|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02338 |
PLN02338 |
3-phosphoshikimate 1-carboxyvinyltransferase |
22-489 |
0e+00 |
|
3-phosphoshikimate 1-carboxyvinyltransferase
Pssm-ID: 177972 [Multi-domain] Cd Length: 443 Bit Score: 877.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 22 ASEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVETHSENNRAVVEGCGG 101
Cdd:PLN02338 1 AEEITLQPIKEISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEEDSENNRAVVEGCGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 102 VFPASIDSKSDIELYLGNAGTAMRPLTAAVTAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVN 181
Cdd:PLN02338 81 KFPVSGDSKEDVELFLGNAGTAMRPLTAAVTAAGGNASYVLDGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPVRVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 182 ANGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSESWDRFFVKGGQKY 261
Cdd:PLN02338 161 AAGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSDSWDRFFIKGGQKY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 262 KSPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSRDAFGMRHLRA 341
Cdd:PLN02338 241 KSPGNAYVEGDASSASYFLAGAAITGGTVTVEGCGTTSLQGDVKFAEVLEKMGAKVEWTENSVTVTGPPRDAFGGKHLKA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 342 IDVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGAT 421
Cdd:PLN02338 321 IDVNMNKMPDVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRK-------------------------LGAT 375
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42571811 422 VEEGSDYCVITPPKKVKPAEIDTYDDHRMAMAFSLAACADVPITINDPGCTRKTFPDYFQVLERITKH 489
Cdd:PLN02338 376 VEEGPDYCIITPPKKLKPAEIDTYDDHRMAMAFSLAACGDVPVTINDPGCTRKTFPTYFDVLESIAKH 443
|
|
| AroA |
COG0128 |
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ... |
23-486 |
2.08e-180 |
|
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439898 Cd Length: 421 Bit Score: 511.94 E-value: 2.08e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 23 SEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEtHSENNRAVVEGCGGV 102
Cdd:COG0128 2 SSLTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIE-ELDGGTLRVTGVGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 103 FPASidsksDIELYLGNAGTAMRPLTAAvtAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTlGTNCPPVRVNA 182
Cdd:COG0128 81 LKEP-----DAVLDCGNSGTTMRLLTGL--LALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESR-GGGYLPLTIRG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 183 nGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSEsWDRFFVKGGQKYK 262
Cdd:COG0128 153 -GPLKGGEYEIPGSASSQFKSALLLAGPLAEGGLEITVTGELESKPYRDHTERMLRAFGVEVEVEG-YRRFTVPGGQRYR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 263 sPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGpsrdafgmRHLRAI 342
Cdd:COG0128 231 -PGDYTVPGDISSAAFFLAAAAITGSEVTVEGVGLNSTQGDTGILDILKEMGADIEIENDGITVRG--------SPLKGI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 343 DVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATV 422
Cdd:COG0128 302 DIDLSDIPDEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRK-------------------------LGADV 356
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42571811 423 EEGSDYCVITPPKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERI 486
Cdd:COG0128 357 EETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGLrAEGPVTIDDAECVAKSFPDFFELLESL 421
|
|
| aroA |
TIGR01356 |
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ... |
35-489 |
2.80e-178 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273574 Cd Length: 409 Bit Score: 506.04 E-value: 2.80e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 35 GLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthSENNRAVVEGCGGVFPasidsksDIE 114
Cdd:TIGR01356 1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIE--DGGEVAVIEGVGGKEP-------QAE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 115 LYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNanGGLPGGKVKLS 194
Cdd:TIGR01356 72 LDLGNSGTTARLLTGVLALADGE--VVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTIS--GPLPGGIVYIS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 195 GSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSESwDRFFVKGGQKYKSPGnAYVEGDAS 274
Cdd:TIGR01356 148 GSASSQYKSALLLAAPALQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDG-RKIVVPGGQKYGPQG-YDVPGDYS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 275 SASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSRdafgmrhLRAIDVNMNKMPDVAM 354
Cdd:TIGR01356 226 SAAFFLAAAAITGGRVTLENLGINPTQGDKAIIIVLEEMGADIEVEEDDLIVEGASG-------LKGIKIDMDDMIDELP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 355 TLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGSDYCVITPP 434
Cdd:TIGR01356 299 TLAVLAAFAEGVTRITGAEELRVKESDRIAAIAEELRK-------------------------LGVDVEEFEDGLYIRGK 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 42571811 435 KKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERITKH 489
Cdd:TIGR01356 354 KELKGAVVDTFGDHRIAMAFAVAGLvAEGEVLIDDPECVAKSFPSFFDVLERLGAN 409
|
|
| EPSP_synthase |
cd01556 |
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ... |
33-486 |
2.57e-164 |
|
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.
