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Conserved domains on  [gi|42570993|ref|NP_973570|]
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actin-related protein C1A [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-246 2.12e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLviL 96
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--T 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVF 172
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAtgKLLRtlTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 173 StfikgVDTkyahylngaffllKQQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVD---------DVGPSPLAQS 243
Cdd:COG2319 274 D-----LAT-------------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlatgkllrtLTGHTGAVRS 335


                ...
gi 42570993 244 VAF 246
Cdd:COG2319 336 VAF 338
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-246 2.12e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLviL 96
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--T 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVF 172
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAtgKLLRtlTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 173 StfikgVDTkyahylngaffllKQQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVD---------DVGPSPLAQS 243
Cdd:COG2319 274 D-----LAT-------------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlatgkllrtLTGHTGAVRS 335


                ...
gi 42570993 244 VAF 246
Cdd:COG2319 336 VAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-282 5.45e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 5.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  48 LHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVILRLnrAALCVQWSPKENKFAVGSGAKTVCIcy 127
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 128 yeqennWWVSKLIRKR----HESSVTSVAWHPNNVLLATTSTDGKCRVFSTfikgVDTKYAHYLNGAFfllkqqilqldl 203
Cdd:cd00200  78 ------WDLETGECVRtltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----ETGKCLTTLRGHT------------ 135

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42570993 204 sySWAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLAQSVAFRDlplrDVLFISekmvigVGYDSNPMVFASDDTGIW 282
Cdd:cd00200 136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG----EVNSVA------FSPDGEKLLSSSSDGTIK 202
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-173 3.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.65e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 42570993    142 KRHESSVTSVAWHPNNVLLATTSTDGKCRVFS 173
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
144-173 1.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 42570993   144 HESSVTSVAWHPNNVLLATTSTDGKCRVFS 173
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
17-246 2.12e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLviL 96
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--T 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVF 172
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAtgKLLRtlTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 173 StfikgVDTkyahylngaffllKQQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVD---------DVGPSPLAQS 243
Cdd:COG2319 274 D-----LAT-------------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDlatgkllrtLTGHTGAVRS 335


                ...
gi 42570993 244 VAF 246
Cdd:COG2319 336 VAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
17-221 3.34e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYKSLSQdhwERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVil 96
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT-- 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVF 172
Cdd:COG2319 286 GHSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAtgKLLRtlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 42570993 173 StfikgVDTKyahylngaffllkQQILQLDLSYSWAFGVKWSPSGNTLA 221
Cdd:COG2319 358 D-----LATG-------------ELLRTLTGHTGAVTSVAFSPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
10-246 2.49e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 2.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  10 AESITCHAWSPDLSMVALCPNNTEVHIYKSLSqdhWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEW 89
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT---GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  90 VPTLVilRLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTST 165
Cdd:COG2319 239 LRTLT--GHSGSVRSVAFSPDGRLLASGSADGTVRL--------WDLAtgELLRtlTGHSGGVNSVAFSPDGKLLASGSD 308

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 166 DGKCRVFStfikgVDTkyahylngaffllKQQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLA---- 241
Cdd:COG2319 309 DGTVRLWD-----LAT-------------GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRtltg 370

                       250
                ....*....|
gi 42570993 242 -----QSVAF 246
Cdd:COG2319 371 htgavTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
17-233 2.22e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVil 96
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLW---DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT-- 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennWWVS--KLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVF 172
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLAtgKLLRtlTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570993 173 StfikgVDTkyahylngaffllKQQILQLDLSYSWAFGVKWSPSGNTLAYVGHSSMIYFVD 233
Cdd:COG2319 232 D-----LAT-------------GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-282 5.45e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 5.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  48 LHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVILRLnrAALCVQWSPKENKFAVGSGAKTVCIcy 127
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 128 yeqennWWVSKLIRKR----HESSVTSVAWHPNNVLLATTSTDGKCRVFSTfikgVDTKYAHYLNGAFfllkqqilqldl 203
Cdd:cd00200  78 ------WDLETGECVRtltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----ETGKCLTTLRGHT------------ 135

