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Conserved domains on  [gi|41054928|ref|NP_955775|]
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cyclin-G1 [Danio rerio]

Protein Classification

cyclin-G1( domain architecture ID 15334747)

cyclin-G1 may play a role in growth regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 2.07e-60

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410286  Cd Length: 98  Bit Score: 187.34  E-value: 2.07e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  51 LRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 41054928 131 VHDMMRMEKIILEKLNWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98
 
Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 2.07e-60

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 187.34  E-value: 2.07e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  51 LRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 41054928 131 VHDMMRMEKIILEKLNWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 18-149 1.38e-19

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 82.56  E-value: 1.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928    18 KSLLDQESRYQPKLCglrVIESAQDNGLRMTVKLRDYqvreLLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCV 97
Cdd:pfam00134   4 QYLRELELKYLPKPD---YMDQQPDINPKMRAILIDW----LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41054928    98 GLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNWKV 149
Cdd:pfam00134  77 GVTCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
66-159 1.28e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 70.57  E-value: 1.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  66 FGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:COG5024 227 FGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVL 304

                        90
                ....*....|....
gi 41054928 146 NWKVKAPTALHFLR 159
Cdd:COG5024 305 DFNISWPSPMSFLR 318
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 59-143 1.50e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.22  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928     59 LLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLaSDLIRISQNrFTVHDMMRME 138
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT--EETPPWT-KELVHYTGY-FTEEEILRME 78


                   ....*
gi 41054928    139 KIILE 143
Cdd:smart00385  79 RLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 2.07e-60

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 187.34  E-value: 2.07e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  51 LRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 41054928 131 VHDMMRMEKIILEKLNWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 52-145 7.39e-43

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 142.11  E-value: 7.39e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  52 RDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFTV 131
Cdd:cd20523   1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDLIRISQCGCTA 80

                        90
                ....*....|....
gi 41054928 132 HDMMRMEKIILEKL 145
Cdd:cd20523  81 ADLMRMEGIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 51-146 1.69e-41

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 138.83  E-value: 1.69e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  51 LRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFT 130
Cdd:cd20584   1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                        90
                ....*....|....*.
gi 41054928 131 VHDMMRMEKIILEKLN 146
Cdd:cd20584  81 VSDLKRMEKIISEKLH 96
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 52-147 3.20e-34

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 120.11  E-value: 3.20e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  52 RDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFTV 131
Cdd:cd20526   2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSV 81

                        90
                ....*....|....*.
gi 41054928 132 HDMMRMEKIILEKLNW 147
Cdd:cd20526  82 AEVLRMERIILDKLHW 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 18-149 1.38e-19

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 82.56  E-value: 1.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928    18 KSLLDQESRYQPKLCglrVIESAQDNGLRMTVKLRDYqvreLLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCV 97
Cdd:pfam00134   4 QYLRELELKYLPKPD---YMDQQPDINPKMRAILIDW----LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 41054928    98 GLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNWKV 149
Cdd:pfam00134  77 GVTCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 66-146 4.90e-15

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 70.25  E-value: 4.90e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  66 FGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:cd20507  51 FKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPPEIKDFVYITDNAYTREEILQMERDILKTL 128


                .
gi 41054928 146 N 146
Cdd:cd20507 129 D 129
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
66-159 1.28e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 70.57  E-value: 1.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  66 FGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:COG5024 227 FGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVL 304

                        90
                ....*....|....
gi 41054928 146 NWKVKAPTALHFLR 159
Cdd:COG5024 305 DFNISWPSPMSFLR 318
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 50-147 3.04e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 64.55  E-value: 3.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  50 KLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQN-R 128
Cdd:cd20528   5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYLCNsV 84

                        90
                ....*....|....*....
gi 41054928 129 FTVHDMMRMEKIILEKLNW 147
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 66-147 4.47e-13

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 65.44  E-value: 4.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  66 FGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:cd20567  68 FELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTL 145


