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Conserved domains on  [gi|41053435|ref|NP_956770|]
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GPI mannosyltransferase 3 [Danio rerio]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 45-514 2.67e-107

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member PLN02816:

Pssm-ID: 473917  Cd Length: 546  Bit Score: 331.23  E-value: 2.67e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   45 ITVFIVLVRLLNCVLVQTSFVPDEFWQSLEISHRMVFGYGYETWEWKEGIRGYSYPLLFALMYKLLQLISYDTVYLLVFV 124
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  125 PRVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSRTLTNTTETALTTLALCFYPLPGSKT-----HS 199
Cdd:PLN02816 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypvNR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  200 SWKyLTLVSLAVVIRPTALIVWFPLIFYHFCTDQDKLKLITHRYFPIGVLALGVSTLIDSFFYGKWIFVQWNFLKFNVLH 279
Cdd:PLN02816 201 KWG-LVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLS 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  280 NVGEFYGSHPWHWYWTQGLPVVIGPHLPLVLHGCLLStrKHTILLLTIIWTTAVYSLLAHKEFRFIYPVLPFCMIFCGLS 359
Cdd:PLN02816 280 SGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYA 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  360 LAKLQAWRKAAAGA-------------------------LLLFNLCPALYTGLVHQRGALDVMHVLQPLCVSSQSPNppe 414
Cdd:PLN02816 358 FAQMEVSGSSSSSSvtkkkqvprqnhtkwspklrlsvyfLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKS--- 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  415 LLFLMPCHSTPLYSHLHCPLKLRFLECPPdlTGRQDYMDEADVFFSDPLHWLNTSFPLRSTLPSHLVLFDSLQKEISSFL 494
Cdd:PLN02816 435 ILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFM 512

                        490       500
                 ....*....|....*....|
gi 41053435  495 EENSFAKQAEIFHTHFPEGR 514
Cdd:PLN02816 513 IQHSFKEVRRFFHAHFKVDR 532
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 45-514 2.67e-107

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 331.23  E-value: 2.67e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   45 ITVFIVLVRLLNCVLVQTSFVPDEFWQSLEISHRMVFGYGYETWEWKEGIRGYSYPLLFALMYKLLQLISYDTVYLLVFV 124
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  125 PRVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSRTLTNTTETALTTLALCFYPLPGSKT-----HS 199
Cdd:PLN02816 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypvNR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  200 SWKyLTLVSLAVVIRPTALIVWFPLIFYHFCTDQDKLKLITHRYFPIGVLALGVSTLIDSFFYGKWIFVQWNFLKFNVLH 279
Cdd:PLN02816 201 KWG-LVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLS 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  280 NVGEFYGSHPWHWYWTQGLPVVIGPHLPLVLHGCLLStrKHTILLLTIIWTTAVYSLLAHKEFRFIYPVLPFCMIFCGLS 359
Cdd:PLN02816 280 SGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYA 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  360 LAKLQAWRKAAAGA-------------------------LLLFNLCPALYTGLVHQRGALDVMHVLQPLCVSSQSPNppe 414
Cdd:PLN02816 358 FAQMEVSGSSSSSSvtkkkqvprqnhtkwspklrlsvyfLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKS--- 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  415 LLFLMPCHSTPLYSHLHCPLKLRFLECPPdlTGRQDYMDEADVFFSDPLHWLNTSFPLRSTLPSHLVLFDSLQKEISSFL 494
Cdd:PLN02816 435 ILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFM 512

                        490       500
                 ....*....|....*....|
gi 41053435  495 EENSFAKQAEIFHTHFPEGR 514
Cdd:PLN02816 513 IQHSFKEVRRFFHAHFKVDR 532
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 48-431 1.53e-94

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 293.89  E-value: 1.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435    48 FIVLVRLLNCVLVQTSfVPDEFWQSLEISHRMVFGYGYETWEW--KEGIRGYSYPLLFALMYKLLQLISYDTVYLLVFVP 125
Cdd:pfam03901   5 LLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWspKYGIRSYLYPLLFALPYYLLARLFGDSKYLVFYAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   126 RVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSRTLTNTTETALTTLALCFYPLPGSKTHSSWKYLT 205
Cdd:pfam03901  84 RLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVSNYKYLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   206 LVS----LAVVIRPTALIVWFPLIFYHFC-TDQDKLKLITHRYFPIGVLAL----GVSTLIDSFFYGKWIFVQWNFLKFN 276
Cdd:pfam03901 164 AVLliaaLAILGRPTSALLWLPLVLYLLLrLRGKRLKLFLFLAISLGLLVAllvlGAVILIDSYFYGRFVFTPLNFLKYN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   277 VLHNVGEFYGSHPWHWYWTQGLPVVIGPHLPLVLHGCLLSTRKHT----ILLLTIIWTTAVYSLLAHKEFRFIYPVLPFC 352
Cdd:pfam03901 244 VLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVsrlsQLLAPILIWLFIYSLQPHKEERFLYPVYPLI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   353 MIFCGLSLAKLQAWRKAAAGAL------LLFNLCPALYTGLVHQRGAL----DVMHVLQPLCVSSQSP--NPPELLFLMP 420
Cdd:pfam03901 324 LLSAAIALTRLSRRSWKVRKKLsllfllLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPRENRNPagPPVNVCIGME 403

