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Conserved domains on  [gi|41054139|ref|NP_956139|]
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glutamate--cysteine ligase regulatory subunit [Danio rerio]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 85-213 3.99e-14

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19071:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 251  Bit Score: 70.20  E-value: 3.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFI-APPPLPEGEAQTLTHLQplWQELESLVQSQKIAAIGTS 163
Cdd:cd19071  54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIhWPVPGKEGGSKEARLET--WRALEELVDEGLVRSIGVS 131

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41054139 164 DLDKTLLEQLYNWAQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 85-213 3.99e-14

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 70.20  E-value: 3.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFI-APPPLPEGEAQTLTHLQplWQELESLVQSQKIAAIGTS 163
Cdd:cd19071  54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIhWPVPGKEGGSKEARLET--WRALEELVDEGLVRSIGVS 131

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41054139 164 DLDKTLLEQLYNWAQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 82-213 7.26e-07

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 49.23  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139    82 PEEREELKVSVKL-FLTEWDCSSIRSAVDMACLS-----LGVSQLDSVFIA--PPPLPEGEAqtlthlqplWQELESLVQ 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEeslkrLGTDYIDLYYLHwpDPDTPIEET---------WDALEELKK 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41054139   154 SQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCVMPP-DLTAFAKEFDIQLLTHS 213
Cdd:pfam00248 129 EGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAYS 189
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 85-209 1.22e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 45.43  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDmACLS-LGVSQLDSVFI-APPPLPEGEAqtlthlqplWQELESLVQSQKIAAIGT 162
Cdd:COG0656  58 REELFVTTKVWNDNHGYDDTLAAFE-ESLErLGLDYLDLYLIhWPGPGPYVET---------WRALEELYEEGLIRAIGV 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 41054139 163 SDLDKTLLEQLYNWAQIKPSSNQV--NLASccvMPPDLTAFAKEFDIQL 209
Cdd:COG0656 128 SNFDPEHLEELLAETGVKPAVNQVelHPYL---QQRELLAFCREHGIVV 173
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 85-213 3.99e-14

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 70.20  E-value: 3.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFI-APPPLPEGEAQTLTHLQplWQELESLVQSQKIAAIGTS 163
Cdd:cd19071  54 REELFITTKLWPTDHGYERVREALEESLKDLGLDYLDLYLIhWPVPGKEGGSKEARLET--WRALEELVDEGLVRSIGVS 131

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41054139 164 DLDKTLLEQLYNWAQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19071 132 NFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVVQAYS 180
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 85-213 4.03e-10

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 58.78  E-value: 4.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLtewDCSSIRSAVDMACLSLGVSQLDSVFIAPPPLPEGEAQTLthlQPLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19120  65 REDLFITTKVSP---GIKDPREALRKSLAKLGVDYVDLYLIHSPFFAKEGGPTL---AEAWAELEALKDAGLVRSIGVSN 138

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNLASCCVMP-PDLTAFAKEFDIQLLTHS 213
Cdd:cd19120 139 FRIEDLEELLDTAKIKPAVNQIEFHPYLYPQqPALLEYCREHGIVVSAYS 188
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 85-208 6.25e-09

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 55.41  E-value: 6.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPPPLPEGEAQTLTHLQPLWQELESLVQSQKIAAIGTSD 164
Cdd:cd19135  66 REDLFLTTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVKETRAETWRALEELYDEGLCRAIGVSN 145

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQ 208
Cdd:cd19135 146 FLIEHLEQLLEDCSVVPHVNQVEF-HPFQNPVELIEYCRDNNIV 188
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 85-186 9.10e-08

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 51.96  E-value: 9.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP-------PLPEGEAQTLTHLQPLWQELESLVQSQKI 157
Cdd:cd19125  68 REDLFITSKLWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPvrlkkgaHMPEPEEVLPPDIPSTWKAMEKLVDSGKV 147

                        90       100
                ....*....|....*....|....*....
gi 41054139 158 AAIGTSDLDKTLLEQLYNWAQIKPSSNQV 186
Cdd:cd19125 148 RAIGVSNFSVKKLEDLLAVARVPPAVNQV 176
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 82-213 7.26e-07

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 49.23  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139    82 PEEREELKVSVKL-FLTEWDCSSIRSAVDMACLS-----LGVSQLDSVFIA--PPPLPEGEAqtlthlqplWQELESLVQ 153
Cdd:pfam00248  58 PVKRDKVVIATKVpDGDGPWPSGGSKENIRKSLEeslkrLGTDYIDLYYLHwpDPDTPIEET---------WDALEELKK 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41054139   154 SQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCVMPP-DLTAFAKEFDIQLLTHS 213
Cdd:pfam00248 129 EGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAYS 189
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 85-213 1.95e-06

