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Conserved domains on  [gi|41053617|ref|NP_956579|]
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proton-coupled folate transporter [Danio rerio]

Protein Classification

MFS transporter( domain architecture ID 13024586)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 42-464 0e+00

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 779.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  42 SVTVEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGGC--NASTVHDPLQTEVETLTAHWSLYINLGGFLVGLF 119
Cdd:cd17449   1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGCasNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 120 MVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTF 199
Cdd:cd17449  81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 200 RVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCRLYSSDA 279
Cdd:cd17449 161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 280 PPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGL 359
Cdd:cd17449 241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 360 TSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLH 439
Cdd:cd17449 321 ISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCSLVATGIFNSLYPATLH 400

                       410       420
                ....*....|....*....|....*
gi 41053617 440 FMKGFPFVFGAAILLIPAGIIGGLG 464
Cdd:cd17449 401 FMKGFPFLFGAALLLIPAGIIGLLE 425
 
Name Accession Description Interval E-value
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 42-464 0e+00

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 779.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  42 SVTVEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGGC--NASTVHDPLQTEVETLTAHWSLYINLGGFLVGLF 119
Cdd:cd17449   1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGCasNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 120 MVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTF 199
Cdd:cd17449  81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 200 RVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCRLYSSDA 279
Cdd:cd17449 161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 280 PPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGL 359
Cdd:cd17449 241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 360 TSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLH 439
Cdd:cd17449 321 ISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCSLVATGIFNSLYPATLH 400

                       410       420
                ....*....|....*....|....*
gi 41053617 440 FMKGFPFVFGAAILLIPAGIIGGLG 464
Cdd:cd17449 401 FMKGFPFLFGAALLLIPAGIIGLLE 425
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
114-413 9.80e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.48  E-value: 9.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMylklPVFWFLIGRICSGLSGdfNAILAGCFAYVADTSE 193
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGA--GALFPAALALIADLVP 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQavcr 273
Cdd:COG2814 129 PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL---- 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 274 lyssdappgRRSKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSW 353
Cdd:COG2814 205 ---------RRPRLLLLLLLAFLLGFGFFALFTYLPLY-LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41053617 354 VALVGLTSNMVGLVVISVADTTALMFTGYGLC-FLFMASTPVLRSKLSKLVDPAEQGALFA 413
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLgFGFGLLFPLLQALVAELAPPEARGRASG 335
MFS_1 pfam07690
Major Facilitator Superfamily;
114-427 3.29e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.44  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVqaavYLTVMYLKLPVFWFLIGRICSGLSGdfNAILAGCFAYVADTSE 193
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL----GLLLLLFASSLWLLLVLRVLQGLGA--GALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARlfstRHHQAVCR 273
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA----EEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   274 LYSSDAPPGRRSKLWLYILCFFLVVTVHLGCSDLYV----LYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQccl 349
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQevlgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL--- 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053617   350 edsWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAST-PVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSS 427
Cdd:pfam07690 269 ---LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVfPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
109-253 2.41e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 46.87  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   109 INLGGFLVG-LFMVILLGSWSDRAGRRLVLIIPSLGLAV-QAAVYLTVMYLKLpvfwfLIGRICSGLSGdfNAILAGCFA 186
Cdd:TIGR00880   2 LLLAGYALGqLIYSPLSGLLTDRFGRKPVLLVGLFIFVLsTAMFALSSNITVL-----IIARFLQGFGA--AFALVAGAA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41053617   187 YVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPET 253
Cdd:TIGR00880  75 LIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
 
Name Accession Description Interval E-value
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 42-464 0e+00

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 779.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  42 SVTVEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGGC--NASTVHDPLQTEVETLTAHWSLYINLGGFLVGLF 119
Cdd:cd17449   1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGCasNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 120 MVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTF 199
Cdd:cd17449  81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 200 RVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCRLYSSDA 279
Cdd:cd17449 161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 280 PPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGL 359
Cdd:cd17449 241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 360 TSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLH 439
Cdd:cd17449 321 ISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCSLVATGIFNSLYPATLH 400

                       410       420
                ....*....|....*....|....*
gi 41053617 440 FMKGFPFVFGAAILLIPAGIIGGLG 464
Cdd:cd17449 401 FMKGFPFLFGAALLLIPAGIIGLLE 425
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 42-461 1.93e-79