Pssm-ID: 238797 Cd Length: 409 Bit Score: 470.50 E-value: 2.57e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 33 ISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthSENNRAVVEGCGGVFPasidsKSD 112
Cdd:cd01556 1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIE--EEGGTVEIVGGGGLGL-----PPE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 113 IELYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNanGGLPGGKVK 192
Cdd:cd01556 74 AVLDCGNSGTTMRLLTGLLALQGGD--SVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGG--GGLKGGEVE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 193 LSGSISSQYLTALLMAAPLALGDVEIEIVdKLISVPYVEMTLKLMERFGVSAEHSEsWDRFFVKGGQKYKSPgNAYVEGD 272
Cdd:cd01556 150 IPGAVSSQFKSALLLAAPLAEGPTTIIIG-ELESKPYIDHTERMLRAFGAEVEVDG-YRTITVKGGQKYKGP-EYTVEGD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 273 ASSASYFLAGAAITGETVTVEGCGTTSlqGDVKFAEVLEKMGCKVSWT-ENSVTVTGPsrdafgmRHLRAIDVNMNKMPD 351
Cdd:cd01556 227 ASSAAFFLAAAAITGSEIVIKNVGLNS--GDTGIIDVLKEMGADIEIGnEDTVVVESG-------GKLKGIDIDGNDIPD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 352 VAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGSDYCVI 431
Cdd:cd01556 298 EAPTLAVLAAFAEGPTRIRNAAELRVKESDRIAAMATELRK-------------------------LGADVEETEDGLII 352
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 42571811 432 TP-PKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERI 486
Cdd:cd01556 353 EGgPLKGAGVEVYTYGDHRIAMSFAIAGLvAEGGVTIEDPECVAKSFPNFFEDLESL 409
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
28-483 |
1.03e-147 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 428.64 E-value: 1.03e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 28 QPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILG-LNVETHSENNRAVVEGCGGVFPAS 106
Cdd:pfam00275 1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGaEIIKLDDEKSVVIVEGLGGSFEAP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 107 idskSDIELYLGNAGTAMRPLTAAvtAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNangGL 186
Cdd:pfam00275 81 ----EDLVLDMGNSGTALRPLTGR--LALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVR---GL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 187 PGGKVKLSGSISSQYLTALLMAAPLALGDvEIEIVDkLISVPYVEMTLKLMERFGVSAEHSESWDRFFVKGGQKYKSpGN 266
Cdd:pfam00275 152 RLGGIHIDGDVSSQFVTSLLMLAALLAEG-TTTIEN-LASEPYIDDTENMLKKFGAKIEGSGTELSITVKGGEKLPG-QE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 267 AYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSrdafgmrHLRAIDVNM 346
Cdd:pfam00275 229 YRVEGDRSSAAYFLVAAAITGGTVTVENVGINSLQGDEALLEILEKMGAEITQEEDADIVVGPP-------GLRGKAVDI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 347 NKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGS 426
Cdd:pfam00275 302 RTAPDPAPTTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRR-------------------------LGADVEELP 356
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 42571811 427 DYCVITPP-KKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVL 483
Cdd:pfam00275 357 DGLIIIPAvKELKGAEVDSYGDHRIAMALALAGLvAEGETIIDDIECTDRSFPDFEEKL 415
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02338 |
PLN02338 |
3-phosphoshikimate 1-carboxyvinyltransferase |
22-489 |
0e+00 |
|
3-phosphoshikimate 1-carboxyvinyltransferase
Pssm-ID: 177972 [Multi-domain] Cd Length: 443 Bit Score: 877.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 22 ASEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVETHSENNRAVVEGCGG 101
