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Conserved domains on  [gi|41387160|ref|NP_957094|]
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protein FAM3A precursor [Danio rerio]

Protein Classification

FAM3C domain-containing protein( domain architecture ID 10195373)

FAM3C (FAM3 Metabolism Regulating Signaling Molecule C) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 53-222 6.38e-116

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


:

Pssm-ID: 260114  Cd Length: 171  Bit Score: 328.07  E-value: 6.38e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  53 HKYKCGLSAPCPPKHLAFRLTSGAANVIGPKICLEDKIILSSAKNNVGRGLNIALVNGVTGDVLEIRAFDMWAGDVSELL 132
Cdd:cd13940   2 PKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160 133 KFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRDSWVFVGAKGIENKSPFEQRMKNSKSNNKYEGWP 212
Cdd:cd13940  82 EFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGWP 161

                       170
                ....*....|
gi 41387160 213 ESLEMDGCIP 222
Cdd:cd13940 162 EMIEMEGCIP 171
 
Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 53-222 6.38e-116

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 328.07  E-value: 6.38e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  53 HKYKCGLSAPCPPKHLAFRLTSGAANVIGPKICLEDKIILSSAKNNVGRGLNIALVNGVTGDVLEIRAFDMWAGDVSELL 132
Cdd:cd13940   2 PKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160 133 KFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRDSWVFVGAKGIENKSPFEQRMKNSKSNNKYEGWP 212
Cdd:cd13940  82 EFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGWP 161

                       170
                ....*....|
gi 41387160 213 ESLEMDGCIP 222
Cdd:cd13940 162 EMIEMEGCIP 171
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 101-188 3.60e-36

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 122.75  E-value: 3.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160   101 RGLNIALVNGVTGDVLEIRAFDMW-AGDVSELLKFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRD 179
Cdd:pfam15711   1 RGINVVVVDACTGKVLDSKSFDTYsYSDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFRD 80


                  ....*....
gi 41387160   180 SWVFVGAKG 188
Cdd:pfam15711  81 SWAFIGFKG 89
 
Name Accession Description Interval E-value
ILEI_FAM3C cd13940
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ...
 53-222 6.38e-116

Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development.


Pssm-ID: 260114  Cd Length: 171  Bit Score: 328.07  E-value: 6.38e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  53 HKYKCGLSAPCPPKHLAFRLTSGAANVIGPKICLEDKIILSSAKNNVGRGLNIALVNGVTGDVLEIRAFDMWAGDVSELL 132
Cdd:cd13940   2 PKYKCGLSKPCPEDHFAFRIISGAANVVGPKICFEGKIIMSSVLNNVGRGLNIALVNGETGEVLKTGFFDMYSGDVKPLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160 133 KFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRDSWVFVGAKGIENKSPFEQRMKNSKSNNKYEGWP 212
Cdd:cd13940  82 EFLKSIKPGSIVLVASFDDPATKLNDEARKLFAELGSSSIKSLGFRDNWVFVGGKGIKTKSPFEKHIKNDKDTNKYEGWP 161

                       170
                ....*....|
gi 41387160 213 ESLEMDGCIP 222
Cdd:cd13940 162 EMIEMEGCIP 171
PANDER_FAM3B cd13939
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ...
 56-222 2.95e-57

Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver.


Pssm-ID: 260113  Cd Length: 175  Bit Score: 179.35  E-value: 2.95e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  56 KCGLSAPCPPKHLAFRLTSGAANVIGPKICLEDKIILSSAKNNVGRGLNIALVNGVTGDVLEIRAFDMWAGDVSE-LLKF 134
Cdd:cd13939   4 KCDHWSPCAPNQYAYRIRSGGGKDIMPEICFEDNMLITGKEGNSNRGINIAVVSYETGKVVATKYFDMYEGDFSGpMIEF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160 135 IRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRDSWVFVGAKGIENKSPFEQRMKN--SKSNNKYEGWP 212
Cdd:cd13939  84 INKIPKKSLVFVVTHDDGSTKLKDPAKKAIEDLGSKEIRNLKFRSAWVFIAAKGFQLPDNIEKEKINhsDGSKNRYSGWP 163

                       170
                ....*....|
gi 41387160 213 ESLEMDGCIP 222
Cdd:cd13939 164 AEIQIEGCIP 173
PANDER_like cd13936
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ...
 68-221 2.45e-38

Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer.