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 251.43  E-value: 1.93e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  42 SVTVEPVMFLSTFSIVLQAPLCTQYlwdrlsedvgyngtktggcnastvhdplqteveTLTAHWSLYINLGGFLVGLFMV 121
Cdd:cd17386   1 MLNVEPIVFLYMFASVLSGPVTQNF---------------------------------VYAANFYLYMNLMGSIPPLFSS 47

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 122 ILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLK--LPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTF 199
Cdd:cd17386  48 LFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTtvPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISSEKKRTY 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 200 RVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVpetvtpdpqarlfstrhhqavcrlyssda 279
Cdd:cd17386 128 RMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL----------------------------- 178

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 280 ppgrrSKLWLYILCFFLVVTVHLGCSDLYVLYELSaPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCL---EDSWVAL 356
Cdd:cd17386 179 -----TLLILLLLAAFLTIFVLSGESDVLYLFVLE-KFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLlkmSDSTLAM 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 357 VGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPA 436
Cdd:cd17386 253 LGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKA 332

                       410       420
                ....*....|....*....|....*
gi 41053617 437 TLHFMKGFPFVFGAAILLIPAGIIG 461
Cdd:cd17386 333 TLTTFPGFFFLLSAGLLLIPVILIG 357
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 45-461 3.88e-78

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 249.26  E-value: 3.88e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  45 VEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGG------CNASTVHDPLQTEVETLTAHWSLYINLGGFLVGL 118
Cdd:cd17448   4 VEPVVALYAFASFMTYPLIQQYVYRRLWEETSNSTYISSSnishceKNKSSPAFVFQEEVQKKTSLFNMQMDLSGLIPSL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 119 FMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERG-SR 197
Cdd:cd17448  84 IVTLILVSYSDRHGRKFSIILPSIGALLTSLSYCLVSYFSFPLNLLIASSFISGLFGGFTTFIGGCFAYVADLCKDHkQK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 198 TFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFvpetvtpdpqarlfstrhhqavcrlyss 277
Cdd:cd17448 164 TIRMAVVDMILGVLTGLAGLSSGYFIRALGFNWPFLTIALLHVVNLLYILFF---------------------------- 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 278 dappgrrskLWLYILCFFLVVT---VHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWV 354
Cdd:cd17448 216 ---------LVVLCLLLFAFSTyllANFGGASIFILYELNAPLCWNEVLVGYGSAASTAIFLTSFVGVALFSRCLPDIYI 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 355 ALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALY 434
Cdd:cd17448 287 VFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNSIY 366

                       410       420
                ....*....|....*....|....*..
gi 41053617 435 PATLHFMKGFPFVFGAAILLIPAGIIG 461
Cdd:cd17448 367 AATVAWFPGFSFLLSAGLCLIPASLLC 393
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 123-455 1.70e-27

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 113.50  E-value: 1.70e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 123 LLGSWSDRAGRRLVLIIPSLGLAVQaavYLtVMYLKLPVFWFLIGRICSGLSGdfnAILAGCFAYVADTSERGSRTFRVA 202
Cdd:cd17388  57 ILGALSDRFGRRPVLLLSLAGAALD---YL-LMAFAPTLWWLYLGRIIAGITG---ATGAVAAAYIADVTPPEQRARNFG 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 203 ILEACLGLAGMFASIIGGqWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDpQARLFSTRHHQAVCRLYSSDAPPG 282
Cdd:cd17388 130 LLGAAFGLGFIAGPALGG-LLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPE-RRRAFRWRRANPFGSLRWLTGFPG 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 283 rrskLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYLTSLTGL-RAMQCCLEDSWVALVGLTS 361
Cdd:cd17388 208 ----LLGLLAVFFLIQLIGQVPATTWVLF-TEDRFDWSPTMVGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAA 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 362 NMVGLVVISVADTTALMFTGygLCFLFMAS--TPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLH 439
Cdd:cd17388 283 DALGFLLLAFATQGWMVFPI--LILLALGGiaGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPA 360

                       330
                ....*....|....*.
gi 41053617 440 FMKGFPFVFGAAILLI 455
Cdd:cd17388 361 TWPGLAWIIGAALYLI 376
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 82-461 3.23e-27

