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Conserved domains on  [gi|41053660|ref|NP_956569|]
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bromodomain-containing protein 9 [Danio rerio]

Protein Classification

bromodomain-containing protein( domain architecture ID 10144772)

bromodomain-containing protein with a DUF3512 domain, plays a role in chromatin remodeling and regulation of transcription; it acts as a chromatin reader that recognizes and binds acylated histones

CATH:  1.20.920.10
Gene Ontology:  GO:0005515|GO:0006338|GO:0006357|GO:0070577
PubMed:  26472704|1350857|34548613|28847823|31582847
SCOP:  4000871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 318-496 5.65e-71

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


:

Pssm-ID: 463436  Cd Length: 186  Bit Score: 227.51  E-value: 5.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   318 NACSLTDSTAEEHVLALVEHAADEARDRINRFMPNSKIGYLKKDTEGSLMYVVVNQD--PEGEEEETHPVDLSSLANKLI 395
Cdd:pfam12024   1 KFEALPDDMTPEEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPAdpDAGEPGAERPVTLGMLVGKLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   396 PGLTSL-GFKDDRRHKVTFLS----SAYNTQTLQNNSIYPDLHPEEMDMLYSAYGDETGVQCALSLQEFVKGCGGFTKRL 470
Cdd:pfam12024  81 SGTNTLqGFKEDKRNKVTPVSylnyGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYMLKM 160

                         170       180
                  ....*....|....*....|....*.
gi 41053660   471 VDDLLDKMTAGDHSKAVVQIRQKRNL 496
Cdd:pfam12024 161 VDDLLDLLTNGEHSKTLKELEEKRNE 186
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 170-267 2.20e-57

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99945  Cd Length: 98  Bit Score: 188.39  E-value: 2.20e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05513   1 PLQKALEQLIRQLQRKDPHGFFAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPD 80

                        90
                ....*....|....*...
gi 41053660 250 TVYYKAAKKLLHTGFKMM 267
Cdd:cd05513  81 TIYYKAAKKLLHSGMKIL 98
 
Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 318-496 5.65e-71

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


Pssm-ID: 463436  Cd Length: 186  Bit Score: 227.51  E-value: 5.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   318 NACSLTDSTAEEHVLALVEHAADEARDRINRFMPNSKIGYLKKDTEGSLMYVVVNQD--PEGEEEETHPVDLSSLANKLI 395
Cdd:pfam12024   1 KFEALPDDMTPEEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPAdpDAGEPGAERPVTLGMLVGKLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   396 PGLTSL-GFKDDRRHKVTFLS----SAYNTQTLQNNSIYPDLHPEEMDMLYSAYGDETGVQCALSLQEFVKGCGGFTKRL 470
Cdd:pfam12024  81 SGTNTLqGFKEDKRNKVTPVSylnyGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYMLKM 160

                         170       180
                  ....*....|....*....|....*.
gi 41053660   471 VDDLLDKMTAGDHSKAVVQIRQKRNL 496
Cdd:pfam12024 161 VDDLLDLLTNGEHSKTLKELEEKRNE 186
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 170-267 2.20e-57

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 188.39  E-value: 2.20e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05513   1 PLQKALEQLIRQLQRKDPHGFFAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPD 80

                        90
                ....*....|....*...
gi 41053660 250 TVYYKAAKKLLHTGFKMM 267
Cdd:cd05513  81 TIYYKAAKKLLHSGMKIL 98
BROMO smart00297
bromo domain;
169-269 4.85e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 102.74  E-value: 4.85e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660    169 TPHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRP 248
Cdd:smart00297   6 KKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGP 85

                           90       100
                   ....*....|....*....|.
gi 41053660    249 ETVYYKAAKKLLHTGFKMMSK 269
Cdd:smart00297  86 DSEVYKDAKKLEKFFEKKLRE 106
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 175-258 4.21e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.45  E-value: 4.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   175 LEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYK 254
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                  ....
gi 41053660   255 AAKK 258
Cdd:pfam00439  81 AAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 164-395 4.35e-16

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 80.23  E-value: 4.35e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 164 QENEATPHQQLLEHFLRLLQRKDAH-GFFAF--PVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCD 240
Cdd:COG5076 139 EDELLYADNKAIAKFKKQLFLRDGRfLSSIFlgLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFD 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 241 NAMVYNRPETVYYKAAKKLLHTGFKMMSKQAAILGDDDIAPE----EPVTEMMPIHTEY---------PKKSKKQPVKEP 307
Cdd:COG5076 219 NCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSIKPGreerEERESVLITNSQAhvgawpflrPVSDEEVPDYYK 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 308 IISDMYELEGNacsltdstaeEHVLALVEHAADEARDRINRFMPNSKIGYlkkdTEGSLMYVVvnQDPEGEEEETHPVDL 387
Cdd:COG5076 299 DIRDPMDLSTK----------ELKLRNNYYRPEETFVRDAKLFFDNCVMY----NGEVTDYYK--NANVLEDFVIKKTRL 362


