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Conserved domains on  [gi|34485720|ref|NP_899243|]
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echinoderm microtubule-associated protein-like 5 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1063 1.76e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  725 GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWDWK 804
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSD--KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  805 KGEKLSIARGSKDKIFVVKMNPYvpDKLITAGIKH--MKFWRKAGGGLIGRkgyigTLGKNDTMMCAVYGWTEEMAFSGT 882
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  883 STGDVCIW--RDIFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYaikraalapgskgllledn 958
Cdd:cd00200  155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTL------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  959 psiraislghghilvgtkngeilevdksgpitllvQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
Cdd:cd00200  216 -----------------------------------RGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        330       340
                 ....*....|....*....|....*
gi 34485720 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 9.76e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 9.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  293 --GDHILVGTQDSEIfEIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319  256 pdGRLLASGSADGTV-RLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34485720  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1428-1815 1.37e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 1.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1507
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1508 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1585
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1586 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1663
Cdd:COG2319  221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1664 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1743
Cdd:COG2319  281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34485720 1744 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1815
Cdd:COG2319  329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
895-1266 2.10e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTY-----AIKRAALAPGSKglllednpsiraislg 967
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGrlLASASADGTVRLWDLATGLLLRTLtghtgAVRSVAFSPDGK---------------- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  968 hgHILVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGG 1043
Cdd:COG2319  134 --TLASGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1044 RCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNVMSSKRVGICKG 1123
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1124 ATSYITHIDWDIRGKLLqvntgakeqlffeAPRGKKQTIpsveveKIawasWTSVLGLCcegIWPVIGEVTDVTASCLTS 1203
Cdd:COG2319  287 HSGGVNSVAFSPDGKLL-------------ASGSDDGTV------RL----WDLATGKL---LRTLTGHTGAVRSVAFSP 340

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34485720 1204 DKMVLATGDDLGFVKLFRYPTKGKFGKFKryvAHSTHVTNVRWTYDDSMLVTlGGTDMSLMVW 1266
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 7.08e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.08e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 34485720      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1697-1970 2.90e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 2.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1697 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1774
Cdd:cd00200    5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1775 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1845
Cdd:cd00200   75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1846 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1923
Cdd:cd00200  150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 34485720 1924 FDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1970
Cdd:cd00200  204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 9.09e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 9.09e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 34485720    672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1339-1410 8.86e-15

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.66  E-value: 8.86e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34485720   1339 VRGSRPPVSraPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451    4 IRGRPGAVY--PPSNYYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1063 1.76e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  725 GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWDWK 804
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSD--KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  805 KGEKLSIARGSKDKIFVVKMNPYvpDKLITAGIKH--MKFWRKAGGGLIGRkgyigTLGKNDTMMCAVYGWTEEMAFSGT 882
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  883 STGDVCIW--RDIFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYaikraalapgskgllledn 958
Cdd:cd00200  155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTL------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  959 psiraislghghilvgtkngeilevdksgpitllvQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
Cdd:cd00200  216 -----------------------------------RGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        330       340
                 ....*....|....*....|....*
gi 34485720 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
720-1112 6.32e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 6.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  720 QRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVV 799
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSAD--GTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  800 LWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGGGLIgrkgyigtlgkndtmmcavygwtee 876
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLL------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  877 mafsgtstgdvciwrdiflvKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYAikraalapgskgll 954
Cdd:COG2319  198 --------------------RTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWDLATGKLLRTLT-------------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  955 lEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLS 1028
Cdd:COG2319  244 -GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGELLRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1029 PSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFID 1108
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                 ....
gi 34485720 1109 IYNV 1112
Cdd:COG2319  398 LWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 9.76e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 9.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  293 --GDHILVGTQDSEIfEIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319  256 pdGRLLASGSADGTV-RLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34485720  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1428-1815 1.37e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 1.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1507
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1508 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1585
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1586 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1663
Cdd:COG2319  221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1664 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1743
Cdd:COG2319  281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34485720 1744 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1815
Cdd:COG2319  329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-353 4.88e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 4.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  213 SGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlretdqgYKGLSVR 287
Cdd:cd00200  152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  288 SVCW--RGDHILVGTQDS--EIFEIVVQERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200  224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
895-1266 2.10e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTY-----AIKRAALAPGSKglllednpsiraislg 967
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGrlLASASADGTVRLWDLATGLLLRTLtghtgAVRSVAFSPDGK---------------- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  968 hgHILVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGG 1043
Cdd:COG2319  134 --TLASGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1044 RCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNVMSSKRVGICKG 1123
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1124 ATSYITHIDWDIRGKLLqvntgakeqlffeAPRGKKQTIpsveveKIawasWTSVLGLCcegIWPVIGEVTDVTASCLTS 1203
Cdd:COG2319  287 HSGGVNSVAFSPDGKLL-------------ASGSDDGTV------RL----WDLATGKL---LRTLTGHTGAVRSVAFSP 340