Cdd:PLN02338 1 AEEITLQPIKEISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEEDSENNRAVVEGCGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 102 VFPASIDSKSDIELYLGNAGTAMRPLTAAVTAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVN 181
Cdd:PLN02338 81 KFPVSGDSKEDVELFLGNAGTAMRPLTAAVTAAGGNASYVLDGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPVRVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 182 ANGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSESWDRFFVKGGQKY 261
Cdd:PLN02338 161 AAGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSDSWDRFFIKGGQKY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 262 KSPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSRDAFGMRHLRA 341
Cdd:PLN02338 241 KSPGNAYVEGDASSASYFLAGAAITGGTVTVEGCGTTSLQGDVKFAEVLEKMGAKVEWTENSVTVTGPPRDAFGGKHLKA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 342 IDVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGAT 421
Cdd:PLN02338 321 IDVNMNKMPDVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRK-------------------------LGAT 375
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42571811 422 VEEGSDYCVITPPKKVKPAEIDTYDDHRMAMAFSLAACADVPITINDPGCTRKTFPDYFQVLERITKH 489
Cdd:PLN02338 376 VEEGPDYCIITPPKKLKPAEIDTYDDHRMAMAFSLAACGDVPVTINDPGCTRKTFPTYFDVLESIAKH 443
|
|
| PRK11860 |
PRK11860 |
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase; |
27-488 |
0e+00 |
|
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
Pssm-ID: 237003 [Multi-domain] Cd Length: 661 Bit Score: 531.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 27 LQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVETHSENnrAVVEGCGGVFPAS 106
Cdd:PRK11860 9 LPPLLSAGGTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDT--YRITGLGGQFPVK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 107 idsksDIELYLGNAGTAMRPLTAAVTAAGGnaSYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNANGGL 186
Cdd:PRK11860 87 -----QADLFLGNAGTAMRPLTAALALLGG--EYELSGVPRMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPAPLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 187 PGGKVKLSGSISSQYLTALLMAAPLALG-DVEIEIVDKLISVPYVEMTLKLMERFGVSAEHsESWDRFFVKGGQKYKSPG 265
Cdd:PRK11860 160 LDAPIRVRGDVSSQFLTALLMALPLVARrDITIEVVGELISKPYIEITLNLLARFGIAVQR-EGWQRFTIPAGSRYRSPG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 266 NAYVEGDASSASYFLAGAAI-TGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSRDafgmrhLRAIDV 344
Cdd:PRK11860 239 EIHVEGDASSASYFIAAGAIaGGAPVRIEGVGRDSIQGDIRFAEAARAMGAQVTSGPNWLEVRRGAWP------LKAIDL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 345 NMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEE 424
Cdd:PRK11860 313 DCNHIPDAAMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRK-------------------------LGATVEE 367
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42571811 425 GSDYCVITPPKKV---KPAEIDTYDDHRMAMAFSLAA--CADVPITINDPGCTRKTFPDYFQVLERITK 488
Cdd:PRK11860 368 GADYIRVTPPAQAadwKAAAIHTYDDHRMAMCFSLAAfnPAGLPVRINDPKCVAKTFPDYFEALFSVAQ 436
|
|
| AroA |
COG0128 |
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ... |
23-486 |
2.08e-180 |
|
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439898 Cd Length: 421 Bit Score: 511.94 E-value: 2.08e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 23 SEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEtHSENNRAVVEGCGGV 102
Cdd:COG0128 2 SSLTIAPPSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIE-ELDGGTLRVTGVGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 103 FPASidsksDIELYLGNAGTAMRPLTAAvtAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTlGTNCPPVRVNA 182
