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Conserved domains on  [gi|41152508|ref|NP_954887|]
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cystatin-related protein 2 precursor [Rattus norvegicus]

Protein Classification

C1 family peptidase; cystatin family protein( domain architecture ID 10036435)

C1 family peptidase (also called papain family protein) is a papain-like cysteine peptidase that catalyzes the hydrolysis of peptide bonds in substrates using a catalytic dyad of Cys and His residues| cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 117-174 8.57e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 45.50  E-value: 8.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41152508    117 TIYYITLP-GSVRCRKLLSKLVNCPFEEQTEqlkrEICYFQLYPDYIEQNIRSVRFNCY 174
Cdd:smart00043  53 TNYYLKVEvGETNCKKLSVDLENCPFLDQGE----KFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 41-135 3.23e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 40.92  E-value: 3.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152508  41 MEKNKLNDVYDIFKFLYNKFSHDTYLSNIKNQSFTMNTW-GFGEIEVVKTKCRKIDSDFYKCSFQWEFCNIKRTPGVTIY 119
Cdd:cd00042   8 ANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVaGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTA 87

                        90
                ....*....|....*.
gi 41152508 120 YITLPGSVRCRKLLSK 135
Cdd:cd00042  88 KVWEKPWENFKELLSF 103
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 117-174 8.57e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.50  E-value: 8.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41152508    117 TIYYITLP-GSVRCRKLLSKLVNCPFEEQTEqlkrEICYFQLYPDYIEQNIRSVRFNCY 174
Cdd:smart00043  53 TNYYLKVEvGETNCKKLSVDLENCPFLDQGE----KFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 41-135 3.23e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 40.92  E-value: 3.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152508  41 MEKNKLNDVYDIFKFLYNKFSHDTYLSNIKNQSFTMNTW-GFGEIEVVKTKCRKIDSDFYKCSFQWEFCNIKRTPGVTIY 119
Cdd:cd00042   8 ANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVaGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTA 87

                        90
                ....*....|....*.
gi 41152508 120 YITLPGSVRCRKLLSK 135
Cdd:cd00042  88 KVWEKPWENFKELLSF 103
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 117-174 8.57e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.50  E-value: 8.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 41152508    117 TIYYITLP-GSVRCRKLLSKLVNCPFEEQTEqlkrEICYFQLYPDYIEQNIRSVRFNCY 174
Cdd:smart00043  53 TNYYLKVEvGETNCKKLSVDLENCPFLDQGE----KFCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 41-135 3.23e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 40.92  E-value: 3.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152508  41 MEKNKLNDVYDIFKFLYNKFSHDTYLSNIKNQSFTMNTW-GFGEIEVVKTKCRKIDSDFYKCSFQWEFCNIKRTPGVTIY 119
Cdd:cd00042   8 ANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVaGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEEGKKKFCTA 87

                        90
                ....*....|....*.
gi 41152508 120 YITLPGSVRCRKLLSK 135
Cdd:cd00042  88 KVWEKPWENFKELLSF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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