BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203    1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203   81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 255003719 333 IKCTKCPEVFQGVEKLVFHMRAQHFifMCPRCGKQFNHSSNLNRH-MNVHR 382
Cdd:cd20908    2 PWCYYCDREFDDEKILIQHQKAKHF--KCHICHKKLYTAGGLAVHcLQVHK 50

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719 361 CPRCGKQFNHSSNLN---RHMNVHRG-VKSHSCGICGKCFTQKSTLHDHLN--LHSG--ARPYRC--SYCDVRFAHKPAI 430
Cdd:COG5048  260 SPRSSLPTASSQSSSpneSDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDAL 339

                         90
                 ....*....|....*...
gi 255003719 431 RRHLKEQHGKTTAENVLE 448
Cdd:COG5048  340 KRHILLHTSISPAKEKLL 357

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203    1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203   81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719    34 DVTIVADSLKFRGHKVILAACSPFLRDQFLLNP--SSELQVSLMH-SARIVADLLLSCYTGALEFAVRDIVNYLTAASYL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDvSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 255003719   111 QMEHVVEKCRNALSQFI 127
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 255003719  359 FMCPRCGKQFNHSSNLNRHMNVH 381
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 255003719  373 NLNRHMNVHRGVKSHSCGICGKCFTQ 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719 326 SGNPLKNiKC--TKCPEVFQGVEKLVFHMRAQHFIFMCPRCG---KQFNH------SSNLNRHMNV---HRGVKSHS-CG 390
Cdd:COG5236  146 MEDLLSF-KCpkSKCHRRCGSLKELKKHYKAQHGFVLCSECIgnkKDFWNeirlfrSSTLRDHKNGgleEEGFKGHPlCI 224

                         90       100       110
                 ....*....|....*....|....*....|.
gi 255003719 391 ICGKCFTQKSTLHDHLNLhsgaRPYRCSYCD 421
Cdd:COG5236  225 FCKIYFYDDDELRRHCRL----RHEACHICD 251

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 255003719  415 YRCSYCDVRFAHKPAIRRHLKEQHG 439
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203    1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203   81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18197    1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18197   81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18220    1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18220   81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQF---------LLNPSSELQVSLMH-SARIVADL 84
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvLVSPAGKCVLDLHHvTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 255003719  85 LLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCrnalSQFIEPKI 131
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC----SEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  32 FCDVTIVADSLKFRGHKVILAACSPFLRDQFL--LNPSSELQVSL-MHSARIVADLLLSCYTGALEFAVRDIVNYLTAAS 108
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSsgMKESSSSEIELdDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                 ..
gi 255003719 109 YL 110
Cdd:cd18186   81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLSCYTGALE 94
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 255003719  95 FAVRDIVNYLTAASYLQMEHVVEKCRNALSQ 125
Cdd:cd18200   81 LCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  20 LRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLlnpsSELQVSLMHSARI-------VADLLLSCYTGA 92
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFT----SEMAESKQDSITIkdideeaVELLVDFAYTGK 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  93 LEFAVRDIVNYLTAASYLQMEHVVEKCrnalSQFIE 128
Cdd:cd18238   79 LTLTVDNVQSLLYAASLLQVEEVAKAC----CEFMK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSLMHSARI------VADLLLS- 87
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF----AGGMSESSKDVVQIhgvepdIFHILLDf 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18256   79 IYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   6 EVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLL 85
Cdd:cd18289    3 QMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQIL 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 255003719  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEK 118
Cdd:cd18289   83 SFCYTGKLTMAASEQLVVMYTAGFLQIQHIVER 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  14 GHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFL--LNPSSELQVSLMH-SARIVADLLLSCYT 90
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTseMSEKGKSEVELQGlTASTMEILLDFVYT 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255003719  91 GALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSLMH-------SARIVADLL 85
Cdd:cd18250    2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF----AGELRESRADrvvlhgvSAEILGLLL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 255003719  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18250   78 DFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSLMHSARI-------VADLL 85
Cdd:cd18338    2 PRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMF----TGEMSESRAKRVRIkevdgwtLKMLI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 255003719  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18338   78 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  18 ATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNpSSELQVSLMHSARIVADLLLSCYTGALEFAV 97
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG-YSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQ 89

                         90       100
                 ....*....|....*....|....*...
gi 255003719  98 RDIVNYLTAASYLQMEHVVEKCRNALSQ 125
Cdd:cd18208   90 SEALQILTAASILQIKTVIDECTRIVSQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719   6 EVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLL 85
Cdd:cd18290    1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQIL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 255003719  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEK 118
Cdd:cd18290   81 SFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSlmHSARIV-------ADLL 85
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF----TGDLSES--RANRVTlqdvdgkALLL 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  86 L--SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKC 119
Cdd:cd18235   76 LidYVYTAEIQVTEENVQVLLPAANLLQLTDVRDAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACS----PFLRDQFLLNpSSELQVSLMHSARIVADLLL 86
Cdd:cd18331    3 QFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSglfySIFTDQLKCN-LSVINLDPEINPEGFNILLD 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 255003719  87 SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCR 120
Cdd:cd18331   82 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSP----FLRDQFLLNPSSELQVSLMhSARIVADLLL 86
Cdd:cd18325    2 EFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMyfhlFYRDQLDKRDIVHLNSDIV-TAPAFSLLLE 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 255003719  87 SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18325   81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKL 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  32 FCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMH--SARIVADLLLSCYTGALEFAVRDIVNYLTAASY 109
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPdvPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ..
gi 255003719 110 LQ 111
Cdd:cd18315   81 LQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSP----FLRDQFLLNPSSELQVSLMhSARIVADLLL 86
Cdd:cd18324    2 EFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMyfhlFYKDQLDKRDIVHLNSDIV-TAPAFALLLE 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 255003719  87 SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQ 125
Cdd:cd18324   81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  14 GHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLN---PSSELQVSLM-HSARIVADLLLSCY 89
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgavSSHEAVVDLSgFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 255003719  90 TGALEFAVRDIVNYLTAASYLQMEHVVEKCRN 121
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEICES 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  20 LRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNP----SSELQVSLMH-SARIVADLLLSCYTGAL- 93
Cdd:cd18245    2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPpkddGSTYKIELEGiSVEVMEEILDYIYTGQIk 81

                         90       100
                 ....*....|....*....|....*...
gi 255003719  94 --EFAVRDIVNyltAASYLQMEHVVEKC 119
Cdd:cd18245   82 lsEDNIQDIVQ---AADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255003719  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSL---MHSARIVADLLLS 87
Cdd:cd18194    2 EFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLnsdIVTAPAFGLLLDF 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 255003719  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18194   82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRL 117