                ....*...
gi 41053660 388 SSLANKLI 395
Cdd:COG5076 363 IREYPKLI 370
 
Name Accession Description Interval E-value
DUF3512 pfam12024
Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. ...
 318-496 5.65e-71

Domain of unknown function (DUF3512); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with pfam00439.


Pssm-ID: 463436  Cd Length: 186  Bit Score: 227.51  E-value: 5.65e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   318 NACSLTDSTAEEHVLALVEHAADEARDRINRFMPNSKIGYLKKDTEGSLMYVVVNQD--PEGEEEETHPVDLSSLANKLI 395
Cdd:pfam12024   1 KFEALPDDMTPEEILEQVQKAAKEARDRLSRRKPNSKMGFLRRKKDGTTTLNILNPAdpDAGEPGAERPVTLGMLVGKLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   396 PGLTSL-GFKDDRRHKVTFLS----SAYNTQTLQNNSIYPDLHPEEMDMLYSAYGDETGVQCALSLQEFVKGCGGFTKRL 470
Cdd:pfam12024  81 SGTNTLqGFKEDKRNKVTPVSylnyGPFSSYAPTYDSTFANLTKEESDLLYSTYGDETGVQYAESIQEFVKDCGDYMLKM 160

                         170       180
                  ....*....|....*....|....*.
gi 41053660   471 VDDLLDKMTAGDHSKAVVQIRQKRNL 496
Cdd:pfam12024 161 VDDLLDLLTNGEHSKTLKELEEKRNE 186
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 170-267 2.20e-57

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 188.39  E-value: 2.20e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05513   1 PLQKALEQLIRQLQRKDPHGFFAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPD 80

                        90
                ....*....|....*...
gi 41053660 250 TVYYKAAKKLLHTGFKMM 267
Cdd:cd05513  81 TIYYKAAKKLLHSGMKIL 98
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 171-267 3.63e-28

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 108.23  E-value: 3.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 171 HQQLLEHFLRLLQRK--DAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRP 248
Cdd:cd04369   1 LKKKLRSLLDALKKLkrDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGP 80

                        90
                ....*....|....*....
gi 41053660 249 ETVYYKAAKKLLHTGFKMM 267
Cdd:cd04369  81 GSPIYKDAKKLEKLFEKLL 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 170-259 1.08e-26

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 104.17  E-value: 1.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05509   1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                        90
                ....*....|
gi 41053660 250 TVYYKAAKKL 259
Cdd:cd05509  81 TEYYKCANKL 90
BROMO smart00297
bromo domain;
169-269 4.85e-26

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 102.74  E-value: 4.85e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660    169 TPHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRP 248
Cdd:smart00297   6 KKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGP 85

                           90       100
                   ....*....|....*....|.
gi 41053660    249 ETVYYKAAKKLLHTGFKMMSK 269
Cdd:smart00297  86 DSEVYKDAKKLEKFFEKKLRE 106
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 170-259 9.01e-25

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 98.63  E-value: 9.01e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05512   1 PLEVLLRKTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80

                        90
                ....*....|
gi 41053660 250 TVYYKAAKKL 259
Cdd:cd05512  81 TIFYRAAVRL 90
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 175-258 4.21e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.45  E-value: 4.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660   175 LEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYK 254
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                  ....
gi 41053660   255 AAKK 258
Cdd:pfam00439  81 AAEK 84
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 169-259 7.71e-20

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 84.67  E-value: 7.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 169 TPHQQllEHFLRLLQ----RKDAHgFFAFPVtDAIA---PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDN 241
Cdd:cd05500   2 TKHQH--KFLLSSIRslkrLKDAR-PFLVPV-DPVKlniPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDN 77

                        90
                ....*....|....*...
gi 41053660 242 AMVYNRPETVYYKAAKKL 259
Cdd:cd05500  78 CLTFNGPEHPVSQMGKRL 95
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 191-275 1.89e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 78.46  E-value: 1.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 191 FAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLLHTGFKMMSKQ 270
Cdd:cd05511  21 FHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEMLELAEELLAER 100


