|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
15-475 |
0e+00 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 554.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetveLLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17428 179 --------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIA 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYITTK 414
Cdd:cd17428 221 LIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVTTK 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055405 415 IVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLAA 475
Cdd:cd17428 301 TVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLAA 361
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
15-474 |
1.26e-89 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 278.67 E-value: 1.26e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetveLLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGlIDGIA 334
Cdd:cd17352 179 --------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLG-IDESD 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SLTSYITT 413
Cdd:cd17352 220 AAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYsSLTPVILA 299
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLA 474
Cdd:cd17352 300 DLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
15-474 |
3.20e-70 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 229.22 E-value: 3.20e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNlpgyylkqraalqrtedpEPLYSKPTAIiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKE------------------PPDNQARLHV------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpYGQYFCETVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17314 192 ----------------------------QKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSF 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADmRWVNSLYLYALTLIGSGTALLLIPVSKSY--LGLQILSAAVGFFSGNWSLTSYIT 412
Cdd:cd17314 244 VTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSYGGLFTVYPAT 322
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055405 413 TK-IVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLA 474
Cdd:cd17314 323 VStVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
15-473 |
2.28e-63 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 210.46 E-value: 2.28e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetveLLQDRVFMAFCI-AMFLFSLGAFPPVLFMEDVAQSeGLIDGI 333
Cdd:cd17429 179 --------------------------------------LFTNKVFVAFIFwALFAYCSFVIPFIHLPEIVKLY-GLSEQN 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 334 ALIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYITT 413
Cdd:cd17429 220 DKFPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYFSLMPVVTE 299
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17429 300 DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
11-493 |
7.52e-59 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 201.51 E-value: 7.52e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 11 DGGWGWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGV 90
Cdd:TIGR00892 13 DGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 91 MVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGL 170
Cdd:TIGR00892 93 LASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 171 EGCLLIIGALALNLMACAGPMRPLnlpgyylkqraalqrteDPEPLYSKPtaiiiesgsdlKTKPGLAENTTTVKllink 250
Cdd:TIGR00892 173 RGSFLILGGLLLHCCVCGALMRPV-----------------GPSQRVSKS-----------KSKEGLPPDGSTKK----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 251 dptelqdsegerkvhiLSSSIIARAIKKWMrpygqyfceTVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLI 330
Cdd:TIGR00892 220 ----------------LSKKSTAEKINRFL---------DFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 331 DGIALIpLVSIVAMTTGIGKLILGVLADMRWVNS--LYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGF-FSGNWSL 407
Cdd:TIGR00892 275 EYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIRPhvQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLsFGSVGAL 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 408 TSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLAALPCWNRTAQEGN 487
Cdd:TIGR00892 354 LFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQK 433
|
....*.
gi 41055405 488 SQAEED 493
Cdd:TIGR00892 434 AALERE 439
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
15-474 |
3.21e-57 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 194.92 E-value: 3.21e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLPGyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPG-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaRAIKKWMRPygqYFCETVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLiDGIA 334
Cdd:cd17423 185 -------------------DPPAPPRSL---SAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGL-GEYQ 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSY-ITT 413
Cdd:cd17423 242 AAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFsVLP 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLvSGVFLFLA 474
Cdd:cd17423 322 ELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLL-LGSLILLT 381
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
15-473 |
1.91e-45 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 163.00 E-value: 1.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLPGYylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17422 161 LVVGALQLNIVVCGALLRVLKEPGF------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvellqdrvfmaFCIAMF-LF-SLGAFPPVLFMEDVAQSEGLIDG 332
Cdd:cd17422 186 -----------------------------------------------ICYALFgLFaTLGFFAPQLYIIPLSLSLGIDQD 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 333 IALIpLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWS---LTS 409
Cdd:cd17422 219 WAAY-MLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAgthIPL 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41055405 410 YITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17422 298 LAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
15-473 |
4.10e-44 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 160.39 E-value: 4.10e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAF-----QEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSG 89
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 90 VMVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFG 169
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 170 LEGCLLIIGALALNLMACAGPMRPLNLPgyylkqraalqrTEDPeplyskptaiiiesgsdlKTKPGLaentttvkllin 249
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPS------------PEDP------------------KSKPGR------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 250 kdptelqdSEGERKVHILSSSIIARAIKKWMRpygqyfcetvellqdRVFMAFCIAMFLFslGAFPPVLFMEDVAQSEGL 329
Cdd:cd17420 199 --------RTLHSRINLFLRKIFNVEIFKRKR---------------YVIWALGIPLALF--GYFVPYVHLMKFVKEEFF 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 330 IDGIALIPLVSIvAMTTGIGKLILGVLADM-RWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SL 407
Cdd:cd17420 254 PGKDVNVPLMCI-GITSGIGRLIFGVIADMpPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFiSI 332
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055405 408 TSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17420 333 MAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
15-474 |
3.27e-41 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 151.80 E-value: 3.27e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPLDF---------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17430 183 -------------------------------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEA 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIpLVSIVAMTTGIGKLILGVLADMRWV--NSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGN-WSLTSYI 411
Cdd:cd17430 226 AF-LLSILGFIDIFARPACGVVAGLKWVrpRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMvGALQFEV 304
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055405 412 TTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLA 474
Cdd:cd17430 305 LMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALG 367
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
15-476 |
5.93e-38 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 142.65 E-value: 5.93e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVgGFIYATLQNELIELFGLEGCL 174
