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Conserved domains on  [gi|41152191|ref|NP_957039|]
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endothelial differentiation-related factor 1 homolog [Danio rerio]

Protein Classification

EDF1/MBF1 family transcription factor( domain architecture ID 12094462)

EDF1/MBF1 family transcription factor such as vertebrate endothelial differentiation-related factor (EDF1) and multiprotein bridging factor 1 (MBF1), which function as transcriptional coactivators

Gene Ontology:  GO:0003677
PubMed:  2644244|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-70 1.40e-23

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


:

Pssm-ID: 462508  Cd Length: 68  Bit Score: 86.91  E-value: 1.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41152191     5 DWDTVTVLRKKGS-AAQSKSKQAVTAAQRKGEAVETSKKWAAGQNKQHVVT-KNTAKLDRETEELSHQ 70
Cdd:pfam08523   1 DWDSVTVIGKKAPrATVARSESALNAARRSGAVVETEKKFYAGTNKAHHGEgQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 75-131 3.27e-12

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 58.03  E-value: 3.27e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 41152191  75 EVGKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:COG1813  12 DYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
 
Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-70 1.40e-23

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


Pssm-ID: 462508  Cd Length: 68  Bit Score: 86.91  E-value: 1.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41152191     5 DWDTVTVLRKKGS-AAQSKSKQAVTAAQRKGEAVETSKKWAAGQNKQHVVT-KNTAKLDRETEELSHQ 70
Cdd:pfam08523   1 DWDSVTVIGKKAPrATVARSESALNAARRSGAVVETEKKFYAGTNKAHHGEgQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 75-131 3.27e-12

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 58.03  E-value: 3.27e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 41152191  75 EVGKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:COG1813  12 DYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
80-132 1.86e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 47.90  E-value: 1.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 41152191     80 IQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKLR 132
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 77-131 1.35e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.62  E-value: 1.35e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 41152191  77 GKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSL 55
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 80-132 1.51e-07

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 45.61  E-value: 1.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 41152191    80 IQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKLR 132
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLD 53
 
Name Accession Description Interval E-value
MBF1 pfam08523
Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 ...
 5-70 1.40e-23

Multiprotein bridging factor 1; This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (pfam01381) is found to its C-terminus.


Pssm-ID: 462508  Cd Length: 68  Bit Score: 86.91  E-value: 1.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41152191     5 DWDTVTVLRKKGS-AAQSKSKQAVTAAQRKGEAVETSKKWAAGQNKQHVVT-KNTAKLDRETEELSHQ 70
Cdd:pfam08523   1 DWDSVTVIGKKAPrATVARSESALNAARRSGAVVETEKKFYAGTNKAHHGEgQNTAKLDRETEELKHE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 75-131 3.27e-12

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 58.03  E-value: 3.27e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 41152191  75 EVGKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:COG1813  12 DYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
80-132 1.86e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 47.90  E-value: 1.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 41152191     80 IQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKLR 132
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLD 54
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 77-131 1.35e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.62  E-value: 1.35e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 41152191  77 GKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSL 55
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 80-132 1.51e-07

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 45.61  E-value: 1.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 41152191    80 IQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKLR 132
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLD 53
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
71-131 5.65e-06

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.91  E-value: 5.65e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41152191  71 RVPLEVGKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:COG1396   3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSL 63
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
75-131 5.39e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 39.06  E-value: 5.39e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 41152191  75 EVGKVIQQGRQNKGLTQKDLATKINEKPQIIAEYECGKAIPNNQVMGKIERAIGLKL 131
Cdd:COG1476   4 KLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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