                ....*
gi 41053660 271 AAILG 275
Cdd:cd05511 101 EEKLT 105
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 164-395 4.35e-16

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 80.23  E-value: 4.35e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 164 QENEATPHQQLLEHFLRLLQRKDAH-GFFAF--PVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCD 240
Cdd:COG5076 139 EDELLYADNKAIAKFKKQLFLRDGRfLSSIFlgLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFD 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 241 NAMVYNRPETVYYKAAKKLLHTGFKMMSKQAAILGDDDIAPE----EPVTEMMPIHTEY---------PKKSKKQPVKEP 307
Cdd:COG5076 219 NCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSIKPGreerEERESVLITNSQAhvgawpflrPVSDEEVPDYYK 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 308 IISDMYELEGNacsltdstaeEHVLALVEHAADEARDRINRFMPNSKIGYlkkdTEGSLMYVVvnQDPEGEEEETHPVDL 387
Cdd:COG5076 299 DIRDPMDLSTK----------ELKLRNNYYRPEETFVRDAKLFFDNCVMY----NGEVTDYYK--NANVLEDFVIKKTRL 362


                ....*...
gi 41053660 388 SSLANKLI 395
Cdd:COG5076 363 IREYPKLI 370
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 180-259 4.30e-15

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 71.16  E-value: 4.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 180 RLLQRKdaHGFFAFPV---TDAIA---PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYY 253
Cdd:cd05498  11 ELFSKK--HKAYAWPFykpVDPEAlglHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVH 88


                ....*.
gi 41053660 254 KAAKKL 259
Cdd:cd05498  89 AMARKL 94
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 191-261 5.19e-15

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 71.24  E-value: 5.19e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41053660 191 FAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLLH 261
Cdd:cd05507  24 FLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVEMQR 94
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 171-260 1.57e-14

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 69.67  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 171 HQQLLEHFLRLLQRKDAHGFFAfPVtDAIA---PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNR 247
Cdd:cd05506   2 MKQCGTLLRKLMKHKWGWVFNA-PV-DVVAlglPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNP 79

                        90
                ....*....|...
gi 41053660 248 PETVYYKAAKKLL 260
Cdd:cd05506  80 PGNDVHTMAKELL 92
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 173-246 2.13e-13

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 66.24  E-value: 2.13e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053660 173 QLLEHFLRLLQRKDAHGFFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYN 246
Cdd:cd05503   3 ALCETILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFN 76
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 172-260 2.61e-13

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 66.65  E-value: 2.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 172 QQLLEhflRLLQRKDAHGFFAfPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETV 251
Cdd:cd05504  18 EQLLV---EIVKHKDSWPFLR-PVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTS 93


                ....*....
gi 41053660 252 YYKAAKKLL 260
Cdd:cd05504  94 VYKAGTRLQ 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 191-259 1.93e-12

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 63.84  E-value: 1.93e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41053660 191 FAFPVtDAIA---PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKL 259
Cdd:cd05499  24 FLDPV-DPVAlniPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQL 94
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 191-259 3.06e-12

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 63.46  E-value: 3.06e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41053660 191 FAFPVTdAIAPGYSMIIKHPMDFSTMKDKI---AANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKL 259
Cdd:cd05502  25 FHEPVS-PSVPNYYKIIKTPMDLSLIRKKLqpkSPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKEL 95
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 191-261 7.94e-12

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 62.37  E-value: 7.94e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41053660 191 FAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNrPETvyYKAAKKLLH 261
Cdd:cd05528  24 FTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYN-PDR--DPADKLIRS 91
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 172-259 1.07e-11

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 61.69  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 172 QQLLEHFLRLL-----QRKDAHGFFAfPVTDAI--APGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMV 244
Cdd:cd05495   2 EELRQALMPTLeklykQDPESLPFRQ-PVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWL 80

                        90
                ....*....|....*
gi 41053660 245 YNRPETVYYKAAKKL 259
Cdd:cd05495  81 YNRKTSRVYKYCTKL 95
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 201-256 6.14e-11

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 59.63  E-value: 6.14e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053660 201 PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAA 256
Cdd:cd05515  37 PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDA 92
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 191-248 2.57e-10

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 57.55  E-value: 2.57e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 41053660 191 FAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRP 248
Cdd:cd05505  21 FREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYEN 78
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 170-259 3.09e-10

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 57.45  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 170 PHQQLLEHFLRLLQRKDahgffafpvtdaIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPE 249
Cdd:cd05517  18 PSGRLISELFQKLPSKV------------LYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPG 85

