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Conserved domains on  [gi|42572759|ref|NP_974475|]
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AUTOPHAGY 6 [Arabidopsis thaliana]

Protein Classification

beclin family protein( domain architecture ID 16048792)

beclin family protein plays an essential role in autophagy and other membrane-trafficking events, such as human beclin-2 that is involved in 2 distinct lysosomal degradation pathways: acting as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover

Gene Ontology:  GO:0006914|GO:0000045|GO:0045324
PubMed:  26071895|31776982
SCOP:  4004436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 304-363 4.54e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


:

Pssm-ID: 461178  Cd Length: 176  Bit Score: 119.18  E-value: 4.54e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   304 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 363
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 170-298 8.48e-30

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


:

Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 111.53  E-value: 8.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   170 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 249
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 42572759   250 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 298
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 304-363 4.54e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 119.18  E-value: 4.54e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   304 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 363
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 170-298 8.48e-30

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 111.53  E-value: 8.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   170 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 249
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 42572759   250 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 298
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
173-303 2.76e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.05  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759  173 LECMRVLSDKLEK-EVEDVTRDVEAYEACVQRLEGETQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQLKE 251
Cdd:PRK03918 502 AEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEE 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42572759  252 LEFKG-----NRFNELEDRY--WQEFNNFQFQLIAHQEERDAILAKIEVSQAHLELLNK 303
Cdd:PRK03918 582 LGFESveeleERLKELEPFYneYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 304-363 4.54e-32

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 119.18  E-value: 4.54e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   304 TNVLIDAFPIRNDGEFGTINNFRLGRLPAIKVEWDEINAAWGQACLLLHTMCNYFRPKFQ 363
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQ 60
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 170-298 8.48e-30

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 111.53  E-value: 8.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759   170 PLCLECMRVLSDKLEKEVEDVTRDVEAYEACVQRLEgeTQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQL 249
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLE--KETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAEL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 42572759   250 KELEFKGNRFNELEDRYWQEFNNFQFQLIAHQEERDAILAKIEVSQAHL 298
Cdd:pfam17675  79 EALEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
173-303 2.76e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.05  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572759  173 LECMRVLSDKLEK-EVEDVTRDVEAYEACVQRLEGETQDVLSEADFLKEKKKIEEEERKLVAAIEETEKQNAEVNHQLKE 251
Cdd:PRK03918 502 AEQLKELEEKLKKyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEE 581

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 42572759  252 LEFKG-----NRFNELEDRY--WQEFNNFQFQLIAHQEERDAILAKIEVSQAHLELLNK 303
Cdd:PRK03918 582 LGFESveeleERLKELEPFYneYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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