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Conserved domains on  [gi|41053907|ref|NP_956272|]
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growth arrest-specific protein 6 precursor [Danio rerio]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-439 1.84e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 125.22  E-value: 1.84e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907 306 TGFTAEFDLRTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGVVSRVTSSGPQVNDGQWHKISVEEQGRSLVIKID 385
Cdd:cd00110  20 TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVSVERNGRSVTLSVD 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41053907 386 REAVMKIAVNGDLFTLNKNMhelNLTVGGVPFRDDGLVSRVNPRLDGCMKDWRW 439
Cdd:cd00110 100 GERVVESGSPGGSALLNLDG---PLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 21-82 2.19e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


:

Pssm-ID: 214503  Cd Length: 65  Bit Score: 99.31  E-value: 2.19e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053907     21 VSVSSRQAHQFLRRTRRANQV-FEETKQGHLERECVEEKCTKEEAREVFENDPETEYFYPKYQ 82
Cdd:smart00069   3 VFLSRQEANKVLRRQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 493-622 9.25e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   493 LRAASSMGVLFALVRQDRVPFSISLSDyhpGTLQWTkhVLVSLGDVVVGSVPVNLSDGQTHTVNVTMSGNDSVLEVDAQL 572
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVN---GRLVLR--YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41053907   573 AQMEMMEGvDSLDLTSSYSTFIGGIP-DVSLVSSPVSAFFTGCM-DVRVNGQ 622
Cdd:pfam02210  76 VVSSLPPG-ESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIrDVRVNGE 126
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-183 7.96e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 41053907   149 CISGNGGCEHVCNNTMGSYKCSCEDGYRL-SGHHSC 183
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELqDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
185-215 3.85e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 3.85e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41053907   185 DVDECVETPDVC-GSAHCSNLIGGLECLCDEG 215
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
227-252 3.52e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 3.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 41053907   227 DVDEC--ETHVCEE--ECVNTPGSFRCFCD 252
Cdd:pfam07645   1 DVDECatGTHNCPAntVCVNTIGSFECRCP 30
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-439 1.84e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 125.22  E-value: 1.84e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907 306 TGFTAEFDLRTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGVVSRVTSSGPQVNDGQWHKISVEEQGRSLVIKID 385
Cdd:cd00110  20 TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVSVERNGRSVTLSVD 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41053907 386 REAVMKIAVNGDLFTLNKNMhelNLTVGGVPFRDDGLVSRVNPRLDGCMKDWRW 439
Cdd:cd00110 100 GERVVESGSPGGSALLNLDG---PLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
309-439 9.09e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.28  E-value: 9.09e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907    309 TAEFDLRTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGV-VSRVTSSGPQVNDGQWHKISVEEQGRSLVIKIDRE 387
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSgPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 41053907    388 AVMKIAVNGDLFTLNKNMhelNLTVGGVPFRDDGLVSRVNPRLDGCMKDWRW 439
Cdd:smart00282  81 NRVSGESPGGLTILNLDG---PLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 21-82 2.19e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 99.31  E-value: 2.19e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053907     21 VSVSSRQAHQFLRRTRRANQV-FEETKQGHLERECVEEKCTKEEAREVFENDPETEYFYPKYQ 82
Cdd:smart00069   3 VFLSRQEANKVLRRQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
Laminin_G_1 pfam00054
Laminin G domain;
315-436 8.99e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 91.22  E-value: 8.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   315 RTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGVVSRVTSSGPQVNDGQWHKISVEEQGRSLVIKIDREAVMKIAV 394
Cdd:pfam00054   2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 41053907   395 N-GDLFTLNKNMhelNLTVGGVPfrDDGLVSR---VNPRLDGCMKD 436
Cdd:pfam00054  82 PlGATTDLDVDG---PLYVGGLP--SLGVKKRrlaISPSFDGCIRD 122
