|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
137-436 |
1.46e-45 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 164.70 E-value: 1.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 137 KPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTRKVVGIIKrtkkragvpeeptnAHYGVIFTVAVSPDQKFIASGGF 216
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--------------GHSGAVTSVAFSPDGKLLASGSD 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 217 DQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSKQRVAT 296
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 297 VGGRDRSARLWKVEDESQL-MFSGLQNCVSldCVAMI-NEEHFATGSADGSIALWSFWKKRALHvrkqahgTQNGSGRWI 374
Cdd:COG2319 263 SGSADGTVRLWDLATGELLrTLTGHSGGVN--SVAFSpDGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAV 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193204868 375 VALAVLPYSDLLASGSNEGELKLWKIsENFRQLTPFFSYSipGFINSINFAPNGKSIVVGAG 436
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSA 392
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
132-435 |
5.47e-43 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 154.42 E-value: 5.47e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 132 LEISYKPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTrkvvGIIKRTKKragvpeeptnAHYGVIFTVAVSPDQKFI 211
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLK----------GHTGPVRDVAASADGTYL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 212 ASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSK 291
Cdd:cd00200 67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 292 QRVATVGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVA-MINEEHFATGSADGSIALWSFWKKRALHvrkqahgTQNG 369
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVAtLTGHTGEVN--SVAfSPDGEKLLSSSSDGTIKLWDLSTGKCLG-------TLRG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193204868 370 SGRWIVALAVLPYSDLLASGSNEGELKLWKIsENFRQLTPFFSYSipGFINSINFAPNGKSIVVGA 435
Cdd:cd00200 218 HENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHT--NSVTSLAWSPDGKRLASGS 280
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
227-266 |
1.66e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 1.66e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 193204868 227 SLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWD 266
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
193-224 |
5.65e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 5.65e-05
10 20 30
....*....|....*....|....*....|..
gi 193204868 193 NAHYGVIFTVAVSPDQKFIASGGFDQVVKIWN 224
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
198-424 |
7.39e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 45.46 E-value: 7.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 198 VIFTVAVSPDQKFIASGGFDQVVKIWNFDSLehIKDLSGHRGPIFSLTFQLKTN----NLYSASQ------DRSVKMWDI 267
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFECESI--IKDGRDIHYPVVELASRSKLSgicwNSYIKSQvassnfEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 268 DQLGLVDTMYGHQDGVQQIGVLSKQRVATVGGRDR-SARLWKVEDESQLmfSGLQNCVSLDCVAMINE--EHFATGSADG 344
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSI--GTIKTKANICCVQFPSEsgRSLAFGSADH 640
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 345 SIALWSfwkkraLHVRKQAHGTQNGSGRwIVALAVLPYSDLLASGSNEGELKLWKISENFRQL--TPFFSYSipGFINSI 422
Cdd:PLN00181 641 KVYYYD------LRNPKLPLCTMIGHSK-TVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGIneTPLHSFM--GHTNVK 711
|
..
gi 193204868 423 NF 424
Cdd:PLN00181 712 NF 713
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
137-436 |
1.46e-45 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 164.70 E-value: 1.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 137 KPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTRKVVGIIKrtkkragvpeeptnAHYGVIFTVAVSPDQKFIASGGF 216
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT--------------GHSGAVTSVAFSPDGKLLASGSD 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 217 DQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSKQRVAT 296
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 297 VGGRDRSARLWKVEDESQL-MFSGLQNCVSldCVAMI-NEEHFATGSADGSIALWSFWKKRALHvrkqahgTQNGSGRWI 374
Cdd:COG2319 263 SGSADGTVRLWDLATGELLrTLTGHSGGVN--SVAFSpDGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAV 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193204868 375 VALAVLPYSDLLASGSNEGELKLWKIsENFRQLTPFFSYSipGFINSINFAPNGKSIVVGAG 436
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT--GAVTSVAFSPDGRTLASGSA 392
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
132-435 |
5.47e-43 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 154.42 E-value: 5.47e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 132 LEISYKPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTrkvvGIIKRTKKragvpeeptnAHYGVIFTVAVSPDQKFI 211
