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Conserved domains on  [gi|656214632|ref|NP_919407|]
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platelet-derived growth factor alpha polypeptide a precursor [Danio rerio]

Protein Classification

PDGF_N and PDGF domain-containing protein( domain architecture ID 10520088)

PDGF_N and PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-94 2.10e-31

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


:

Pssm-ID: 461394  Cd Length: 78  Bit Score: 109.06  E-value: 2.10e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 656214632   21 EEAPIPRELIERLSNSEIHSISDLQRILEMDFLENEVLEDVKQGH--HKEHLYDSRNLKN--LHSRRKRSIEEAVPAV 94
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHraHSDHSSSSVDLKRrqLHSRRKRSIEEAVPAV 78
PDGF pfam00341
PDGF/VEGF domain;
95-178 2.19e-28

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 101.21  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632   95 CKTRTVIYEIPRSQVDPTAANFLiwPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQVQLEDHL 174
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 656214632  175 ECVC 178
Cdd:pfam00341  79 QCEC 82
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-94 2.10e-31

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 109.06  E-value: 2.10e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 656214632   21 EEAPIPRELIERLSNSEIHSISDLQRILEMDFLENEVLEDVKQGH--HKEHLYDSRNLKN--LHSRRKRSIEEAVPAV 94
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHraHSDHSSSSVDLKRrqLHSRRKRSIEEAVPAV 78
PDGF pfam00341
PDGF/VEGF domain;
95-178 2.19e-28

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 101.21  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632   95 CKTRTVIYEIPRSQVDPTAANFLiwPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQVQLEDHL 174
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 656214632  175 ECVC 178
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 93-178 8.66e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 92.10  E-value: 8.66e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632    93 AVCKTRTVIYEIPRSQVDPTaaNFLIWPPCVEVRRCSGCCNTSNMRCHPSKKHhrNVKVAKVEYVRRRPKlREVQVQLED 172
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETS--NVTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*.
gi 656214632   173 HLECVC 178
Cdd:smart00141  76 HTKCEC 81
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 93-181 4.34e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 87.81  E-value: 4.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632  93 AVCKTRTVIYEIPRSQVDPTaaNFLIWPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVrRRPKLREVQVQLED 172
Cdd:cd00135    1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPK-RKPRSKLVEISFEE 77


                 ....*....
gi 656214632 173 HLECVCTSR 181
Cdd:cd00135   78 HTECECRPR 86
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 120-178 5.78e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 44.23  E-value: 5.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632 120 PPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQV-QLEDHLECVC 178
Cdd:PHA02661  71 PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEHTKCKC 130
 
Name Accession Description Interval E-value
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-94 2.10e-31

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 109.06  E-value: 2.10e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 656214632   21 EEAPIPRELIERLSNSEIHSISDLQRILEMDFLENEVLEDVKQGH--HKEHLYDSRNLKN--LHSRRKRSIEEAVPAV 94
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHraHSDHSSSSVDLKRrqLHSRRKRSIEEAVPAV 78
PDGF pfam00341
PDGF/VEGF domain;
95-178 2.19e-28

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 101.21  E-value: 2.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632   95 CKTRTVIYEIPRSQVDPTAANFLiwPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQVQLEDHL 174
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 656214632  175 ECVC 178
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 93-178 8.66e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 92.10  E-value: 8.66e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632    93 AVCKTRTVIYEIPRSQVDPTaaNFLIWPPCVEVRRCSGCCNTSNMRCHPSKKHhrNVKVAKVEYVRRRPKlREVQVQLED 172
Cdd:smart00141   1 SQCKPRETVVEVSREYPDET--NFLFKPPCVTVKRCGGCCNDEGLECVPTETS--NVTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*.
gi 656214632   173 HLECVC 178
Cdd:smart00141  76 HTKCEC 81
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 93-181 4.34e-23

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 87.81  E-value: 4.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632  93 AVCKTRTVIYEIPRSQVDPTaaNFLIWPPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVrRRPKLREVQVQLED 172
Cdd:cd00135    1 SSCKPRETLVEISEELPDET--NTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPK-RKPRSKLVEISFEE 77


                 ....*....
gi 656214632 173 HLECVCTSR 181
Cdd:cd00135   78 HTECECRPR 86
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 120-178 5.78e-06

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 44.23  E-value: 5.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 656214632 120 PPCVEVRRCSGCCNTSNMRCHPSKKHHRNVKVAKVEYVRRRPKLREVQV-QLEDHLECVC 178
Cdd:PHA02661  71 PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNFQTiSVEEHTKCKC 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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