BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  26 GNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELM 105
Cdd:cd18401   1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                        90       100
                ....*....|....*....|....
gi 33636730 106 AEAKYYLIQGLVSLCQAALQDKKD 129
Cdd:cd18401  81 AEAKYYLIQGLVDMCQAALQDKKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  26 GNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELM 105
Cdd:cd18401   1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                        90       100
                ....*....|....*....|....
gi 33636730 106 AEAKYYLIQGLVSLCQAALQDKKD 129
Cdd:cd18401  81 AEAKYYLIQGLVDMCQAALQDKKD 104

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730     29 YVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEvLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQsrQEIQELMAEA 108
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK-ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPE--ENVEELLELA 77

                           90
                   ....*....|....*....
gi 33636730    109 KYYLIQGLVSLCQAALQDK 127
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  26 GNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELM 105
Cdd:cd18401   1 GNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELM 80

                        90       100
                ....*....|....*....|....
gi 33636730 106 AEAKYYLIQGLVSLCQAALQDKKD 129
Cdd:cd18401  81 AEAKYYLIQGLVDMCQAALQDKKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  27 NKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMA 106
Cdd:cd18400   1 SKYVKLNVGGSLHYTTVQTLTKQDTMLKAMFSGRVEVLTDSEGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELEELLG 80

                        90       100
                ....*....|....*....|...
gi 33636730 107 EAKYYLIQGLVSLCQAALQDKKD 129
Cdd:cd18400  81 EARYYLVQGLVEDCQLALQQKRD 103

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730    30 VQLNVGGSLHYTTVRALTR-HDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDtVTLPQSRQ-EIQELMAE 107
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRfPDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTG-GKLHRPEEvCLDEFLEE 79

                          90
                  ....*....|....
gi 33636730   108 AKYYLIQGL-VSLC 120
Cdd:pfam02214  80 AEFYGLDELaLELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEA 108
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDpDSLLAALFSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVELEELLAEA 80

                ...
gi 33636730 109 KYY 111
Cdd:cd18316  81 EFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSlHYTTVRA-LTRH-DTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAE 107
Cdd:cd18365   3 VNLNVGGV-HYTTTLAtLTRFpDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLLRE 81

                        90
                ....*....|
gi 33636730 108 AKYYLIQGLV 117
Cdd:cd18365  82 ADFYQIEPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEA 108
Cdd:cd18394   5 VTLNVGGHLYTTSLSTLTRYpDSMLGAMFRGDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLLRKEA 84

                        90       100
                ....*....|....*....|...
gi 33636730 109 KYYLIQGLVSlcqaALQDKKDSY 131
Cdd:cd18394  85 DFYQIEPLIQ----CLNDPKPLY 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFSG--RMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMA 106
Cdd:cd18367   5 VELNVGGQVYTTSLSTLIKDpDSLLGRMFSGknRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLKR 84

                        90
                ....*....|....*.
gi 33636730 107 EAKYYLIQGLVSLCQA 122
Cdd:cd18367  85 EAEYFQLPELVKALRA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  29 YVQLNVGGSLHYTTVRALTR--HDTMLKAMFSGRMEV--LTDKEGWILIDRCGKHFGTILNYLRDDTVTLpQSRQEIQEL 104
Cdd:cd18368   2 WIKLNVGGRIFTTTRSTLVKkePDSMLARMFSDDSTWpsSRDENGAYLIDRSPEYFEPILNYLRHGQLIL-NDGLNPLGV 80

                        90
                ....*....|...
gi 33636730 105 MAEAKYYLIQGLV 117
Cdd:cd18368  81 LEEAKFFGIQSLI 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEA 108
Cdd:cd18364   2 VTLNVGGYLYITQRQTLTKYpDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALEA 81

                ...
gi 33636730 109 KYY 111
Cdd:cd18364  82 DFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTR-HDTMLKAMFSGRM--EVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMA 106
Cdd:cd18396   6 VELNVGGQVYVTKHSTLLSvPDSTLASMFSRRAarELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEKERLLR 85

                        90
                ....*....|...
gi 33636730 107 EAKYYLIQGLVSL 119
Cdd:cd18396  86 EAEYFQLGDLVKL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTR-HDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRddTVTLPQSRQEIQELMAEA 108
Cdd:cd18363   4 INLNVGGKRFSTSRQTLTWiPDSFFTSLLSGRISSLKDETGAIFIDRDPKLFSIILNYLR--TKEIDLRNVDISSLRHEA 81

                ....*
gi 33636730 109 KYYLI 113
Cdd:cd18363  82 EFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  28 KYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKE--GWILIDRCGKHFGTILNYLRDDTVTLPQSRQEiQELM 105
Cdd:cd18391   1 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDetGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGVL 79

                        90       100
                ....*....|....*....|..
gi 33636730 106 AEAKYYLIQGLVSLCQAALQDK 127
Cdd:cd18391  80 EEAEFYNIGPLIRIIKDRMEEK 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLH---YTTVRALTrhDTMLKAMFSGRM--EVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQEL 104
Cdd:cd18397   5 VELNVGGQVYvtrHTTLVSVP--DSLLWHMFSQQKpgELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRL 82

                        90
                ....*....|....*
gi 33636730 105 MAEAKYYLIQGLVSL 119
Cdd:cd18397  83 QREAEFFQLPELVKR 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  28 KYVQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDKE--GWILIDRCGKHFGTILNYLRDDTVTLPQSRQEiQEL 104
Cdd:cd18389   1 KWVRLNVGGTYFVSTKQTLCRDpKSFLYRLCQEDPDLDSDKDetGAYLIDRDPTYFGPILNYLRHGKLIINKELAE-EGV 79

                        90       100
                ....*....|....*....|....*
gi 33636730 105 MAEAKYYLIQGLVSLCQAALQDKKD 129
Cdd:cd18389  80 LEEAEFYNIASLVRLVKERIRDNEN 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEA 108
Cdd:cd18375   3 VTLNVGGKKFTTRPSTLRRFpDSRLARMLDGKDQDFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDYNRLAREA 82

                        90
                ....*....|.
gi 33636730 109 KYYLIQGLVSL 119
Cdd:cd18375  83 EFYGLYSLADL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  30 VQLNVGGSLHYTTVRALTRH-DTMLKAMFsGRMEVLTDKE--GWILIDRCGKHFGTILNYLRDDTVTLPQSrQEIQELMA 106
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHpDTLLGRMF-KPGREFTFPNetGEYFIDRDPTVFRTILNYYRTGKLNCPDG-ISIPDLRE 78

                ....*
gi 33636730 107 EAKYY 111
Cdd:cd18187  79 ECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636730  26 GNKYVQLNVGGSLHYTTVRALTRH-DTMLKAMFSGRMEVLTDK-EGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQE 103
Cdd:cd18387   1 SNAPVHIDVGGHMYTSSLATLTKYpESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80

                        90
                ....*....|...
gi 33636730 104 LMAEAKYYLIQGL 116
Cdd:cd18387  81 LYEEAKYFQLQPM 93