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLK----------GHTGPVRDVAASADGTYL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 212 ASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSK 291
Cdd:cd00200 67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 292 QRVATVGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVA-MINEEHFATGSADGSIALWSFWKKRALHvrkqahgTQNG 369
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVAtLTGHTGEVN--SVAfSPDGEKLLSSSSDGTIKLWDLSTGKCLG-------TLRG 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193204868 370 SGRWIVALAVLPYSDLLASGSNEGELKLWKIsENFRQLTPFFSYSipGFINSINFAPNGKSIVVGA 435
Cdd:cd00200 218 HENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHT--NSVTSLAWSPDGKRLASGS 280
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
108-457 |
8.22e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 157.00 E-value: 8.22e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 108 RDDAVARTGTQVKRVADVVELEDDLEISYKPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTrkvvgiikrtkkraGV 187
Cdd:COG2319 46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT--------------GL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 188 PEEPTNAHYGVIFTVAVSPDQKFIASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTF----QLktnnLYSASQDRSVK 263
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspdgKL----LASGSDDGTVR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 264 MWDIDQLGLVDTMYGHQDGVQQIgVLSK--QRVATvGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVAM-INEEHFAT 339
Cdd:COG2319 188 LWDLATGKLLRTLTGHTGAVRSV-AFSPdgKLLAS-GSADGTVRLWDLATGKLLRtLTGHSGSVR--SVAFsPDGRLLAS 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 340 GSADGSIALWSFWKKRALHvrkqahgTQNGSGRWIVALAVLPYSDLLASGSNEGELKLWKISENfRQLTPFFSYSipGFI 419
Cdd:COG2319 264 GSADGTVRLWDLATGELLR-------TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHT--GAV 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 193204868 420 NSINFAPNGKSIVVGAGkehkDG--RWWvDREARNQVVIL 457
Cdd:COG2319 334 RSVAFSPDGKTLASGSD----DGtvRLW-DLATGELLRTL 368
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
139-401 |
1.33e-39 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 148.14 E-value: 1.33e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 139 HRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTRKVVGIIKrtkkragvpeeptnAHYGVIFTVAVSPDQKFIASGGFDQ 218
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT--------------GHTGAVRSVAFSPDGKLLASGSADG 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 219 VVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIgVLSK--QRVAT 296
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV-AFSPdgKLLAS 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 297 vGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVAMI-NEEHFATGSADGSIALWSFWKKRALHvrkqahgTQNGSGRWI 374
Cdd:COG2319 306 -GSDDGTVRLWDLATGKLLRtLTGHTGAVR--SVAFSpDGKTLASGSDDGTVRLWDLATGELLR-------TLTGHTGAV 375
|
250 260
....*....|....*....|....*..
gi 193204868 375 VALAVLPYSDLLASGSNEGELKLWKIS 401
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
130-399 |
1.88e-36 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 136.70 E-value: 1.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 130 DDLEISYKPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTRKVVGIIKrtkkragvpeeptnAHYGVIFTVAVSPDQK 209
Cdd:cd00200 41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT--------------GHTSYVSSVAFSPDGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 210 FIASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVL 289
Cdd:cd00200 107 ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 290 SKQRVATVGGRDRSARLWKVEDESQLM-FSGLQNCVsLDCVAMINEEHFATGSADGSIALWSFWKKRALHVrkqAHGTQN 368
Cdd:cd00200 187 PDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGV-NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGHTN 262
|
250 260 270
....*....|....*....|....*....|.
gi 193204868 369 gsgrWIVALAVLPYSDLLASGSNEGELKLWK 399
Cdd:cd00200 263 ----SVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
135-311 |
4.22e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 124.64 E-value: 4.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 135 SYKPHRLSPLCVAFSPDAKYVISCGKESSIVKFNVGTRKVVGIIKrtkkragvpeeptnAHYGVIFTVAVSPDQKFIASG 214
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--------------GHSGGVNSVAFSPDGKLLASG 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 215 GFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSK-QR 293
Cdd:COG2319 307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDgRT 386
|
170
....*....|....*...
gi 193204868 294 VATvGGRDRSARLWKVED 311
Cdd:COG2319 387 LAS-GSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
184-434 |
3.41e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.39 E-value: 3.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 184 RAGVPEEPTNAHYGVIFTVAVSPDQKFIASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVK 263
Cdd:COG2319 24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 264 MWDIDQLGLVDTMYGHQDGVQQIgVLSK--QRVATvGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVAMI-NEEHFAT 339
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSV-AFSPdgKTLAS-GSADGTVRLWDLATGKLLRtLTGHSGAVT--SVAFSpDGKLLAS 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 340 GSADGSIALWSFWKKRALHvrkqahgTQNGSGRWIVALAVLPYSDLLASGSNEGELKLWKISENfRQLTPFFSYSipGFI 419
Cdd:COG2319 180 GSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHS--GSV 249
|
250
....*....|....*
gi 193204868 420 NSINFAPNGKSIVVG 434
Cdd:COG2319 250 RSVAFSPDGRLLASG 264
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
230-436 |
1.27e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 106.65 E-value: 1.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 230 HIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLSKQRVATVGGRDRSARLWKV 309
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 310 EDESQLM-FSGLQNCVSldCVAMINEEHF-ATGSADGSIALWSFWKKRALHvrkqahgTQNGSGRWIVALAVLPYSDLLA 387
Cdd:cd00200 81 ETGECVRtLTGHTSYVS--SVAFSPDGRIlSSSSRDKTIKVWDVETGKCLT-------TLRGHTDWVNSVAFSPDGTFVA 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 193204868 388 SGSNEGELKLWKISENFRQLTpFFSYSipGFINSINFAPNGKSIVVGAG 436
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVAT-LTGHT--GEVNSVAFSPDGEKLLSSSS 197
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
203-458 |
2.09e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 81.11 E-value: 2.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 203 AVSPDQKFIASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDG 282
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 283 VQQIGVLSKQRVATVGGRDRSARLWKVEDESQLM-FSGLQNCVSldCVAM-INEEHFATGSADGSIALWSFWKKRALHvr 360
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRtLTGHTGAVR--SVAFsPDGKTLASGSADGTVRLWDLATGKLLR-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 361 kqahgTQNGSGRWIVALAVLPYSDLLASGSNEGELKLWKIsENFRQLTPFFSYSipGFINSINFAPNGKSIVVGAGkehk 440
Cdd:COG2319 157 -----TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHT--GAVRSVAFSPDGKLLASGSA---- 224
|
250 260
....*....|....*....|
gi 193204868 441 DG--RWWvDREARNQVVILP 458
Cdd:COG2319 225 DGtvRLW-DLATGKLLRTLT 243
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
227-266 |
1.66e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 1.66e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 193204868 227 SLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWD 266
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
193-224 |
1.71e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 1.71e-05
10 20 30
....*....|....*....|....*....|..
gi 193204868 193 NAHYGVIFTVAVSPDQKFIASGGFDQVVKIWN 224
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
193-224 |
5.65e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 5.65e-05
10 20 30
....*....|....*....|....*....|..
gi 193204868 193 NAHYGVIFTVAVSPDQKFIASGGFDQVVKIWN 224
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
229-266 |
5.94e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 5.94e-05
10 20 30
....*....|....*....|....*....|....*...
gi 193204868 229 EHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWD 266
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
198-424 |
7.39e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 45.46 E-value: 7.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 198 VIFTVAVSPDQKFIASGGFDQVVKIWNFDSLehIKDLSGHRGPIFSLTFQLKTN----NLYSASQ------DRSVKMWDI 267
Cdd:PLN00181 485 LVCAIGFDRDGEFFATAGVNKKIKIFECESI--IKDGRDIHYPVVELASRSKLSgicwNSYIKSQvassnfEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 268 DQLGLVDTMYGHQDGVQQIGVLSKQRVATVGGRDR-SARLWKVEDESQLmfSGLQNCVSLDCVAMINE--EHFATGSADG 344
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSI--GTIKTKANICCVQFPSEsgRSLAFGSADH 640
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 345 SIALWSfwkkraLHVRKQAHGTQNGSGRwIVALAVLPYSDLLASGSNEGELKLWKISENFRQL--TPFFSYSipGFINSI 422
Cdd:PLN00181 641 KVYYYD------LRNPKLPLCTMIGHSK-TVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGIneTPLHSFM--GHTNVK 711
|
..
gi 193204868 423 NF 424
Cdd:PLN00181 712 NF 713
|
|
| YncE |
COG3391 |
DNA-binding beta-propeller fold protein YncE [General function prediction only]; |
142-259 |
1.11e-04 |
|
DNA-binding beta-propeller fold protein YncE [General function prediction only];
Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 43.91 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 142 SPLCVAFSPDAKYV-ISCGKESSIVKFNVGTRKVVGIIKrtkkragVPEEPTNahygviftVAVSPDQK--FIASGGFDQ 218
Cdd:COG3391 111 GPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIP-------VGAGPHG--------IAVDPDGKrlYVANSGSNT 175
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 193204868 219 VVKI---WNFDSLEHIKDLSGHRGPIFsLTFQLKTNNLYSASQD 259
Cdd:COG3391 176 VSVIvsvIDTATGKVVATIPVGGGPVG-VAVSPDGRRLYVANRG 218
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
211-311 |
6.77e-04 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 42.19 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193204868 211 IASGGFDQVVKIWNFDSLEHIKDLSGHRGPIFSLTFQLKTNNLYSASQDRSVKMWDIDQLGLVDTMYGHQDGVQQIGVLS 290
Cdd:PTZ00421 141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWA 220
|
90 100
....*....|....*....|....*.
gi 193204868 291 KQR--VATVG---GRDRSARLWKVED 311
Cdd:PTZ00421 221 KRKdlIITLGcskSQQRQIMLWDTRK 246
|
|
| |