Cdd:COG0128 81 LKEP-----DAVLDCGNSGTTMRLLTGL--LALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESR-GGGYLPLTIRG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 183 nGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSEsWDRFFVKGGQKYK 262
Cdd:COG0128 153 -GPLKGGEYEIPGSASSQFKSALLLAGPLAEGGLEITVTGELESKPYRDHTERMLRAFGVEVEVEG-YRRFTVPGGQRYR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 263 sPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGpsrdafgmRHLRAI 342
Cdd:COG0128 231 -PGDYTVPGDISSAAFFLAAAAITGSEVTVEGVGLNSTQGDTGILDILKEMGADIEIENDGITVRG--------SPLKGI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 343 DVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATV 422
Cdd:COG0128 302 DIDLSDIPDEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRK-------------------------LGADV 356
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42571811 423 EEGSDYCVITPPKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERI 486
Cdd:COG0128 357 EETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGLrAEGPVTIDDAECVAKSFPDFFELLESL 421
|
|
| aroA |
TIGR01356 |
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ... |
35-489 |
2.80e-178 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273574 Cd Length: 409 Bit Score: 506.04 E-value: 2.80e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 35 GLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthSENNRAVVEGCGGVFPasidsksDIE 114
Cdd:TIGR01356 1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIE--DGGEVAVIEGVGGKEP-------QAE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 115 LYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNanGGLPGGKVKLS 194
Cdd:TIGR01356 72 LDLGNSGTTARLLTGVLALADGE--VVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTIS--GPLPGGIVYIS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 195 GSISSQYLTALLMAAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSESwDRFFVKGGQKYKSPGnAYVEGDAS 274
Cdd:TIGR01356 148 GSASSQYKSALLLAAPALQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDG-RKIVVPGGQKYGPQG-YDVPGDYS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 275 SASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSRdafgmrhLRAIDVNMNKMPDVAM 354
Cdd:TIGR01356 226 SAAFFLAAAAITGGRVTLENLGINPTQGDKAIIIVLEEMGADIEVEEDDLIVEGASG-------LKGIKIDMDDMIDELP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 355 TLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGSDYCVITPP 434
Cdd:TIGR01356 299 TLAVLAAFAEGVTRITGAEELRVKESDRIAAIAEELRK-------------------------LGVDVEEFEDGLYIRGK 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 42571811 435 KKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERITKH 489
Cdd:TIGR01356 354 KELKGAVVDTFGDHRIAMAFAVAGLvAEGEVLIDDPECVAKSFPSFFDVLERLGAN 409
|
|
| EPSP_synthase |
cd01556 |
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ... |
33-486 |
2.57e-164 |
|
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.
Pssm-ID: 238797 Cd Length: 409 Bit Score: 470.50 E-value: 2.57e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 33 ISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthSENNRAVVEGCGGVFPasidsKSD 112
Cdd:cd01556 1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIE--EEGGTVEIVGGGGLGL-----PPE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 113 IELYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNanGGLPGGKVK 192
