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Conserved domains on  [gi|42572583|ref|NP_974387|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pgk2 super family cl34399
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
134-375 7.62e-43

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG2074:

Pssm-ID: 441677  Cd Length: 207  Bit Score: 153.95  E-value: 7.62e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 134 RERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFADEKQNPLLWASTYHAGEyldpvavaeskakr 213
Cdd:COG2074   1 RRMKRPRIILIGGASGVGKSTIAAELARRLGIPRVISTDSIREVMRPIISKELVPTLHTSSYEAYK-------------- 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 214 kakklkgsrgvnsnaqktdagsnSSTTELLshkqmaIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHLSLNFVMGL 293
Cdd:COG2074  67 -----------------------SLSEEEI------IAGFLDQAEAVSPGIEAVIERALKEGESLVIEGVHLVPGFLAEL 117
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 294 MKKHPSIVPFMVYIANEEKHLERFAVRAKYMTLDPAKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATIHA 373
Cdd:COG2074 118 KFNGGNVVMLVLLVSDEELHRERFYSRARYTHANRPGERYLDHFERIRRIQDYLVEQAREHGVPVIENIDLDETVDRILE 197

                ..
gi 42572583 374 TV 375
Cdd:COG2074 198 AI 199
 
Name Accession Description Interval E-value
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
134-375 7.62e-43

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 153.95  E-value: 7.62e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 134 RERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFADEKQNPLLWASTYHAGEyldpvavaeskakr 213
Cdd:COG2074   1 RRMKRPRIILIGGASGVGKSTIAAELARRLGIPRVISTDSIREVMRPIISKELVPTLHTSSYEAYK-------------- 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 214 kakklkgsrgvnsnaqktdagsnSSTTELLshkqmaIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHLSLNFVMGL 293
Cdd:COG2074  67 -----------------------SLSEEEI------IAGFLDQAEAVSPGIEAVIERALKEGESLVIEGVHLVPGFLAEL 117
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 294 MKKHPSIVPFMVYIANEEKHLERFAVRAKYMTLDPAKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATIHA 373
Cdd:COG2074 118 KFNGGNVVMLVLLVSDEELHRERFYSRARYTHANRPGERYLDHFERIRRIQDYLVEQAREHGVPVIENIDLDETVDRILE 197

                ..
gi 42572583 374 TV 375
Cdd:COG2074 198 AI 199
PRK04220 PRK04220
2-phosphoglycerate kinase; Provisional
90-371 3.74e-35

2-phosphoglycerate kinase; Provisional


Pssm-ID: 179793 [Multi-domain]  Cd Length: 301  Bit Score: 135.09  E-value: 3.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583   90 EMYKRRTTVVVSREIFVDVVCDALAEYKYVGRDQRadLILACRIRERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVV 169
Cdd:PRK04220  45 EELKKEGIKEITKEELRRRVYYKLIEKDYEEVAEK--YLLWRRIRKSKEPIIILIGGASGVGTSTIAFELASRLGIRSVI 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  170 STDSIRHMMRSFADEKQNPLLWASTYHAGEYLdpvavaeskakrkakklkgsrgvnsnaqktdagsnsstTELLSHKQMA 249
Cdd:PRK04220 123 GTDSIREVMRKIISKELLPTLHESSYTAWKSL--------------------------------------RRPPPPEPPV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  250 IEGYKAQSEMV---IDS-LDRLITtweeRNESVVVEGVHLslnfVMGLMKK----HPSIVPFMVYIANEEKHLERFAVRA 321
Cdd:PRK04220 165 IYGFERHVEPVsvgVEAvIERALK----EGISVIIEGVHI----VPGFIKEkyleNPNVFMFVLTLSDEEAHKARFYARA 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 42572583  322 KYmTLDPAKnKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATI 371
Cdd:PRK04220 237 RV-SRRPAE-RYLKNFEIIREINDYIVEKAKKHGVPVIENISIEETVDKI 284
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
142-179 3.80e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 41.14  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 42572583   142 VLLCGTSGCGKSTLSALLGSRLGiTTVVSTDSIRHMMR 179
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELG-AVRLSSDDERKRLF 38
 
Name Accession Description Interval E-value
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
134-375 7.62e-43

