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Conserved domains on  [gi|40556298|ref|NP_955019|]
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PR domain zinc finger protein 10 isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 197-317 8.85e-74

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


:

Pssm-ID: 380971  Cd Length: 128  Bit Score: 223.77  E-value: 8.85e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 197 RARASLPLVLYIDRF---LGGVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHlkvsldkGDRKDRDLHEDLWFELSDET 273
Cdd:cd19194   1 RARASLPLILQIFRFgetLGGVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIH-------PLELEEDDGEDLYFDLSDEN 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40556298 274 LCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19194  74 KCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKV 117
zf_PR_Knuckle super family cl39781
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 167-194 1.07e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


The actual alignment was detected with superfamily member pfam18445:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 39.20  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 40556298   167 LWCEECNNAHSSVCPKHGPLHPIPNRPV 194
Cdd:pfam18445  11 IWCTLCERSYPSDCPEHGPVTFIPDTPI 38
 
Name Accession Description Interval E-value
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 197-317 8.85e-74

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 223.77  E-value: 8.85e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 197 RARASLPLVLYIDRF---LGGVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHlkvsldkGDRKDRDLHEDLWFELSDET 273
Cdd:cd19194   1 RARASLPLILQIFRFgetLGGVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIH-------PLELEEDDGEDLYFDLSDEN 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40556298 274 LCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19194  74 KCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKV 117
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 167-194 1.07e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 39.20  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 40556298   167 LWCEECNNAHSSVCPKHGPLHPIPNRPV 194
Cdd:pfam18445  11 IWCTLCERSYPSDCPEHGPVTFIPDTPI 38
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 214-315 4.25e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 36.73  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298   214 GVFSKRRIPKRTQFGP-VEGPLVRGSELKDCYIHLKVSLDKGDRKD--RDLHEDLWFELSDETLC--NWMMFVrpaqNH- 287
Cdd:pfam00856   3 GLFATEDIPKGEFIGEyVEVLLITKEEADKRELLYYDKLELRLWGPylFTLDEDSEYCIDARALYygNWARFI----NHs 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 40556298   288 ----LEQNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:pfam00856  79 cdpnCEVRVVYVNGGPRIVIFALRDIKPGEEL 110
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
214-315 7.27e-03

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 36.09  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSElkdcyihlkvsLDKGDRKDRDLHEDLwFELSDET-----LC-NWMMFVrpaqNH 287
Cdd:COG2940  19 GVFATRDIPKGTLIGEYPGEVITWAE-----------AERREPHKEPLHTYL-FELDDDGvidgaLGgNPARFI----NH 82

                        90       100
                ....*....|....*....|....*....
gi 40556298 288 -LEQNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:COG2940  83 sCDPNCEADEEDGRIFIVALRDIAAGEEL 111
 
Name Accession Description Interval E-value
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 197-317 8.85e-74

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 223.77  E-value: 8.85e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 197 RARASLPLVLYIDRF---LGGVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHlkvsldkGDRKDRDLHEDLWFELSDET 273
Cdd:cd19194   1 RARASLPLILQIFRFgetLGGVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIH-------PLELEEDDGEDLYFDLSDEN 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40556298 274 LCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19194  74 KCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKV 117
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 197-317 2.78e-28

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 106.35  E-value: 2.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 197 RARASLPLVLYIDRFLG---GVFSKRRIPKRTQFGPVEGPLVRgselkdcyihlkvSLDKGDRK-----DRDLHEdLWFE 268
Cdd:cd19199   2 RARSSLPDNLEIRQLEDgseGVFALVPLVKRTQFGPFEAKRVA-------------RLDGFAVFplkvfEKDGSV-VYLD 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 40556298 269 LSDETLCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19199  68 TSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRV 116
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 214-317 5.96e-26

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 98.81  E-value: 5.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLvrgselkdcyihlkvsldkgdrkdrdlhedlwfelsdetlcNWMMFVRPAQNHLEQNLV 293
Cdd:cd10534  18 GVFARRTIPAGTRFGPLEGVV-----------------------------------------NWMRFVRPARNEEEQNLV 56

                        90       100
                ....*....|....*....|....
gi 40556298 294 AYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd10534  57 AYQHGGQIYFRTTRDIPPGEELLV 80
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 197-315 1.91e-23

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 93.68  E-value: 1.91e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 197 RARASLPLVLYIDR-FLG---GVFSKRRIPKRTQFGPVEGPLVRGSELKDcyihlkvSLDKGDRK-----DRDLHEDLwF 267
Cdd:cd19189   1 RARLSLPRQLYLRQsETGaevGVWTKETIPVRTCFGPLIGQQSHSAEVAD-------WTDKAAPHiwkiyHNDVLEFC-I 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 40556298 268 ELSDETLCNWMMFVRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:cd19189  73 ITTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQEL 120
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 214-317 5.98e-19