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34485720 1204 DKMVLATGDDLGFVKLFRYPTKGKFGKFKryvAHSTHVTNVRWTYDDSMLVTlGGTDMSLMVW 1266
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1476-1778 7.80e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 7.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1476 HSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLagra 1554
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSdKTIRLWDL---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1555 llSKKGLLSTLEDARmQTMLAIAFGANNLTFTGTIS-GDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDGLIVTGgker 1632
Cdd:cd00200   81 --ETGECVRTLTGHT-SYVSSVAFSPDGRILSSSSRdKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS---- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1633 pSKEGGAVKLWD-QELRRCRAFRLETGQatdcVRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLA 1709
Cdd:cd00200  153 -SSQDGTIKLWDlRTGKCVATLTGHTGE----VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVA 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34485720 1710 THPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 1778
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1140 4.75e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 4.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALApgskglllednpsiRAISLGHGH-I 971
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVR--------------DVAASADGTyL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  972 LVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSP 1050
Cdd:cd00200   67 ASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1051 DGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITH 1130
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250
                 ....*....|
gi 34485720 1131 IDWDIRGKLL 1140
Cdd:cd00200  225 VAFSPDGYLL 234
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 7.08e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.08e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 34485720      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1697-1970 2.90e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 2.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1697 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1774
Cdd:cd00200    5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1775 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1845
Cdd:cd00200   75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1846 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1923
Cdd:cd00200  150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 34485720 1924 FDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1970
Cdd:cd00200  204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 9.09e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 9.09e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 34485720    672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1339-1410 8.86e-15

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.66  E-value: 8.86e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34485720   1339 VRGSRPPVSraPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451    4 IRGRPGAVY--PPSNYYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
1709-1975 2.89e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1709 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 1787
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1788 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLqVSSGCYKR-HVYEVPSGKhlm 1866
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGK--- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1867 dhaaidritwatwtsilgdeVLGIWSRHAEkaDVNCACVSHSGISLVTGDDFGMVKLFDfpcPEKFAKHKRFLGHSPHVT 1946
Cdd:COG2319  154 --------------------LLRTLTGHSG--AVTSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVR 208