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 47.91  E-value: 1.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDcsSIRSAVDMACLSLGVSQLD------SVFIAP-------PPLPEGEA---QTLTHLQPlWQEL 148
Cdd:cd19121  68 REDLFVTTKLWSTYHR--RVELCLDRSLKSLGLDYVDlylvhwPVLLNPngnhdlfPTLPDGSRdldWDWNHVDT-WKQM 144

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41054139 149 ESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCvmpP--DLTAFAKEFDIQLLTHS 213
Cdd:cd19121 145 EKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENHPYL---PqqELVDFCKEKGILIEAYS 208
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 85-209 2.39e-06

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 47.43  E-value: 2.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDsVFIAPPPLPEGEAQTlthlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19126  63 REELFVTTKLWNDDQRARRTEDAFQESLDRLGLDYVD-LYLIHWPGKDKFIDT-------WKALEKLYASGKVKAIGVSN 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQL 209
Cdd:cd19126 135 FQEHHLEELLAHADVVPAVNQVEF-HPYLTQKELRGYCKSKGIVV 178
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 85-209 1.22e-05

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 45.43  E-value: 1.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDmACLS-LGVSQLDSVFI-APPPLPEGEAqtlthlqplWQELESLVQSQKIAAIGT 162
Cdd:COG0656  58 REELFVTTKVWNDNHGYDDTLAAFE-ESLErLGLDYLDLYLIhWPGPGPYVET---------WRALEELYEEGLIRAIGV 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 41054139 163 SDLDKTLLEQLYNWAQIKPSSNQV--NLASccvMPPDLTAFAKEFDIQL 209
Cdd:COG0656 128 SNFDPEHLEELLAETGVKPAVNQVelHPYL---QQRELLAFCREHGIVV 173
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 85-188 1.53e-05

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 45.26  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIappplpegeaqtltHlQPL------WQELESLVQSQKIA 158
Cdd:cd19133  63 REELFITTKLWIQDAGYEKAKKAFERSLKRLGLDYLDLYLI--------------H-QPFgdvygaWRAMEELYKEGKIR 127

                        90       100       110
                ....*....|....*....|....*....|
gi 41054139 159 AIGTSDLDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19133 128 AIGVSNFYPDRLVDLILHNEVKPAVNQIET 157
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 84-188 1.58e-05

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 45.31  E-value: 1.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPPPLPEGEAQTLTHL----------------QPLWQE 147
Cdd:cd19122  68 KREDLFICTKVWNHLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKLgpdgkyvilkdltenpEPTWRA 147

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 41054139 148 LESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19122 148 MEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 84-188 1.59e-05

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 45.09  E-value: 1.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDsVFIAPPPLPEGEAQTLTHlqplWQELESLVQSQKIAAIGTS 163
Cdd:cd19127  61 DRSDIFVTTKLWISDYGYDKALRGFDASLRRLGLDYVD-LYLLHWPVPNDFDRTIQA----YKALEKLLAEGRVRAIGVS 135

                        90       100
                ....*....|....*....|....*
gi 41054139 164 DLDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19127 136 NFTPEHLERLIDATTVVPAVNQVEL 160
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 85-213 1.71e-05

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 45.09  E-value: 1.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP-------PLPEGEAQTLTHLQ-PL---WQELESLVQ 153
Cdd:cd19123  69 REDLWITSKLWNNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPvalkkgvGFPESGEDLLSLSPiPLedtWRAMEELVD 148

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139 154 SQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19123 149 KGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVEL-HPYLQQPELLAFCRDNGIHLTAYS 207
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 85-186 3.78e-05

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 44.37  E-value: 3.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP-PLPEGEAQ------------TLTHLQPLWQELESL 151
Cdd:cd19129  63 REDLFVTTKLWNTNHRPERVKPAFEASLKRLQLDYLDLYLIHTPfAFQPGDEQdprdangnviydDGVTLLDTWRAMERL 142

                        90       100       110
                ....*....|....*....|....*....|....*
gi 41054139 152 VQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQV 186
Cdd:cd19129 143 VDEGRCKAIGLSDVSLEKLREIFEAARIKPAVVQV 177
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 85-207 4.21e-05