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 153.95  E-value: 7.62e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 134 RERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFADEKQNPLLWASTYHAGEyldpvavaeskakr 213
Cdd:COG2074   1 RRMKRPRIILIGGASGVGKSTIAAELARRLGIPRVISTDSIREVMRPIISKELVPTLHTSSYEAYK-------------- 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 214 kakklkgsrgvnsnaqktdagsnSSTTELLshkqmaIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHLSLNFVMGL 293
Cdd:COG2074  67 -----------------------SLSEEEI------IAGFLDQAEAVSPGIEAVIERALKEGESLVIEGVHLVPGFLAEL 117
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583 294 MKKHPSIVPFMVYIANEEKHLERFAVRAKYMTLDPAKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATIHA 373
Cdd:COG2074 118 KFNGGNVVMLVLLVSDEELHRERFYSRARYTHANRPGERYLDHFERIRRIQDYLVEQAREHGVPVIENIDLDETVDRILE 197

                ..
gi 42572583 374 TV 375
Cdd:COG2074 198 AI 199
PRK04220 PRK04220
2-phosphoglycerate kinase; Provisional
90-371 3.74e-35

2-phosphoglycerate kinase; Provisional


Pssm-ID: 179793 [Multi-domain]  Cd Length: 301  Bit Score: 135.09  E-value: 3.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583   90 EMYKRRTTVVVSREIFVDVVCDALAEYKYVGRDQRadLILACRIRERKESVTVLLCGTSGCGKSTLSALLGSRLGITTVV 169
Cdd:PRK04220  45 EELKKEGIKEITKEELRRRVYYKLIEKDYEEVAEK--YLLWRRIRKSKEPIIILIGGASGVGTSTIAFELASRLGIRSVI 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  170 STDSIRHMMRSFADEKQNPLLWASTYHAGEYLdpvavaeskakrkakklkgsrgvnsnaqktdagsnsstTELLSHKQMA 249
Cdd:PRK04220 123 GTDSIREVMRKIISKELLPTLHESSYTAWKSL--------------------------------------RRPPPPEPPV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  250 IEGYKAQSEMV---IDS-LDRLITtweeRNESVVVEGVHLslnfVMGLMKK----HPSIVPFMVYIANEEKHLERFAVRA 321
Cdd:PRK04220 165 IYGFERHVEPVsvgVEAvIERALK----EGISVIIEGVHI----VPGFIKEkyleNPNVFMFVLTLSDEEAHKARFYARA 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 42572583  322 KYmTLDPAKnKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATI 371
Cdd:PRK04220 237 RV-SRRPAE-RYLKNFEIIREINDYIVEKAKKHGVPVIENISIEETVDKI 284
PRK12337 PRK12337
2-phosphoglycerate kinase; Provisional
77-368 1.15e-26

2-phosphoglycerate kinase; Provisional


Pssm-ID: 183452 [Multi-domain]  Cd Length: 475  Bit Score: 114.10  E-value: 1.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583   77 VAGDVDKNKSKPFEMYKRRTTV-VVSREIFVDVVCDALAEYkyVGRDQRADLILACRIRERKESVTVLLCGTSGCGKSTL 155
Cdd:PRK12337 194 LAPDVARRLARETERDLRRSGDrVVRRDQLRRKVEALLLEE--AGEEVARRYRLLRSIRRPPRPLHVLIGGVSGVGKSVL 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  156 SALLGSRLGITTVVSTDSIRHMMRSFADEKQNPLLWASTYHAGEYLDPVAvaeskakrkakklkgsrgvnsnaqktDAGS 235
Cdd:PRK12337 272 ASALAYRLGITRIVSTDAVREVLRAMVSKDLLPTLHASTFNAWRALLPPG--------------------------EGLP 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  236 NSSTTELLshkqmaIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHLslnfVMGLMkKHPS-----IVPFMVYIANE 310
Cdd:PRK12337 326 AEPTRAEV------LRGFRDQVQQVAVGLGAIQERSAQEGTSLVLEGVHL----VPGYL-RHPYqagalVVPMLVTLPDE 394
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572583  311 EKHLERFAVRAKYMTLDPAKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSV 368
Cdd:PRK12337 395 ALHRRRFELRDRETGASRPRERYLRHFEEIRLIQDHLLRLARQEGVPVLPGEDLDESI 452
PRK12338 PRK12338
hypothetical protein; Provisional
136-402 8.29e-22

