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Conserved domains on  [gi|42570919|ref|NP_973533|]
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Nucleotidylyl transferase superfamily protein [Arabidopsis thaliana]

Protein Classification

nucleotidyl transferase family protein; glutamine/glutamate--tRNA ligase( domain architecture ID 10791485)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases| glutamine/glutamate--tRNA ligase catalyzes the attachment of glutamate or glutamine to tRNA(Glu) or tRNA(Gln); in some organisms, the non-discriminating form of glutamate--tRNA ligase aminoacylates both tRNA(Glu) and tRNA(Gln) with Glu, which is converted to Gln when appropriate by a transamidation enzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02886 PLN02886
aminoacyl-tRNA ligase
 19-411 0e+00

aminoacyl-tRNA ligase


:

Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 726.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   19 SRLGSLTRLLSKPTSLSgsfssisVTGQGFRCCCSVATDDTS-------PSVKKRVVSGVQPTGSVHLGNYLGAIKNWVA 91
Cdd:PLN02886   1 SSLGSLGRLLSKPGPLS-------GSASSASCCSAATAATAPekeappkVARKKRVVSGVQPTGSIHLGNYLGAIKNWVA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   92 LQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQF 171
Cdd:PLN02886  74 LQETYDTFFCVVDLHAITLPHDPRELGKATRSTAAIYLACGIDPSKASVFVQSHVPAHAELMWLLSCSTPIGWLNKMIQF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  172 KEKSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIAQRVNHLYGGKKWKKLGGyeifRGGSLFK 251
Cdd:PLN02886 154 KEKSRKAGDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRDIAERVNNLYGGRKWKKLGG----RGGSVFK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  252 IPEPLIPQAGARVMSLTDGLSKMSKSAPSDQSRINLLDSKDLIVDKIKRCKTDSFAGLEFDNAERPECNNLLSIYQIVSG 331
Cdd:PLN02886 230 VPEALIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDPPDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTG 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  332 KKKEEVMEECKDMSWGTFKPLLADALIEHLSPIQARYQEIIAEPEYLDKILSEGADRAEELGAVTMRNMYQAMGYYQRRR 411
Cdd:PLN02886 310 KTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFVQRRR 389
 
Name Accession Description Interval E-value
PLN02886 PLN02886
aminoacyl-tRNA ligase
 19-411 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 726.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   19 SRLGSLTRLLSKPTSLSgsfssisVTGQGFRCCCSVATDDTS-------PSVKKRVVSGVQPTGSVHLGNYLGAIKNWVA 91
Cdd:PLN02886   1 SSLGSLGRLLSKPGPLS-------GSASSASCCSAATAATAPekeappkVARKKRVVSGVQPTGSIHLGNYLGAIKNWVA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   92 LQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQF 171
Cdd:PLN02886  74 LQETYDTFFCVVDLHAITLPHDPRELGKATRSTAAIYLACGIDPSKASVFVQSHVPAHAELMWLLSCSTPIGWLNKMIQF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  172 KEKSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIAQRVNHLYGGKKWKKLGGyeifRGGSLFK 251
Cdd:PLN02886 154 KEKSRKAGDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRDIAERVNNLYGGRKWKKLGG----RGGSVFK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  252 IPEPLIPQAGARVMSLTDGLSKMSKSAPSDQSRINLLDSKDLIVDKIKRCKTDSFAGLEFDNAERPECNNLLSIYQIVSG 331
Cdd:PLN02886 230 VPEALIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDPPDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTG 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  332 KKKEEVMEECKDMSWGTFKPLLADALIEHLSPIQARYQEIIAEPEYLDKILSEGADRAEELGAVTMRNMYQAMGYYQRRR 411
Cdd:PLN02886 310 KTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFVQRRR 389
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 64-406 2.20e-177