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 43.94  E-value: 4.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMaclSLGVSQLDSV--FIAPPPLP----EGEAQTLTH---------LQPLWQELE 149
Cdd:cd19154  69 REDLFITTKLWTHEHAPEDVEEALRE---SLKKLQLEYVdlYLIHAPAAfkddEGESGTMENgmsihdavdVEDVWRGME 145

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 41054139 150 SLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLAscCVMP-PDLTAFAKEFDI 207
Cdd:cd19154 146 KVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECH--LYFPqKELVEFCKKHNI 202
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 84-186 4.35e-05

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 44.05  E-value: 4.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  84 EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDsVFIAPPPL-------------PEGEAQTLTHLQPLWQELES 150
Cdd:cd19128  57 KREDLFITSKLWPTMHQPENVKEQLLITLQDLQLEYLD-LFLIHWPLafdmdtdgdprddNQIQSLSKKPLEDTWRAMEQ 135

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 41054139 151 LVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQV 186
Cdd:cd19128 136 CVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQI 171
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 85-207 5.50e-05

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 43.66  E-value: 5.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPPplpeGEAQTLTHlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19156  63 REEVFVTTKLWNSDQGYESTLAAFEESLEKLGLDYVDLYLIHWP----VKGKFKDT----WKAFEKLYKEKKVRAIGVSN 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNLASCCVMPPdLTAFAKEFDI 207
Cdd:cd19156 135 FHEHHLEELLKSCKVAPMVNQIELHPLLTQEP-LRKFCKEKNI 176
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 85-188 7.47e-05

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 43.13  E-value: 7.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIA-PPPLPEGEAQTlthlqplWQELESLVQSQKIAAIGTS 163
Cdd:cd19131  63 REELFITTKLWNSDQGYDSTLRAFDESLRKLGLDYVDLYLIHwPVPAQDKYVET-------WKALIELKKEGRVKSIGVS 135

                        90       100
                ....*....|....*....|....*
gi 41054139 164 DLDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19131 136 NFTIEHLQRLIDETGVVPVVNQIEL 160
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 85-209 1.05e-04

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 42.76  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPPpLPEGEAQTlthlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19157  64 REELFITSKVWNADQGYDSTLKAFEASLERLGLDYLDLYLIHWP-VKGKYKET-------WKALEKLYKDGRVRAIGVSN 135

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNLAScCVMPPDLTAFAKEFDIQL 209
Cdd:cd19157 136 FQVHHLEDLLADAEIVPMVNQVEFHP-RLTQKELRDYCKKQGIQL 179
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 85-213 1.79e-04

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 42.05  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP------PLPE--------GEAQTLTHLQ-PL---WQ 146
Cdd:cd19113  68 REELFLTSKLWNNFHDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvPIEEkyppgfycGDGDNFVYEDvPIldtWK 147

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41054139 147 ELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCVMpPDLTAFAKEFDIQLLTHS 213
Cdd:cd19113 148 ALEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQ-PKLIEYAQKAGITITAYS 213
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 85-188 7.31e-04

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 40.28  E-value: 7.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDsVFIAPPPLPEGEAQTLThlqplWQELESLVQSQKIAAIGTSD 164
Cdd:cd19130  63 RDELFVTTKLWNDRHDGDEPAAAFAESLAKLGLDQVD-LYLVHWPTPAAGNYVHT-----WEAMIELRAAGRTRSIGVSN 136

                        90       100
                ....*....|....*....|....
gi 41054139 165 LDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19130 137 FLPPHLERIVAATGVVPAVNQIEL 160
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 77-186 9.65e-04

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 40.06  E-value: 9.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  77 TEAITPE---EREELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP--------PLPEGEAQTL----THL 141
Cdd:cd19106  54 KEKVGPGkavPREDLFVTSKLWNTKHHPEDVEPALRKTLKDLQLDYLDLYLIHWPyafergdnPFPKNPDGTIrydsTHY 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 41054139 142 QPLWQELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQV 186
Cdd:cd19106 134 KETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQV 178
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 145-254 1.11e-03

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 39.54  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139 145 WQELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCVMpPDLTAFAKEFDIQ-------------LLT 211
Cdd:cd19136 122 WRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNQVEFHPHLVQ-KELLKFCKDHGIHlqaysslgsgdlrLLE 200

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 41054139 212 HSDPKELISAAGFQEAvqgssqelQVddwRLEWVLR--YSIIVKS 254
Cdd:cd19136 201 DPTVLAIAKKYGRTPA--------QV---LLRWALQqgIGVIPKS 234
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 85-207 1.15e-03

