|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
smart00349 |
krueppel associated box; |
15-73 |
4.32e-30 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 113.07 E-value: 4.32e-30
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 68226738 15 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 73
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
|
|
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
14-55 |
3.53e-22 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 89.84 E-value: 3.53e-22
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 68226738 14 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 55
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
15-54 |
6.69e-19 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 80.67 E-value: 6.69e-19
10 20 30 40
....*....|....*....|....*....|....*....|
gi 68226738 15 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 54
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
229-670 |
5.28e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 72.42 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 229 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 305
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 306 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 384
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 385 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 464
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 465 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 531
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 532 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 611
Cdd:COG5048 345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 68226738 612 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 670
Cdd:COG5048 410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
509-951 |
1.61e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 64.72 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 509 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 586
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 587 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 658
Cdd:COG5048 110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 659 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 738
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 739 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 813
Cdd:COG5048 244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 814 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 878
Cdd:COG5048 315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68226738 879 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 951
Cdd:COG5048 395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
497-522 |
7.92e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 37.74 E-value: 7.92e-04
10 20
....*....|....*....|....*.
gi 68226738 497 SLSKHKRIHTGEKPYKCKECGKAFRS 522
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
143-212 |
2.92e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 2.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68226738 143 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 212
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
749-772 |
3.63e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.63e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
smart00349 |
krueppel associated box; |
15-73 |
4.32e-30 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 113.07 E-value: 4.32e-30
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 68226738 15 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 73
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
|
|
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
14-55 |
3.53e-22 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 89.84 E-value: 3.53e-22
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 68226738 14 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 55
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
15-54 |
6.69e-19 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 80.67 E-value: 6.69e-19
10 20 30 40
....*....|....*....|....*....|....*....|
gi 68226738 15 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 54
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
229-670 |
5.28e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 72.42 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 229 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 305
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 306 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 384
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 385 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 464
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 465 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 531
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 532 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 611
Cdd:COG5048 345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 68226738 612 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 670
Cdd:COG5048 410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
453-856 |
6.01e-12 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 68.95 E-value: 6.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 453 KLYKCEVCGKAFYYPSRLSNHKKIHTGEKPFQCEV--CGKAFCFPSSLSKHKRIHTGEKPYKC-KECGKAFRSLSSLSKH 529
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 530 KRIHTGEKPYKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVC-GQAFHVPSKLSHHKIIHTGEKPykcevcgKAFCIPL 608
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 609 LLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIH-KGMHTGEKPYKCEDCGKA 687
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 688 F---------HYPSLLSKHKRIHTgekPYQCEVCGKDFHVSSSLSKHR--IIHTGE--KPYKC--EICGKTFRFSSSLSK 752
Cdd:COG5048 265 LptassqsssPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 753 HKRNHTGKKPYKC--EECGKAFHFPSI------LAKHKISHTgEKPYNCDL--CGKAFHYASLLSKHKMIHTGEKPH--K 820
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncK 420
|
410 420 430
....*....|....*....|....*....|....*.
gi 68226738 821 CDICGKAFHYPSKLSNHKKIHTGEKPYKCEVCGNVF 856
Cdd:COG5048 421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
509-951 |
1.61e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 64.72 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 509 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 586
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 587 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 658
Cdd:COG5048 110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 659 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 738
Cdd:COG5048 180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 739 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 813
Cdd:COG5048 244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 814 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 878
Cdd:COG5048 315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68226738 879 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 951
Cdd:COG5048 395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
116-559 |
9.73e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 62.02 E-value: 9.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 116 MNPNKCEECARSFHSPSLSSEENRIHTGEKPYKCEV--CGKAFCIPLLLSKHKRVHTgenlykcevcgkafQHPSRLSRH 193
Cdd:COG5048 31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH--------------NNPSDLNSK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 194 KKIHSEEKPYKCEVCGKAFHFPSLLLVHKRVHTGEKPYK-------CEICDKAFHYPSILSKHKRIHTGEKPYKCE---E 263
Cdd:COG5048 97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPansL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 264 CGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSgEKPFKCEVCGKAFRILSLLSKH-KIIHTEENP 342
Cdd:COG5048 177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 343 YKCEVCGKAFDYPSRLSTHAKMHTGEK------PYKCEVCQKAFRSLSSLSKHKR--IHTEDNYY----NNELCGKAFIY 410
Cdd:COG5048 256 SASESPRSSLPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKpfscPYSLCGKLFSR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 411 PSRLSKHKRICAGEKPYKC--EVCGKAFHVSSLLSKHRTIHtgeklykcevcgkafyyPSRLSNHKKIHTGEKPFQCEVC 488
Cdd:COG5048 336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNF 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68226738 489 GKAFCFPSSLSKHKRihTGEKPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKCEECGKaFHYPSLLSKHKI 559
Cdd:COG5048 399 KRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
620-933 |
2.12e-08 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 57.78 E-value: 2.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 620 ENPYNSQVCSKAFVYPSKlSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHKGMHTGEKPYKCED--CGKAFHYPSLLSKH 697
Cdd:COG5048 4 TSSQSSSSNNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 698 KRIHTGEKPYQCEVCGKDFHVSSSLSKHRIIHTGE-KPYKCEICGKTFRF---------SSSLSKHKRNHTGKKPYKC-- 765
Cdd:COG5048 83 LRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSrdpqlpdllSISNLRNNPLPGNNSSSVNtp 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 766 ------------EECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSKHKMIHTgEKPHKCDICGKAFHYPSK 833
Cdd:COG5048 163 qsnslhpplpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 834 LSNH-KKIHTGEKPYKCEVCGNVFCFASS---------LSKHKRIHTgenPYKCEVCGKAFYYPSLLSKHK--IIHTGE- 900
Cdd:COG5048 242 SQSPsSLSSSDSSSSASESPRSSLPTASSqssspnesdSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318
|
330 340 350
....*....|....*....|....*....|....*.