                ..
gi 41054928 146 NW 147
Cdd:cd20567 146 EF 147
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 59-143 1.50e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.22  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928     59 LLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLaSDLIRISQNrFTVHDMMRME 138
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKT--EETPPWT-KELVHYTGY-FTEEEILRME 78


                   ....*
gi 41054928    139 KIILE 143
Cdd:smart00385  79 RLLLE 83
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 72-147 7.08e-11

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 57.78  E-value: 7.08e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41054928  72 TFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20559  19 TFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEELFIQMEMHILNTLNW 94
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 71-147 9.37e-11

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 58.85  E-value: 9.37e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054928  71 ETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEeekNVPLASDLIRI-SQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20515  75 EVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKE---TIPLTAEKLCIyTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 66-147 1.40e-10

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 58.08  E-value: 1.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  66 FGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:cd20568  55 FRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTL 132


                ..
gi 41054928 146 NW 147
Cdd:cd20568 133 EF 134
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 59-145 2.95e-10

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 56.18  E-value: 2.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  59 LLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKtsEEEKNVPLASDLIRISQNRFTVHDMMRME 138
Cdd:cd20536   9 LIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACK--QEEIYPPEVKDLLALCCGAYTREQICNLE 86


                ....*..
gi 41054928 139 KIILEKL 145
Cdd:cd20536  87 CIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 59-146 1.88e-09

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 53.86  E-value: 1.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  59 LLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRME 138
Cdd:cd20542   8 LVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKF--EERFPPEVATLCYLTDDSYSKKQVLRME 85


                ....*...
gi 41054928 139 KIILEKLN 146
Cdd:cd20542  86 RRVLRRLR 93
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 71-146 2.99e-09

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 54.18  E-value: 2.99e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41054928  71 ETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLN 146
Cdd:cd20504  54 ETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAKY--EEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 71-147 5.06e-09

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 53.47  E-value: 5.06e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054928  71 ETFSFAVNLLDRFLAVMKIQPKH-LSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20519  56 ETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAKL--EEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 59-147 9.71e-09

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 51.93  E-value: 9.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  59 LLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQ---PKHLSCVGLCCFYIAVKTseEEKNVPLASDL-IRISQNRFTVHDM 134
Cdd:cd20543   9 ILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkdkPWMLQLLAVACLSLAAKM--EETDVPLLVDLqVEEPKYVFEAKTI 86

                        90
                ....*....|...
gi 41054928 135 MRMEKIILEKLNW 147
Cdd:cd20543  87 QRMELLVLSTLEW 99
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 18-147 1.07e-08

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 53.07  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  18 KSLLDQESRYQPKLCGLRVIESAQDNGLRMTVKLRDYQVRELLSLTRffgfcaETFSFAVNLLDRFLAVMKIQPKHLSCV 97
Cdd:cd20574  28 QNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEE------EVFPLAMNYLDRFLAVVPTRKCHLQLL 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 41054928  98 GLCCFYIAVKTSEeekNVPLASDLIRI-SQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20574 102 GAVCMFLASKLKE---TIPLTAEKLCIyTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 56-140 3.10e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 50.10  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  56 VRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEEEKNVplaSDLIRISQNrfTVHDMM 135
Cdd:cd00043   3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTL---KEIAKVSGV--SEKELR 77


                ....*
gi 41054928 136 RMEKI 140
Cdd:cd00043  78 KAEKE 82
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 29-147 1.12e-07

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 49.86  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  29 PKLCG---------LRVIESAQD------NGLRMTVKLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKH 93
Cdd:cd20566   2 PQLCSdyvkdiyqyLRQLEVQQSirphylDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41054928  94 LSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20566  82 LQLVGVTALLLASKY--EEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 71-147 1.47e-07

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 49.98  E-value: 1.47e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41054928  71 ETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTSEeekNVPLASDLIRI-SQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20573  74 EVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKE---TIPLTAEKLCIyTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 18-147 3.10e-07