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 39.57  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPPP--LPEGEAQTLTHLQPL-------WQELESLVQSQ 155
Cdd:cd19116  69 REDLFITTKLWNSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVafKENNDSESNGDGSLSdidyletWRGMEDLVKLG 148

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41054139 156 KIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNlasccVMP----PDLTAFAKEFDI 207
Cdd:cd19116 149 LTRSIGVSNFNSEQINRLLSNCNIKPAVNQIE-----VHPtltqEKLVAYCQSNGI 199
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 131-213 2.11e-03

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 39.05  E-value: 2.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139 131 PEGEAQ--TLTHLQPLWQELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLaSCCVMPPDLTAFAKEFDIQ 208
Cdd:cd19155 127 PTGEHKqdYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNARIKPANLQVEL-HVYLQQKDLVDFCSTHSIT 205


                ....*
gi 41054139 209 LLTHS 213
Cdd:cd19155 206 VTAYA 210
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 85-213 3.38e-03

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 38.25  E-value: 3.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWdcSSIRSAVDMACLSLGVSQLDSVFIA-PPPL--------PEGEAQTLTHLQ-----PLWQELES 150
Cdd:cd19117  67 REEIFITTKLWCTWH--RRVEEALDQSLKKLGLDYVDLYLMHwPVPLdpdgndflFKKDDGTKDHEPdwdfiKTWELMQK 144

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41054139 151 LVQSQKIAAIGTSDLDKTLLEQLYN--WAQIKPSSNQVNLASccVMP-PDLTAFAKEFDIQLLTHS 213
Cdd:cd19117 145 LPATGKVKAIGVSNFSIKNLEKLLAspSAKIVPAVNQIELHP--LLPqPKLVDFCKSKGIHATAYS 208
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 85-213 4.39e-03

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 37.92  E-value: 4.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIA--------------PPPLPEGEAQTL----THLQPLWQ 146
Cdd:cd19114  61 REDLFIVTKLWNNFHGKDHVREAFDRQLKDYGLDYIDLYLIHfpipaayvdpaenyPFLWKDKELKKFpleqSPMQECWR 140

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054139 147 ELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNLASccVMPPD-LTAFAKEFDIQLLTHS 213
Cdd:cd19114 141 EMEKLVDAGLVRNIGIANFNVQLILDLLTYAKIKPAVLQIEHHP--YLQQKrLIDWAKKQGIQITAYS 206
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 84-213 5.14e-03

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 37.78  E-value: 5.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  84 EREELKVSVKLflteWDCS----SIRSAVDMACLSLGVSQLDSVFI---------------APPPLPEGEAQ--TLTHLQ 142
Cdd:cd19118  64 KREDLFITSKL----WNNShrpeYVEPALDDTLKELGLDYLDLYLIhwpvafkptgdlnplTAVPTNGGEVDldLSVSLV 139

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41054139 143 PLWQELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNlASCCVMPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19118 140 DTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIE-AHPLLLQDELVDYCKSKNIHITAYS 209
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 137-186 5.16e-03

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 37.85  E-value: 5.16e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 41054139 137 TLTHLQPLWQELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQV 186
Cdd:cd19112 134 VTISLETTWHAMEKLVSAGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQI 183
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 85-188 5.39e-03

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 37.48  E-value: 5.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDcsSIRSAVDMACLSLGVSQLDSVFIA-PPPL-----PEGEAQTLT-------------HLQpLW 145
Cdd:cd19119  71 REELFITTKVWPTFYD--EVERSLDESLKALGLDYVDLLLVHwPVCFekdsdDSGKPFTPVnddgktryaasgdHIT-TY 147

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 41054139 146 QELESLVQSQKIAAIGTSDLDKTLLEQLYNWAQIKPSSNQVNL 188
Cdd:cd19119 148 KQLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVEL 190
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 85-213 9.70e-03

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 36.48  E-value: 9.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054139  85 REELKVSVKLFLTEWDCSSIRSAVDMACLSLGVSQLDSVFIAPP----PLPEgeaqTLthlqplwQELESLVQSQKIAAI 160
Cdd:cd19073  54 REDLFITTKVWRDHLRPEDLKKSVDRSLEKLGTDYVDLLLIHWPnptvPLEE----TL-------GALKELKEAGKVKSI 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 41054139 161 GTSDLDKTLLEQLYNWAQIKPSSNQVNLASCCVmPPDLTAFAKEFDIQLLTHS 213
Cdd:cd19073 123 GVSNFTIELLEEALDISPLPIAVNQVEFHPFLY-QAELLEYCRENDIVITAYS 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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