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDF---------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGlIDGIA 334
Cdd:cd17421 182 -------------------------------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLG-IDPMD 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SLTSYITT 413
Cdd:cd17421 224 ASFIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYlALLLPVLV 303
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLAAL 476
Cdd:cd17421 304 DLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEPL 366
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
15-475 |
2.64e-32 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 126.85 E-value: 2.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLPGyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvellqdrvFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17424 185 --------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQA 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIpLVSIVAMTTGIGKLILGVLADMRWV----NSLYLYALTLigSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SLTS 409
Cdd:cd17424 221 AF-LMSILGVIDIIGNITFGWLTDRRCLkkyrYFCYLFAVGM--DGLCCLFLPILKTFPLLVPFSFTFGYFDGAYvALIP 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055405 410 YITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLAA 475
Cdd:cd17424 298 VVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
15-473 |
9.05e-31 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 123.06 E-value: 9.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNlpgyylkqraalqrtedPEPLYSkptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIG-----------------PKPFLD------------------------------------ 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17426 188 ------------------------------------LTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESA 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIpLVSIVAMTTGIGKLILGVLADMRWVNS--LYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYIT 412
Cdd:cd17426 232 AF-LLSILAFVDMVARPSMGIVANTKWVRPriQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFET 310
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41055405 413 -TKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17426 311 lMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFI 372
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
15-471 |
1.68e-29 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 119.90 E-value: 1.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAF-----QEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSG 89
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 90 VMVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFG 169
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 170 LEGCLLIIGALALNLMACAGPMRPLnlpgyylkqraaLQRTEDpeplyskptaiiiesgsdlKTKPGLAENTTTVKLLIN 249
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPL------------VPMKKD-------------------KEGKKRKFKCPPLKKIFN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 250 kdptelqdsegerkVHILSSsiiaRAIKKWmrpygqyfcetvellqdrvfmAFCIAMFLFslGAFPP-VLFMEDVAQSEG 328
Cdd:cd17464 210 --------------FNIWKS----TGYRIW---------------------AFGIPAALF--GYFVPyVHLMNHVKERFG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 329 liDGIALIPLVSIVAMTTGIGKLILGVLAD-MRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-S 406
Cdd:cd17464 249 --EDVNKEVLLMCIGITSGIGRLIFGRVADyIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFiS 326
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41055405 407 LTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFL 471
Cdd:cd17464 327 IMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
15-473 |
2.49e-28 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 115.68 E-value: 2.49e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNlpgyylkqraalqrtedpePLYSKPTAIIIESGSdlktkpglaentttvkllinkdpte 254
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLG-------------------PLFKHRGFLIYLSGN------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvellqdrvfmafcIAMFlfsLGAFPPVLFMEDVAQSEGlIDGIA 334
Cdd:cd17427 197 -------------------------------------------------VIMF---LGFFAPIVFLAPYAKHMG-IDEYS 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNS--LYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYIT 412
Cdd:cd17427 224 AAFLLSILAFVDMFARPSMGLVANSKWIRPriQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFET 303
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41055405 413 -TKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17427 304 lMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFI 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-473 |
6.40e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.28 E-value: 6.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 96 LMLSAFAPNISFLIFsYGIVVGMGCGLVYAATLTITCQYFDK-RRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:COG2223 84 LLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGpmrplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkLLINKDPTE 254
Cdd:COG2223 163 LILGILLLVVAVLAW--------------------------------------------------------LFLRDPPAG 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 LQDSEGERKVHILsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:COG2223 187 AAAAAKASLRDQL------------------------EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSkSYLGLQILSAAVGFFSGNWS-LTSYITT 413
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNgAVFALVP 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
15-472 |
9.51e-27 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 111.59 E-value: 9.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCG-LVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGC 173
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 174 LLIIGALALNLMacagpmrplnLPGYYLKQRaalqrteDPEPLYSKPtaiiiesgsdlKTKPGLAENTTTVKllinkdpt 253
Cdd:cd17355 161 LLVLALLALLVL----------VPVLLLLRR-------RPADLALRA-----------YDDASPASPGSTLK-------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 254 elqdsegerkvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFL--FSLGAFPPVLFMEDVAQSEGLID 331
Cdd:cd17355 205 --------------------------------------EALRSASFWLLALAFFLcgFAVVGLIVHLVPYLADRGISPAA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 332 GIALIPLVSIVAMttgIGKLILGVLADmRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWS-LTSY 410
Cdd:cd17355 247 AAVALALIGLFNI---VGRLLSGWLGD-RYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVpLTAA 322
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41055405 411 ITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLF 472
Cdd:cd17355 323 LAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
15-474 |
1.19e-26 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 111.02 E-value: 1.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAG 94
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 95 GLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPlnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyFCetvellQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:cd17425 180 --------------------------------FC------SNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKA 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIpLVSIVAMTTGIGKLILGVLADMRWVNS--LYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGF-FSGNWSLTSYI 411
Cdd:cd17425 222 AL-LLSILGFINIFMRPLAGLLSGLPVFKGrrIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSIsMSGIGSLIFQV 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055405 412 TTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFLA 474
Cdd:cd17425 301 LMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLS 363
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
16-473 |
7.08e-25 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 106.16 E-value: 7.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSfGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:cd17353 3 WLVLLGAVLMHLIL-GYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 96 LMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLL 175
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 176 IIGALALNLMAcagpmrplnlpgyylkqrAALQRTEDPEPLYSKPTAiiiesgsdlktkpgLAENTTTVKLLINKDPTel 255
