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Conserved domains on  [gi|42572467|ref|NP_974329|]
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RHOMBOID-like protein 14 [Arabidopsis thaliana]

Protein Classification

Rhomboid and zf-RanBP domain-containing protein( domain architecture ID 10414922)

Rhomboid and zf-RanBP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid super family cl21536
Rhomboid family; This family contains integral membrane proteins that are related to ...
 1-121 1.46e-08

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


The actual alignment was detected with superfamily member pfam01694:

Pssm-ID: 451297  Cd Length: 147  Bit Score: 52.22  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572467     1 MMSLLWKGIKLETSMGSSEFASMVFtLIGMSQGVTLLLAksllllfdydrAYYNEYAVGFSGVLFAMKVVLNSQAEDYSS 80
Cdd:pfam01694  27 MLALLFFGGPLERILGSVRFLLLYL-LSGIAGSLLSYLF-----------SPLSTPSVGASGAIFGLLGALLVLGPRNRI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 42572467    81 VYGILVPTK--YAAWAELILVQMFVP--NASFLGHLGGILAGIIY 121
Cdd:pfam01694  95 LLFGLIGALlaLLLFILLNLVLGLLPgnGVSNLAHLGGLLVGLLL 139
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
179-203 7.15e-05

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.87  E-value: 7.15e-05
                          10        20
                  ....*....|....*....|....*
gi 42572467   179 PGIWRCQSCTYDNSGWLSACEMCGS 203
Cdd:pfam00641   2 EGDWDCSKCLVQNFATSTKCVACQA 26
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 1-121 1.46e-08

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 52.22  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572467     1 MMSLLWKGIKLETSMGSSEFASMVFtLIGMSQGVTLLLAksllllfdydrAYYNEYAVGFSGVLFAMKVVLNSQAEDYSS 80
Cdd:pfam01694  27 MLALLFFGGPLERILGSVRFLLLYL-LSGIAGSLLSYLF-----------SPLSTPSVGASGAIFGLLGALLVLGPRNRI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 42572467    81 VYGILVPTK--YAAWAELILVQMFVP--NASFLGHLGGILAGIIY 121
Cdd:pfam01694  95 LLFGLIGALlaLLLFILLNLVLGLLPgnGVSNLAHLGGLLVGLLL 139
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
179-203 7.15e-05

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.87  E-value: 7.15e-05
                          10        20
                  ....*....|....*....|....*
gi 42572467   179 PGIWRCQSCTYDNSGWLSACEMCGS 203
Cdd:pfam00641   2 EGDWDCSKCLVQNFATSTKCVACQA 26
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 182-202 1.47e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.99  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|.
gi 42572467    182 WRCQSCTYDNSGWLSACEMCG 202
Cdd:smart00547   3 WECPACTFLNFASRSKCFACG 23
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 1-121 1.46e-08

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 52.22  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572467     1 MMSLLWKGIKLETSMGSSEFASMVFtLIGMSQGVTLLLAksllllfdydrAYYNEYAVGFSGVLFAMKVVLNSQAEDYSS 80
Cdd:pfam01694  27 MLALLFFGGPLERILGSVRFLLLYL-LSGIAGSLLSYLF-----------SPLSTPSVGASGAIFGLLGALLVLGPRNRI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 42572467    81 VYGILVPTK--YAAWAELILVQMFVP--NASFLGHLGGILAGIIY 121
Cdd:pfam01694  95 LLFGLIGALlaLLLFILLNLVLGLLPgnGVSNLAHLGGLLVGLLL 139
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
179-203 7.15e-05

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.87  E-value: 7.15e-05
                          10        20
                  ....*....|....*....|....*
gi 42572467   179 PGIWRCQSCTYDNSGWLSACEMCGS 203
Cdd:pfam00641   2 EGDWDCSKCLVQNFATSTKCVACQA 26
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 182-202 1.47e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 34.99  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|.
gi 42572467    182 WRCQSCTYDNSGWLSACEMCG 202
Cdd:smart00547   3 WECPACTFLNFASRSKCFACG 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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