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 497.26  E-value: 2.20e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:COG0180   3 KKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIA 223
Cdd:COG0180  83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 224 QRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGARVMSLtDGLSKMSKsapSDQSRINLLDSKDLIVDKIKRCKT 303
Cdd:COG0180 163 RRFNHRY----------------GEVFPEPEALIPEEGARIPGL-DGRKKMSK---SYGNTINLLDDPKEIRKKIKSAVT 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 304 DSfAGLEFDNAERPECNNLLSIYQIVSGK-KKEEVMEECK--DMSWGTFKPLLADALIEHLSPIQARYQEIIAEPEYLDK 380
Cdd:COG0180 223 DS-ERLRYDDPGKPEVCNLFTIYSAFSGKeEVEELEAEYRagGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDE 301

                       330       340
                ....*....|....*....|....*.
gi 42570919 381 ILSEGADRAEELGAVTMRNMYQAMGY 406
Cdd:COG0180 302 ILAEGAEKARAIAAKTLAEVREAMGL 327
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 64-405 5.18e-120

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 351.63  E-value: 5.18e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919    64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQ-LGKATTDTAALYLACGIDVSKASVFV 142
Cdd:TIGR00233   2 KFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDaLRKAREELAADYLAVGLDPEKTFIFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   143 QSHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGVenaSVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREI 222
Cdd:TIGR00233  82 QSDYPEHYELAWLLSCQVTFGELKRMTQFKDKSQAENV---PIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   223 AQRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGARVMSLTDglSKMSKSAPSdqSRINLLDSKDLIVDKIKRCK 302
Cdd:TIGR00233 159 AERFNKKF----------------KNFFPKPESLISKFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   303 TDSFAGLEFDNAERPECNNLLSIYQIVS-----GKKKEEVMEECKD--MSWGTFKPLLADALIEHLSPIQARYQEIIAep 375
Cdd:TIGR00233 219 TDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEAYKSgkLGYGECKKALIEVLQEFLKEIQERRAEIAE-- 296

                         330       340       350
                  ....*....|....*....|....*....|
gi 42570919   376 EYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:TIGR00233 297 EILDKILEPGAKKARETANKTLADVYKAMG 326
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 66-360 9.23e-118

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 344.18  E-value: 9.23e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  66 RVVSGVQPTGSVHLGNYLGAIKNWVALQDT-YETLFIIVDHHAITLPY-DTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:cd00806   1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAgYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKegVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIA 223
Cdd:cd00806  81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQ--GESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 224 QRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQaGARVMSLTDGLSKMSKSAPSdqSRINLLDSKDLIVDKIKRCKT 303
Cdd:cd00806 159 RRFNKLY----------------GEIFPKPAALLSK-GAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAAT 219

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570919 304 DSFAGLEFDNAERPECNNLLSIYQIVSGKKKEEV--MEECK--DMSWGTFKPLLADALIEH 360
Cdd:cd00806 220 DGGRTEHRRDGGGPGVSNLVEIYSAFFNDDDEELeeIDEYRsgGLGYGECKKLLAEAIQEF 280
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
66-362 6.90e-92

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 278.78  E-value: 6.90e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919    66 RVVSGVQPTGSVHLGnYLGAIKNWVALQ-DTYETLFIIVDHHAITLPYD---TRQLGKATTDTAAL---YLACGIDVSKA 138
Cdd:pfam00579   7 RVYSGIDPTGPLHLG-YLVPLMKLRQFQqAGHEVFFLIGDLHAIIGDPSkspERKLLSRETVLENAikaQLACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   139 SVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQFKE-KSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIE 217
Cdd:pfam00579  86 EIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDvKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   218 LAREIAQRVNHlyggkkwkklggyeifrggSLFKIPEPLIPqagaRVMSLTDGLSKMSKSAPSdqSRINLLDSKDLIVDK 297
Cdd:pfam00579 166 LGRDLARRFNK-------------------KIFKKPVGLTN----PLLTGLDGGKKMSKSAGN--SAIFLDDDPESVYKK 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570919   298 IKRCKTDSFAGLEFDNAERPECNN-LLSIYQIVSGKKK----EEVMEECKDM--SWGTFKPLLADALIEHLS 362
Cdd:pfam00579 221 IQKAYTDPDREVRKDLKLFTFLSNeEIEILEAELGKSPyreaEELLAREVTGlvHGGDLKKAAAEAVNKLLQ 292
 