Cdd:cd17353 162 ILGIIFLIIIV------------------IGAFLIRDPPKGWVPPGV--------------DPLANNAENSPRDYTPR-- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 256 qdsegerkvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIAL 335
Cdd:cd17353 208 ------------------------------------EMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIA 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 336 IPLVSIVAMTTGIGKLILGVLADmRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGF-FSGNWSLTSYITTK 414
Cdd:cd17353 252 ALAVSILSIFNGGGRPFWGWLSD-KIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTAD 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 41055405 415 IVGIERLGQAHGILMCFGGFGIALGPPVVGwFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17353 331 FFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-472 |
4.49e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.88 E-value: 4.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 23 FMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFA 102
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 103 PNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKR-RGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALA 181
Cdd:cd06174 82 PSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 182 LNLMACAgpmrplnlpgyylkqraalqrtedpeplyskPTAIIIESGSDLKTKPGLAENTTTVKLLInkdptelqdsege 261
Cdd:cd06174 161 LALLAAI-------------------------------LLLLVVPDPPESARAKNEEASSKSVLKLL------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 262 rkvhilsssiiaraikkwmrpygqyfcetVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSI 341
Cdd:cd06174 197 -----------------------------KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 342 VAMTTGIGKLILGVLADmRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSY-ITTKIVGIER 420
Cdd:cd06174 248 FGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFaLIAELFPPEI 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 41055405 421 LGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLF 472
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-475 |
2.48e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 92.63 E-value: 2.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 8 STLDGGWGWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIF 87
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 88 SGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYF-DKRRGLALGIVTTGTSVGGFIYATLQNELIE 166
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 167 LFGLEGCLLIIGALALNLMACAgpmrplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkl 246
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALLR---------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 247 linkdptelqdsegerkvhilsssiiaraikkwmrpygqyfcetvellqdrvFMAFCIAMFLFSLGAFPPVLFMEDVAQS 326
Cdd:COG2271 182 ----------------------------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVE 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 327 EGLIDGIALIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFS-GNW 405
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLgGAF 289
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 406 SLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAFYLSGTCVLVSGVFLFLAA 475
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
15-472 |
9.79e-17 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 81.77 E-value: 9.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGM-----TAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSG 89
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 90 VMVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFG 169
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 170 LEGCLLIIGALALNLMACAGPMRplnlpgyylkqraalqrtedpepLYSKPTAIIIESGsdlktkpglaentttvkllin 249
Cdd:cd17465 161 LAHTFQVLSLFMFIQIFLSLTYK-----------------------VFRRKTYRIWAFG--------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 250 kdptelqdsegerkvhilsssiIARAIKKWMRPYgqyfcetvellqdrvfmafciamflfslgafppVLFMEDVAQSEGL 329
Cdd:cd17465 197 ----------------------IATAVLGYFVPY---------------------------------VHLMKYVEEEFKE 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 330 IDGIALIPLVsiVAMTTGIGKLILGVLAD-MRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SL 407
Cdd:cd17465 222 NKREWVLLVC--IGASSGIGRLMSGKIGDlIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFiTI 299
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41055405 408 TSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLF 472
Cdd:cd17465 300 MAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLF 364
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-477 |
3.27e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.22 E-value: 3.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 1 MAAVKSESTLDGGWGWMIVVASFMAQFLSFGSP-QSVGVLypewLSAFQEGKGMTAWVGSMVSGVALIT----SPVCSAC 75
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPL----LPEIRADLGLSATQAGLLTTLPLLAfglfAPLAPRL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 76 VDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGF 155
Cdd:COG2807 77 ARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 156 IYATLQNELIELFGLEGCLLIIGALALNLMACAGPmrplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkp 235
Cdd:COG2807 156 LAAGLTVPLAAALGWRGALAVWALLALLALLLWLP--------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 236 glaentttvkLLINKDPTELQDSEGERKVHILSSsiiaraikkwmrpygqyfcetvellqdRVFMAFCIAMFLFSLGAFP 315
Cdd:COG2807 191 ----------LLRRRPAAAAAAPAAASLRSLWRS---------------------------PLAWLLTLFFGLQSLLYYA 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 316 PVLFMEDVAQSEGLIDGIALIpLVSIVAMTTGIGKLILGVLAD-MRWVNSLYLYALTLIGSGTA-LLLIPVSKSYLGLQI 393
Cdd:COG2807 234 VVAWLPPILRDAGLSAATAGL-LLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPWLWAVL 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 394 LSAAVGF-FSGNWSLTSYITTkivGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLF 472
Cdd:COG2807 313 LGLGQGGlFPLALTLIGLRAR---TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
....*
gi 41055405 473 LAALP 477
Cdd:COG2807 390 LAGRP 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-438 |
1.39e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.01 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 96 LMLSAFAPNISFLIFSyGIVVGMGCGLVYAATLTITCQYFD-KRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCL 174
Cdd:COG2814 89 SLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRPLNLPGYYLKQRAALQrtedpeplyskptaiiiesgsdlktkpglaentttvkllinkdpte 254
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLR---------------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 lqdsegerkvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIA 334
Cdd:COG2814 202 -------------------------------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 335 LIPLVSIVAMTTGIGKLILGVLADmrWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGF-FSGNWSLTSYITT 413
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFgFGLLFPLLQALVA 322
|
410 420
....*....|....*....|....*
gi 41055405 414 KIVGIERLGQAHGILMCFGGFGIAL 438
Cdd:COG2814 323 ELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-440 |
5.77e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 73.22 E-value: 5.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 23 FMAQFLSFGSPQSVGVLYPEWLS-AFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAF 101
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 102 APNISFLIFSyGIVVGMGCGLVYAATLTITCQYF-DKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGAL 180
Cdd:pfam07690 82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 181 ALNLMacagpmrplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttVKLLINKDPTELQDSEG 260
Cdd:pfam07690 161 SLLAA----------------------------------------------------------VLLLLPRPPPESKRPKP 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 261 ERKVHILSSSIIaraikkwmrpygqyfcetVELLQDRVFMAFcIAMFLFSLGAFPPVLFMEDVAQSEGLiDGIALIPLVS 340
Cdd:pfam07690 183 AEEARLSLIVAW------------------KALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGLLLG 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 341 IVAMTTGIGKLILGVLAD-MRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIVGI 418
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPK 322
|
410 420
....*....|....*....|..
