeeIILYGQSVG 149
Cdd:COG0596  25 PVVLLHGLPGSSYEWRPLIPALAAGYRV-I-APDLRGHGRSD-KPAGGYTLDDLADDLAALLDALGLER--VVLVGHSMG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 150 SGPTLHMASRL-KRLRGVVLHSAILSGIRVLYP---------VKMTLWFDIFKNIDKIRHVNSQVLVIHGTNDEIVDLSH 219
Cdd:COG0596 100 GMVALELAARHpERVAGLVLVDEVLAALAEPLRrpglapealAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPAL 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 42573099 220 GKRLWELAKeKYDPLWVKGGGHCNLETYPE-YIKHLKKFVNA 260
Cdd:COG0596 180 ARRLAELLP-NAELVVLPGAGHFPPLEQPEaFAAALRDFLAR 220
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
72-241 3.37e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 47.24  E-value: 3.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  72 LYSHGNAADLGQMVELFIELRAHlRVNIMSYDYSGYGAStgkPSEFNT------YYDIEAVYSCLRSDYgikqEEIILYG 145
Cdd:COG1647  19 LLLHGFTGSPAEMRPLAEALAKA-GYTVYAPRLPGHGTS---PEDLLKttwedwLEDVEEAYEILKAGY----DKVIVIG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 146 QSVGSGPTLHMASRLKRLRGVVLHSAILS-------GIRVLYPVK--MTLWFDIFKNIDK-------------------- 196
Cdd:COG1647  91 LSMGGLLALLLAARYPDVAGLVLLSPALKiddpsapLLPLLKYLArsLRGIGSDIEDPEVaeyaydrtplralaelqrli 170

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 42573099 197 ------IRHVNSQVLVIHGTNDEIVDLSHGKRLWE-LAKEKYDPLWVKGGGH 241
Cdd:COG1647 171 revrrdLPKITAPTLIIQSRKDEVVPPESARYIYErLGSPDKELVWLEDSGH 222
YpfH COG0400
Predicted esterase [General function prediction only];
67-260 5.72e-06

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 46.05  E-value: 5.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  67 ARFTLLYSHG---NAADLGQMVE-------LFIELRA------------HLRVNIMSYDYSGYGASTGKPSEFntyydIE 124
Cdd:COG0400   4 AAPLVVLLHGyggDEEDLLPLAPelalpgaAVLAPRApvpegpggrawfDLSFLEGREDEEGLAAAAEALAAF-----ID 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099 125 AvyscLRSDYGIKQEEIILYGQSVGSGPTLHMASRL-KRLRGVVLHSAilsgirvlYPVKMTLWFDIFKNIDKIRhvnsq 203
Cdd:COG0400  79 E----LEARYGIDPERIVLAGFSQGAAMALSLALRRpELLAGVVALSG--------YLPGEEALPAPEAALAGTP----- 141

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42573099 204 VLVIHGTNDEIVDLSHGKRLWE-LAKEKYDPLWVK-GGGHcnlETYPEYIKHLKKFVNA 260
Cdd:COG0400 142 VFLAHGTQDPVIPVERAREAAEaLEAAGADVTYREyPGGH---EISPEELADARAWLAE 197
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
95-241 8.76e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 42.46  E-value: 8.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099  95 LRVNimsydYSGYGASTGkpsefnTY-------YDIEAVYSCLRSDYGikqEEIILYGQSVGSGPTLHMASRLKRLRGVV 167
Cdd:COG2945  59 LRFN-----FRGVGRSEG------EFdegrgelDDAAAALDWLRAQNP---LPLWLAGFSFGAYVALQLAMRLPEVEGLI 124

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42573099 168 LHSAilsgirvlyPVKMtlwFDIfkniDKIRHVNSQVLVIHGTNDEIVDLSHGKRLWELAKEKYDPLWVKGGGH 241
Cdd:COG2945 125 LVAP---------PVNR---YDF----SFLAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 70-176 1.96e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 42.11  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099    70 TLLYSHGNAADLGQMVELFIEL-RAHLRVnIMsYDYSGYGASTGKPSEFN-TYYDIEAVYSCLRSDYGIKQeeIILYGQS 147
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALaRDGFRV-IA-LDLRGFGKSSRPKAQDDyRTDDLAEDLEYILEALGLEK--VNLVGHS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 42573099   148 VGSGPTLHMASRL-KRLRGVVLHSAILSGI 176
Cdd:pfam00561  78 MGGLIALAYAAKYpDRVKALVLLGALDPPH 107
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 133-260 2.35e-04

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 41.59  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099   133 DYGIKQEEIILYGQSVGSGPTLHMASRL-KRLRGVVlhsaILSGirvLYPVKMTLWFDIFKNIDKIrhvnsQVLVIHGTN 211
Cdd:pfam02230  99 KKGIPSSRIIIGGFSQGAMLALYSALTLpLPLGGIV----AFSG---FLPLPTKFPSHPNLVTKKT-----PIFLIHGEE 166

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 42573099   212 DEIVDLSHGKRLWELAK---EKYDPLWVKGGGHcnlETYPEYIKHLKKFVNA 260
Cdd:pfam02230 167 DPVVPLALGKLAKEYLKtslNKVELKIYEGLAH---SICGREMQDIKKFLSK 215
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 75-168 1.05e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 39.38  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573099    75 HGnaadLGQMVELFIELRAHlRVNIMSYDYSGYGASTGKPSEFNTYYDIEAVYsclrsDYGIKQEEIILYGQSVGSGPTL 154
Cdd:pfam12697   5 HG----AGLSAAPLAALLAA-GVAVLAPDLPGHGSSSPPPLDLADLADLAALL-----DELGAARPVVLVGHSLGGAVAL 74

                          90
                  ....*....|....
gi 42573099   155 HMASRLkRLRGVVL 168
Cdd:pfam12697  75 AAAAAA-LVVGVLV 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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