Cdd:cd01556 74 AVLDCGNSGTTMRLLTGLLALQGGD--SVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGG--GGLKGGEVE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 193 LSGSISSQYLTALLMAAPLALGDVEIEIVdKLISVPYVEMTLKLMERFGVSAEHSEsWDRFFVKGGQKYKSPgNAYVEGD 272
Cdd:cd01556 150 IPGAVSSQFKSALLLAAPLAEGPTTIIIG-ELESKPYIDHTERMLRAFGAEVEVDG-YRTITVKGGQKYKGP-EYTVEGD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 273 ASSASYFLAGAAITGETVTVEGCGTTSlqGDVKFAEVLEKMGCKVSWT-ENSVTVTGPsrdafgmRHLRAIDVNMNKMPD 351
Cdd:cd01556 227 ASSAAFFLAAAAITGSEIVIKNVGLNS--GDTGIIDVLKEMGADIEIGnEDTVVVESG-------GKLKGIDIDGNDIPD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 352 VAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGSDYCVI 431
Cdd:cd01556 298 EAPTLAVLAAFAEGPTRIRNAAELRVKESDRIAAMATELRK-------------------------LGADVEETEDGLII 352
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 42571811 432 TP-PKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERI 486
Cdd:cd01556 353 EGgPLKGAGVEVYTYGDHRIAMSFAIAGLvAEGGVTIEDPECVAKSFPNFFEDLESL 409
|
|
| PRK02427 |
PRK02427 |
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
24-488 |
3.82e-163 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 235037 [Multi-domain] Cd Length: 435 Bit Score: 468.47 E-value: 3.82e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 24 EIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthseNNRAVVEGCGGvf 103
Cdd:PRK02427 4 MLLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIE----DDEVVVEGVGG-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 104 pASIDSKSDIeLYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQLGADVECTlGTNCPPVRVNan 183
Cdd:PRK02427 78 -GGLKEPEDV-LDCGNSGTTMRLLTGLLALQPGE--VVLTGDESLRKRPMGRLLDPLRQMGAKIEGR-DEGYLPLTIR-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 184 GGLPGGKVKLSGSISSQY----------LTAllmaaplalGDVEIEIVDKLISVPYVEMTLKLMERFGVSAEHSESWD-- 251
Cdd:PRK02427 151 GGKKGGPIEYDGPVSSQFvksllllaplFAE---------GDTETTVIEPLPSRPHTEITLRMLRAFGVEVENVEGWGyr 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 252 RFFVKGGQKYKsPGNAYVEGDASSASYFLAGAAIT-GETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTvtGPS 330
Cdd:PRK02427 222 RIVIKGGQRLR-GQDITVPGDPSSAAFFLAAAAITgGSEVTITNVGLNSTQGGKAIIDVLEKMGADIEIENEREG--GEP 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 331 RDAFGMRH--LRAIDVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahs 408
Cdd:PRK02427 299 VGDIRVRSseLKGIDIDIPDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRK---------------- 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 409 kkfcgicvqLGATVEEGSDYCVITPPKKVkpAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERIT 487
Cdd:PRK02427 363 ---------LGAEVEETEDGLIITGGPLA--GVVDSYGDHRIAMAFAIAGLaAEGPVTIDDPECVAKSFPDFFEDLASLG 431
|
.
gi 42571811 488 K 488
Cdd:PRK02427 432 A 432
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
28-483 |
1.03e-147 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 428.64 E-value: 1.03e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 28 QPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILG-LNVETHSENNRAVVEGCGGVFPAS 106
Cdd:pfam00275 1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGaEIIKLDDEKSVVIVEGLGGSFEAP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 107 idskSDIELYLGNAGTAMRPLTAAvtAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNangGL 186
Cdd:pfam00275 81 ----EDLVLDMGNSGTALRPLTGR--LALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVR---GL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 187 PGGKVKLSGSISSQYLTALLMAAPLALGDvEIEIVDkLISVPYVEMTLKLMERFGVSAEHSESWDRFFVKGGQKYKSpGN 266