                        250       260       270
                 ....*....|....*....|....*....|....
gi 34485720 1947 NIRFTSGDRHVVSaGGDDCSLFVW-----KCVHT 1975
Cdd:COG2319  209 SVAFSPDGKLLAS-GSADGTVRLWdlatgKLLRT 241
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 1749-1831 1.66e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   1749 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1827
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                   ....
gi 34485720   1828 DIPS 1831
Cdd:pfam12894   81 DLIT 84
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-802 4.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 34485720     760 TIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:smart00320    1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1698-1730 4.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 34485720    1698 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1730
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 34485720    314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-353 2.43e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 34485720     315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
762-802 5.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 5.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 34485720    762 KPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:pfam00400    2 KLLKTLEGHTG-SVTSLAFSPDGKLLASGSDD--GTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1063 1.76e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  725 GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWDWK 804
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSD--KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  805 KGEKLSIARGSKDKIFVVKMNPYvpDKLITAGIKH--MKFWRKAGGGLIGRkgyigTLGKNDTMMCAVYGWTEEMAFSGT 882
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  883 STGDVCIW--RDIFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYaikraalapgskgllledn 958
Cdd:cd00200  155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTL------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  959 psiraislghghilvgtkngeilevdksgpitllvQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
Cdd:cd00200  216 -----------------------------------RGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        330       340
                 ....*....|....*....|....*
gi 34485720 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
720-1112 6.32e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 6.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  720 QRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVV 799
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSAD--GTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  800 LWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGGGLIgrkgyigtlgkndtmmcavygwtee 876
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLL------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  877 mafsgtstgdvciwrdiflvKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYAikraalapgskgll 954
Cdd:COG2319  198 --------------------RTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWDLATGKLLRTLT-------------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  955 lEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLS 1028
Cdd:COG2319  244 -GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGELLRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1029 PSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFID 1108
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                 ....
gi 34485720 1109 IYNV 1112
Cdd:COG2319  398 LWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 9.76e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 9.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  293 --GDHILVGTQDSEIfEIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319  256 pdGRLLASGSADGTV-RLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34485720  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1428-1815 1.37e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 1.37e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1507
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1508 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1585
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1586 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1663
Cdd:COG2319  221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1664 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1743
Cdd:COG2319  281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34485720 1744 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1815
Cdd:COG2319  329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-353 4.88e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 4.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  213 SGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlretdqgYKGLSVR 287
Cdd:cd00200  152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  288 SVCW--RGDHILVGTQDS--EIFEIVVQERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200  224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
52-354 5.58e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 5.58e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   52 HRQKFYRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNA 131
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  132 VCVWDWKRGKMLSMAPGHTDRIFDISWDlyqPN--KLVSCGV-KHIKFWSLcgnaltpKRGVFGKT--GDLQTILCLACA 206
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSAdGTVRLWDL-------ATGKLLRTltGHSGSVRSVAFS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  207 RDELT-YSGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIdlretdQG 280
Cdd:COG2319  256 PDGRLlASGSADGTVRLWdlATGELLRTLTG-HSGGVNSVAFSPDGklLASGSDDGTVRLWDLaTGKLLRTL------TG 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34485720  281 YKGlSVRSVCWR--GDHILVGTQDSEI--FEIvvqERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:COG2319  329 HTG-AVRSVAFSpdGKTLASGSDDGTVrlWDL---ATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
719-1063 6.60e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 6.60e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  719 TQRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTV 798
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDD--GTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  799 VLWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGGGLIGrkgyigTLGKNDtmmcavyGWTE 875
Cdd:COG2319  187 RLWDLATGKLLRTLTGHTGAVRSVAFSP---DgkLLASGSAdGTVRLWDLATGKLLR------TLTGHS-------GSVR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  876 EMAFS--------GTSTGDVCIWR--DIFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYaikr 943
Cdd:COG2319  251 SVAFSpdgrllasGSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTL---- 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  944 aalapgskglllednpsiraislghghilvgtkngeilevdksgpitllvQGHmEGEVWGLATHPYLPICATVSDDKTLR 1023
Cdd:COG2319  327 --------------------------------------------------TGH-TGAVRSVAFSPDGKTLASGSDDGTVR 355