                        90
                ....*....|
gi 41053660 250 TVYYKAAKKL 259
Cdd:cd05517  86 SQVYKDANAI 95
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 171-259 6.02e-10

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 56.68  E-value: 6.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 171 HQQLLEHFLRLLQRKDAHG-----FFAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVY 245
Cdd:cd05518   2 KKRMLALFLYVLEYREGSGrrlcdLFMEKPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHY 81

                        90
                ....*....|....
gi 41053660 246 NRPETVYYKAAKKL 259
Cdd:cd05518  82 NEEGSQVYEDANIL 95
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 201-262 7.95e-10

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 56.19  E-value: 7.95e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41053660 201 PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLLHT 262
Cdd:cd05519  37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKA 98
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 184-259 1.45e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 55.51  E-value: 1.45e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41053660 184 RKDAHGFFAFPvTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKL 259
Cdd:cd05516  22 RQLAEVFIQLP-SRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVL 96
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 191-256 1.54e-09

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 55.91  E-value: 1.54e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41053660 191 FAFPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAA 256
Cdd:cd05510  29 FLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSDPSHPLRRH 94
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 191-259 4.06e-09

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 54.35  E-value: 4.06e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41053660 191 FAFPVtDAIA---PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKL 259
Cdd:cd05497  26 FQQPV-DAVKlnlPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTL 96
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 173-259 4.27e-09

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 54.65  E-value: 4.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 173 QLLEHFLRLLQRKDAhgffafpvtdaiaPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVY 252
Cdd:cd05524  24 ILCESFIRVPKRRNE-------------PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPE 90


                ....*..
gi 41053660 253 YKAAKKL 259
Cdd:cd05524  91 HKDACKL 97
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 157-260 7.91e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 53.50  E-value: 7.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 157 VRACRTQQEneatphQQLLEHFLRLLQRKdahgffafpvtdaIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFK 236
Cdd:cd05520  12 IRNARNNQG------QLLAEPFLKLPSKR-------------KYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLN 72

                        90       100
                ....*....|....*....|....
gi 41053660 237 LMCDNAMVYNRPETVYYKAAKKLL 260
Cdd:cd05520  73 LMFENAKRYNVPNSRIYKDAEKLQ 96
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 173-259 1.32e-08

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 53.49  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 173 QLLEHFLRLLQRKDAhGFFAFPVtDAIA--PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPET 250
Cdd:cd05529  31 SGLDKLLLSLQLEIA-EYFEYPV-DLRAwyPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNS 108


                ....*....
gi 41053660 251 VYYKAAKKL 259
Cdd:cd05529 109 EIAKKAKRL 117
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 166-246 1.48e-08

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 53.23  E-value: 1.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 166 NEATPHQQLLEHFLRLLQRKDAHGFFAfPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVY 245
Cdd:cd05496   2 DESDWKKQCKELVNLMWDCEDSEPFRQ-PVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSY 80


                .
gi 41053660 246 N 246
Cdd:cd05496  81 T 81
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 173-260 3.17e-08

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 51.62  E-value: 3.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 173 QLLEHFLRLLQRKDAHGFFAfPVTDAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVY 252
Cdd:cd05508   6 KLLKFALERMKQPGAEPFLK-PVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKL 84


                ....*...
gi 41053660 253 YKAAKKLL 260
Cdd:cd05508  85 TQAAKAIV 92
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 197-260 7.21e-08

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 50.84  E-value: 7.21e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053660 197 DAIAPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETVYYKAAKKLL 260
Cdd:cd05492  33 ATKLPKRRRLIHTHLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHGADSEQYDAARWLY 96
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 172-259 4.34e-07

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 48.39  E-value: 4.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053660 172 QQLLEHFLRLLQRKDAhgffafpvtdaiaPGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYNRPETV 251
Cdd:cd05522  22 RLLTLHFEKLPDKARE-------------PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQ 88


                ....*...
gi 41053660 252 YYKAAKKL 259
Cdd:cd05522  89 EYKDAVLL 96
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 201-256 6.18e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 45.39  E-value: 6.18e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053660 201 PGYSMIIKHPMDFSTMKDKIaaNEYKTITEFKADFKLMCDNAMVYNRPETVYYKAA 256
Cdd:cd05521  38 PDYYKIIKNPLSLNTVKKRL--PHYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYA 91
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 201-246 9.52e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 38.91  E-value: 9.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41053660 201 PGYSMIIKHPMDFSTMKDKIAANEYKTITEFKADFKLMCDNAMVYN 246
Cdd:cd05525  39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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