Cdd:pfam00275 152 RLGGIHIDGDVSSQFVTSLLMLAALLAEG-TTTIEN-LASEPYIDDTENMLKKFGAKIEGSGTELSITVKGGEKLPG-QE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 267 AYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPSrdafgmrHLRAIDVNM 346
Cdd:pfam00275 229 YRVEGDRSSAAYFLVAAAITGGTVTVENVGINSLQGDEALLEILEKMGAEITQEEDADIVVGPP-------GLRGKAVDI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 347 NKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKvkfffslslsvysahskkfcgicvqLGATVEEGS 426
Cdd:pfam00275 302 RTAPDPAPTTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRR-------------------------LGADVEELP 356
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 42571811 427 DYCVITPP-KKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVL 483
Cdd:pfam00275 357 DGLIIIPAvKELKGAEVDSYGDHRIAMALALAGLvAEGETIIDDIECTDRSFPDFEEKL 415
|
|
| PRK11861 |
PRK11861 |
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
4-480 |
3.12e-129 |
|
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 183343 [Multi-domain] Cd Length: 673 Bit Score: 390.22 E-value: 3.12e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 4 GSEIRPVKVRASVSTAEKASEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGl 83
Cdd:PRK11861 222 GAKPAPAVRSDTSGTGSHMEHLDLGPFSHAQGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLG- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 84 nVETHSENNRAVVEGCGGVFPASIdsksdIELYLGNAGTAMRPLTAAVTAAGGNasYVLDGVPRMRERPIGDLVVGLKQL 163
Cdd:PRK11861 301 -VKLSRDGGTCVVGGTRGAFTAKT-----ADLFLGNAGTAVRPLTAALAVNGGE--YRIHGVPRMHERPIGDLVDGLRQI 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 164 GADVECTLGTNCPPVRVNANGGLPGGKVKLSGSISSQYLTALLMA---APLALGDVEIEIVDKLISVPYVEMTLKLMERF 240
Cdd:PRK11861 373 GARIDYEGNEGFPPLRIRPATISVDAPIRVRGDVSSQFLTALLMTlplVKAKDGASVVEIDGELISKPYIEITIKLMARF 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 241 GVSAEHsESWDRFFVKGGQKYKSPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWT 320
Cdd:PRK11861 453 GVTVER-DGWQRFTVPAGVRYRSPGTIMVEGDASSASYFLAAGALGGGPLRVEGVGRASIQGDVGFANALMQMGANVTMG 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 321 ENSVTVTGPSRDafgMRHLRAIDVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKVkfffsls 400
Cdd:PRK11861 532 DDWIEVRGIGHD---HGRLAPIDMDFNLIPDAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKV------- 601
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 401 lsvysahskkfcgicvqlGATVEEGSDYCVITPPKKVKP-AEIDTYDDHRMAMAFSLAACADVPITINDPGCTRKTFPDY 479
Cdd:PRK11861 602 ------------------GATVEEGADYLVVTPPAQLTPnASIDTYDDHRMAMCFSLVSLGGVPVRINDPKCVGKTFPDY 663
|
.
gi 42571811 480 F 480
Cdd:PRK11861 664 F 664
|
|
| EPT-like |
cd01554 |
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ... |
33-486 |
2.03e-100 |
|
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.
Pssm-ID: 238795 Cd Length: 408 Bit Score: 307.61 E-value: 2.03e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 33 ISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEthSENNRAVVEGCGG-VFPAsidskS 111
Cdd:cd01554 1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEIE--DKDGVITIQGVGMaGLKA-----P 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 112 DIELYLGNAGTAMRPLTAAVtaAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVnaNGGLPGGKV 191
Cdd:cd01554 74 QNALNLGNSGTAIRLISGVL--AGADFEVELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLPPLLK--GGKNLGPIH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 192 KLSGSISSQYLTALLMAAPLALGDVEIEIVdklISVPYVEMTLKLMERFGVSAEhSESWDRFFVKGGQKYKSPgNAYVEG 271