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 34485720 1024 IWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:COG2319  356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
260-802 1.80e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 1.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  260 RLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHcEGELWALAVHPTKPL 339
Cdd:COG2319   14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  340 AVTGSDDRSVRIWSLVDHALIARCNM-EEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSP 418
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  419 DGTYLAVGCNDSSVDIYGVAQrykkvGECLGSL----SFITHLDWSSDSRYLQTNDGNGK-RLfYRMPGGKEVTSTEEik 493
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLAT-----GKLLRTLtghtGAVRSVAFSPDGKLLASGSADGTvRL-WDLATGKLLRTLTG-- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  494 gvHWASWTCVSglevngiWpkysdindinSVDGnyigQVLVTADDYGIIKLFRypcLRKGAKFRKYIGHSAHVTNVRWSH 573
Cdd:COG2319  245 --HSGSVRSVA-------F----------SPDG----RLLASGSADGTVRLWD---LATGELLRTLTGHSGGVNSVAFSP 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  574 DYQWVISiGGADHSVFQWkfiperklkdavhiapqesladshsdesdsdlsdvpeldseieqetqltyrrqvykedlpql 653
Cdd:COG2319  299 DGKLLAS-GSDDGTVRLW-------------------------------------------------------------- 315

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  654 keqckekqksatskrrERAPGNSIRLHfvhgyrgydcrsnlfytqigeivyhvaavgviynrqqntqrfyLGHDDDILCL 733
Cdd:COG2319  316 ----------------DLATGKLLRTL-------------------------------------------TGHTGAVRSV 336

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34485720  734 TIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:COG2319  337 AFSPDGKTLASG--SDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSAD--GTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
1502-1970 2.01e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 2.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1502 TITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSkkgllsTLEDARMQTMLAIAFGAN 1581
Cdd:COG2319   17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA------TLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1582 NLTFTGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQ 1659
Cdd:COG2319   91 RLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRLWD----------LATGK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1660 atdcvrsvcrgkgkiLVGTrnaeiievgeknaacnilVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNK 1739
Cdd:COG2319  154 ---------------LLRT------------------LTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1740 VNlGHAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
Cdd:COG2319  200 LT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1818 PTLNRIsycKDIPSFVIQMDFSADSSYLqVSSGCYKR-HVYEVPSGKHLMDHAAidritwatwtsilgdevlgiwsrhaE 1896
Cdd:COG2319  279 ELLRTL---TGHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKLLRTLTG-------------------------H 329

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 34485720 1897 KADVNCACVSHSGISLVTGDDFGMVKLFDfpcPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSaGGDDCSLFVW 1970
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
251-591 2.06e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 2.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  251 ATGGRDGCIRLWDLTFKPITVIDLRETDqgykglSVRSVCWR--GDHILVGTQDSEI--FEIvvqERNKPFLIMQGHcEG 326
Cdd:COG2319   94 ASASADGTVRLWDLATGLLLRTLTGHTG------AVRSVAFSpdGKTLASGSADGTVrlWDL---ATGKLLRTLTGH-SG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  327 ELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIK 405
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  406 DRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrykkvGECLGSL----SFITHLDWSSDSRYLQTNDGNGKrlfyrmp 481
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLtghsGGVNSVAFSPDGKLLASGSDDGT------- 311

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  482 ggkevtsteeIKGVHWASWTCVSGLEVNGIWpkysdindINSVDGNYIGQVLVTADDYGIIKLFRypcLRKGAKFRKYIG 561
Cdd:COG2319  312 ----------VRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTG 370