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 112.54  E-value: 3.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  82 TGGCNASTVHDPLQTEVETLTAHWSLYINLGGFLvglfMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPV 161
Cdd:cd17450  33 TSSSSNRGLEDAQQKAISNFYMIYNLVAGLSPLL----PAYLLAKLGDRRHRKITICVPLLGYLLSRALLLLVILLDWPL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 162 FWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGqwrraqgyinpfwlvlatnlt 241
Cdd:cd17450 109 EVMYGAAALNGLTGGFTAYWAGVMALASLASSEGRRSVRLITIELVYGLAGFLGSLASG--------------------- 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 242 aalyaYLFVPETVTpdpqarlfstrHHQAVCRLYSSdappgrrskLWLYILC-----FFLVVTVHL-------------G 303
Cdd:cd17450 168 -----HIFVHYTIN-----------HHQGAILAACS---------LVLYVLCllysvFVLKITIALlfvgailydlavaG 222

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 304 CSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYG 383
Cdd:cd17450 223 GMDVLSVFVLKEPLSWGAVEVGYGNAAGYMIFITSFLGVFVFSRCLRDTTMIMIGMVSFSSGILIMAFVKWTFMFYIARA 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 384 LCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLHFMKGFPFVFGAAILL---IPAGII 460
Cdd:cd17450 303 VMLFALIPLPTIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDWFPGFCFILSSILGFlsiIPISIV 382


                .
gi 41053617 461 G 461
Cdd:cd17450 383 A 383
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 113-459 1.34e-23

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 101.50  E-value: 1.34e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 113 GFLVGLFMV------ILLGSWSDRAGRRLVLIIPSLGlavqAAVYLTVMYLKLPVFWFLIGRICSGLsgdFNAILAGCFA 186
Cdd:cd17330  37 GLLQSSYSLgqflasPLWGRLSDRYGRKPVLLLSLAG----SAVSYVLLGLSRNLWLLFLARFLDGL---TGGNVSVAQA 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 187 YVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPetvtpdpqarlfstr 266
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP--------------- 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 267 hhqavcrlyssdappgrrsKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQ 346
Cdd:cd17330 175 -------------------PLRRLLLVYFLIALAFAGLESVFSLF-LKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRL 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 347 -CCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAST-PVLRSKLSKLVDPAEQGALFASVACVEGLCSL 424
Cdd:cd17330 235 aKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVfPALSALLSKSVPSKEQGKAQGIIQSLQSLARI 314

                       330       340       350
                ....*....|....*....|....*....|....*
gi 41053617 425 VSSGVFNALYPATLHfmkGFPFVFGAAILLIPAGI 459
Cdd:cd17330 315 IGPLLAGPLYSFLGP---GVPFLLAAGLLLIALFL 346
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
114-413 9.80e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.48  E-value: 9.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMylklPVFWFLIGRICSGLSGdfNAILAGCFAYVADTSE 193
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGA--GALFPAALALIADLVP 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQavcr 273
Cdd:COG2814 129 PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL---- 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 274 lyssdappgRRSKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSW 353
Cdd:COG2814 205 ---------RRPRLLLLLLLAFLLGFGFFALFTYLPLY-LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR 274

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41053617 354 VALVGLTSNMVGLVVISVADTTALMFTGYGLC-FLFMASTPVLRSKLSKLVDPAEQGALFA 413
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLgFGFGLLFPLLQALVAELAPPEARGRASG 335
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 108-459 2.17e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 74.39  E-value: 2.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 108 YINLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLTVMYLKlPVFWFLIGRICSGLSGDFnaILAGCFAY 187
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLL---GLLLFALGALLFAFAP-SFWLLLLGRFLLGLGSGL--IDPAVLAL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 188 VADTSERGSRTFRVAILEACLGLAGMFASIIGGQW--RRAQGYINPFWLVLATNLTAALYAYLFVPEtvTPDPQARLFST 265
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVPD--PPESARAKNEE 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 266 RHHQAVCRLYSSdapPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAY-LTSLTGLRA 344
Cdd:cd06174 187 ASSKSVLKLLKR---VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF-LLDLGGLSVAVAGLLLSLFGLAGaLGSLLLGLL 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 345 MQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAS-TPVLRSKLSKLVDPAEQGALFASVACVEGLCS 423
Cdd:cd06174 263 SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGlLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 41053617 424 LVSSGVFNALYPATLHFmkGFPFVFGAAILLIPAGI 459
Cdd:cd06174 343 AIGPLLAGFLLAATFGL--TGAFLVLAVLLLLAAIL 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 114-460 1.11e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.14  E-value: 1.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMylklPVFWFLIGRICSGLSGdfNAILAGCFAYVADTSE 193
Cdd:cd17325  41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT----SYWQLLLARFLQGLAS--AAVWPAAMALIADIAP 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCR 273
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 274 LyssdappGRRSKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYL--TSLTGLRAMQccLED 351
Cdd:cd17325 195 L-------LRDRRLLALFLAIFVLAFAFGALEPFLPLY-AAELGGLSPAQIGLLFGAQGLASAlsQPPAGKLSDR--IGR 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 352 SWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMA-STPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVF 430
Cdd:cd17325 265 KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344

