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Conserved domains on  [gi|41055052|ref|NP_956663|]
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transmembrane protein 134 [Danio rerio]

Protein Classification

TMEM134 family protein( domain architecture ID 10531326)

TMEM134 family protein is a DUF872 domain-containing protein similar to human transmembrane protein 134 that is involved in ORF2-mediated NF-kappaB pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 68-204 5.58e-57

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


:

Pssm-ID: 399128  Cd Length: 115  Bit Score: 175.70  E-value: 5.58e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055052    68 YQNLENEDALGGTVNSSfnnffkisdpatlsycssQWSFSTLSSVTQLSAhccgWTSHPLVKKNRRVVLASFLLLITGVA 147
Cdd:pfam05915   1 YQNLENEDDDSLYGNSS------------------QYSPSTLSSTPQRSY----WTRHPLVKKNWKVVLAAFLLLLLGLV 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 41055052   148 LIFTGIVIQLNPHAGVSSAIFFVPGFLLFIPGVYHVIYISCAVRGRRGFKFFYLPYF 204
Cdd:pfam05915  59 LLFTGIFIFINPHEGVSSAVFFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 68-204 5.58e-57

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 175.70  E-value: 5.58e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055052    68 YQNLENEDALGGTVNSSfnnffkisdpatlsycssQWSFSTLSSVTQLSAhccgWTSHPLVKKNRRVVLASFLLLITGVA 147
Cdd:pfam05915   1 YQNLENEDDDSLYGNSS------------------QYSPSTLSSTPQRSY----WTRHPLVKKNWKVVLAAFLLLLLGLV 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 41055052   148 LIFTGIVIQLNPHAGVSSAIFFVPGFLLFIPGVYHVIYISCAVRGRRGFKFFYLPYF 204
Cdd:pfam05915  59 LLFTGIFIFINPHEGVSSAVFFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 68-204 5.58e-57

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 175.70  E-value: 5.58e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055052    68 YQNLENEDALGGTVNSSfnnffkisdpatlsycssQWSFSTLSSVTQLSAhccgWTSHPLVKKNRRVVLASFLLLITGVA 147
Cdd:pfam05915   1 YQNLENEDDDSLYGNSS------------------QYSPSTLSSTPQRSY----WTRHPLVKKNWKVVLAAFLLLLLGLV 58

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 41055052   148 LIFTGIVIQLNPHAGVSSAIFFVPGFLLFIPGVYHVIYISCAVRGRRGFKFFYLPYF 204
Cdd:pfam05915  59 LLFTGIFIFINPHEGVSSAVFFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
DUF308 pfam03729
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ...
 143-201 5.26e-03

Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).


Pssm-ID: 427468  Cd Length: 73  Bit Score: 34.40  E-value: 5.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41055052   143 ITGVALIFTGIVIQLNPHAGVSSAIFFVpGFLLFIPGVYHVIYISCAVRGRRGFKFFYL 201
Cdd:pfam03729   1 LLGILLIILGILALIWPGAALLALVILI-GILLLVSGILQLIAAFALRKFGGGGFWWLL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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