                        330       340       350
                 ....*....|....*....|....*....|
gi 34485720  562 HSAHVTNVRWSHDYQWVISiGGADHSVFQW 591
Cdd:COG2319  371 HTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-435 3.73e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 3.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  148 GHTDRIFDISWDlYQPNKLVSCGV-KHIKFWSLCGNalTPKRGVFGKTGDLQTilCLACARDELTYSGALNGDIYVW--K 224
Cdd:cd00200    7 GHTGGVTCVAFS-PDGKLLATGSGdGTIKVWDLETG--ELLRTLKGHTGPVRD--VAASADGTYLASGSSDKTIRLWdlE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  225 GINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIdlretdQGYKGlSVRSVCWRGDHILV--G 299
Cdd:cd00200   82 TGECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVeTGKCLTTL------RGHTD-WVNSVAFSPDGTFVasS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  300 TQDSEIFEIVVQErNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPIRCAAVNADG 378
Cdd:cd00200  154 SQDGTIKLWDLRT-GKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDG 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 34485720  379 IHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
Cdd:cd00200  232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
1457-1733 1.12e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 1.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1457 SIHIWDAMNKQTLSILRCyHSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTq 1536
Cdd:COG2319  143 TVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1537 FVSVGV-KHVKFWTLAGRALLSkkgllsTLEDARmQTMLAIAFGANNLTF-TGTISGDVCVWK-DHILCRIVARAHNGPV 1613
Cdd:COG2319  219 LASGSAdGTVRLWDLATGKLLR------TLTGHS-GSVRSVAFSPDGRLLaSGSADGTVRLWDlATGELLRTLTGHSGGV 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1614 FAMYTTLRDGLIVTGGkerpskEGGAVKLWDQELRRC-RAFRLETGQatdcVRSVC-RGKGKILVGTRNAEIIEVGE-KN 1690
Cdd:COG2319  292 NSVAFSPDGKLLASGS------DDGTVRLWDLATGKLlRTLTGHTGA----VRSVAfSPDGKTLASGSDDGTVRLWDlAT 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 34485720 1691 AACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIAD 1733
Cdd:COG2319  362 GELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1428-1925 9.03e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 9.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1507
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-GHTAAVLSVAFSPDGRLLASASAD--GTVRLWD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1508 WQEGAKIASRAGHNQRIFVAEFRPDSDTqFVSVGV-KHVKFWTLAGRALLSkkgllstledarmqtmlaiafgannlTFT 1586
Cdd:COG2319  107 LATGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSAdGTVRLWDLATGKLLR--------------------------TLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1587 GtisgdvcvwkdhilcrivaraHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdCVR 1665
Cdd:COG2319  160 G---------------------HSGAVTSV-AFSPDGkLLASGS------DDGTVRLWD----------LATGK---LLR 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1666 SVcrgkgkilvgtrnaeiievgeknaacnilvNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHA 1745
Cdd:COG2319  199 TL------------------------------TGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHS 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1746 A--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRI 1823
Cdd:COG2319  247 GsvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1824 sycKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKhlmdhaaidritwatwtsilgdeVLGIWSRHAekADVNCA 1903
Cdd:COG2319  327 ---TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-----------------------LLRTLTGHT--GAVTSV 378

                        490       500
                 ....*....|....*....|..
gi 34485720 1904 CVSHSGISLVTGDDFGMVKLFD 1925
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
895-1266 2.10e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTY-----AIKRAALAPGSKglllednpsiraislg 967
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGrlLASASADGTVRLWDLATGLLLRTLtghtgAVRSVAFSPDGK---------------- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  968 hgHILVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGG 1043
Cdd:COG2319  134 --TLASGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1044 RCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNVMSSKRVGICKG 1123
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1124 ATSYITHIDWDIRGKLLqvntgakeqlffeAPRGKKQTIpsveveKIawasWTSVLGLCcegIWPVIGEVTDVTASCLTS 1203
Cdd:COG2319  287 HSGGVNSVAFSPDGKLL-------------ASGSDDGTV------RL----WDLATGKL---LRTLTGHTGAVRSVAFSP 340