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 42-81 9.22e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 85.28  E-value: 9.22e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 41053907    42 FEETKQGHLERECVEEKCTKEEAREVFENDPETEYFYPKY 81
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 493-622 9.25e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   493 LRAASSMGVLFALVRQDRVPFSISLSDyhpGTLQWTkhVLVSLGDVVVGSVPVNLSDGQTHTVNVTMSGNDSVLEVDAQL 572
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVN---GRLVLR--YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41053907   573 AQMEMMEGvDSLDLTSSYSTFIGGIP-DVSLVSSPVSAFFTGCM-DVRVNGQ 622
Cdd:pfam02210  76 VVSSLPPG-ESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIrDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 466-620 8.54e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 8.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907 466 SAFYPGHGFAYFNHSHGDNQTLSVHVTLRAASSMGVLFALVRQDRVPF-SISLSDyhpGTLqwtkHVLVSLGD-VVVGSV 543
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFlALELED---GRL----VLRYDLGSgSLVLSS 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053907 544 PVNLSDGQTHTVNVTMSGNDSVLEVDaQLAQMEMMEGVDSLDLTSSYSTFIGGIPDVSLVSS-PVSAFFTGCM-DVRVN 620
Cdd:cd00110  74 KTPLNDGQWHSVSVERNGRSVTLSVD-GERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGlPVSPGFVGCIrDLKVN 151
LamG smart00282
Laminin G domain;
488-622 1.10e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.91  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907    488 SVHVTLRAASSMGVLFALVRQDRVPF-SISLSDyhpGTLQWtkHVLVSLGDVVVGSVPVNLSDGQTHTVNVTMSGNDSVL 566
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYlALELRD---GRLVL--RYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTL 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41053907    567 EVDAQLAQ-MEMMEGVDSLDLTSSYstFIGGIPDVSLVS-SPVSAFFTGCM-DVRVNGQ 622
Cdd:smart00282  76 SVDGGNRVsGESPGGLTILNLDGPL--YLGGLPEDLKLPpLPVTPGFRGCIrNLKVNGK 132
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-183 7.96e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 41053907   149 CISGNGGCEHVCNNTMGSYKCSCEDGYRL-SGHHSC 183
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELqDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
185-215 3.85e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 3.85e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41053907   185 DVDECVETPDVC-GSAHCSNLIGGLECLCDEG 215
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
145-180 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41053907    145 DVDECISGNGgCEH--VCNNTMGSYKCSCEDGYRLSGH 180
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 145-177 6.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 6.89e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 41053907 145 DVDECISGNG-GCEHVCNNTMGSYKCSCEDGYRL 177
Cdd:cd00054   1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
227-252 3.52e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 3.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 41053907   227 DVDEC--ETHVCEE--ECVNTPGSFRCFCD 252
Cdd:pfam07645   1 DVDECatGTHNCPAntVCVNTIGSFECRCP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
227-252 4.19e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 4.19e-04
                           10        20
                   ....*....|....*....|....*....
gi 41053907    227 DVDECET-HVCEE--ECVNTPGSFRCFCD 252
Cdd:smart00179   1 DIDECASgNPCQNggTCVNTVGSYRCECP 29
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 225-255 1.20e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 1.20e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 41053907 225 CVDVDECET--HVCEEECVNTPGSFRCFCDGRL 255
Cdd:cd01475 184 CVVPDLCATlsHVCQQVCISTPGSYLCACTEGY 216
EGF_CA smart00179
Calcium-binding EGF-like domain;
185-216 3.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.41e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 41053907    185 DVDECvETPDVCGS-AHCSNLIGGLECLCDEGF 216
Cdd:smart00179   1 DIDEC-ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 185-220 5.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 5.39e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 41053907 185 DVDECvETPDVCG-SAHCSNLIGGLECLCDEGFIYDN 220