gi 41055405 419 ERLGQAHGILMCFGGFGIALGP 440
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
55-473 |
9.07e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 9.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 55 AWVGSMVSGVA---LITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTIT 131
Cdd:cd17325 31 AQIGLIVAAYAlaqLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 132 CQYF-DKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMACAGPMRPlnlpgyylkqraalqrt 210
Cdd:cd17325 110 ADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP----------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 211 edpeplyskptaiiiESGSDLKTKPGLAENTTTVKLLINKDPTelqdsegerkvhILSSSIIaraikkwmrpygqyfcet 290
Cdd:cd17325 173 ---------------EPRPPPNKRAVSAARLRSGLRLLLRDRR------------LLALFLA------------------ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 291 vellqdRVFMAFCIAMFLFSLgafpPVLFMEDVAQSEGLIdGIALiplvSIVAMTTGIGKLILGVLADmrWVNSLYLYAL 370
Cdd:cd17325 208 ------IFVLAFAFGALEPFL----PLYAAELGGLSPAQI-GLLF----GAQGLASALSQPPAGKLSD--RIGRKPLILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 371 TLIGSGTALLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDw 449
Cdd:cd17325 271 GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD- 349
|
410 420
....*....|....*....|....
gi 41055405 450 TQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-182 |
1.81e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 5 KSESTLDGGWGWMIVVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPV 84
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 85 TIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYF-DKRRGLALGIVTTGTSVGGFIYATLQNE 163
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170
....*....|....*....
gi 41055405 164 LIELFGLEGCLLIIGALAL 182
Cdd:COG0477 161 LVAALGWRWIFLINAPLGL 179
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
22-471 |
3.03e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.79 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 22 SFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAF 101
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 102 APNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKR-RGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGAL 180
Cdd:cd17475 81 VGSYPVLLVLL-FLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 181 AlnlMACAGpmrplnlpgyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttVKLLINKDPtelqdseG 260
Cdd:cd17475 160 S---ILAAV------------------------------------------------------LFWLFYREP-------P 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 261 ERKVHILSSSIIARAIKkwmrpygqyfcetvELLQDRVFMAFCIAMFL-----FSLGAFPPVLFMEDVAQSEGLIDGial 335
Cdd:cd17475 176 AASAATESASTLLRSLK--------------EVLRNRDVWLIAIAGALlvapqFALLTFLLLFLHDHLGLSVVAAGA--- 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 336 ipLVSIVAMTTGIGKLILGVLADMRWVNS--LYLYALTLIGSGT--ALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYI 411
Cdd:cd17475 239 --LLAVAQLGGALGRIGLGRVSDRVFGGRrrPVLVITAAIAAAAllVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLT 316
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41055405 412 -TTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFL 471
Cdd:cd17475 317 lVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
297-479 |
4.33e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 297 RVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLiDGIALIPLVSIVAMTTGIGKLILGVLADmrWVNSLYLYALTLIGSG 376
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-SAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 377 TALLLIPVSKSYLGLQILSAAVGFF-SGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDL 455
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRA 165
|
170 180
....*....|....*....|....
gi 41055405 456 AFYLSGTCVLVSGVFLFLAALPCW 479
Cdd:COG2271 166 AFLILGLPGLLLALLRFWLLALAY 189
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
299-473 |
1.02e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.04 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 299 FMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIdGIalipLVSIVAMTTGIGKLILGVLADmRWvNSLYLYALTLIGSGTA 378
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEI-GL----LLTLFSLGYALAQPLAGRLSD-RF-GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 379 LLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAF 457
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAF 154
|
170
....*....|....*.
gi 41055405 458 YLSGTCVLVSGVFLFL 473
Cdd:pfam07690 155 LILAILSLLAAVLLLL 170
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-189 |
2.23e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 14 WGWMIVVASFMAQFLSFGSPQSVGVlypeWLSAF-QEGKGMTAWVGSMV----SGVALITSPVCSACVDNFGARPVTIFS 88
Cdd:COG0738 207 LKNPRLLLGGLAIFLYVGAEGAIGD----WLPLYlKDVLGLSEATAALGlslfWGGMTIGRFLGGFLLKRFGPVRLLRLS 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 89 GVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELF 168
Cdd:COG0738 283 ALLAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF 361
|
170 180
....*....|....*....|.
