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Conserved domains on  [gi|42571287|ref|NP_973734|]
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nodulin MtN21 /EamA-like transporter family protein [Arabidopsis thaliana]

Protein Classification

DMT family transporter( domain architecture ID 706274)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; similar to Arabidopsis thaliana protein WALLS ARE THIN 1 (WAT1) and WAT1-related proteins

Gene Ontology:  GO:0016020|GO:0022857
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN00411 super family cl28283
nodulin MtN21 family protein; Provisional
16-298 3.84e-29

nodulin MtN21 family protein; Provisional


The actual alignment was detected with superfamily member PLN00411:

Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 114.28  E-value: 3.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   16 LLLLNR-KTRPQITFRLMVDHFVSGLLGaSLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFRTENVKiLKTKAGM 94
Cdd:PLN00411  61 LFFTNRsRSLPPLSVSILSKIGLLGFLG-SMYVITGYIGIEYSNPTLASAISNITPALTFILAIIFRMEKVS-FKERSSV 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   95 LKVIGTLICISGALFLTFYKGPQISNSHSHSHGGASHNNNDQDKAN-NWLLGCLYLTIGTVLLSLWMLFQGTLSIKYPCK 173
Cdd:PLN00411 139 AKVMGTILSLIGALVVIFYHGPRVFVASSPPYLNFRQLSPPLSSSNsDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  174 YSSTCLMSIFAAFQCALLSLY-KSRDVNDWIIddRFVITVIIyagVVGQAMTT----VATTWGIKKLGAVFASAFFPLTL 248
Cdd:PLN00411 219 FTVSFLYTVCVSIVTSMIGLVvEKNNPSVWII--HFDITLIT---IVTMAIITsvyyVIHSWTVRHKGPLYLAIFKPLSI 293
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 42571287  249 ISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLWGKNKETESSTALSSG 298
Cdd:PLN00411 294 LIAVVMGAIFLNDSLYLGCLIGGILITLGFYAVMWGKANEEKDQLLSFSG 343
 
Name Accession Description Interval E-value
PLN00411 PLN00411
nodulin MtN21 family protein; Provisional
16-298 3.84e-29

nodulin MtN21 family protein; Provisional


Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 114.28  E-value: 3.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   16 LLLLNR-KTRPQITFRLMVDHFVSGLLGaSLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFRTENVKiLKTKAGM 94
Cdd:PLN00411  61 LFFTNRsRSLPPLSVSILSKIGLLGFLG-SMYVITGYIGIEYSNPTLASAISNITPALTFILAIIFRMEKVS-FKERSSV 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   95 LKVIGTLICISGALFLTFYKGPQISNSHSHSHGGASHNNNDQDKAN-NWLLGCLYLTIGTVLLSLWMLFQGTLSIKYPCK 173
Cdd:PLN00411 139 AKVMGTILSLIGALVVIFYHGPRVFVASSPPYLNFRQLSPPLSSSNsDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  174 YSSTCLMSIFAAFQCALLSLY-KSRDVNDWIIddRFVITVIIyagVVGQAMTT----VATTWGIKKLGAVFASAFFPLTL 248
Cdd:PLN00411 219 FTVSFLYTVCVSIVTSMIGLVvEKNNPSVWII--HFDITLIT---IVTMAIITsvyyVIHSWTVRHKGPLYLAIFKPLSI 293
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 42571287  249 ISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLWGKNKETESSTALSSG 298
Cdd:PLN00411 294 LIAVVMGAIFLNDSLYLGCLIGGILITLGFYAVMWGKANEEKDQLLSFSG 343
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
15-287 1.77e-19

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 86.43  E-value: 1.77e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  15 FLLLLNRKTRPQITFRLMVDHFVSGLLGASLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFrtenvkiLKTKAGM 94
Cdd:COG0697  48 PLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALL-------LGERLSR 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  95 LKVIGTLICISGALFLTFykgpqisnsHSHSHGGAShnnndqdkannwLLGCLYLTIGTVLLSLWMLFQGTLSIKYPcKY 174
Cdd:COG0697 121 RRWLGLLLGFAGVLLIVG---------PGGGGGGGS------------LLGDLLALLAALSWALYTVLTRRLSRRLD-PL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287 175 SSTCLMSIFAAFQCALLSLYksrdVNDWIIDDRFVITVIIYAGVVGQAMTTVATTWGIKKLGAVFASAFFPLTLISATLF 254
Cdd:COG0697 179 TLTFWQMLVGALLLLPLALL----TGLPLPLSAAAWLALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLL 254
                       250       260       270
                ....*....|....*....|....*....|...
gi 42571287 255 DFLILHTPLYLGSVIGSLVTITGLYMFLWGKNK 287
Cdd:COG0697 255 GWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
143-283 1.95e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 40.64  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   143 LLGCLYLTIGTVLLSLWMLFQGTLSIKYPcKYSSTCLMSIFAAFQCALLSLYKSRdvndWIIDDRFVITVIIYAGVVGQA 222
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRIS-PLTLTFWRFLIAGILLLPFALFTGG----KLVIPLKSWLALLYLGVLGTF 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42571287   223 MTTVATTWGIKKLGAVFASAFFPLTLISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLW 283
Cdd:pfam00892  76 LGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
PLN00411 PLN00411
nodulin MtN21 family protein; Provisional
16-298 3.84e-29