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42570993 204 sySWAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLAQSVAFRDlplrDVLFISekmvigVGYDSNPMVFASDDTGIW 282
Cdd:cd00200 136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG----EVNSVA------FSPDGEKLLSSSSDGTIK 202
WD40 COG2319
WD40 repeat [General function prediction only];
17-174 6.18e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 6.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  17 AWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVil 96
Cdd:COG2319 253 AFSPDGRLLASGSADGTVRLW---DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-- 327

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42570993  97 RLNRAALCVQWSPKENKFAVGSGAKTVCIcyYEQENNWWVSKLirKRHESSVTSVAWHPNNVLLATTSTDGKCRVFST 174
Cdd:COG2319 328 GHTGAVRSVAFSPDGKTLASGSDDGTVRL--WDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-173 2.11e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  12 SITCHAWSPDLSMVALCPNNTEVHIYKSlsqDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVP 91
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLWDL---RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  92 TLVilRLNRAALCVQWSPKENKFAVGSGAKTVCIcyyeqennW-WVSKLIRKR---HESSVTSVAWHPNNVLLATTSTDG 167
Cdd:cd00200 214 TLR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTlsgHTNSVTSLAWSPDGKRLASGSADG 283


                ....*.
gi 42570993 168 KCRVFS 173
Cdd:cd00200 284 TIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-221 3.78e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 3.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993   9 FAESITCHAWSPDLSMVALCPNNTEVHIYKSLSQdhwERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAE 88
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  89 WVPTLVILrlNRAALCVQWSPKENKFAVGSGAKTVCIcyYEQENNWWVSKLIRkrHESSVTSVAWHPNNVLLATTSTDGK 168
Cdd:cd00200 169 CVATLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKL--WDLSTGKCLGTLRG--HENGVNSVAFSPDGYLLASGSEDGT 242

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 42570993 169 CRVFSTfikgvdtkyahylngaffLLKQQILQLDLSYSWAFGVKWSPSGNTLA 221
Cdd:cd00200 243 IRVWDL------------------RTGECVQTLSGHTNSVTSLAWSPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-174 3.95e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 3.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  12 SITCHAWSPDLSMVALCPNNTEVHIYkslSQDHWERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAE--- 88
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcvr 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  89 -------WVPTLVILRLNR------------------------------AALCVQWSPkENKFAVGSGA-KTVCICYYEQ 130
Cdd:cd00200  88 tltghtsYVSSVAFSPDGRilssssrdktikvwdvetgkclttlrghtdWVNSVAFSP-DGTFVASSSQdGTIKLWDLRT 166

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 42570993 131 EnnwwvsKLIR--KRHESSVTSVAWHPNNVLLATTSTDGKCRVFST 174
Cdd:cd00200 167 G------KCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
47-246 5.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 5.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993  47 RLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWSLEGAEWVPTLVILRLNRAAlcVQWSPKENKFAVGSGAKTVCIc 126
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS--VAFSPDGRLLASASADGTVRL- 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570993 127 yYEQENNWWVSKLirKRHESSVTSVAWHPNNVLLATTSTDGKCRVFStfikgVDTkyahylngaffllKQQILQLDLSYS 206
Cdd:COG2319 105 -WDLATGLLLRTL--TGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-----LAT-------------GKLLRTLTGHSG 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 42570993 207 WAFGVKWSPSGNTLAYVGHSSMIYFVDDVGPSPLA---------QSVAF 246
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtltghtgavRSVAF 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-173 3.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.65e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 42570993    142 KRHESSVTSVAWHPNNVLLATTSTDGKCRVFS 173
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
144-173 1.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 42570993   144 HESSVTSVAWHPNNVLLATTSTDGKCRVFS 173
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-83 7.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 42570993     45 WERLHVLQKHDQIVSGIDWSSKSNKIVTVSHDRNSYVWS 83
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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