Cdd:cd01554 150 YEDPIASAQVKSALMFAALLAKGETVIIEA---AKEPTINHTENMLQTFGGHIS-VQGTKKIVVQGPQKLTGQ-KYVVPG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 272 DASSASYFLAGAAITGETVTVEGCGTTSlqGDVKFAEVLEKMGCKVSWTENSVTVTgpsrdafgMRHLRAIDVNMN---K 348
Cdd:cd01554 225 DISSAAFFLVAAAIAPGRLVLQNVGINE--TRTGIIDVLRAMGAKIEIGEDTISVE--------SSDLKATEICGAlipR 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 349 MPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKVkfffslslsvysahskkfcgicvqlGATVEEGSDY 428
Cdd:cd01554 295 LIDELPIIALLALQAQGTTVIKDAEELKVKETDRIFVVADELNSM-------------------------GADIEPTADG 349
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 42571811 429 CVITPPKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLERI 486
Cdd:cd01554 350 MIIKGKEKLHGARVNTFGDHRIGMMTALAALvADGEVELDRAEAINTSYPSFFDDLESL 408
|
|
| PRK14806 |
PRK14806 |
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ... |
26-486 |
1.87e-28 |
|
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 237820 [Multi-domain] Cd Length: 735 Bit Score: 119.33 E-value: 1.87e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 26 VLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGLNVEThSENNRAVVEGCG--GVF 103
Cdd:PRK14806 305 SVLPGGAVKGTIRVPGDKSISHRSIMLGSLAEGVTEVEGFLEGEDALATLQAFRDMGVVIEG-PHNGRVTIHGVGlhGLK 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 104 PASidsksdIELYLGNAGTAMRpLTAAVTAAGGNASyVLDGVPRMRERPIGDLVVGLKQLGADVECtlGTNC-PPVRVna 182
Cdd:PRK14806 384 APP------GPLYMGNSGTSMR-LLSGLLAAQSFDS-VLTGDASLSKRPMERVAKPLREMGAVIET--GEEGrPPLSI-- 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 183 ngglPGGKVkLSG------SISSQYLTALLMAAPLALGDVeieivdkliSVPYVEMTLKLMER----FGVSAEhsESWDR 252
Cdd:PRK14806 452 ----RGGQR-LKGihydlpMASAQVKSCLLLAGLYAEGET---------SVTEPAPTRDHTERmlrgFGYPVK--VEGNT 515
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 253 FFVKGGQKYKSpGNAYVEGDASSASYFLAGAAIT-GETVTVEGCGTTSLQgdVKFAEVLEKMGCKVSwTENSVTVTG-PS 330
Cdd:PRK14806 516 ISVEGGGKLTA-TDIEVPADISSAAFFLVAASIAeGSELTLEHVGINPTR--TGVIDILKLMGADIT-LENEREVGGePV 591
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 331 RD-AFGMRHLRAIDVNMNKMP---DVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKVkfffslslsvysa 406
Cdd:PRK14806 592 ADiRVRGARLKGIDIPEDQVPlaiDEFPVLFVAAACAEGRTVLTGAEELRVKESDRIQVMADGLKTL------------- 658
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 407 hskkfcGICvqlgATVEEGSdycVITPPKKVKPAEIDTYDDHRMAMAFSLAAC-ADVPITINDPGCTRKTFPDYFQVLER 485
Cdd:PRK14806 659 ------GID----CEPTPDG---IIIEGGIFGGGEVESHGDHRIAMSFSVASLrASGPITIHDCANVATSFPNFLELANQ 725
|
.
gi 42571811 486 I 486
Cdd:PRK14806 726 V 726
|
|
| EPT_RTPC-like |
cd01553 |
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate ... |
270-486 |
1.67e-26 |
|
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.
Pssm-ID: 238794 Cd Length: 211 Bit Score: 106.59 E-value: 1.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 270 EGDASSASYFLAGAAITGETVTVEGCGTTS-----LQGDVKFAEVLEKM-GCKVSWTEnsvtvTGPSRDAFGMRHLRAID 343
Cdd:cd01553 7 KGGGQILRSFLVLAAISGGPITVTGIRPDRakpglLRQHLTFLKALEKIcGATVEGGE-----LGSDRISFRPGTVRGGD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 344 VNMN-----KMPDVAMTLAVVALFADGPTTIRDVASWRV----KETERMIAICTELRKVkfffslslsvysahskkfcgi 414
Cdd:cd01553 82 VRFAigsagSCTDVLQTILPLLLFAKGPTRLTVTGGTDNpsapPADFIRFVLEPELAKI--------------------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 415 cvqlGATVEEGSD------------YCVITPPKKVKPAEIdtyddhRMAMAFSLAACADVpitINDPGCTRKTFPDYFQV 482
Cdd:cd01553 141 ----GAHQEETLLrhgfypagggvvATEVSPVEKLNTAQL------RQLVLPMLLASGAV---EFTVAHPSCHLLTNFAV 207
|
....
