NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|37675387|ref|NP_922945|]
View 

C-type lectin domain family 7 member A isoform f [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ly49 super family cl07131
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
40-67 2.92e-09

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


The actual alignment was detected with superfamily member pfam08391:

Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 49.28  E-value: 2.92e-09
                          10        20
                  ....*....|....*....|....*...
gi 37675387    40 SPPWRLIAVILGILCLVILVIAVVLGTM 67
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTK 28
 
Name Accession Description Interval E-value
Ly49 pfam08391
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
40-67 2.92e-09

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 49.28  E-value: 2.92e-09
                          10        20
                  ....*....|....*....|....*...
gi 37675387    40 SPPWRLIAVILGILCLVILVIAVVLGTM 67
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTK 28
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
29-71 2.50e-03

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 33.12  E-value: 2.50e-03
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 37675387 29 AVVSEKG-SCAASPPWRLIAVILGILCLVILViaVVLGTMAGFK 71
Cdd:cd21701  6 SVRSEPGpATKTTPPAQLSPLVVAAVCVLLVL--VVLGVLVARK 47
 
Name Accession Description Interval E-value
Ly49 pfam08391
Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or ...
40-67 2.92e-09

Ly49-like protein, N-terminal region; The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).


Pssm-ID: 462461 [Multi-domain]  Cd Length: 119  Bit Score: 49.28  E-value: 2.92e-09
                          10        20
                  ....*....|....*....|....*...
gi 37675387    40 SPPWRLIAVILGILCLVILVIAVVLGTM 67
Cdd:pfam08391   1 SVPWHLIVIALGILCSLLLVTVAVLGTK 28
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
29-71 2.50e-03

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 33.12  E-value: 2.50e-03
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 37675387 29 AVVSEKG-SCAASPPWRLIAVILGILCLVILViaVVLGTMAGFK 71
Cdd:cd21701  6 SVRSEPGpATKTTPPAQLSPLVVAAVCVLLVL--VVLGVLVARK 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH