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Conserved domains on  [gi|33414517|ref|NP_877975|]
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zinc finger protein 472 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.60e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.60e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33414517     9 PVTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISIG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-491 8.55e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 194 KSYICKQCGKAWSDSCSLLWHERSHIQEKRHTC--KQCGKAFSRPSQLHKHERIHTGEKPYVCTH-CGKAFIDRRTCHNH 270
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 271 ERTHTGVKPFACKQCGKAFLRSCQLLIHERIHTGERPFVCKHCGKAFTYSSAcyYHERIHTGEKPCVCKQcgkAFKCSAY 350
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKD---PSSNLSL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 351 LHIHERSHSGEKPYVCKHCGKAFAYATGCHKHERIH----------TGEKPYMCVQCGKLFTFPRSLHIHERSHSGE--- 417
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSslp 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 418 ---------------------KPYVCKQCGKSFTQGTSLRRHER--IHTGE--KPYVCR--QCGKAFIQRDDCYSHERTH 470
Cdd:COG5048 267 tassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                       330       340
                ....*....|....*....|.
gi 33414517 471 TGEKPFMCVQCGKTFTFSKSL 491
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLL 367
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.60e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.60e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33414517     9 PVTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISIG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
10-50 5.93e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.63  E-value: 5.93e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 33414517     10 VTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISIG 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 4.32e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 4.32e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 33414517  10 VTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISI 49
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-491 8.55e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 194 KSYICKQCGKAWSDSCSLLWHERSHIQEKRHTC--KQCGKAFSRPSQLHKHERIHTGEKPYVCTH-CGKAFIDRRTCHNH 270
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 271 ERTHTGVKPFACKQCGKAFLRSCQLLIHERIHTGERPFVCKHCGKAFTYSSAcyYHERIHTGEKPCVCKQcgkAFKCSAY 350
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKD---PSSNLSL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 351 LHIHERSHSGEKPYVCKHCGKAFAYATGCHKHERIH----------TGEKPYMCVQCGKLFTFPRSLHIHERSHSGE--- 417
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSslp 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 418 ---------------------KPYVCKQCGKSFTQGTSLRRHER--IHTGE--KPYVCR--QCGKAFIQRDDCYSHERTH 470
Cdd:COG5048 267 tassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                       330       340
                ....*....|....*....|.
gi 33414517 471 TGEKPFMCVQCGKTFTFSKSL 491
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLL 367
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 33414517   434 SLRRHERIHTGEKPYVCRQCGKAFIQ 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.60e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.60e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33414517     9 PVTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISIG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
10-50 5.93e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 77.63  E-value: 5.93e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 33414517     10 VTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISIG 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 4.32e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 4.32e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 33414517  10 VTFEDVAVNFTLGEWTMLDSSQKKLYRDVMKETFMNLISI 49
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-491 8.55e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 194 KSYICKQCGKAWSDSCSLLWHERSHIQEKRHTC--KQCGKAFSRPSQLHKHERIHTGEKPYVCTH-CGKAFIDRRTCHNH 270
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 271 ERTHTGVKPFACKQCGKAFLRSCQLLIHERIHTGERPFVCKHCGKAFTYSSAcyYHERIHTGEKPCVCKQcgkAFKCSAY 350
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKD---PSSNLSL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 351 LHIHERSHSGEKPYVCKHCGKAFAYATGCHKHERIH----------TGEKPYMCVQCGKLFTFPRSLHIHERSHSGE--- 417
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSslp 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 418 ---------------------KPYVCKQCGKSFTQGTSLRRHER--IHTGE--KPYVCR--QCGKAFIQRDDCYSHERTH 470
Cdd:COG5048 267 tassqssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                       330       340
                ....*....|....*....|.
gi 33414517 471 TGEKPFMCVQCGKTFTFSKSL 491
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-383 3.64e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 220 QEKRHTCKQCGKAFSRPSQLHKHER--IHTGE--KPYVCTH--CGKAFIDRRTCHNHERTHTGVKPFACK--QCGKAFL- 290
Cdd:COG5048 286 FSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSp 365

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 291 ----RSCQLLIHERIHTGERPFVCKH--CGKAFTYSSACYYHERIHTGEKPCVCK--QCGKAFKCSAYLHIHERSHSGEK 362
Cdd:COG5048 366 llnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHA 445

                       170       180
                ....*....|....*....|.
gi 33414517 363 PYVCKHCGKAFAYATGCHKHE 383
Cdd:COG5048 446 PLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-527 7.11e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 226 CKQCGKAFSRPSQLHKHERIHTGEKPYVCTH--CGKAFIDRRTCHNHERTHTGVKPFAC-KQCGKAFLRSCQLLIHERIH 302
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSS 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 303 TGERPFVCKHCGKAFTYSSACYYHERIHTGEKPCVCKQC-GKAFKCSAYLHIHERSHSgekpyvcKHCGKAFAYATGCHK 381
Cdd:COG5048 116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLSLLI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 382 HERIHTGEKPYMCVQCGKLFTFPRSLHIHERSHSGEKPYVCKQCGKSFT------QGTSLRRHERIHTGEKPYVCRQCGK 455
Cdd:COG5048 189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPRSSLPTA 268

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33414517 456 AFIQRDDCYSHERTHTG-EKPFMCVQCGKTFTFSKSLQIH--EKNHTGE--KPYIC--KQCGKAFTCSTYLLRHERTHS 527
Cdd:COG5048 269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 33414517   434 SLRRHERIHTGEKPYVCRQCGKAFIQ 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-466 2.80e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 278 KPFACKQCGKAFLRSCQLLIHER--IHTGE--RPFVCKH--CGKAFTYSSACYYHERIHTGEKPcvckqcgkaFKCsaYL 351
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP---------AKE--KL 356

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33414517 352 HIHERSHSGEKPYvckhcgkafaYATGCHKHERIHTGEKPYMCVQCGKLFTFPRSLHI--HERSHSGEKPYVCK--QCGK 427
Cdd:COG5048 357 LNSSSKFSPLLNN----------EPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLslHIITHLSFRPYNCKnpPCSK 426

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 33414517 428 SFTQGTSLRRHERIHTGEKPYVCRQCGKaFIQRDDCYSH 466
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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