Pssm-ID: 260110  Cd Length: 149  Bit Score: 130.15  E-value: 2.45e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  68 LAFRLTSGAANViGPKICLEDKIILSsaKNNVGRGLNIALVNGVTGDVLEIRAFDMW-AGDVSELLKFIRPLHEGTLVFV 146
Cdd:cd13936   1 LEVKIASGGGGN-YAKICVNGGVLFD--GDKSGRGINVVVINGDTGKVIATKTFDTYgAGASNDMIDFLNSVPPGSIVLI 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41387160 147 ASFDDPATKLNDEARRIFEELGSTAAKELSFRDSWVFVGAKGIE-NKSPFEQRMknskSNNKYEGWPESLEMDGCI 221
Cdd:cd13936  78 ATKDDASKSLKDEARRALESLGSSLIQNLGFRDSWAFVGQKGIKrPSTEQHEIS----PKNSSWGGPALIQTCFPL 149
ILEI pfam15711
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ...
 101-188 3.60e-36

Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras.


Pssm-ID: 464817  Cd Length: 89  Bit Score: 122.75  E-value: 3.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160   101 RGLNIALVNGVTGDVLEIRAFDMW-AGDVSELLKFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGSTAAKELSFRD 179
Cdd:pfam15711   1 RGINVVVVDACTGKVLDSKSFDTYsYSDSSRLANFLKSIPDGSIVLIATKDEASSKLSDEARKALESLGSSKIDNLGFRD 80


                  ....*....
gi 41387160   180 SWVFVGAKG 188
Cdd:pfam15711  81 SWAFIGFKG 89
PANDER_GnT-1_2_like cd13937
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ...
 84-223 1.43e-19

PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined.


Pssm-ID: 260111  Cd Length: 148  Bit Score: 81.58  E-value: 1.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  84 ICLEDKIILSSAKNNVGRGLNIALVNGVTGDVLEIRAFDMWAGDVSE-LLKFIRPLHEGTLVFVASFDDPATKLNDEARR 162
Cdd:cd13937  14 VSVDGTTVLEDEEAEAGRGIHVVVLNQATGSVMAQRVFDTYSPGEDEaMILFLNMVSDGRILIFTIKDEGSFHLKDEARS 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387160 163 IFEELGSTAAKELSFRDSWVFVGAKGieNKSPFEQRMKNSKSNnkyeGWPESLEMDGCIPL 223
Cdd:cd13937  94 LLKKLGSQKVSKLGWRDMWAMVTRKG--GPVYGEKHSKSPDLS----SWGEPVLLKAEVPL 148
PANDER_like_TMEM2 cd13938
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ...
 93-196 2.51e-13

PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized.


Pssm-ID: 260112  Cd Length: 168  Bit Score: 65.42  E-value: 2.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387160  93 SSAKNNVGRGLNIALVNGVTGDVLEIRAFDMW--AGDVSELLKFIRPLHEGTLVFVASFDDPATKLNDEARRIFEELGST 170
Cdd:cd13938  40 SFERSWGSRGINVRVIDEDTGEVLESDRFDTYesEDESKRLAEFLDQIPPGRIVALAVGDEASKNLEDSARKKIRELGSK 119

                        90       100       110
                ....*....|....*....|....*....|.
gi 41387160 171 AAKELSFRDSWVFVGAKG-----IENKSPFE 196
Cdd:cd13938 120 EIDHLGYRQPWAFVGVKGgpssaVEDRREYE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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