hypothetical protein; Provisional


Pssm-ID: 237066 [Multi-domain]  Cd Length: 319  Bit Score: 96.75  E-value: 8.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  136 RKESVtVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFADEKQNPLLWASTYHAGEYLdpvavaeskakrka 215
Cdd:PRK12338   2 RKPYV-ILIGSASGIGKSTIASELARTLNIKHLIETDFIREVVRGIIGKEYAPALHKSSYNAYTAL-------------- 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  216 kklkgsrgvnsnaqktdagsnSSTTELLSHKQMAIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHLslnfVMGLMK 295
Cdd:PRK12338  67 ---------------------RDKENFKNNEELICAGFEEHASFVIPAIEKVIERAVTDSDDIVIEGVHL----VPGLID 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  296 ----KHPSIVPFMVYIANEEKHLERFAVRAkyMTLDPAkNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATI 371
Cdd:PRK12338 122 ieqfEENASIHFFILSADEEVHKERFVKRA--MEIKRG-GKQLEYFRENRIIHDHLVEQAREHNVPVIKNDDIDCTVKKM 198
                        250       260       270
                 ....*....|....*....|....*....|.
gi 42572583  372 HATVfgclrrRETGEKLYdtTTNTVSVIDDE 402
Cdd:PRK12338 199 LSYI------REVCVTVT--LQHSVDDLDEV 221
PRK12339 PRK12339
mevalonate-3-phosphate 5-kinase;
138-371 9.72e-16

mevalonate-3-phosphate 5-kinase;


Pssm-ID: 105560  Cd Length: 197  Bit Score: 76.37  E-value: 9.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  138 ESVTVLLCGTSGCGKSTLSALLGSRLGITTVVSTDSIRHMMRSFADekQNPLLWASTYHAGEYLdpvavaeskakrkakk 217
Cdd:PRK12339   2 ESTIHFIGGIPGVGKTSISGYIARHRAIDIVLSGDYLREFLRPYVD--DEPVLAKSVYDAWEFY---------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572583  218 lkgsrgvnsnAQKTDagsnssttellshkQMAIEGYKAQSEMVIDSLDRLITTWEERNESVVVEGVHlslnFVMGLM--K 295
Cdd:PRK12339  64 ----------GSMTD--------------ENIVKGYLDQARAIMPGINRVIRRALLNGEDLVIESLY----FHPPMIdeN 115
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572583  296 KHPSIVPFMVYIANEEKHLERFAVRAKYMTLDPAKNKYVKYIRNIRTIQDYLCKRADKHLVPKINNTNVDKSVATI 371
Cdd:PRK12339 116 RTNNIRAFYLYIRDAELHRSRLADRINYTHKNSPGKRLAEHLPEYRTIMDYSIADARGYNIKVIDTDNYREARNPL 191
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
142-202 1.79e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 45.67  E-value: 1.79e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572583 142 VLLCGTSGCGKSTLSALLGSRLGiTTVVSTDSIRHMM--RSFADEKQNPLLWASTY-----HAGEYLD 202
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLG-AVRLRSDVVRKRLfgAGLAPLERSPEATARTYarllaLARELLA 68
COG4639 COG4639
Predicted kinase [General function prediction only];
142-184 4.84e-05

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 43.66  E-value: 4.84e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 42572583 142 VLLCGTSGCGKSTLSALLgsrLGITTVVSTDSIRHMMrsFADE 184
Cdd:COG4639   5 VVLIGLPGSGKSTFARRL---FAPTEVVSSDDIRALL--GGDE 42
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
142-179 3.80e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 41.14  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 42572583   142 VLLCGTSGCGKSTLSALLGSRLGiTTVVSTDSIRHMMR 179
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELG-AVRLSSDDERKRLF 38
AAA_18 pfam13238
AAA domain;
142-170 6.38e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.41  E-value: 6.38e-03
                          10        20
                  ....*....|....*....|....*....
gi 42572583   142 VLLCGTSGCGKSTLSALLGSRLGITTVVS 170
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVR 29
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
119-176 7.49e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 38.15  E-value: 7.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42572583 119 VGRDQRADlilacriRERKESVTVLLCGTSGCGKSTLSALLGSRL---GITTVV-STDSIRH 176
Cdd:COG0529   3 VTREERAA-------LKGQKGFVVWFTGLSGSGKSTLANALERRLferGRHVYLlDGDNVRH 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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