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 81.60  E-value: 5.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPL------VRGSELKDCY-IHlkvsldkgdrKDRDLHedLWFELSDETLCNWMMFVRPAQN 286
Cdd:cd19187  20 GVWSSDYIPRGTRFGPLVGEIytndpvPKGANRKYFWrIY----------SNGEFY--HYIDGFDPSKSNWMRYVNPAHS 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 40556298 287 HLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19187  88 LQEQNLVACQIGMNIYFYTVKPIPPNQELLV 118
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 214-317 3.10e-18

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 79.59  E-value: 3.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELKDC-YIHLkvsLDKGDRKDrdlhedLWFELSDETLCNWMMFVRPAQNHLEQNL 292
Cdd:cd19193  21 GVWAEAPIPKGMVFGPYEGEIVEDEEAADSgYSWQ---IYKGGKLS------HYIDAKDESKSNWMRYVNCARNEEEQNL 91

                        90       100
                ....*....|....*....|....*
gi 40556298 293 VAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19193  92 VAFQYRGKIYYRTCKDIAPGTELLV 116
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 214-317 1.19e-14

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 69.69  E-value: 1.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELkdcyihlkvsldkgdrkDRDLHEDLWFEL-------------SDETLCNWMMF 280
Cdd:cd19196  18 GVFSKTWIKEGTEMGPYTGRIVSPEDV-----------------DPCKNNNLMWEVfnedgtvshfidaSQENHRSWMTF 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 40556298 281 VRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19196  81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLV 117
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 213-317 4.86e-14

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 67.75  E-value: 4.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 213 GGVFSKRRIPKRTQFGPVEGPLVRGSELKDcyihlkvslDKGDRKDRDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNL 292
Cdd:cd19201  20 GGVWAKQPLPEGTRFGPYPGKLVKEPLDPS---------YEWKVEAQGSKGGEGLLLLTEDSGTWLKLVRSADDEDEANL 90

                        90       100
                ....*....|....*....|....*
gi 40556298 293 VAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19201  91 ILYFKGGQIWCEVTKDIPPGEELIL 115
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 214-324 1.06e-13

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 67.04  E-value: 1.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELKDcyihlkvsldkgdrkdrdlHED---LWFELSDETLC----------NWMMF 280
Cdd:cd19198  21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKT-------------------YDDnsfMWEIFEDGKLShfidgrgstgNWMSY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40556298 281 VRPAQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKVqnWIHSC 324
Cdd:cd19198  82 VNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLV--WYGDC 123
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 214-317 2.19e-13

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 65.93  E-value: 2.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHLKVSLDKGDrkdrdlhedlWF--ELSDETLCNWMMFVRPAQNHLEQN 291
Cdd:cd19188  21 GVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRG----------WMcvDASDPTKGNWLRYVNWARSGEEQN 90

                        90       100
                ....*....|....*....|....*.
gi 40556298 292 LVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19188  91 LFPLQINRAIYYKTLKPIAPGEELLC 116
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 214-317 1.31e-12

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 64.31  E-value: 1.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGplVRGSELKDCYIHLKVSLDKGdrkdrdlHEDLWFELSDETLCNWMMFVRPAQNHLEQNLV 293
Cdd:cd19200  27 GVWTKVRIEVGEKFGPFVG--VQRSSVKDPTYAWEIVDEFG-------KVKFWIDASEPGTGNWMKYIRSAPSCEQQNLM 97

                        90       100
                ....*....|....*....|....
gi 40556298 294 AYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19200  98 ACQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 221-317 6.42e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 55.60  E-value: 6.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 221 IPKRTQFGPVEGPLVRG---SELKDCYIHLKVSLDKGDRKDrdlhedlwfELSDETLCNWMMFVRPAQNHLEQNLVAYQ- 296
Cdd:cd19197   1 IPAGLRLGPVPGIFKLGkylSDRKEPGNKKKVRRVRGDYLV---------DESGSPATEWIGLVRAARNNQEQNLEAIAd 71

                        90       100
                ....*....|....*....|..
gi 40556298 297 -YGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19197  72 lPGGQIFYRALRDIQPGEELTV 93
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 214-317 3.43e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 55.27  E-value: 3.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGplVRGSELKDCYIHLKVSL-DKGDRKDRDLHEDLWFELSDETLC---------NWMMFVRP 283
Cdd:cd19213  37 GVWAKRKIEAGERFGPYTG--VQRSTLKDTNFGWEQILnDVEVSSQEGCITKIVDDLGNEKFCvdagqagagSWLKYIRV 114

                        90       100       110
                ....*....|....*....|....*....|....
gi 40556298 284 AQNHLEQNLVAYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19213 115 ACSCDEQNLTACQINEQIYYKVIKDIEPGEELLV 148
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 221-317 1.72e-08