gi 41055405 169 GLEGCLLIIGALALNLMACAG 189
Cdd:COG0738 362 GLRAAFLVPLVCYLLILLLAL 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-474 |
3.01e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.63 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 18 IVVASFMAQFLSFGSpqsVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLM 97
Cdd:COG0738 12 AIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 98 LSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIEL---FGLEGCL 174
Cdd:COG0738 89 LFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 175 LIIGALALNLMACAGPMRplnLPGyylkqraalqrtedpeplyskptaiiiesgsdlktkpglaentttvkllINKDPTE 254
Cdd:COG0738 168 LILAVLLLLLALLFLRSK---LPE-------------------------------------------------IEEEEEE 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 255 LQDSEGERKvhilsssiiaraikkwmrpygqyfcetvELLQDRVFMAFCIAMFLF-----SLGAFPPVLFMEDVAQSEGL 329
Cdd:COG0738 196 AAGSAASLK----------------------------SLLKNPRLLLGGLAIFLYvgaegAIGDWLPLYLKDVLGLSEAT 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 330 IdgiALIPLVSIVAMTtgIGKLILGVLadMRWVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGN-WSLT 408
Cdd:COG0738 248 A---ALGLSLFWGGMT--IGRFLGGFL--LKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLmFPTI 320
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055405 409 SYITTKIVGIERLGQAhGILMCFGGFGIALGPPVVGWFFDWTqSYDLAFYLSGTCVLVSGVFLFLA 474
Cdd:COG0738 321 FSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
52-476 |
1.13e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.71 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 52 GMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSyGIVVGMGCGLVYAATLTIT 131
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAAYA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 132 CQYFDK-RRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMACagpmrplnlpgyylkqraalqrt 210
Cdd:cd17324 113 ADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL----------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 211 edpeplyskptaiiiesgsdlktkpglaentttVKLLINKDPTElqdsegerkvHILSSSIIARAIKKWMRPygqyfcet 290
Cdd:cd17324 170 ---------------------------------LWRLLPSLPPK----------KPGSLGLLSSLLLLLRNP-------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 291 vellqdRVFMAFCIAMFLFS--LGAFPpvlFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLILGVLADMRWVNSLYLY 368
Cdd:cd17324 199 ------RLRLAYLITFLLFGgfFALYT---YLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 369 ALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYITTkiVGIERLGQAHGILMCFGGFGIALGPPVVGWFFD 448
Cdd:cd17324 270 LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR--LAPEARGLASSLYLAAYNLGGALGAALGGLVLD 347
|
410 420
....*....|....*....|....*...
gi 41055405 449 WtqsydlafYLSGTCVLVSGVFLFLAAL 476
Cdd:cd17324 348 H--------GGWAGVGWVGAALLLLALL 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
296-472 |
1.74e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 296 DRVFMAFCIAMFLFSLGAFPPVLFmedVAQSEGLIDGIALIPLVSIVAMTT-GIGKLILGVLADmRWvNSLYLYALTLIG 374
Cdd:cd17370 199 PKAFWLYLLAVALFALGNFSFAFL---ILRAQELGLSAALIPLLYALFNLVyALAAYPAGRLSD-RI-GRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 375 SGTALLLIPVSKSYLGLQILSAAVGFFSGNW-SLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSY 453
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SP 352
|
170
....*....|....*....
gi 41055405 454 DLAFYLSGTCVLVSGVFLF 472
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
297-473 |
1.77e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.05 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 297 RVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGlIDGIALIPLVSIVAMTTGIGKLILGVLADMrwVNSLYLYALTLIGSG 376
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLG-ASPAQAGLVVTAYLLGAALGAPLAGRLADR--FGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 377 TALLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDL 455
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRW 165
|
170
....*....|....*...
gi 41055405 456 AFYLSGTCVLVSGVFLFL 473
Cdd:COG2814 166 VFLVNAVLALLALLLLLR 183
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
302-473 |
1.78e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.35 E-value: 1.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 302 FCIAMFLFSLGAFPPVLFMEDVAQSEGLidGIALIP-LVSIVAMTTGIGKLILGVLADMRWvnSLYLYALTLIGSGTALL 380
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGA--SVAQIGlIVAAYALAQLLFSPPAGRLSDRFG--RKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 381 LIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAFYL 459
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLV 155
|
170
....*....|....
gi 41055405 460 SGTCVLVSGVFLFL 473
Cdd:cd17325 156 CAALALLALVLALL 169
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-182 |
3.14e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 3.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 19 VVASFMAQFLSFGSPQSVGVLYPEWLSA-FQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLM 97
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 98 LSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDKR-RGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLI 176
Cdd:cd17325 281 LLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
....*.
gi 41055405 177 IGALAL 182
Cdd:cd17325 360 AAALLL 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-186 |
3.78e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.36 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 15 GWMIVVASFMAQFLSFGSPQSVGVLYP----EW-LSAFQEGKGMTAWVGSMVSGvALITSPVCsacvDNFGARPVTIFSG 89
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPaisaEWgLDPVQLGFLFSAGLIGMAFG-ALFFGPLA----DRIGRRRVLLWSI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 90 VMVAGGLMLSAFAPNISFLIFsYGIVVGMGCGLVYAATLTITCQYF-DKRRGLALGIVTTGTSVGGFIYATLQNELIELF 168
Cdd:TIGR00895 90 LLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF 168
|
170
....*....|....*...
gi 41055405 169 GLEGcLLIIGALALNLMA 186
Cdd:TIGR00895 169 GWRS-LFYVGGIAPLLLL 185
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
338-473 |
5.09e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 51.99 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 338 LVSIVAMTTGIGKLILGVLADMrwVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIV 416
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDR--SNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGmGWPPCGRTVTKWF 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 41055405 417 GIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFL 169
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
297-473 |
7.90e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.03 E-value: 7.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 297 RVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLILGVLAD-MRWVNSLYLYALTLIGS 375
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 376 GTALLLIPVSKS-YLGLQILSAAVGFFSGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYD 454
Cdd:cd17319 259 AVGLLLAYLTTSpVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYT 338
|
170
....*....|....*....