gi 68226738 901 -KPYKCD--LCGKAFHYPSLLSKHKVIHTGKKPYKC 933
Cdd:COG5048 319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKE 354
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
382-839 |
7.18e-08 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 56.24 E-value: 7.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 382 SLSSLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRICAGEKPYKCEV--CGKAFHVSSLLSKHRTIHTGEKLYKCEV 459
Cdd:COG5048 17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 460 -CGKAFYYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKEC-GKAFRSLSSLSKHKRIHTGEK 537
Cdd:COG5048 97 sLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 538 pykceeCGKAFHYPSLLSKHKIIHTEEKPYKCdvcgQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLSKHKRvH 617
Cdd:COG5048 177 ------SKDPSSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS-P 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 618 TGENPYNSQVCSKAFVYPSKLSKHKKVRTKekpykcevcgkafrFPSLLLIHKGMHTgekPYKCEDCGKAFHYPSLLSKH 697
Cdd:COG5048 246 SSLSSSDSSSSASESPRSSLPTASSQSSSP--------------NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 698 KR--IHTGE--KPYQC--EVCGKDFHVSSSLSKHRIIHTGEKPYKC--EICGKTFRFSS------SLSKHKRNHTGKKPY 763
Cdd:COG5048 309 LRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 764 kCEECGKAFHFP--SILAKHKISHTGEKPYNCD--LCGKAFHYASLLSKHKMIHTGEKPHKCDICGKaFHYPSKLSNHKK 839
Cdd:COG5048 389 -TLSNSCIRNFKrdSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
353-447 |
1.45e-06 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 51.64 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 353 DYPSRLsthaKMHTGEKPYKCEV--CQKAFRSLSSLsKHKRIHTEDNYYNNElcgkafiYPSRlSKHKRICAGEKPYKCE 430
Cdd:COG5189 336 DTPSRM----LKVKDGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHE-------NPSP-EKMNIFSAKDKPYRCE 402
|
90
....*....|....*..
gi 68226738 431 VCGKAFHVSSLLSKHRT 447
Cdd:COG5189 403 VCDKRYKNLNGLKYHRK 419
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
227-310 |
2.04e-05 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 48.18 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 227 GEKPYKCEI--CDKAFHYPSILSKHKrihtgekpyKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSN 304
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 68226738 305 HKKiHS 310
Cdd:COG5189 417 HRK-HS 421
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
675-758 |
8.44e-05 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 46.25 E-value: 8.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 675 GEKPYKCE--DCGKAFHYPSLLsKHKRIHTGekpyqcevCGKDFHVSSSLSKHRIIHTGEKPYKCEICGKTFRFSSSLSK 752
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 68226738 753 HKRNHT 758
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
591-674 |
2.13e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 44.71 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 591 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENPYNSQVCSKafvypsklSKHKKVRTKEKPYKCEVCGKAFRFPSLLLI 668
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 68226738 669 HKGMHT 674
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
283-366 |
2.53e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 44.71 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 283 GEKPYKCEV--CGKAFHYPSRLSNHKKiHSGEKPFKCEVCGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLST 360
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 68226738 361 HAKMHT 366
Cdd:COG5189 417 HRKHSH 422
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
507-586 |
4.36e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 43.94 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 507 GEKPYKCK--ECGKAFRSLSSLSKHKrihtgekpyKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVCGQAFHVPSKLSH 584
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
..
gi 68226738 585 HK 586
Cdd:COG5189 417 HR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
497-522 |
7.92e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 37.74 E-value: 7.92e-04
10 20
....*....|....*....|....*.
gi 68226738 497 SLSKHKRIHTGEKPYKCKECGKAFRS 522
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
731-810 |
9.58e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 42.78 E-value: 9.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 731 GEKPYKCEI--CGKTFRFSSSLSKHKRNHtgkkpykceECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSK 808
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
..
gi 68226738 809 HK 810
Cdd:COG5189 417 HR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
525-548 |
1.50e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 36.97 E-value: 1.50e-03
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
246-268 |
1.92e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 36.58 E-value: 1.92e-03
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
143-212 |
2.92e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 2.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68226738 143 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 212
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
535-604 |
2.97e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 41.24 E-value: 2.97e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68226738 535 GEKPYKCE--ECGKAFHYPSLLSKHKIiHTEekpykcdvCGQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAF 604
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
749-772 |
3.63e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.63e-03
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
871-951 |
3.78e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 40.86 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68226738 871 GENPYKCEV--CGKAFYYPSLLSKHKiihtgekpyKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKAFHYPSRLSK 948
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
...
gi 68226738 949 HKK 951
Cdd:COG5189 417 HRK 419
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
694-716 |
5.82e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.04 E-value: 5.82e-03
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
861-886 |
7.01e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.04 E-value: 7.01e-03
10 20
....*....|....*....|....*.
gi 68226738 861 SLSKHKRIHTGENPYKCEVCGKAFYY 886
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
469-492 |
9.61e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 34.65 E-value: 9.61e-03
|
| |