Cdd:cd00054   1 DIDEC-ASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 306-439 1.84e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 125.22  E-value: 1.84e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907 306 TGFTAEFDLRTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGVVSRVTSSGPQVNDGQWHKISVEEQGRSLVIKID 385
Cdd:cd00110  20 TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVSVERNGRSVTLSVD 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41053907 386 REAVMKIAVNGDLFTLNKNMhelNLTVGGVPFRDDGLVSRVNPRLDGCMKDWRW 439
Cdd:cd00110 100 GERVVESGSPGGSALLNLDG---PLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
309-439 9.09e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.28  E-value: 9.09e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907    309 TAEFDLRTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGV-VSRVTSSGPQVNDGQWHKISVEEQGRSLVIKIDRE 387
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSgPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 41053907    388 AVMKIAVNGDLFTLNKNMhelNLTVGGVPFRDDGLVSRVNPRLDGCMKDWRW 439
Cdd:smart00282  81 NRVSGESPGGLTILNLDG---PLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 21-82 2.19e-25

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 99.31  E-value: 2.19e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053907     21 VSVSSRQAHQFLRRTRRANQV-FEETKQGHLERECVEEKCTKEEAREVFENDPETEYFYPKYQ 82
Cdd:smart00069   3 VFLSRQEANKVLRRQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRYY 65
Laminin_G_1 pfam00054
Laminin G domain;
315-436 8.99e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 91.22  E-value: 8.99e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   315 RTFDPEGVIFFAGGHLNSSWIVLLVHHGKLELQLKYGVVSRVTSSGPQVNDGQWHKISVEEQGRSLVIKIDREAVMKIAV 394
Cdd:pfam00054   2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 41053907   395 N-GDLFTLNKNMhelNLTVGGVPfrDDGLVSR---VNPRLDGCMKD 436
Cdd:pfam00054  82 PlGATTDLDVDG---PLYVGGLP--SLGVKKRrlaISPSFDGCIRD 122
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 314-438 1.69e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.56  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   314 LRTFDPEGVIFFAGGHlNSSWIVLLVHHGKLELQLKYGV-VSRVTSSGPQVNDGQWHKISVEEQGRSLVIKIDREAVMKI 392
Cdd:pfam02210   1 FRTRQPNGLLLYAGGG-GSDFLALELVNGRLVLRYDLGSgPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 41053907   393 AVNGDLFTLNKNmheLNLTVGGVPFRDDGLVSRVNPRLDGCMKDWR 438
Cdd:pfam02210  80 LPPGESLLLNLN---GPLYLGGLPPLLLLPALPVRAGFVGCIRDVR 122
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 42-81 9.22e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 85.28  E-value: 9.22e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 41053907    42 FEETKQGHLERECVEEKCTKEEAREVFENDPETEYFYPKY 81
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 493-622 9.25e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.77  E-value: 9.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   493 LRAASSMGVLFALVRQDRVPFSISLSDyhpGTLQWTkhVLVSLGDVVVGSVPVNLSDGQTHTVNVTMSGNDSVLEVDAQL 572
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVN---GRLVLR--YDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41053907   573 AQMEMMEGvDSLDLTSSYSTFIGGIP-DVSLVSSPVSAFFTGCM-DVRVNGQ 622
Cdd:pfam02210  76 VVSSLPPG-ESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIrDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 466-620 8.54e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 8.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907 466 SAFYPGHGFAYFNHSHGDNQTLSVHVTLRAASSMGVLFALVRQDRVPF-SISLSDyhpGTLqwtkHVLVSLGD-VVVGSV 543
Cdd:cd00110   1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFlALELED---GRL----VLRYDLGSgSLVLSS 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41053907 544 PVNLSDGQTHTVNVTMSGNDSVLEVDaQLAQMEMMEGVDSLDLTSSYSTFIGGIPDVSLVSS-PVSAFFTGCM-DVRVN 620
Cdd:cd00110  74 KTPLNDGQWHSVSVERNGRSVTLSVD-GERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGlPVSPGFVGCIrDLKVN 151
LamG smart00282
Laminin G domain;
488-622 1.10e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.91  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907    488 SVHVTLRAASSMGVLFALVRQDRVPF-SISLSDyhpGTLQWtkHVLVSLGDVVVGSVPVNLSDGQTHTVNVTMSGNDSVL 566
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYlALELRD---GRLVL--RYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTL 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41053907    567 EVDAQLAQ-MEMMEGVDSLDLTSSYstFIGGIPDVSLVS-SPVSAFFTGCM-DVRVNGQ 622