gi 41055405 455 LAFYLSGTCVLVSGVFLFL 473
Cdd:cd17319 339 AAFLFLAAVALLAALLVLL 357
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
289-475 |
1.15e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 289 ETVELLQDRVFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLILGVLAdmRWVNSLYLY 368
Cdd:cd17473 189 ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK--RRLGKRRLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 369 ALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSGnwSLTSYITTKIVGI---ERLGQAHGILMCFGGFGIALGPPVVGW 445
Cdd:cd17473 267 AIGFALMALGFLLLALASGLWVVLLGAILAGLGFG--LLLPTLNSWAMSLvppELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
170 180 190
....*....|....*....|....*....|
gi 41055405 446 FFDWTQSYDLAFYLSGTCVLVSGVFLFLAA 475
Cdd:cd17473 345 LVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
52-472 |
1.20e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 52 GMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTIT 131
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 132 CQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMACAGPMRPLNLPgyYLKQRAALQRTE 211
Cdd:cd17478 110 SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP--EAKKAAAKSSAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 212 DPEPLYSKPTAIIiesgsdlktkpglaentttvkllinkdptelqdsegerkvhilsssiiaraikkwmrpygqyfcetv 291
Cdd:cd17478 188 STLKGVWRALLLL------------------------------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 292 ellqdrVFMAFCIAMFLFSLGAFPPVLFMEdvaqseGLIDGIALIPLVSIVAMTTGIGKLILGVLADmRWvNSLYLYALT 371
Cdd:cd17478 201 ------LIIVFLRSWVLSSLTTFLPFYLVQ------RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD-RF-GRRRVIIAS 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 372 LIGSGTALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYITTKIVGiERLGQAHGILMCFGGFGIALGPPVVGWFFDWTq 451
Cdd:cd17478 267 LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAF- 344
|
410 420
....*....|....*....|.
gi 41055405 452 SYDLAFYLSGTCVLVSGVFLF 472
Cdd:cd17478 345 GLESVLLILALLPLLGALLAF 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-186 |
1.28e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 62 SGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSyGIVVGMGCGLVYAATLTITCQYFDK-RRG 140
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGLLFPALQALAVDLVPPhRRG 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 41055405 141 LALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMA 186
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
36-189 |
1.95e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 36 VGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNI-SFLIFSygI 114
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVlQLALLR--F 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055405 115 VVGMGCGLVYAATLTITCQYF-DKRRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLIIGALALNLMACAG 189
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR 171
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-182 |
1.97e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSFGSPQSVGVLYPEWLSAfqeGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG---SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 96 LMLSAFAPNISFLIFSyGIVVGMGCGLVYAATLTITCQYFDKR-RGLALGIVTTGTSVGGFIYATLQNELIEL-FGLEGC 173
Cdd:cd17473 277 FLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPPElRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtGGLSGA 355
|
....*....
gi 41055405 174 LLIIGALAL 182
Cdd:cd17473 356 FLILGVLAL 364
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
77-182 |
7.00e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.24 E-value: 7.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 77 DNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFD-KRRGLALGIVTTGTSVGGF 155
Cdd:cd17321 56 DRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR-ALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAA 134
|
90 100
....*....|....*....|....*..
gi 41055405 156 IYATLQNELIELFGLEGCLLIIGALAL 182
Cdd:cd17321 135 LGPLLGGLLLELFGWRWIFLINVPIGL 161
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-131 |
7.14e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 7.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSFGSPQSVGVLYpeWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110
....*....|....*....|....*....|....*.
gi 41055405 96 LMLSAFAPNISFLIFsygIVVGMGCGLVYAATLTIT 131
Cdd:COG2211 308 LLLLFFLGPGNLWLL---LVLAALAGIGLGAILVLP 340
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-161 |
1.02e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 16 WMIVVASFMAQFLSFGSPQSVGVLypewlsaFQEGKGMTAWVGSMVSG--------VALITSPVCSACVDNFGARPVTIF 87
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQL-------LQLPTPTGFGLGITEAGllllpgalVMLIAGPLAGRLIARVGPRRVLLI 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055405 88 SGVMVAGGLMLSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRR-----GLALGIVTTGTSVGGFIYATLQ 161
Cdd:cd17504 253 GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRtgiatGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-156 |
1.26e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 19 VVASFMAQFLSFGSPQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARP---VTIFSGVMVAGG 95
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41055405 96 LMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFDK-RRGLALGIVTTGTSVGGFI 156
Cdd:pfam07690 282 LLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGAL 342
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
338-473 |
1.52e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 338 LVSIVAMTTGIGKLILGVLADMrwVNSLYLYALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSG-NWSLTSYITTKIV 416
Cdd:cd17312 43 IGSAFLIAYAVGKFISGFLSDR--SNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSmGWPPCVKLLGNWF 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 41055405 417 GIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAFYLSGTCVLVSGVFLFL 473
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYY-GWRAAFLVPGIVGLVVAIILFF 176
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
289-435 |
2.66e-04 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 43.39 E-value: 2.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 289 ETVELLQDRVFMAFCIAMFLfslGAFPPVLFMEDVAQSEGLIDGIALIP-LVSIVAMTTGIGKLILGVLADM-----RWV 362
Cdd:cd17354 188 EEGEFLKDIDFWLLFISLFL---GVGPGEMFINNLGQIGQSLTGPSNTStLVSLFSIFSFLGRLLSGLLSDLfvrkfRLP 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41055405 363 NSLYLYALTLIGSGTALLLIPVSKSYLgLQILSAAVGF-FSGNWSLTSYITTKIVGIERLGQAHGILMCFGGFG 435
Cdd:cd17354 265 RPSRMVLLLLILSLGHLLQAFGLPSGA-LYVASALIGFgYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIG 337
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-186 |
2.90e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 18 IVVASFMAQFLSfgspQSVGVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLM 97
Cdd:cd17503 1 LLLGAFMAILDT----TIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 98 LSAFAPNISFLIFsYGIVVGMGCGLVYAATLTITCQYFDK-RRGLALGIVTTGTSVGGFIYATLQNELIELFGLEGCLLI 176
Cdd:cd17503 77 LCGLAPNLASLII-FRILQGFGGGVLIPLAQTILLRIYPPeKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
|
170
....*....|...