                         410
                  ....*....|.
gi 41053435   421 CHSTPLYSHLH 431
Cdd:pfam03901 404 CYSTPSSFFLH 414
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 45-514 2.67e-107

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 331.23  E-value: 2.67e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   45 ITVFIVLVRLLNCVLVQTSFVPDEFWQSLEISHRMVFGYGYETWEWKEGIRGYSYPLLFALMYKLLQLISYDTVYLLVFV 124
Cdd:PLN02816  41 IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  125 PRVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSRTLTNTTETALTTLALCFYPLPGSKT-----HS 199
Cdd:PLN02816 121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypvNR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  200 SWKyLTLVSLAVVIRPTALIVWFPLIFYHFCTDQDKLKLITHRYFPIGVLALGVSTLIDSFFYGKWIFVQWNFLKFNVLH 279
Cdd:PLN02816 201 KWG-LVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLS 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  280 NVGEFYGSHPWHWYWTQGLPVVIGPHLPLVLHGCLLStrKHTILLLTIIWTTAVYSLLAHKEFRFIYPVLPFCMIFCGLS 359
Cdd:PLN02816 280 SGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKS--KNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYA 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  360 LAKLQAWRKAAAGA-------------------------LLLFNLCPALYTGLVHQRGALDVMHVLQPLCVSSQSPNppe 414
Cdd:PLN02816 358 FAQMEVSGSSSSSSvtkkkqvprqnhtkwspklrlsvyfLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKS--- 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435  415 LLFLMPCHSTPLYSHLHCPLKLRFLECPPdlTGRQDYMDEADVFFSDPLHWLNTSFPLRSTLPSHLVLFDSLQKEISSFL 494
Cdd:PLN02816 435 ILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFM 512

                        490       500
                 ....*....|....*....|
gi 41053435  495 EENSFAKQAEIFHTHFPEGR 514
Cdd:PLN02816 513 IQHSFKEVRRFFHAHFKVDR 532
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 48-431 1.53e-94

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 293.89  E-value: 1.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435    48 FIVLVRLLNCVLVQTSfVPDEFWQSLEISHRMVFGYGYETWEW--KEGIRGYSYPLLFALMYKLLQLISYDTVYLLVFVP 125
Cdd:pfam03901   5 LLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWspKYGIRSYLYPLLFALPYYLLARLFGDSKYLVFYAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   126 RVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSRTLTNTTETALTTLALCFYPLPGSKTHSSWKYLT 205
Cdd:pfam03901  84 RLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVSNYKYLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   206 LVS----LAVVIRPTALIVWFPLIFYHFC-TDQDKLKLITHRYFPIGVLAL----GVSTLIDSFFYGKWIFVQWNFLKFN 276
Cdd:pfam03901 164 AVLliaaLAILGRPTSALLWLPLVLYLLLrLRGKRLKLFLFLAISLGLLVAllvlGAVILIDSYFYGRFVFTPLNFLKYN 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   277 VLHNVGEFYGSHPWHWYWTQGLPVVIGPHLPLVLHGCLLSTRKHT----ILLLTIIWTTAVYSLLAHKEFRFIYPVLPFC 352
Cdd:pfam03901 244 VLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVsrlsQLLAPILIWLFIYSLQPHKEERFLYPVYPLI 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053435   353 MIFCGLSLAKLQAWRKAAAGAL------LLFNLCPALYTGLVHQRGAL----DVMHVLQPLCVSSQSP--NPPELLFLMP 420
Cdd:pfam03901 324 LLSAAIALTRLSRRSWKVRKKLsllfllLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPRENRNPagPPVNVCIGME 403

                         410
                  ....*....|.
gi 41053435   421 CHSTPLYSHLH 431
Cdd:pfam03901 404 CYSTPSSFFLH 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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