                       330       340       350
                ....*....|....*....|....*....|
gi 41053617 431 NALYpATLHFmkGFPFVFGAAILLIPAGII 460
Cdd:cd17325 345 GFLY-DAFGF--ATPFLAAAALLLLAAVLF 371
MFS_1 pfam07690
Major Facilitator Superfamily;
114-427 3.29e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.44  E-value: 3.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVqaavYLTVMYLKLPVFWFLIGRICSGLSGdfNAILAGCFAYVADTSE 193
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL----GLLLLLFASSLWLLLVLRVLQGLGA--GALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARlfstRHHQAVCR 273
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPA----EEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   274 LYSSDAPPGRRSKLWLYILCFFLVVTVHLGCSDLYV----LYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQccl 349
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQevlgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL--- 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053617   350 edsWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAST-PVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSS 427
Cdd:pfam07690 269 ---LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVfPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 114-267 3.13e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.19  E-value: 3.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLiIPSLGLAVQAAVyltVMYLKLPVFWFLIGRICSGLSGDFNAILAGcfAYVADTSE 193
Cdd:cd17474  44 TLPAAVLMPVAGVLADRFGRKKVL-LPGLLLFGIGGL---LCGLSDSFALLLAGRALQGIGAAGLGPLAL--TLIGDLFE 117

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053617 194 RGSRTFRVAILEACLGLAGMFASIIGGqWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRH 267
Cdd:cd17474 118 GGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 109-252 6.28e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.45  E-value: 6.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 109 INLGGFlvGLFMVIL---LGSWSDRAGRRLVLIIpslGLAVQAAVYLTVMYLKlPVFWFLIGRICSGlSGdfnAILAGCF 185
Cdd:cd17472  36 LALGIY--GLTQAIFqipFGLLSDRIGRKPVILF---GLLLFIAGSLLAAYAT-SIYGLILGRALQG-SG---AISSVVM 105

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41053617 186 AYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPE 252
Cdd:cd17472 106 ALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD 172
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 96-250 6.58e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.42  E-value: 6.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617  96 TEVETLTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLtvMYLKLPVFWFLI-GRICSGLS 174
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI---GLLLSAVALL--LLPLATSFWLLLlLLALLGLG 301

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41053617 175 GDFnaILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFV 250
Cdd:cd17325 302 LGL--VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 101-253 2.18e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 49.42  E-value: 2.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 101 LTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLtVMYLKLPVFWFLIGRICSGLSGdfNAI 180
Cdd:COG0477  46 ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI---GLLLFGLASL-LCGLAPSPELLIAARALQGIGA--GGL 119

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053617 181 LAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLtAALYAYLFVPET 253
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL-LALVLRLRLPES 191
2_A_01_02 TIGR00880
Multidrug resistance protein;
109-253 2.41e-06

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 46.87  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617   109 INLGGFLVG-LFMVILLGSWSDRAGRRLVLIIPSLGLAV-QAAVYLTVMYLKLpvfwfLIGRICSGLSGdfNAILAGCFA 186
Cdd:TIGR00880   2 LLLAGYALGqLIYSPLSGLLTDRFGRKPVLLVGLFIFVLsTAMFALSSNITVL-----IIARFLQGFGA--AFALVAGAA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41053617   187 YVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPET 253
Cdd:TIGR00880  75 LIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
114-253 2.94e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 2.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLIIpSLGLAVQAAVYLTVMYLkLPVFWFLIGRICSGLSgdFNAILAGCFAYVADTSE 193
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALL-PSPALAIALLFLAGFG--LGGAFGLLWALAAELFP 301

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 194 RGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPET 253
Cdd:COG2271 302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 102-268 3.31e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 49.11  E-value: 3.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 102 TAHWSLYINLGGFLVGlfmVILLGSWSDRAGRRLVLIIpSLGLAVQAAVYLTVMylklPVF-WFLIGRICSGLSGDFNAI 180
Cdd:cd17320  35 AVQLTLSAYLLGFALG---QLLYGPLSDRFGRRPVLLA-GLLLFILASLLCALA----SSIeQLLIARFLQGLGAAAGSV 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 181 LAgcFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQA 260
Cdd:cd17320 107 VA--RAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRK 184