gi 41055405 177 ---IGALALNLMA 186
Cdd:cd17503 156 nlpIGILALLLAP 168
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
302-473 |
4.94e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 302 FCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIpLVSIVAMTTGIGKLILGVLADmrWVNSLYLYALTLIGSGTALLL 381
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 382 IPVSKSYLGLQILSAAVGFFSGN-WSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDW-TQSYDLAFYL 459
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLI 157
|
170
....*....|....
gi 41055405 460 SGTCVLVSGVFLFL 473
Cdd:cd06174 158 AAALALLAAILLLL 171
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
20-154 |
1.04e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 20 VASFMAQFLSFGSPQSVGVLYPEWLSAFQeGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLS 99
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 41055405 100 AFAPNISFLIFSyGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGG 154
Cdd:cd06179 80 GTAKSVNMLIGG-QALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGS 133
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-182 |
1.42e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 19 VVASFMAQFLSFGSPQSVGVLYPEWL-SAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLM 97
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLlDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 98 LSAFAPNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKR-RGLALGIVTTGTSVGGFIYATLQNELIEL-FGLEGCLL 175
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFL 364
|
....*..
gi 41055405 176 IIGALAL 182
Cdd:cd06174 365 VLAVLLL 371
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
301-473 |
1.44e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.02 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 301 AFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSivamtTGIGKLILGVLADMRWvNSLYLYALTLIGSGTALL 380
Cdd:cd17474 207 AFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL-----LALGSLFVGRLLKKRF-GARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 381 LIPVSKSYLGLQILSAAVGFFSG--NWSLTSYITTKIVGIERlGQAHGILMCFGGFGIALGPPVVGWFFDWtQSYDLAFY 458
Cdd:cd17474 281 LLGFVPSLALLLIAIVLFGLGLGlnLPLLTTLVTELAPEEER-GTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAPFL 358
|
170
....*....|....*
gi 41055405 459 LSGTCVLVSGVFLFL 473
Cdd:cd17474 359 VGAAIALAAAVLLAL 373
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
303-473 |
2.15e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 303 CIAMFLFSLGAFPPV----LFMEDVAQSEGLIdGIAliplVSIVAMTTGIGKLILGVLADmRWVNSLyLYALTLIGSGTA 378
Cdd:cd17489 2 LLANFFFFLSFYLLLpvlpLYAHDLGGSEAVA-GLV----VGLFTLAALLARPFAGRLLD-RFGRKR-LLLIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 379 LLLIPVSKSYLGLQILSAAVGF-FSGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAF 457
Cdd:cd17489 75 TLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLF 153
|
170
....*....|....*.
gi 41055405 458 YLSGTCVLVSGVFLFL 473
Cdd:cd17489 154 IVAAVLALLALLLVFL 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
293-479 |
2.51e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 293 LLQDRVFMAFCIAMFLFSLGAFPP----VLFMEDVAQsegliDGIALIPLVSIVAMTTGI-GKLILGVLADMRWVNSLYL 367
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVaallLYYFKYVLG-----LSAALVGLLLALYFLAALlGAPLWPRLAKRFGKKKAFI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 368 YALTLIGSGTALLLIPVSKSYLGLQILSAAVGFFSG-----NWSLTSYIT---TKIVGIERLGQAHGILMCFGGFGIALG 439
Cdd:COG2211 299 IGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGailvlPWAMLADVVdydEWKTGRRREGLYFGIFTFAIKLGQALA 378
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 41055405 440 PPVVGWFFDWT-------QSYDLAFYLSGTCVLVSGVFLFLAALPCW 479
Cdd:COG2211 379 GALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
56-123 |
3.28e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.86 E-value: 3.28e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41055405 56 WVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFSYgIVVGMGCGLV 123
Cdd:cd17315 38 LVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR-FLLGLGVGLA 104
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-154 |
3.65e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 20 VASFMAQFLSFGSPQSVGVLYPEWLsafQEGKGMTAWVGSMV----SGVALITSPVCSACVDNFGARPVTIFSGVMVAGG 95
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYL---QGVLGYSPLQAGLAllplALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41055405 96 LMLSAFAPN---ISFLIFSYgIVVGMGCGLVYAATLTITCQYFDK-RRGLALGIVTTGTSVGG 154
Cdd:cd17321 248 LLLLALLGAdssVWLLLPGL-VLLGLGLGLFATPLTNAALSSVPKeKAGAASGILNTARQLGG 309
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
298-470 |
3.95e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 298 VFMAFCIAMFLFSLGAFPPVLfmedvAQSEGLIDGIALIpLVSIVAMTTGIGKLILGVLADM---RWVnslyLYALTLIG 374
Cdd:cd17477 194 LLGAFVAGFLEGAFYSLLPLY-----GLRLGLSVAQAAL-LLAAFVLGGLLLQWPLGWLADRfdrRRV----LLGCALLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 375 SGTALLLIPVSKSYLGLQILSAAVGFFSGN-WSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSY 453
Cdd:cd17477 264 ALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPH 343
|
170
....*....|....*..