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34485720 1204 DKMVLATGDDLGFVKLFRYPTKGKFGKFKryvAHSTHVTNVRWTYDDSMLVTlGGTDMSLMVW 1266
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 712-929 2.29e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 2.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  712 IYNRQQNTQRFYL-GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASV 790
Cdd:cd00200   77 LWDLETGECVRTLtGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTLRGHTDW-VNSVAFSPDGTFVASS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  791 GIDdsHTVVLWDWKKGEKLSIARGSKDKIFVVKmnpYVPD--KLITAGI-KHMKFWRKAGGGLigrkgyIGTL-GKNDTM 866
Cdd:cd00200  154 SQD--GTIKLWDLRTGKCVATLTGHTGEVNSVA---FSPDgeKLLSSSSdGTIKLWDLSTGKC------LGTLrGHENGV 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34485720  867 MCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTVKAHDGPVFSM--HALEKGFVTGGKDGIVALWD 929
Cdd:cd00200  223 NSVAFSPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1476-1778 7.80e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 7.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1476 HSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLagra 1554
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSdKTIRLWDL---- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1555 llSKKGLLSTLEDARmQTMLAIAFGANNLTFTGTIS-GDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDGLIVTGgker 1632
Cdd:cd00200   81 --ETGECVRTLTGHT-SYVSSVAFSPDGRILSSSSRdKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS---- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1633 pSKEGGAVKLWD-QELRRCRAFRLETGQatdcVRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLA 1709
Cdd:cd00200  153 -SSQDGTIKLWDlRTGKCVATLTGHTGE----VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVA 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34485720 1710 THPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 1778
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-592 3.20e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  228 LIRTIQGaHAAGIFSM--NACEEGFATGGRDGCIRLWDLTFKpitviDLRETDQGYKGlSVRSVCWRGDH--ILVGTQDS 303
Cdd:cd00200    1 LRRTLKG-HTGGVTCVafSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADGtyLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  304 EIFeIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNM-EEPIRCAAVNADGIHLA 382
Cdd:cd00200   74 TIR-LWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  383 LGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRyKKVGECLGSLSFITHLDWSSD 462
Cdd:cd00200  152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  463 SRYLqtndgngkrlfyrmpggkevtsteeikgvhwaswtcvsglevngiwpkysdindinsvdgnyigqvlVTADDYGII 542
Cdd:cd00200  231 GYLL-------------------------------------------------------------------ASGSEDGTI 243

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 34485720  543 KLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWK 592
Cdd:cd00200  244 RVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1140 4.75e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 4.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGIVALWDDSFERCLKTYAIKRAALApgskglllednpsiRAISLGHGH-I 971
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVR--------------DVAASADGTyL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  972 LVGTKNGEILEVD-KSGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSP 1050
Cdd:cd00200   67 ASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1051 DGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITH 1130
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        250
                 ....*....|
gi 34485720 1131 IDWDIRGKLL 1140
Cdd:cd00200  225 VAFSPDGYLL 234
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 7.08e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.08e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 34485720      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1697-1970 2.90e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 2.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1697 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1774
Cdd:cd00200    5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1775 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1845
Cdd:cd00200   75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1846 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1923
Cdd:cd00200  150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 34485720 1924 FDfpcPEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW 1970
Cdd:cd00200  204 WD---LSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVW 246
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 9.09e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 9.09e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 34485720    672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1418-1730 1.92e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 1.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1418 YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSIHIWDaMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGL 1497
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLL---ATG----SGD-----GTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1498 DpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAgrallsKKGLLSTLEDARMQTMlAIA 1577
Cdd:cd00200   72 D--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------TGKCLTTLRGHTDWVN-SVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1578 F-GANNLTFTGTISGDVCVWKDHIL-CRIVARAHNGPVFAMYTTLRDGLIVTGGkerpskEGGAVKLWDQELRRCRA-FR 1654
Cdd:cd00200  143 FsPDGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLGtLR 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34485720 1655 LETGQATDCVRSvcrGKGKILVGTRNAEIIEVGE-KNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1730
Cdd:cd00200  217 GHENGVNSVAFS---PDGYLLASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1339-1410 8.86e-15