                ....*...
gi 41053617 261 RLFSTRHH 268
Cdd:cd17320 185 PLLSSLLR 192
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 113-413 4.94e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.74  E-value: 4.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 113 GFLVGLFMV------ILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVmylkLPVFWFLIGRICSGLSgdFNAILAGCFA 186
Cdd:cd17489  34 GLVVGLFTLaallarPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA----TSVALLLVLRLIHGIG--WGAFTTAAAT 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 187 YVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAyLFVPETVTPDPQARLFSTR 266
Cdd:cd17489 108 LVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV-FLVKDPPPVAAEEAEAGTR 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 267 HHQAVcrlyssdappgRRSKLWLYILCFFLVVTVHLGCSDLYVLYelsaplcwGPELIGYGSAAKHLAYLTSLTGLRAMQ 346
Cdd:cd17489 187 AFRRL-----------VEKKVLPPALILFLASIAYGAISTFLPLY--------AAERGISNAGLFFTVYAIALLLSRPFS 247

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053617 347 CCLEDSW----VALVGLTSNMVGLVVISVADTTALMFTG---YGLCFLFMAstPVLRSKLSKLVDPAEQGALFA 413
Cdd:cd17489 248 GKLSDRKgpktVIIPGLLLLALGLLLLSFAGSPWMLLLAavlYGLGFGLLF--PALQALAVDLVPPHRRGAANG 319
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
109-455 7.22e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.31  E-value: 7.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 109 INLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLtvMYLKLPVFW-FLIGRICSGLSgdFNAILAGCFAY 187
Cdd:COG0738  48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLL---GLLLMALGLL--LFALAPSYPlLLLALFLLGLG--LGLLDVAANPY 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 188 VADTsERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQ---GYINPFWLVLATNLTAALYAYLF-VPETVTPDPQARLF 263
Cdd:COG0738 121 VAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGS 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 264 STRHHQAVcrlyssdappgRRSKLWLYILCFFLVVTVHLGCSDLYVLYeLSAPLCWGPELIGYGSAAKHLAYLTS-LTGL 342
Cdd:COG0738 200 AASLKSLL-----------KNPRLLLGGLAIFLYVGAEGAIGDWLPLY-LKDVLGLSEATAALGLSLFWGGMTIGrFLGG 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 343 RAMQcCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAST-PVLRSKLSKLVdPAEQGALFASVACVEGL 421
Cdd:COG0738 268 FLLK-RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFSLALDGL-GKRTAAAVSAVLIMGIV 345

                       330       340       350
                ....*....|....*....|....*....|....*
gi 41053617 422 CSLVSSGVFNALYPAT-LHFMKGFPFVFGAAILLI 455
Cdd:COG0738 346 GGAIGPPLIGFLADAFgLRAAFLVPLVCYLLILLL 380
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 122-260 8.39e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 47.99  E-value: 8.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 122 ILLGSWSDRAGRRLVLIIPSLGLAVQAAVyltVMYLKLPVFWFLIGRICSGLSGD----FNAILAGCFAYvadtsERGSR 197
Cdd:cd17490  49 IPLGILSDRIGKRKLFIIIGLLFTVLASL---IMILFPSPWGLLIARFLSGIAAAtwvsFTVLYASYFPP-----DEAAK 120

