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Conserved domains on  [gi|41055833|ref|NP_956456|]
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arginine and glutamate-rich protein 1-B [Danio rerio]

Protein Classification

ARGLU domain-containing protein( domain architecture ID 12173154)

ARGLU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 126-265 5.75e-30

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


:

Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 110.14  E-value: 5.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   126 TARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILVDNN 205
Cdd:pfam15346  12 TARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREAELEEERRKEEEERKKREELERILEENN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   206 RKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQKQQKEEQKMILGKGKSRPKLSFSL 265
Cdd:pfam15346  92 RKIEEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQQKILNKKNSRPKLSFSL 151
 
Name Accession Description Interval E-value
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 126-265 5.75e-30

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 110.14  E-value: 5.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   126 TARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILVDNN 205
Cdd:pfam15346  12 TARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREAELEEERRKEEEERKKREELERILEENN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   206 RKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQKQQKEEQKMILGKGKSRPKLSFSL 265
Cdd:pfam15346  92 RKIEEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQQKILNKKNSRPKLSFSL 151
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 83-249 2.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 2.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833  83 RALSKRSAVDEKQKKEEEEKKVEMERQRRIRQQEIEERLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKR 162
Cdd:COG1196 292 ELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833 163 IMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILvDNNRKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQK 242
Cdd:COG1196 372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-ALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450


                ....*..
gi 41055833 243 QQKEEQK 249
Cdd:COG1196 451 EAELEEE 457
 
Name Accession Description Interval E-value
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 126-265 5.75e-30

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 110.14  E-value: 5.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   126 TARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILVDNN 205
Cdd:pfam15346  12 TARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREAELEEERRKEEEERKKREELERILEENN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833   206 RKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQKQQKEEQKMILGKGKSRPKLSFSL 265
Cdd:pfam15346  92 RKIEEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQQKILNKKNSRPKLSFSL 151
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 134-183 6.54e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 6.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 41055833   134 VAKRVEEELEKRKDEIEREVlRRVEEAKRIMEKQLLEELERQRHAELAAQ 183
Cdd:pfam03154 585 LAKKREEALEKAKREAEQKA-REEKEREKEKEKEREREREREREAERAAK 633
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 83-249 2.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 2.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833  83 RALSKRSAVDEKQKKEEEEKKVEMERQRRIRQQEIEERLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKR 162
Cdd:COG1196 292 ELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055833 163 IMEKQLLEELERQRHAELAAQKAREEEEKSKREELEKILvDNNRKIADAQAKLAEDQLRIVEEQRKIHEERMKLEQERQK 242
Cdd:COG1196 372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-ALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450


                ....*..
gi 41055833 243 QQKEEQK 249
Cdd:COG1196 451 EAELEEE 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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