gi 41055405 454 DLAFYLSGTCVLVSGVF 470
Cdd:cd17477 344 GLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
372-475 |
4.52e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 4.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 372 LIGSGTALLLIPVSKSYLG-LQILSAAVGFFSGNWSlTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWT 450
Cdd:cd17380 258 FLGPALFLLLLSHTDSFSLaLLCMSVALGLSAFSSS-GVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEAT 336
|
90 100
....*....|....*....|....*
gi 41055405 451 QSYDLAFYLSGTCVLVSGVFLFLAA 475
Cdd:cd17380 337 GSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
302-477 |
4.83e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 302 FCIAMFLFSLGAFPPV--LFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLIlgvladmRWVNSLYLYALTLIGSGTAL 379
Cdd:cd17477 3 LSVALLGLGSGLLLPLlsLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLI-------RRVGHIRAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 380 LLIPVSKSYLGLQILSAAVGF-FSGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFfdwTQSYDLAFY 458
Cdd:cd17477 76 LLLALTDSPWVWFLLRFVMGIgLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV---GTAGALPFL 152
|
170
....*....|....*....
gi 41055405 459 LSGTCVLVSGVFLFLAALP 477
Cdd:cd17477 153 IAAVLLLLALVPLLLTRRA 171
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
300-473 |
5.34e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 300 MAFCIAMFLFSLGAFPPVLFMEDVAQSEGL-IDGIALIplVSIVAMTTGIGKLILGVLADMrwVNSLYLYALTLIGSGTA 378
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVsVAQAGLL--VSAYALGYALGALLLGPLSDR--IERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 379 LLLIPVSKSYLGLQILSAAVGFF-SGNWSLTSYITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAF 457
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAF 156
|
170
....*....|....*.
gi 41055405 458 YLSGTCVLVSGVFLFL 473
Cdd:cd17324 157 LAIAVLALLAALLLWR 172
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
17-182 |
5.97e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 17 MIVVASFMA---QFLSFGSPQSVGVLYPEWL--SAFQEGKGMTAWVGSMVSGVALITSPVCsacvDNFGARPVTIFSGVM 91
Cdd:cd17490 195 KLLFFSLLAilqQMITFSTTFGFTPLIAKQLgaSSFQLGLLSIIYLLPNALASLLSGTLFY----KKLGERNTIIIGFLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 92 VAGGLMLSAFAPNISFLIFSYgIVVGMGCGLVYAATLTITCQYFD-KRRGLALGIVTTGTSVGGFIYATLQNELIELFGL 170
Cdd:cd17490 271 LGAYCFLIPFAPNLTLLYLLQ-ALNGFGTGILFPLLMSLSIEGVPaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGL 349
|
170
....*....|..
gi 41055405 171 EGCLLIIGALAL 182
Cdd:cd17490 350 QTGFFVIGVIAL 361
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
296-474 |
7.84e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 296 DRVFMAFCIAMFLFSLgAFPPVLFMEDVAQSEGLIDGIALIPLVSIVAMTtgIGKLILGVLADMRWVNSLYLYALTLIGS 375
Cdd:cd17489 193 EKKVLPPALILFLASI-AYGAISTFLPLYAAERGISNAGLFFTVYAIALL--LSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 376 GTALLLIPVSKSYLGLqilsAAVGFFSGNWSLTSYITTKIVGI---ERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqS 452
Cdd:cd17489 270 GLLLLSFAGSPWMLLL----AAVLYGLGFGLLFPALQALAVDLvppHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-G 344
|
170 180
....*....|....*....|..
gi 41055405 453 YDLAFYLSGTCVLVSGVFLFLA 474
Cdd:cd17489 345 YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
304-474 |
7.85e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 304 IAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIPLVSIVAMTTGIGKLILGVLADMRwvNSLYLYALTLIGSGTALLLIP 383
Cdd:cd06173 215 LALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR--RRGRLLLIGALLLGLALLVLG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 384 VSKSYLGLQILSAAVGFFSGNWSLTSY-ITTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTqSYDLAFYLSGT 462
Cdd:cd06173 293 LSPSLWLLLAALFLLGLAGGLFNVPLNtLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GLSAVFLLAGA 371
|
170
....*....|..
gi 41055405 463 CVLVSGVFLFLA 474
Cdd:cd06173 372 LLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
298-472 |
8.92e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 298 VFMAFCIAMFLFSLGAFPPVLFMEDVAQSEGLIDGIALIplVSIVAMttgIGKLILGVLADMRWVNSLYLYALTLIGSGT 377
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL--ISLGAL---VGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 378 ALLLIPVSKSYLGLQILSAAVGFFSGNWSLTSYI-TTKIVGIERLGQAHGILMCFGGFGIALGPPVVGWFFDWTQSYDLA 456
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAyLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVP 337
|
170
....*....|....*.
gi 41055405 457 FYLSGTCVLVSGVFLF 472
Cdd:cd17316 338 ALILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
37-171 |
9.96e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.44 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055405 37 GVLYPEWLSAFQEGKGMTAWVGSMVSGVALITSPVCSACVDNFGARPVTIFSGVMVAGGLMLSAFAPNISFLIFsYGIVV 116
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALA 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 41055405 117 GMGCGLVYAATLTITCQYFD-KRRGLALGIVTTGTSVGGFIYATLQNELIELFGLE 171
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPaRHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPE 153
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