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Conserved domains on  [gi|41327734|ref|NP_958440|]
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epidermal growth factor receptor isoform c precursor [Homo sapiens]

Protein Classification

Recep_L_domain and FU domain-containing protein( domain architecture ID 12013518)

Recep_L_domain and FU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.72e-42

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 146.04  E-value: 1.72e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327734   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 7.26e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 121.96  E-value: 7.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327734   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain super family cl08303
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-403 2.59e-03

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


The actual alignment was detected with superfamily member pfam01030:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 37.21  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41327734   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITG 403
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITG 34
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.72e-42

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 146.04  E-value: 1.72e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327734   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 7.26e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 121.96  E-value: 7.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327734   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 3.83e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 40.97  E-value: 3.83e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327734 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-403 2.59e-03

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 37.21  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41327734   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITG 403
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITG 34
FU smart00261
Furin-like repeats;
231-266 5.44e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 34.79  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41327734    231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPP 266
Cdd:smart00261   6 PCHPECA-TCTGPGPDDCTSCKHGFflDGGKCVSECPP 42
 
Name Accession Description Interval E-value
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.72e-42

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 146.04  E-value: 1.72e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327734   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 7.26e-34

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 121.96  E-value: 7.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327734   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 190-298 5.26e-06

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 45.44  E-value: 5.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734   190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG--------KSPSDC--CHNQCA-----AGCTGPRESDCLVCRKF 254
Cdd:pfam14843   2 CDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNIlqgepreyVVNSTCvpCHPECLpqngtATCSGPGADNCTKCAHF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 41327734   255 RDEATCKDTCpplmlynPTTYQMDVNPEGKYSFGATCVKKCPRN 298
Cdd:pfam14843  82 RDGPHCVSSC-------PSGVLGENDLIWKYADANGVCQPCHPN 118
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 3.83e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 40.97  E-value: 3.83e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327734 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-403 2.59e-03

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 37.21  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 41327734   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITG 403
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITG 34
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 187-249 4.60e-03

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 36.97  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327734   187 CQKCDPSC----PNGSCWGAGEENCQKLTKIICAQQCSGRCrgksPSDC-------------------CHNQCAAGCTGP 243
Cdd:pfam14843  51 CVPCHPEClpqnGTATCSGPGADNCTKCAHFRDGPHCVSSC----PSGVlgendliwkyadangvcqpCHPNCTQGCTGP 126


                  ....*.
gi 41327734   244 RESDCL 249
Cdd:pfam14843 127 GLTGCP 132
FU smart00261
Furin-like repeats;
231-266 5.44e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 34.79  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41327734    231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPP 266
Cdd:smart00261   6 PCHPECA-TCTGPGPDDCTSCKHGFflDGGKCVSECPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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