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Conserved domains on  [gi|339895911|ref|NP_956573|]
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Golgi membrane protein 1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
42-336 4.42e-05

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 45.81  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   42 ELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELMEKTHHRQQENAINSWRQEKENLQLNISSSAKAVQNM 121
Cdd:PTZ00108 1110 ELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  122 KNRMKSLLEDVNKMQSELKSCHSSMDTLTKKANSDKTRCNKEIEATKEECSVKIAAAKQEKLKTAEKVDPQDAD------ 195
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDdlskeg 1269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  196 GPEQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNldaqvetnelvvekdAKDAVILQDTPIAASKltnksetlKKP 275
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTK---------------KKVKKRLEGSLAALKK--------KKK 1326
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 339895911  276 AYEAVAEAVEdiKEPAPKDAEAVldEADILEPKENEAGIGDANEEDDVGIGDANQEEDDED 336
Cdd:PTZ00108 1327 SEKKTARKKK--SKTRVKQASAS--QSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDED 1383
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
42-336 4.42e-05

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 45.81  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   42 ELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELMEKTHHRQQENAINSWRQEKENLQLNISSSAKAVQNM 121
Cdd:PTZ00108 1110 ELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  122 KNRMKSLLEDVNKMQSELKSCHSSMDTLTKKANSDKTRCNKEIEATKEECSVKIAAAKQEKLKTAEKVDPQDAD------ 195
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDdlskeg 1269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  196 GPEQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNldaqvetnelvvekdAKDAVILQDTPIAASKltnksetlKKP 275
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTK---------------KKVKKRLEGSLAALKK--------KKK 1326
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 339895911  276 AYEAVAEAVEdiKEPAPKDAEAVldEADILEPKENEAGIGDANEEDDVGIGDANQEEDDED 336
Cdd:PTZ00108 1327 SEKKTARKKK--SKTRVKQASAS--QSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDED 1383
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
19-129 1.87e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  19 MAALISCILLLAFNYWVSNSRNVELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELMEKThHRQQENAIN 98
Cdd:COG4942    1 MRKLLLLALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARR-IRALEQELA 79
                         90       100       110
                 ....*....|....*....|....*....|.
gi 339895911  99 SWRQEKENLQLNISSSAKAVQNMKNRMKSLL 129
Cdd:COG4942   80 ALEAELAELEKEIAELRAELEAQKEELAELL 110
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
62-182 1.91e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 40.61  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   62 EREEQS--KLKAEDEMHRQNEQlELMEK-----THHRQQENAINSWRQEKENLQLNISSSAKAVQNMKNRMKSlledvnk 134
Cdd:pfam09726 398 VRLEQDikKLKAELQASRQTEQ-ELRSQissltSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQ------- 469
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 339895911  135 MQSELKSCHSSMDTLTKKANSDKTRcNKEIEATKEECSVKIAAAKQEK 182
Cdd:pfam09726 470 LEKRLKAEQEARASAEKQLAEEKKR-KKEEEATAARAVALAAASRGEC 516
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
162-407 2.99e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   162 KEIEATKEECSVKIAAAKQEKLKTAEKVDPQDADGP-EQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNLDAQVET 240
Cdd:TIGR00927  663 SGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEiEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVE 742
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   241 NELVVEKDAKDAVILQDTPIAASKLTNKSETLKKPAYEAVAEAVEDIkepapkdaeavldeadilEPKENEAGIGDANEE 320
Cdd:TIGR00927  743 DEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDG------------------EMKGDEGAEGKVEHE 804
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   321 DDVGIGDANQEEDDEDLKLKAGDLKEEDaavGKEDAIMyDNEGEIEKQLSQIKDENQGAGQDLEDDVANYNGDDENQPES 400
Cdd:TIGR00927  805 GETEAGEKDEHEGQSETQADDTEVKDET---GEQELNA-ENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEE 880

                   ....*..
gi 339895911   401 EDEKQAE 407
Cdd:TIGR00927  881 EEEEEEE 887
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
42-336 4.42e-05