Name Accession Description Interval E-value
PLN02886 PLN02886
aminoacyl-tRNA ligase
 19-411 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 726.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   19 SRLGSLTRLLSKPTSLSgsfssisVTGQGFRCCCSVATDDTS-------PSVKKRVVSGVQPTGSVHLGNYLGAIKNWVA 91
Cdd:PLN02886   1 SSLGSLGRLLSKPGPLS-------GSASSASCCSAATAATAPekeappkVARKKRVVSGVQPTGSIHLGNYLGAIKNWVA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   92 LQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQF 171
Cdd:PLN02886  74 LQETYDTFFCVVDLHAITLPHDPRELGKATRSTAAIYLACGIDPSKASVFVQSHVPAHAELMWLLSCSTPIGWLNKMIQF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  172 KEKSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIAQRVNHLYGGKKWKKLGGyeifRGGSLFK 251
Cdd:PLN02886 154 KEKSRKAGDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRDIAERVNNLYGGRKWKKLGG----RGGSVFK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  252 IPEPLIPQAGARVMSLTDGLSKMSKSAPSDQSRINLLDSKDLIVDKIKRCKTDSFAGLEFDNAERPECNNLLSIYQIVSG 331
Cdd:PLN02886 230 VPEALIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDPPDVIANKIKRCKTDSFPGLEFDNPERPECNNLLSIYQLVTG 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  332 KKKEEVMEECKDMSWGTFKPLLADALIEHLSPIQARYQEIIAEPEYLDKILSEGADRAEELGAVTMRNMYQAMGYYQRRR 411
Cdd:PLN02886 310 KTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLKEGADAAAEIADRTLANVYQAMGFVQRRR 389
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 64-409 0e+00

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 533.51  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:PRK00927   1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYECFFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGvENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIA 223
Cdd:PRK00927  81 SHVPEHAELAWILNCITPLGELERMTQFKDKSAKQK-ENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  224 QRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGARVMSLTDGLSKMSKSAPSDQSRINLLDSKDLIVDKIKRCKT 303
Cdd:PRK00927 160 RRFNNLY----------------GEVFPVPEPLIPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVT 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  304 DS--FAGLEFDNAERPECNNLLSIYQIVSGKKKEEVMEECKDMS--WGTFKPLLADALIEHLSPIQARYQEIIAEPEYLD 379
Cdd:PRK00927 224 DSerLREIRYDLPNKPEVSNLLTIYSALSGESIEELEAEYEAGGkgYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLD 303

                        330       340       350
                 ....*....|....*....|....*....|
gi 42570919  380 KILSEGADRAEELGAVTMRNMYQAMGYYQR 409
Cdd:PRK00927 304 EILAEGAEKARAVASKTLKEVREAMGLLRK 333
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 64-406 2.20e-177

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 497.26  E-value: 2.20e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:COG0180   3 KKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIA 223
Cdd:COG0180  83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNGKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 224 QRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGARVMSLtDGLSKMSKsapSDQSRINLLDSKDLIVDKIKRCKT 303
Cdd:COG0180 163 RRFNHRY----------------GEVFPEPEALIPEEGARIPGL-DGRKKMSK---SYGNTINLLDDPKEIRKKIKSAVT 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 304 DSfAGLEFDNAERPECNNLLSIYQIVSGK-KKEEVMEECK--DMSWGTFKPLLADALIEHLSPIQARYQEIIAEPEYLDK 380
Cdd:COG0180 223 DS-ERLRYDDPGKPEVCNLFTIYSAFSGKeEVEELEAEYRagGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDE 301

                       330       340
                ....*....|....*....|....*.
gi 42570919 381 ILSEGADRAEELGAVTMRNMYQAMGY 406
Cdd:COG0180 302 ILAEGAEKARAIAAKTLAEVREAMGL 327
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 64-405 5.18e-120