nodulin MtN21 family protein; Provisional


Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 114.28  E-value: 3.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   16 LLLLNR-KTRPQITFRLMVDHFVSGLLGaSLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFRTENVKiLKTKAGM 94
Cdd:PLN00411  61 LFFTNRsRSLPPLSVSILSKIGLLGFLG-SMYVITGYIGIEYSNPTLASAISNITPALTFILAIIFRMEKVS-FKERSSV 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   95 LKVIGTLICISGALFLTFYKGPQISNSHSHSHGGASHNNNDQDKAN-NWLLGCLYLTIGTVLLSLWMLFQGTLSIKYPCK 173
Cdd:PLN00411 139 AKVMGTILSLIGALVVIFYHGPRVFVASSPPYLNFRQLSPPLSSSNsDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAA 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  174 YSSTCLMSIFAAFQCALLSLY-KSRDVNDWIIddRFVITVIIyagVVGQAMTT----VATTWGIKKLGAVFASAFFPLTL 248
Cdd:PLN00411 219 FTVSFLYTVCVSIVTSMIGLVvEKNNPSVWII--HFDITLIT---IVTMAIITsvyyVIHSWTVRHKGPLYLAIFKPLSI 293
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 42571287  249 ISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLWGKNKETESSTALSSG 298
Cdd:PLN00411 294 LIAVVMGAIFLNDSLYLGCLIGGILITLGFYAVMWGKANEEKDQLLSFSG 343
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
15-287 1.77e-19

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 86.43  E-value: 1.77e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  15 FLLLLNRKTRPQITFRLMVDHFVSGLLGASLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFrtenvkiLKTKAGM 94
Cdd:COG0697  48 PLLLLRGRRLPPLSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALL-------LGERLSR 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287  95 LKVIGTLICISGALFLTFykgpqisnsHSHSHGGAShnnndqdkannwLLGCLYLTIGTVLLSLWMLFQGTLSIKYPcKY 174
Cdd:COG0697 121 RRWLGLLLGFAGVLLIVG---------PGGGGGGGS------------LLGDLLALLAALSWALYTVLTRRLSRRLD-PL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287 175 SSTCLMSIFAAFQCALLSLYksrdVNDWIIDDRFVITVIIYAGVVGQAMTTVATTWGIKKLGAVFASAFFPLTLISATLF 254
Cdd:COG0697 179 TLTFWQMLVGALLLLPLALL----TGLPLPLSAAAWLALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLL 254
                       250       260       270
                ....*....|....*....|....*....|...
gi 42571287 255 DFLILHTPLYLGSVIGSLVTITGLYMFLWGKNK 287
Cdd:COG0697 255 GWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
143-283 1.95e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 40.64  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287   143 LLGCLYLTIGTVLLSLWMLFQGTLSIKYPcKYSSTCLMSIFAAFQCALLSLYKSRdvndWIIDDRFVITVIIYAGVVGQA 222
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRIS-PLTLTFWRFLIAGILLLPFALFTGG----KLVIPLKSWLALLYLGVLGTF 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42571287   223 MTTVATTWGIKKLGAVFASAFFPLTLISATLFDFLILHTPLYLGSVIGSLVTITGLYMFLW 283
Cdd:pfam00892  76 LGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
15-112 7.69e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.10  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571287    15 FLLLLNRKTRPQITFRLMVDHFVSGLLGASLMQFFFLLGLSYTSATVSCALVSMLPAITFALALIFrtenvkiLKTKAGM 94
Cdd:pfam00892  46 LPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLL-------LGEKLTL 118
                          90
                  ....*....|....*...
gi 42571287    95 LKVIGTLICISGALFLTF 112
Cdd:pfam00892 119 KQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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