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053617 198 TfrVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQA 260
Cdd:cd17490 121 A--MGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVL 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 115-262 9.57e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.61  E-value: 9.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 115 LVGLFMVILLGSWSDRAGRRLVLIipsLGLAVQAAVYLTVMYLKLPvFWFLIGRICSGLSGDFnaILAGCFAYVADTSER 194
Cdd:cd17329  46 VAGIVASLIGGRLADRFGRKPVML---AGLLLRALGFALLGFAHSP-WLFAIALVLTGFGGGL--FEPASEAMIADVTTP 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41053617 195 GSRTFRVAILEACLGLAGMFASIIGGqWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARL 262
Cdd:cd17329 120 ENRTRAFSLLYWAINLGVAIGPLLGG-LLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEK 186
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
114-454 1.61e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.18  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAV-QAAVYLTVMYLklpvfWFLIGRICSGLSGdfNAILAGCFAYVADTS 192
Cdd:COG2223  50 VLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIgLLLLALAVSYW-----LLLLLGLLLGIGG--GGSFAVGIALVSKWF 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 193 ERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVC 272
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 273 rlyssdappgRRSKLWLYILCFFLVVTVHLGcsdlyvlyeLSAplcWGPELI--GYGSAAKHLAYLTSLTGLRAMQCC-- 348
Cdd:COG2223 203 ----------RDPRFWLLSLLYFGTFGSFIG---------FSS---WLPPYLvdQFGLSAATAGLLAALFALLGALGRpl 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 349 ---LED----SWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLF-----MASTPVLrskLSKLVDPAEQGALFASVA 416
Cdd:COG2223 261 ggwLSDriggRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLalgggNGAVFAL---VPDIFPTKNAGAVYGLVG 337

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 41053617 417 CVEGLCSLVSSGVFNALYPATLHFMKGFpFVFGAAILL 454
Cdd:COG2223 338 AAGGLGGFLGPLLFGALLDATGSYTAAF-LVFAVLALV 374
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
101-249 2.21e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 101 LTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSgdFNAI 180
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI---VFALMALGLLLLALALGSLWLFLVLFLLLGLA--LGGG 312

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 181 LAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQG-YINPFWLVLATNLTAALYAYLF 249
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLL 382
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 101-219 5.31e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.29  E-value: 5.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 101 LTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVyltvMYLKLPVFWFLIGRICSGLSgdFNAI 180
Cdd:cd17316  33 LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL----IGLLPTPILLLVLRFLQGIG--IGGE 106

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 41053617 181 LAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIG 219
Cdd:cd17316 107 YPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVA 145
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
115-476 1.32e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 115 LVGLFMVILLGSWSDRA----GRR---LVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSgdFNAILAGCFAY 187
Cdd:COG2211  57 LWDAITDPLIGALSDRTrtrwGRRrpwILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLA--YTLVNIPYSAL 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 188 VAD-TSERGSRTFRVAILEACLGLAGMFASIIGGQWRR------AQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQA 260
Cdd:COG2211 135 GAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 261 RLFStrhhQAVCRLYSSdaPPGRRskLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLA-----Y 335
Cdd:COG2211 215 VSLK----ESLKALLKN--RPFLL--LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGaplwpR 286

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 336 LTSLTGLRamqccledsWVALVGLTSNMVGLVVISVA--DTTALMFTGYGLCFLFMAST-PVLRSKLSKLVDPAEQ---- 408
Cdd:COG2211 287 LAKRFGKK---------KAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAIlVLPWAMLADVVDYDEWktgr 357

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 409 ---GALFASVACVEGLCSLVSSGVFNALY------------PATLHFMKGFPFVFGAAILLIPAGIIGGLGCQEKRESRE 473
Cdd:COG2211 358 rreGLYFGIFTFAIKLGQALAGALAGLLLalfgyvagaaqsPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEI 437


                ...
gi 41053617 474 NRE 476
Cdd:COG2211 438 RAE 440
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 118-252 2.49e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.98  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 118 LFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLtVMYLKLPVFWFLIGRICSGLsgdFNAILAGCFAYVADTSERGSR 197
Cdd:cd17390  45 LFSSPLVGSWSDVVGRRPVLLI---CLLLTALGYV-LLGFSTSLALLFLSRIPLGI---FKHTQSLCKAYLSDLVSEQER 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053617 198 TFRVAILEACLGLAGMFASIIGGQW-RRAQGYINPFWLVLATNLTAALYAYLFVPE 252
Cdd:cd17390 118 SRVLGRFNAASSLGFILGPVVGGHLaETDGGFYYVALLCSAIFILNAGLVWFLLSK 173
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
101-220 3.62e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 101 LTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIpslGLAVQAAVYLTVMYLKL-PVFWFLIGRICSGL-SGDFN 178
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII---GLLLAALGLLLLFFLGPgNLWLLLVLAALAGIgLGAIL 337