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 351.63  E-value: 5.18e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919    64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQ-LGKATTDTAALYLACGIDVSKASVFV 142
Cdd:TIGR00233   2 KFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDaLRKAREELAADYLAVGLDPEKTFIFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   143 QSHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGVenaSVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREI 222
Cdd:TIGR00233  82 QSDYPEHYELAWLLSCQVTFGELKRMTQFKDKSQAENV---PIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   223 AQRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGARVMSLTDglSKMSKSAPSdqSRINLLDSKDLIVDKIKRCK 302
Cdd:TIGR00233 159 AERFNKKF----------------KNFFPKPESLISKFFPRLMGLSG--KKMSKSDPN--SAIFLTDTPKQIKKKIRKAA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   303 TDSFAGLEFDNAERPECNNLLSIYQIVS-----GKKKEEVMEECKD--MSWGTFKPLLADALIEHLSPIQARYQEIIAep 375
Cdd:TIGR00233 219 TDGGRVTLFEHREKPGVPNLLVIYQYLSfflidDDKLKEIYEAYKSgkLGYGECKKALIEVLQEFLKEIQERRAEIAE-- 296

                         330       340       350
                  ....*....|....*....|....*....|
gi 42570919   376 EYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:TIGR00233 297 EILDKILEPGAKKARETANKTLADVYKAMG 326
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 66-360 9.23e-118

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 344.18  E-value: 9.23e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  66 RVVSGVQPTGSVHLGNYLGAIKNWVALQDT-YETLFIIVDHHAITLPY-DTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:cd00806   1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEAgYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKegVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREIA 223
Cdd:cd00806  81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQ--GESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 224 QRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQaGARVMSLTDGLSKMSKSAPSdqSRINLLDSKDLIVDKIKRCKT 303
Cdd:cd00806 159 RRFNKLY----------------GEIFPKPAALLSK-GAFLPGLQGPSKKMSKSDPN--NAIFLTDSPKEIKKKIMKAAT 219

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570919 304 DSFAGLEFDNAERPECNNLLSIYQIVSGKKKEEV--MEECK--DMSWGTFKPLLADALIEH 360
Cdd:cd00806 220 DGGRTEHRRDGGGPGVSNLVEIYSAFFNDDDEELeeIDEYRsgGLGYGECKKLLAEAIQEF 280
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
66-362 6.90e-92

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 278.78  E-value: 6.90e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919    66 RVVSGVQPTGSVHLGnYLGAIKNWVALQ-DTYETLFIIVDHHAITLPYD---TRQLGKATTDTAAL---YLACGIDVSKA 138
Cdd:pfam00579   7 RVYSGIDPTGPLHLG-YLVPLMKLRQFQqAGHEVFFLIGDLHAIIGDPSkspERKLLSRETVLENAikaQLACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   139 SVFVQSHVPAHVELMWLLCSSTPIGWLQKMIQFKE-KSRKEGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIE 217
Cdd:pfam00579  86 EIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDvKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   218 LAREIAQRVNHlyggkkwkklggyeifrggSLFKIPEPLIPqagaRVMSLTDGLSKMSKSAPSdqSRINLLDSKDLIVDK 297
Cdd:pfam00579 166 LGRDLARRFNK-------------------KIFKKPVGLTN----PLLTGLDGGKKMSKSAGN--SAIFLDDDPESVYKK 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570919   298 IKRCKTDSFAGLEFDNAERPECNN-LLSIYQIVSGKKK----EEVMEECKDM--SWGTFKPLLADALIEHLS 362
Cdd:pfam00579 221 IQKAYTDPDREVRKDLKLFTFLSNeEIEILEAELGKSPyreaEELLAREVTGlvHGGDLKKAAAEAVNKLLQ 292
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 64-405 3.90e-82