gi 42571811 483 LERI 486
Cdd:cd01553 208 LEAL 211
|
|
| MurA |
COG0766 |
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ... |
34-344 |
2.72e-06 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440529 Cd Length: 416 Bit Score: 49.60 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 34 SGLIKLPGSKslsNRIL-LLAA--LSEGTTVVDNLLNSDDINYMLDALKILGLNVEtHSENNRAVVEgcggvfPASIDSK 110
Cdd:COG0766 13 SGEVRISGAK---NAALpILAAalLTDGPVTLRNVPDLSDVRTMLELLESLGVKVE-RDDGGTLTID------ASNINST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 111 S-DIELylgnaGTAMR-------PL-----TAAVTAAGGNASyvldGVprmreRPIgDL-VVGLKQLGADVECTLGTncp 176
Cdd:COG0766 83 EaPYEL-----VRKMRasilvlgPLlarfgEARVSLPGGCAI----GA-----RPI-DLhLKGLEALGAEIEIEHGY--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 177 pVRVNANGgLPGGKVKLsgsissqyltallmaaplalgDV---------------------------EIEIVDkLISVpy 229
Cdd:COG0766 145 -IEARAGR-LKGARIYL---------------------DFpsvgatenimmaavlaegttvienaarEPEIVD-LANF-- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 230 vemtLKLM-----------------ERFGvSAEHSESWDRffvkggqkykspgnayVEgdassASYFLAGAAITGETVTV 292
Cdd:COG0766 199 ----LNAMgakiegagtdtitiegvEKLH-GAEHTVIPDR----------------IE-----AGTFLVAAAITGGDVTV 252
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 42571811 293 EGCGTTSLQGdvkFAEVLEKMGCKVSWTENSVTVTGPSRdafgmrhLRAIDV 344
Cdd:COG0766 253 KNVIPEHLEA---VLAKLREAGVEIEEGDDGIRVRGPGR-------LKAVDI 294
|
|
| UdpNAET |
cd01555 |
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ... |
33-371 |
2.51e-05 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.
Pssm-ID: 238796 Cd Length: 400 Bit Score: 46.31 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 33 ISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKILGlnVETHSENNRAVVegcggvfpasIDSkSD 112
Cdd:cd01555 1 LSGEVRISGAKNAALPILAAALLTDEPVTLRNVPDLLDVETMIELLRSLG--AKVEFEGENTLV----------IDA-SN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 113 IELYLGNAGTA--MR-------PL-----TAAVTAAGGNAsyvldgvprMRERPIgDL-VVGLKQLGADVECTLGTncpp 177
Cdd:cd01555 68 INSTEAPYELVrkMRasilvlgPLlarfgEARVSLPGGCA---------IGARPV-DLhLKGLEALGAKIEIEDGY---- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 178 VRVNANGGLPGGKVKLS-----GSISSqyltalLMAAPLALGDVEI-------EIVDkLISVpyvemtLKLMerfGVSAE 245
Cdd:cd01555 134 VEAKAAGRLKGARIYLDfpsvgATENI------MMAAVLAEGTTVIenaarepEIVD-LANF------LNKM---GAKIE 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571811 246 HSESwDRFFVKG-----GQKYKspgnayVEGDASSASYFLAGAAITGETVTVEGCGTTSLQgdvKFAEVLEKMGCKVSWT 320
Cdd:cd01555 198 GAGT-DTIRIEGverlhGAEHT------VIPDRIEAGTFLVAAAITGGDITVENVIPEHLE---AVLAKLREMGAKIEIG 267
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 42571811 321 ENSVTVTGPSRDafgmrhLRAIDVNMNKMP----DVAMTLAVVALFADGPTTIRD 371
Cdd:cd01555 268 EDGIRVDGDGGR------LKAVDIETAPYPgfptDLQAQFMALLTQAEGTSVITE 316
|
|
| PRK09369 |
PRK09369 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated |
279-344 |
5.54e-04 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
Pssm-ID: 236486 Cd Length: 417 Bit Score: 42.33 E-value: 5.54e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42571811 279 FLAGAAITGETVTVEGCGTTSLQGdvkFAEVLEKMGCKVSWTENSVTVTGPsrdafgmRHLRAIDV 344
Cdd:PRK09369 240 FLVAAAITGGDVTIRGARPEHLEA---VLAKLREAGAEIEEGEDGIRVDMP-------GRLKAVDI 295
|
|
| |