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.66  E-value: 8.86e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34485720   1339 VRGSRPPVSraPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451    4 IRGRPGAVY--PPSNYYPKDDLDQKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1664-1971 2.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1664 VRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVN 1741
Cdd:cd00200   12 VTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1742 lGHAA--RTVCYSPEGDMVAIGMKNGefiillvsSLKIW----GKK----RDRRCAIHDIRFSPDSRYLAVGSSENSVDF 1811
Cdd:cd00200   91 -GHTSyvSSVAFSPDGRILSSSSRDK--------TIKVWdvetGKClttlRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1812 YDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMDHaaidritwatwtsilgdevlgiw 1891
Cdd:cd00200  162 WDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL----------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1892 srHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFpcpEKFAKHKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVWK 1971
Cdd:cd00200  216 --RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-178 4.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 4.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   46 VYSPREHR-QKFYRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSV 124
Cdd:cd00200  161 LWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASG 237

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 34485720  125 GLDSKnaVCVWDWKRGKMLSMAPGHTDRIFDISWDlYQPNKLVSCGV-KHIKFWS 178
Cdd:cd00200  238 SEDGT--IRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKRLASGSAdGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1709-1975 2.89e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1709 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 1787
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1788 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLqVSSGCYKR-HVYEVPSGKhlm 1866
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGK--- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1867 dhaaidritwatwtsilgdeVLGIWSRHAEkaDVNCACVSHSGISLVTGDDFGMVKLFDfpcPEKFAKHKRFLGHSPHVT 1946
Cdd:COG2319  154 --------------------LLRTLTGHSG--AVTSVAFSPDGKLLASGSDDGTVRLWD---LATGKLLRTLTGHTGAVR 208

                        250       260       270
                 ....*....|....*....|....*....|....
gi 34485720 1947 NIRFTSGDRHVVSaGGDDCSLFVW-----KCVHT 1975
Cdd:COG2319  209 SVAFSPDGKLLAS-GSADGTVRLWdlatgKLLRT 241
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1785-1975 3.19e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1785 RCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRisyCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGK- 1863
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEc 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720 1864 --HLMDHAaiDRITWATW-------TSILGDEVLGIWSRHAEK---------ADVNCACVSHSGISLVTGDDFGMVKLFD 1925
Cdd:cd00200   86 vrTLTGHT--SYVSSVAFspdgrilSSSSRDKTIKVWDVETGKclttlrghtDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 34485720 1926 FPCPEKFakhKRFLGHSPHVTNIRFtSGDRHVVSAGGDDCSLFVW-----KCVHT 1975
Cdd:cd00200  164 LRTGKCV---ATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWdlstgKCLGT 214
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 1749-1831 1.66e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.96  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720   1749 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1827
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                   ....
gi 34485720   1828 DIPS 1831
Cdd:pfam12894   81 DLIT 84
WD40 pfam00400
WD domain, G-beta repeat;
1698-1730 3.66e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 3.66e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 34485720   1698 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1730
Cdd:pfam00400    8 EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-802 4.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.14e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 34485720     760 TIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:smart00320    1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1698-1730 4.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 34485720    1698 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1730
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 34485720    314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 250-354 2.33e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485720  250 FATGGRDGCIRLWDLTF--KPITVIDLRETdqGYKGLSVRSvcwRGDHILVGTQDSEIFEIVVQErNKPFLIMQGHCEGE 327
Cdd:cd22857  195 IVTGTGYHQVRLYDTRAqrRPVVSVDFGET--PIKAVAEDP---DGHTVYVGDTSGDLASIDLRT-GKLLGCFKGKCGGS 268

                         90       100
                 ....*....|....*....|....*..
gi 34485720  328 LWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:cd22857  269 IRSIARHPELPLIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-353 2.43e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 34485720     315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 994-1026 3.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 3.54e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 34485720     994 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 1026
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
762-802 5.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 5.42e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 34485720    762 KPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:pfam00400    2 KLLKTLEGHTG-SVTSLAFSPDGKLLASGSDD--GTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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