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 255.16  E-value: 3.90e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITL-PYDTRQLGKATTDTAALYLACGIDVSKASVFV 142
Cdd:PRK12282   2 KPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTDnAKNPEKIRRNILEVALDYLAVGIDPAKSTIFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  143 QSHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRKEGVENA-SVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELARE 221
Cdd:PRK12282  82 QSQIPELAELTMYYMNLVTVARLERNPTVKTEIAQKGFGRSiPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQTRE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  222 IAQRVNHLYggkkwkklggyeifrGGSLFKIPEPLIPQAGaRVMSLtDGLSKMSKsapSDQSRINLLDSKDLIVDKIKRC 301
Cdd:PRK12282 162 IVRRFNSLY---------------GTDVLVEPEALLPEAG-RLPGL-DGKAKMSK---SLGNAIYLSDDADTIKKKVMSM 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  302 KTDSfAGLEFDNAERPECNNLLSIYQIVSGKKK--EEVMEECK-----DMswgTFKPLLADALIEHLSPIQARYQEIIAE 374
Cdd:PRK12282 222 YTDP-NHIRVEDPGKVEGNVVFTYLDAFDPDKAevAELKAHYQrgglgDV---KCKRYLEEVLQELLAPIRERRAEFAKD 297

                        330       340       350
                 ....*....|....*....|....*....|.
gi 42570919  375 PEYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:PRK12282 298 PGYVLEILKAGSEKAREVAAQTLSEVKDAMG 328
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 65-405 1.38e-75

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 240.24  E-value: 1.38e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   65 KRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYETLFIIVDHHAITLPYDTRQ-LGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:PRK12283   3 DRVLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHYETPEvIEKNVWDMVIDWLAAGVDPAQATLFIQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  144 SHVPAHVELMWLLCSSTPIGWLQKMIQFKEKSRK-EGVENASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIELAREI 222
Cdd:PRK12283  83 SKVPEHAELHLLLSMITPLGWLERVPTYKDQQEKlKEKDLSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTREI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  223 AQRVNHLY--------------GGKKWKKLGGYEIFR--------------------------------------GGSLF 250
Cdd:PRK12283 163 ARRFNHLYgrepgfeekaeaaiKKLGKKRAKLYHELRnayqeegddealeqarallqeqqnlsmgdrerlfgyleGAGKI 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  251 KIPEP--LIPQAgARVMSLtDGlSKMSKSApsdQSRINLLDSKDLIVDKIKRCKTDSfAGLEFDNAERPECNNLLSIYQI 328
Cdd:PRK12283 243 ILPEPqaLLTEA-SKMPGL-DG-QKMSKSY---GNTIGLREDPESVTKKIRTMPTDP-ARVRRTDPGDPEKCPVWQLHQV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  329 VSGKK-KEEVMEECKDMSWGTF--KPLLADALIEHLSPIQARYQEIIAEPEYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:PRK12283 316 YSDEEtKEWVQKGCRSAGIGCLecKQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREAMG 395
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 64-405 4.90e-75

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 236.93  E-value: 4.90e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   64 KKRVVSGVQPTGSVHLGNYLGAIKNWVALQDTYE--TLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVF 141
Cdd:PRK12556   3 EKIMLTGIKPTGYPHLGNYIGAIKPALQMAKNYEgkALYFIADYHALNAVHDPEQFRSYTREVAATWLSLGLDPEDVIFY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  142 VQSHVPAHVELMWLLCSSTPIGWLQKMIQFK---EKSRKEGVE-NASV--GLFTYPDLMTADILLYQSDFVPVGEDQKQH 215
Cdd:PRK12556  83 RQSDVPEIFELAWILSCLTPKGLMNRAHAYKakvDQNKEAGLDlDAGVnmGLYTYPILMAADILLFQATHVPVGKDQIQH 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  216 IELAREIAQRVNHLYggkkwkklggyeifrgGSLFKIPEPLIPQAGArVMSLTDGlSKMSKSApsdQSRINLLDSKDLIV 295
Cdd:PRK12556 163 IEIARDIATYFNHTF----------------GDTFTLPEYVIQEEGA-ILPGLDG-RKMSKSY---GNVIPLFAEQEKLR 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  296 DKIKRCKTDSfagLEFDNAERPECNNLLSIYQIVSGKKKEEVMEE--CKDMSWGTFKPLLADALIEHLSPIQARYQEIIA 373
Cdd:PRK12556 222 KLIFKIKTDS---SLPNEPKDPETSALFTIYKEFATEEEVQSMREkyETGIGWGDVKKELFRVVDRELAGPREKYAMYMN 298