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 49.22  E-value: 3.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  18 KSLLDQESRYQPKLCGLRVIESAQDNGLRmtvKLRDYQVRELLSLTRffgfCAE-TFSFAVNLLDRFLAVMKIQPKHLSC 96
Cdd:cd20575  28 QNLLRLEERYVPRVSYFQCVQREIKPYMR---KMLAYWMLEVCEEQK----CEEeVFPLAMNYVDRYLSCVPTRKAQLQL 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 41054928  97 VGLCCFYIAVKTSEeekNVPLASDLIRI-SQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20575 101 LGAVCMLLASKLRE---TTPLTIEKLCIyTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 47-147 7.01e-07

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 47.75  E-value: 7.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  47 MTVKLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQ 126
Cdd:cd20561  32 ITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKF--EEIYPPEVAEFVYITD 109

                        90       100
                ....*....|....*....|.
gi 41054928 127 NRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20561 110 DTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 20-145 8.85e-07

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 47.91  E-value: 8.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  20 LLDQESRYQPKLCGLRviesAQDNglrMTVKLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGL 99
Cdd:cd20560  44 LREAELKHRPKPGYMR----KQPD---ITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGT 116

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 41054928 100 CCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKL 145
Cdd:cd20560 117 AAILLASKY--EEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 71-146 1.58e-06

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 46.86  E-value: 1.58e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41054928  71 ETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLN 146
Cdd:cd20508  67 ETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF--DERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 50-147 6.00e-06

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 45.28  E-value: 6.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  50 KLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFL---AVMKIQPKHLScvgLCCFYIAVKTseEEKNVPLASDLIRISQ 126
Cdd:cd20524  53 LLVRYYEKKLLEFCRAFKLPDSVLATALTYFKRFYlknSVMEYHPKEIM---LTCLYLACKV--EEFNISIDQFVGNIKE 127

                        90       100
                ....*....|....*....|.
gi 41054928 127 NRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20524 128 SEKTAEIILEYELLLLQGLNF 148
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 55-147 1.53e-05

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 42.93  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  55 QVRELLsLTRFFGFCAE------TFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVKTseeEKNVPL-ASDLIRISQN 127
Cdd:cd20517   4 DNRKIL-LTWMFLVCESfeldknVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKI---RTVKPItVSKLTYLSCD 79

                        90       100
                ....*....|....*....|
gi 41054928 128 RFTVHDMMRMEKIILEKLNW 147
Cdd:cd20517  80 CFTNLELINQEKDILEALKW 99
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 34-147 1.76e-05

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 43.71  E-value: 1.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  34 LRVIESAQD------NGLRMTVKLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMKIQPKHLSCVGLCCFYIAVK 107
Cdd:cd20565  12 LRQLEEEQAvrpkylEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASK 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 41054928 108 TseEEKNVPLASDLIRISQNRFTVHDMMRMEKIILEKLNW 147
Cdd:cd20565  92 Y--EEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 50-147 1.94e-04

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 40.60  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  50 KLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMK-IQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNR 128
Cdd:cd20580  41 KMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDGA 118

                        90
                ....*....|....*....
gi 41054928 129 FTVHDMMRMEKIILEKLNW 147
Cdd:cd20580 119 CSEDDILDMELIILKALKW 137
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 50-147 2.83e-04

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 40.25  E-value: 2.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41054928  50 KLRDYQVRELLSLTRFFGFCAETFSFAVNLLDRFLAVMK-IQPKHLSCVGLCCFYIAVKTseEEKNVPLASDLIRISQNR 128
Cdd:cd20579  41 KMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIAAKL--EEIYPPKLHQFAYVTDGA 118

                        90
                ....*....|....*....
gi 41054928 129 FTVHDMMRMEKIILEKLNW 147
Cdd:cd20579 119 CTEDEILSMELIIMKALKW 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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