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 41053617 179 AILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGG 220
Cdd:COG2211 338 VLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAG 379
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 114-297 6.17e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 6.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 114 FLVGLFMVI----------LLGSWSDRAGRRLVLIIpsLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILag 183
Cdd:cd17471  32 LQIGIFMTLsalsgivvsqWLGRLSDRGGDRKPLIL--LALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQL-- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 184 cFAYVADTSERGSR---TFRVAILEACLGLAGMF----ASIIGGQWrraqGYINPFWLVLATNLTAALYAYLFVPEtVTP 256
Cdd:cd17471 108 -FALAREYADRSSGrdaTLFNSVLRAAFSLAWVIgpplAFLLLDVL----GFTGLFLLAALLYLVVALLVLFLLPS-VKP 181

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 41053617 257 DPQARLFStrhhqavcrlySSDAPPGRRSKLWLYILCFFLV 297
Cdd:cd17471 182 PAQKATPA-----------SSLVKAPVNRRLLLLFAAFTLL 211
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 111-253 1.26e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 41.11  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 111 LGGFLVGLFMVI------LLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLpvfwFLIGRICSGLSGdfnAILAGC 184
Cdd:cd17389  65 FGGLIGSLFSLLqflsspITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTI----FLLSRIVGGISK---GNVSLS 137

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053617 185 FAYVADTSERGSRTFRVAILEACLGLAGMFASIIGG------QWRRAQGYINPFWLVLATNLTAALYAYLFVPET 253
Cdd:cd17389 138 TAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAyfasftRSLGEVFFSMPALFALVLALADLLFIFFFLPET 212
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 122-249 2.43e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 40.29  E-value: 2.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 122 ILLGSWSDRAGRRLVLIIpslGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSgdFNAILAGCFAYVADTSerGSRTFRV 201
Cdd:cd17353 267 PFWGWLSDKIGRKNTLSI---AFLIQGVAMFLLPFIGSVAVLFVLGVALIGFC--YGGGFALFPALTADFF--GTKNAGT 339

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41053617 202 --AILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLF 249
Cdd:cd17353 340 nyGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 352-460 3.16e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.83  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 352 SWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMAST-PVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVF 430
Cdd:cd17370 264 KKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343

                        90       100       110
                ....*....|....*....|....*....|
gi 41053617 431 NALYPatlHFMKGFPFVFGAAILLIPAGII 460
Cdd:cd17370 344 GYLWD---LISPSAAFLFSAVLALIALLLL 370
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 102-412 6.02e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.98  E-value: 6.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 102 TAHWSLYINLGGFLVGLFMVILlGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVM---YLKLPVFWFLIGRICSGLSGDF- 177
Cdd:COG2270  51 TALWGYALAIAGLLVALLAPVL-GAIADRSGRKKPFLAFFTLLGVLATAALFFVapgGLWLGLLLFVLANIGFEGSLVFy 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 178 NAILAGcfayVADTSERG---SRTFRVAILEACLGLAGMFASIIGGQWR---------RAQGYINPFWLVLatnltAALY 245
Cdd:COG2270 130 NAFLPD----IATPEEIGrvsGLGWALGYLGGVLLLLINLALFLKPEAFglpdageavRISFLLTALWWLL-----FALP 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 246 AYLFVPETVTPDPQARLFSTRhhQAVCRLYSSDAPPGRRSKLWLYILCFFLVvtvhlgcSD-LYVLYELSAP-----LCW 319
Cdd:COG2270 201 LFLFLPERPRPGPAPPRGAVR--AGFRELRRTLRELRRYRDLLRFLLAYFFY-------RDgVQTVIAFAGIyaagvLGF 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 320 GP-ELIGYGSAAKHLAYLTSLTGLRamqccLEDSW-------VALVGLTSnmVGLVVISVadTTALMFTGYGLCF-LFMA 390
Cdd:COG2270 272 STtELIVFGLLVQIVAALGALLFGR-----LDDRIgpkrvilVSLVIWIV--VCLAAYFL--TTALAFWILGLLIgLVMG 342

                       330       340
                ....*....|....*....|...
gi 41053617 391 STPVL-RSKLSKLVDPAEQGALF 412
Cdd:COG2270 343 GIQALsRSLLARLIPPGREAEFF 365
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 107-250 7.27e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.66  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053617 107 LYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSG-LSGDFNAILAGCF 185
Cdd:cd17369 267 LLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGvLHGMMYGPQAAFL 346

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41053617 186 AYVADTSERGSRtfrvaileacLGLAGMFASIIGgqwrraqGYINPF---WLVLATNLTAALYAYLFV 250
Cdd:cd17369 347 AELFPTRVRYTG----------ASLGYQLGAILG-------GGFAPLiatALVAATGSWWPVALYLAA 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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