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Conserved domains on  [gi|225543323|ref|NP_941073|]
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genetic suppressor element 1 isoform 1 [Mus musculus]

Protein Classification

DUF3736 domain-containing protein( domain architecture ID 10576119)

DUF3736 domain-containing protein similar to Genetic suppressor element 1 (GSE1), which is a proline rich protein that may function as a novel oncogene in breast cancer

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3736 pfam12540
Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is ...
 742-883 4.62e-32

Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.


:

Pssm-ID: 463624 [Multi-domain]  Cd Length: 135  Bit Score: 121.83  E-value: 4.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543323   742 QRRKLVSKLDLEERRRREAQEKGYYYDlddsydESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELV 821
Cdd:pfam12540    1 QLRRLVSKLDLEEKRRKEARENGDSYD------ESDEEEVRAELLKVPSQPPLKLDASVEKVAFLRTFGLTTLQMRKELI 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543323   822 AQKRRKRRRMLRERSPSPPAVQcKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLT 883
Cdd:pfam12540   75 IEKRRKRRRMLQERSPSPPAVS-KRTTPTPPHLLSTPYSPEEMVQDPDFEDKKRFLAQFPLS 135
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1127-1204 1.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543323 1127 RQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAELRSQKQKMVSERERLQAELDHLRK 1204
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309
 
Name Accession Description Interval E-value
DUF3736 pfam12540
Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is ...
 742-883 4.62e-32

Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.


Pssm-ID: 463624 [Multi-domain]  Cd Length: 135  Bit Score: 121.83  E-value: 4.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543323   742 QRRKLVSKLDLEERRRREAQEKGYYYDlddsydESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELV 821
Cdd:pfam12540    1 QLRRLVSKLDLEEKRRKEARENGDSYD------ESDEEEVRAELLKVPSQPPLKLDASVEKVAFLRTFGLTTLQMRKELI 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543323   822 AQKRRKRRRMLRERSPSPPAVQcKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLT 883
Cdd:pfam12540   75 IEKRRKRRRMLQERSPSPPAVS-KRTTPTPPHLLSTPYSPEEMVQDPDFEDKKRFLAQFPLS 135
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1127-1204 1.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543323 1127 RQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAELRSQKQKMVSERERLQAELDHLRK 1204
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309
 
Name Accession Description Interval E-value
DUF3736 pfam12540
Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is ...
 742-883 4.62e-32

Protein of unknown function (DUF3736); This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.


Pssm-ID: 463624 [Multi-domain]  Cd Length: 135  Bit Score: 121.83  E-value: 4.62e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543323   742 QRRKLVSKLDLEERRRREAQEKGYYYDlddsydESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELV 821
Cdd:pfam12540    1 QLRRLVSKLDLEEKRRKEARENGDSYD------ESDEEEVRAELLKVPSQPPLKLDASVEKVAFLRTFGLTTLQMRKELI 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 225543323   822 AQKRRKRRRMLRERSPSPPAVQcKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLT 883
Cdd:pfam12540   75 IEKRRKRRRMLQERSPSPPAVS-KRTTPTPPHLLSTPYSPEEMVQDPDFEDKKRFLAQFPLS 135
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1127-1204 1.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543323 1127 RQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAELRSQKQKMVSERERLQAELDHLRK 1204
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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