                        330       340       350
                 ....*....|....*....|....*....|..
gi 42570919  374 EPEYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:PRK12556 299 EPSLLDEALEKGAERAREIAKPNLAEIKKAIG 330
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 66-405 1.64e-62

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 207.55  E-value: 1.64e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   66 RVVSGVQPTGSVHLGNYLGAIKNWVA--LQDTYETLFIIVDHHAITLPYDTRQLGKATTDTAALYLACGIDVSKASVFVQ 143
Cdd:PRK12284   4 RVLTGITTTGTPHLGNYAGAIRPAIAasRQPGVESFYFLADYHALIKCDDPARIQRSTLEIAATWLAAGLDPERVTFYRQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  144 SHVPAHVELMWLLCSSTPIGWLQKMIQFK---EKSRKEGVE---NASVGLFTYPDLMTADILLYQSDFVPVGEDQKQHIE 217
Cdd:PRK12284  84 SDIPEIPELTWLLTCVAGKGLLNRAHAYKaavDKNVAAGEDpdaGVTAGLFMYPVLMAADILMFNAHKVPVGRDQIQHIE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  218 LAREIAQRVNHLYggkkwkklggyeifrGGSLFKIPEPLIPQAGARVMSLtDGlSKMSKSApsdQSRINLLDSKDLIVDK 297
Cdd:PRK12284 164 MARDIAQRFNHLY---------------GGEFFVLPEAVIEESVATLPGL-DG-RKMSKSY---DNTIPLFAPREELKKA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  298 IKRCKTDSFAGLEfdnAERPECNNLLSIYQIVSGKKKEEVM-EECKD-MSWGTFKPLLADALIEHLSPIQARYQEIIAEP 375
Cdd:PRK12284 224 IFSIVTDSRAPGE---PKDTEGSALFQLYQAFATPEETAAFrQALADgIGWGDAKQRLFERIDRELAPMRERYEALIARP 300

                        330       340       350
                 ....*....|....*....|....*....|
gi 42570919  376 EYLDKILSEGADRAEELGAVTMRNMYQAMG 405
Cdd:PRK12284 301 ADIEDILLAGAAKARRIATPFLAELREAVG 330
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 69-359 2.32e-34

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 128.57  E-value: 2.32e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  69 SGVQPTG-SVHLGNYLGaIKNWVALQDT-YETLFIIVDHHAIT----------LPYDTRQLGKATTDTAALYLACGIDVS 136
Cdd:cd00395   4 CGIDPTAdSLHIGHLIG-LLTFRRFQHAgHRPIFLIGGQTGIIgdpsgkkserTLNDPEEVRQNIRRIAAQYLAVGIFED 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 137 --KASVFVQSHVP---AHVELMWLLCSSTPIGWLQKMIQFKEKSrKEGVenaSVGLFTYPDLMTADILLYQS----DFVP 207
Cdd:cd00395  83 ptQATLFNNSDWPgplAHIQFLRDLGKHVYVNYMERKTSFQSRS-EEGI---SATEFTYPPLQAADFLLLNTtegcDIQP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 208 VGEDQKQHIELAREIAQRVNhlyggkkwkklggyeifrggsLFKIPEPLIPqagARVMSLTDglSKMSKSAPSDQSRINL 287
Cdd:cd00395 159 GGSDQWGNITLGRELARRFN---------------------GFTIAEGLTI---PLVTKLDG--PKFGKSESGPKWLDTE 212

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42570919 288 LDSKDLIVDKIKRcKTDSfaglefdnaerpecnNLLSIYQIVSGKKKEEV----MEECKDMSWGTFKPLLADALIE 359
Cdd:cd00395 213 KTSPYEFYQFWIN-AVDS---------------DVINILKYFTFLSKEEIerleQEQYEAPGYRVAQKTLAEEVTK 272
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 67-385 2.34e-14