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 45.81  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   42 ELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELMEKTHHRQQENAINSWRQEKENLQLNISSSAKAVQNM 121
Cdd:PTZ00108 1110 ELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  122 KNRMKSLLEDVNKMQSELKSCHSSMDTLTKKANSDKTRCNKEIEATKEECSVKIAAAKQEKLKTAEKVDPQDAD------ 195
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDdlskeg 1269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  196 GPEQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNldaqvetnelvvekdAKDAVILQDTPIAASKltnksetlKKP 275
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTK---------------KKVKKRLEGSLAALKK--------KKK 1326
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 339895911  276 AYEAVAEAVEdiKEPAPKDAEAVldEADILEPKENEAGIGDANEEDDVGIGDANQEEDDED 336
Cdd:PTZ00108 1327 SEKKTARKKK--SKTRVKQASAS--QSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDED 1383
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
144-353 3.24e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 42.67  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911 144 SSMDTLTKKANSDKTRcnKEIEATKEECSVKIAAAKQEKLKTAEKVDPQDADGPEQKVLKAKSDVLASNDLNKNPAEPPN 223
Cdd:PRK05901   6 TKAELAAEEEAKKKLK--KLAAKSKSKGFITKEEIKEALESKKKTPEQIDQVLIFLSGMVKDTDDATESDIPKKKTKTAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911 224 GKPDVDSPSNLDAQVETNElvVEKDAKDAVILQDTPIAASKLTNKSETLKKPAYEAVAEAVEDIKEPAPKDAEAVLDEAD 303
Cdd:PRK05901  84 KAAAAKAPAKKKLKDELDS--SKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDDDLDDDDIDDDDDDEDDDEDDD 161
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 339895911 304 ILEPKENEAGIGDANEEDDVGIGDanqEEDDEDLKLKAGDLKEEDAAVGK 353
Cdd:PRK05901 162 DDDVDDEDEEKKEAKELEKLSDDD---DFVWDEDDSEALRQARKDAKLTA 208
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
177-368 7.95e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 41.52  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911 177 AAKQEKLKTAEKVDPQDADGPEQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNLDAQVETNELVVEKDAKDAVILQ 256
Cdd:PRK05901  15 EAKKKLKKLAAKSKSKGFITKEEIKEALESKKKTPEQIDQVLIFLSGMVKDTDDATESDIPKKKTKTAAKAAAAKAPAKK 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911 257 DTPIAASKLTnKSETLKKPAYEAVAEAVEDIKEPAPKDAEAVLDEADILEPKENEAgigDANEEDDVGIGDANQEEDDED 336
Cdd:PRK05901  95 KLKDELDSSK-KAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDDDLDDDDIDD---DDDDEDDDEDDDDDDVDDEDE 170
                        170       180       190
                 ....*....|....*....|....*....|..
gi 339895911 337 LKLKAGDLKEEDAAVGKEDAIMYDNEGEIEKQ 368
Cdd:PRK05901 171 EKKEAKELEKLSDDDDFVWDEDDSEALRQARK 202
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
19-129 1.87e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  19 MAALISCILLLAFNYWVSNSRNVELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELMEKThHRQQENAIN 98
Cdd:COG4942    1 MRKLLLLALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARR-IRALEQELA 79
                         90       100       110
                 ....*....|....*....|....*....|.
gi 339895911  99 SWRQEKENLQLNISSSAKAVQNMKNRMKSLL 129
Cdd:COG4942   80 ALEAELAELEKEIAELRAELEAQKEELAELL 110
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
62-182 1.91e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 40.61  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   62 EREEQS--KLKAEDEMHRQNEQlELMEK-----THHRQQENAINSWRQEKENLQLNISSSAKAVQNMKNRMKSlledvnk 134
Cdd:pfam09726 398 VRLEQDikKLKAELQASRQTEQ-ELRSQissltSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQ------- 469
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 339895911  135 MQSELKSCHSSMDTLTKKANSDKTRcNKEIEATKEECSVKIAAAKQEK 182
Cdd:pfam09726 470 LEKRLKAEQEARASAEKQLAEEKKR-KKEEEATAARAVALAAASRGEC 516
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
162-407 2.99e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   162 KEIEATKEECSVKIAAAKQEKLKTAEKVDPQDADGP-EQKVLKAKSDVLASNDLNKNPAEPPNGKPDVDSPSNLDAQVET 240
Cdd:TIGR00927  663 SGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEiEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVE 742
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   241 NELVVEKDAKDAVILQDTPIAASKLTNKSETLKKPAYEAVAEAVEDIkepapkdaeavldeadilEPKENEAGIGDANEE 320
Cdd:TIGR00927  743 DEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDG------------------EMKGDEGAEGKVEHE 804
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911   321 DDVGIGDANQEEDDEDLKLKAGDLKEEDaavGKEDAIMyDNEGEIEKQLSQIKDENQGAGQDLEDDVANYNGDDENQPES 400
Cdd:TIGR00927  805 GETEAGEKDEHEGQSETQADDTEVKDET---GEQELNA-ENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEE 880

                   ....*..
gi 339895911   401 EDEKQAE 407
Cdd:TIGR00927  881 EEEEEEE 887
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
42-192 4.02e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.75  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895911  42 ELQSKILELEDRIRLLSADREREEQSKLKAEDEMHRQNEQLELME---KTHHRQQENAINSwrQEKENLQLNISSSAKAV 118
Cdd:COG1579   28 ELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEariKKYEEQLGNVRNN--KEYEALQKEIESLKRRI 105
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339895911 119 QNMKNRMKSLLEDVNKMQSELKSCHSSMDTLTKKANSDKTRCNKEIEATKEEcsvkIAAAKQEKLKTAEKVDPQ 192
Cdd:COG1579  106 SDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE----LEELEAEREELAAKIPPE 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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