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Conserved domains on  [gi|40354201|ref|NP_954653|]
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5-hydroxymethyl-dUMP N-hydrolase isoform 2 [Homo sapiens]

Protein Classification

TIR domain-containing protein( domain architecture ID 581104)

TIR (Toll/interleukin-1 receptor) domain-containing protein

CATH:  3.40.50.10140
PubMed:  32002590|29395922|34868065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nuc_deoxyrib_tr super family cl46294
Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 ...
 23-131 1.41e-23

Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyzes the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.


The actual alignment was detected with superfamily member pfam05014:

Pssm-ID: 480634  Cd Length: 117  Bit Score: 88.50  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40354201    23 LYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGarGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQ--PSLG 100
Cdd:pfam05014   1 IYLAGPLVFLPDAKAYYARLRALLAQNGTDGLYPLEDNEAG--LEPAAEWARAIYRADIAGIRAADAVIANLDPfrPDSG 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 40354201   101 VGYELGRAVAFNKRILCL---FRPQSGRGE-HPKP 131
Cdd:pfam05014  79 TAFELGYAAALGKPVLGYttdFRPYRLCVEdFGLP 113
 
Name Accession Description Interval E-value
Nuc_deoxyrib_tr pfam05014
Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 ...
 23-131 1.41e-23

Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyzes the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.


Pssm-ID: 461520  Cd Length: 117  Bit Score: 88.50  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40354201    23 LYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGarGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQ--PSLG 100
Cdd:pfam05014   1 IYLAGPLVFLPDAKAYYARLRALLAQNGTDGLYPLEDNEAG--LEPAAEWARAIYRADIAGIRAADAVIANLDPfrPDSG 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 40354201   101 VGYELGRAVAFNKRILCL---FRPQSGRGE-HPKP 131
Cdd:pfam05014  79 TAFELGYAAALGKPVLGYttdFRPYRLCVEdFGLP 113
RCL COG3613
Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism];
31-126 2.51e-16

Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism];


Pssm-ID: 442831  Cd Length: 142  Bit Score: 70.78  E-value: 2.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40354201  31 GGREDRTLYERIVSRLRRFG-TVLTEHVAAAElgARGEEAAGGDRLIHEQDLEWLQQADVVVAEVT--QPSLGVGYELGR 107
Cdd:COG3613   6 FSPDERERNERLKALLREHGfEVFSPQDDQAE--EEGLAAEETAEAIFQADLAAIRRADLVVANLDgaEPDSGTAFEIGY 83

                        90       100
                ....*....|....*....|..
gi 40354201 108 AVAFNKRILCL---FRPQSGRG 126
Cdd:COG3613  84 AYALGKPVIGYttdDRPLGERG 105
 
Name Accession Description Interval E-value
Nuc_deoxyrib_tr pfam05014
Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 ...
 23-131 1.41e-23

Nucleoside 2-deoxyribosyltransferase; Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyzes the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides.


Pssm-ID: 461520  Cd Length: 117  Bit Score: 88.50  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40354201    23 LYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGarGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQ--PSLG 100
Cdd:pfam05014   1 IYLAGPLVFLPDAKAYYARLRALLAQNGTDGLYPLEDNEAG--LEPAAEWARAIYRADIAGIRAADAVIANLDPfrPDSG 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 40354201   101 VGYELGRAVAFNKRILCL---FRPQSGRGE-HPKP 131
Cdd:pfam05014  79 TAFELGYAAALGKPVLGYttdFRPYRLCVEdFGLP 113
RCL COG3613
Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism];
31-126 2.51e-16

Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism];


Pssm-ID: 442831  Cd Length: 142  Bit Score: 70.78  E-value: 2.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40354201  31 GGREDRTLYERIVSRLRRFG-TVLTEHVAAAElgARGEEAAGGDRLIHEQDLEWLQQADVVVAEVT--QPSLGVGYELGR 107
Cdd:COG3613   6 FSPDERERNERLKALLREHGfEVFSPQDDQAE--EEGLAAEETAEAIFQADLAAIRRADLVVANLDgaEPDSGTAFEIGY 83

                        90       100
                ....*....|....*....|..
gi 40354201 108 AVAFNKRILCL---FRPQSGRG 126
Cdd:COG3613  84 AYALGKPVIGYttdDRPLGERG 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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