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 73.75  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   67 VVSGVQPTGSVHLGNYLgAIKNWVALQDTYETLFI-IVDHHAitlpYDTRQLGKATTDTAAL-----YLACGIDVSKASV 140
Cdd:PRK12285  69 VYTGFMPSGPMHIGHKM-VFDELKWHQEFGANVYIpIADDEA----YAARGLSWEETREWAYeyildLIALGFDPDKTEI 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  141 FVQShvpAHVELMWLlcsSTPIGwlqKMIQFKEKSRKEGV-ENASVGLFTYPDLMTADILLYQSDF------VPVGEDQK 213
Cdd:PRK12285 144 YFQS---ENIKVYDL---AFELA---KKVNFSELKAIYGFtGETNIGHIFYPATQAADILHPQLEEgpkptlVPVGIDQD 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  214 QHIELAREIAQRVNhlyggkkwkklGGYEIFRGGSLFkipeplipqagARVM-SLTDGlsKMSKSAPsdQSRINLLDSKD 292
Cdd:PRK12285 215 PHIRLTRDIAERLH-----------GGYGFIKPSSTY-----------HKFMpGLTGG--KMSSSKP--ESAIYLTDDPE 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  293 LIVDKIKRCKTDSFAGLEFD-----NAErpECnnllSIYQ------IVSGKKKEEVMEECK--DMSWGTFKPLLADALIE 359
Cdd:PRK12285 269 TVKKKIMKALTGGRATLEEQrklggEPD--EC----VVYElllyhlEEDDKELKEIYEECRsgELLCGECKKEAAEKIAE 342

                        330       340
                 ....*....|....*....|....*.
gi 42570919  360 HLSPIQARYQEIIaepEYLDKILSEG 385
Cdd:PRK12285 343 FLKEHQEKREEAR---EILEKYLYDG 365
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
 67-277 6.53e-06

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 45.55  E-value: 6.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  67 VVSGVQPTGSVHLGNYLGAIKNWVALQ----DTYETLFI--IVDHHAITlpydtrqlgkattdtaalylacgidVSKASV 140
Cdd:cd00802   2 TFSGITPNGYLHIGHLRTIVTFDFLAQayrkLGYKVRCIalIDDAGGLI-------------------------GDPANK 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 141 FVQSHvPAHVELMwllcsstpigwlqkMIQFKEksrkegvenasvgLFTYPDLMTADILL---YQSDFVPVGEDQKQHIE 217
Cdd:cd00802  57 KGENA-KAFVERW--------------IERIKE-------------DVEYMFLQAADFLLlyeTECDIHLGGSDQLGHIE 108

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919 218 LAREIAQRVNhlyggkkwkklggyeifrggsLFKIPEPLIPqagARVMSltDGLSKMSKS 277
Cdd:cd00802 109 LGLELLKKAG---------------------GPARPFGLTF---GRVMG--ADGTKMSKS 142
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 64-300 3.32e-05

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 45.63  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919   64 KKRVVSGVQPTGSVHLGNYLGAIKnwVA-LQDT-YETLFIIVDHHA-ITLPYDTRQLGKATTDTAALYLACGIDVSKASv 140
Cdd:PRK08560  30 EPKAYIGFEPSGKIHLGHLLTMNK--LAdLQKAgFKVTVLLADWHAyLNDKGDLEEIRKVAEYNKKVFEALGLDPDKTE- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  141 FV-----QSHVPAHVELMWLLCSSTpigwLQKMIQ-FKEKSRKEgvENASVGLFTYPDLMTADILLYQSDFVPVGEDQ-K 213
Cdd:PRK08560 107 FVlgsefQLDKEYWLLVLKLAKNTT----LARARRsMTIMGRRM--EEPDVSKLVYPLMQVADIFYLDVDIAVGGMDQrK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570919  214 QHIeLAREIAQRVNhlyggkkwkklggyeifrggslFKIP----EPLIPqagarvmSLTDGLSKMSKSAPsdQSRINLLD 289
Cdd:PRK08560 181 IHM-LAREVLPKLG----------------------YKKPvcihTPLLT-------GLDGGGIKMSKSKP--GSAIFVHD 228

                        250
                 ....*....|.
gi 42570919  290 SKDLIVDKIKR 300
Cdd:PRK08560 229 SPEEIRRKIKK 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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