Cdd:smart00282  76 SVDGGNRVsGESPGGLTILNLDGPL--YLGGLPEDLKLPpLPVTPGFRGCIrNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
494-625 2.19e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.87  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053907   494 RAASSMGVLFALVRQDRVPF-SISLSDYHPgtlqwtkHVLVSLGD--VVVGSvPVNLSDGQTHTVNVTMSGNDSVLEVDA 570
Cdd:pfam00054   2 RTTEPSGLLLYNGTQTERDFlALELRDGRL-------EVSYDLGSgaAVVRS-GDKLNDGKWHSVELERNGRSGTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 41053907   571 QLAQMEMMEGVDSLDLTSSYSTFIGGIPDVSLVSS--PVSAFFTGCM-DVRVNGQLLD 625
Cdd:pfam00054  74 EARPTGESPLGATTDLDVDGPLYVGGLPSLGVKKRrlAISPSFDGCIrDVIVNGKPLD 131
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-183 7.96e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 41053907   149 CISGNGGCEHVCNNTMGSYKCSCEDGYRL-SGHHSC 183
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELqDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
185-215 3.85e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.77  E-value: 3.85e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41053907   185 DVDECVETPDVC-GSAHCSNLIGGLECLCDEG 215
Cdd:pfam07645   1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
145-180 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41053907    145 DVDECISGNGgCEH--VCNNTMGSYKCSCEDGYRLSGH 180
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
145-174 2.74e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 2.74e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 41053907   145 DVDECISGNGGCEH--VCNNTMGSYKCSCEDG 174
Cdd:pfam07645   1 DVDECATGTHNCPAntVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 149-181 3.25e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.05  E-value: 3.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 41053907   149 CISGNGGCeHV---CNNTMGSYKCSCEDGYRLSGHH 181
Cdd:pfam12947   1 CSDNNGGC-HPnatCTNTGGSFTCTCNDGYTGDGVT 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 145-177 6.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 6.89e-05
                        10        20        30
                ....*....|....*....|....*....|....
gi 41053907 145 DVDECISGNG-GCEHVCNNTMGSYKCSCEDGYRL 177
Cdd:cd00054   1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
227-252 3.52e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 3.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 41053907   227 DVDEC--ETHVCEE--ECVNTPGSFRCFCD 252
Cdd:pfam07645   1 DVDECatGTHNCPAntVCVNTIGSFECRCP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
227-252 4.19e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 4.19e-04
                           10        20
                   ....*....|....*....|....*....
gi 41053907    227 DVDECET-HVCEE--ECVNTPGSFRCFCD 252
Cdd:smart00179   1 DIDECASgNPCQNggTCVNTVGSYRCECP 29
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 139-178 7.48e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.60  E-value: 7.48e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 41053907 139 GATCQnDVDECISGNGGCEHVCNNTMGSYKCSCEDGYRLS 178
Cdd:cd01475 181 GKICV-VPDLCATLSHVCQQVCISTPGSYLCACTEGYALL 219
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 225-255 1.20e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 1.20e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 41053907 225 CVDVDECET--HVCEEECVNTPGSFRCFCDGRL 255
Cdd:cd01475 184 CVVPDLCATlsHVCQQVCISTPGSYLCACTEGY 216
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 227-252 1.27e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.27e-03
                        10        20
                ....*....|....*....|....*....
gi 41053907 227 DVDECET-HVCEE--ECVNTPGSFRCFCD 252
Cdd:cd00054   1 DIDECASgNPCQNggTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
185-216 3.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.41e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 41053907    185 DVDECvETPDVCGS-AHCSNLIGGLECLCDEGF 216
Cdd:smart00179   1 DIDEC-ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 185-220 5.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 5.39e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 41053907 185 DVDECvETPDVCG-SAHCSNLIGGLECLCDEGFIYDN 220
Cdd:cd00054   1 DIDEC-ASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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