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 52.17  E-value: 1.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 221 IPKRTQFGPVEGPLVRGSELKDCYIHLKVslDKGDRKDRdlhedlwFELSDETLCNWMMFVRPAQNHLEQNLVAYQYGHH 300
Cdd:cd19195  28 IPKGHIFGPYEGQICTQDKSSGFFSWLIV--DKNNRYKS-------IDGSDETKANWMRYVVISREEREQNLLAFQHSEQ 98

                        90
                ....*....|....*..
gi 40556298 301 VYYTTIKNVEPKQELKV 317
Cdd:cd19195  99 IYFRACRDIRPGEKLRV 115
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 214-317 1.93e-08

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 52.09  E-value: 1.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHLKVSLDKGDRKDRDLHedlWFELSDETLCNWMMFVRPAQNHLEQNLV 293
Cdd:cd19191  18 GICAAQRIPQGTWIGPFEGVLVSPEKQIGAVRNTQHLWEIYDQEGTLQH---FIDGGDPSKSSWMRYIRCARHCGEQNLT 94

                        90       100
                ....*....|....*....|....
gi 40556298 294 AYQYGHHVYYTTIKNVEPKQELKV 317
Cdd:cd19191  95 VVQYRGCIFYRACRDIPRGTELLV 118
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 214-315 4.90e-07

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 48.06  E-value: 4.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSELK---DCYIHLKVSLDKGdrkdrdlhEDLW-FELSDETLCNWMMFVRPAQNHLE 289
Cdd:cd19190  21 GLYTARRVKKGEKFGPFAGEKRMPNELDesmDPRLMWEVRGSKG--------EVLYiLDASNPRHSNWLRFVHEAPSQEQ 92

                        90       100
                ....*....|....*....|....*.
gi 40556298 290 QNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:cd19190  93 KNLAAIQEGENIFYLAVDDIETDTEL 118
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 214-315 3.17e-06

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 46.47  E-value: 3.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPlvRGSELKDCYIHLKVSLDKGDRKdrdlhedLWFELSDETLCNWMMFVRPAQNHLEQNLV 293
Cdd:cd19214  47 GIWTKRKIEVGEKFGPYVGE--QRSNLKDPSYGWEVLDEFGNVK-------FCIDASQPDVGSWLKYIRFAGCYDQHNLV 117

                        90       100
                ....*....|....*....|..
gi 40556298 294 AYQYGHHVYYTTIKNVEPKQEL 315
Cdd:cd19214 118 ACQINDQIFYRAVADIDPGEEL 139
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 195-317 2.90e-05

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 43.19  E-value: 2.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 195 LTRARASLPLvlyiDRFLGGVFSKRRIPKRTQFGPVEGPLVRGSELKDCYIHLKV--------SLDKGDRKDrdlhedlw 266
Cdd:cd19192   6 LWRGGSKSVL----TDIFTSVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDkrvvpyifRVDTGACNG-------- 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40556298 267 felSDETLcNWMMFVRPAQNHLEQNLVAYQYGH-HVYYTTIKNVEPKQELKV 317
Cdd:cd19192  74 ---SSEPS-DWLRLVQPARDRHEQNLEAFRKNEgQVYFRTLRRIRKGEELLV 121
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 167-194 1.07e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 39.20  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*...
gi 40556298   167 LWCEECNNAHSSVCPKHGPLHPIPNRPV 194
Cdd:pfam18445  11 IWCTLCERSYPSDCPEHGPVTFIPDTPI 38
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 214-315 4.25e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 36.73  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298   214 GVFSKRRIPKRTQFGP-VEGPLVRGSELKDCYIHLKVSLDKGDRKD--RDLHEDLWFELSDETLC--NWMMFVrpaqNH- 287
Cdd:pfam00856   3 GLFATEDIPKGEFIGEyVEVLLITKEEADKRELLYYDKLELRLWGPylFTLDEDSEYCIDARALYygNWARFI----NHs 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 40556298   288 ----LEQNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:pfam00856  79 cdpnCEVRVVYVNGGPRIVIFALRDIKPGEEL 110
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
214-315 7.27e-03

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 36.09  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40556298 214 GVFSKRRIPKRTQFGPVEGPLVRGSElkdcyihlkvsLDKGDRKDRDLHEDLwFELSDET-----LC-NWMMFVrpaqNH 287
Cdd:COG2940  19 GVFATRDIPKGTLIGEYPGEVITWAE-----------AERREPHKEPLHTYL-FELDDDGvidgaLGgNPARFI----NH 82

                        90       100
                ....*....|....*....|....*....
gi 40556298 288 -LEQNLVAYQYGHHVYYTTIKNVEPKQEL 315
Cdd:COG2940  83 sCDPNCEADEEDGRIFIVALRDIAAGEEL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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