NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|32565028|ref|NP_872025|]
View 

Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein [Caenorhabditis elegans]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 108-258 3.15e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.81  E-value: 3.15e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 108 RLYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSA 187
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32565028 188 FSFYAAWFTSLYLQARLFRPlFSRLLLPVIQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVA 258
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLR-GSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 108-258 3.15e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.81  E-value: 3.15e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 108 RLYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSA 187
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32565028 188 FSFYAAWFTSLYLQARLFRPlFSRLLLPVIQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVA 258
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLR-GSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
122-257 7.83e-22

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 89.71  E-value: 7.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028    122 FNQLMVDIAKYTIGRQRPHFMDVCRPdigyqtcsqpdlyitdfkCTTTDTKKIHEAQLSFYSGHSAFSFYAAWFTSLYLQ 201
Cdd:smart00014   6 VSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLP 67

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 32565028    202 ARLFRPLFsrlllpviQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFV 257
Cdd:smart00014  68 ARAGRKLL--------IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 115-261 1.58e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.62  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028   115 YFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYitdfkctttdtkkiheaqlSFYSGHSAFSFYAAW 194
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGY-------------------SFPSGHSATAFALAL 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32565028   195 FTSLYLqARLFRPLFSRLLLpviqfLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVALFV 261
Cdd:pfam01569  62 LLALLL-RRLRKIVRVLLAL-----LLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 110-296 3.46e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 78.43  E-value: 3.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  110 YCFIGYFFvGVCFNQLMVDIAKYTIGRQRPHFMDVCRPD-IGYQtcsqpDLYITDFKCTTtDTKKIHEAQLSFYSGHSAF 188
Cdd:PLN02250  98 HAILGLLF-SVLITGVITDAIKDAVGRPRPDFFWRCFPDgKGVF-----HPVTTDVLCTG-AKSVIKEGHKSFPSGHTSW 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  189 SFYAAWFTSLYL--QARLF--RPLFSRLLLPVIQFLLfggAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVAL-FVAE 263
Cdd:PLN02250 171 SFAGLGFLSLYLsgKIRVFdrRGHVAKLCIVFLPLLV---AALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLqFFPP 247

                        170       180       190
                 ....*....|....*....|....*....|...
gi 32565028  264 VFkrrEIPSCGPSNEFGLIRMDRPDGVSNANGN 296
Cdd:PLN02250 248 PY---DIDGWGPHAYFQMLAESRNGAQSSNGIN 277
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 108-258 3.15e-71

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 219.81  E-value: 3.15e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 108 RLYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSA 187
Cdd:cd03384   1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32565028 188 FSFYAAWFTSLYLQARLFRPlFSRLLLPVIQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVA 258
Cdd:cd03384  81 LSMYAAVFLALYLQARLKLR-GSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 116-257 3.28e-32

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 120.02  E-value: 3.28e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 116 FFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGyqtcSQPDLYITDFKCTTTDTKKIHEAQLSFYSGHSAFSFYAAWF 195
Cdd:cd03390  51 LLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGG----TPSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGF 126

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32565028 196 TSLYLQARL----FRPLFSRLLLPVIQFLLfggAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFV 257
Cdd:cd03390 127 LSLYLAGKLhifdPRGSSWRLLLALLPLLL---AILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLS 189
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 109-257 7.33e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 95.22  E-value: 7.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 109 LYCFIGYFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTcsqpdlyitdfkctttdtkkIHEAQLSFYSGHSAF 188
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLL--------------------LTEGGYSFPSGHAAF 60

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32565028 189 SFYAAWFTSLYLQARLFRPLFsrlllpviQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFV 257
Cdd:cd01610  61 AFALALFLALLLPRRLLRLLL--------GLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
acidPPc smart00014
Acid phosphatase homologues;
122-257 7.83e-22

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 89.71  E-value: 7.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028    122 FNQLMVDIAKYTIGRQRPHFMDVCRPdigyqtcsqpdlyitdfkCTTTDTKKIHEAQLSFYSGHSAFSFYAAWFTSLYLQ 201
Cdd:smart00014   6 VSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLP 67

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 32565028    202 ARLFRPLFsrlllpviQFLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFV 257
Cdd:smart00014  68 ARAGRKLL--------IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 115-261 1.58e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.62  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028   115 YFFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDIGYQTCSQPDLYitdfkctttdtkkiheaqlSFYSGHSAFSFYAAW 194
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGY-------------------SFPSGHSATAFALAL 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32565028   195 FTSLYLqARLFRPLFSRLLLpviqfLLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVALFV 261
Cdd:pfam01569  62 LLALLL-RRLRKIVRVLLAL-----LLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
 110-296 3.46e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 78.43  E-value: 3.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  110 YCFIGYFFvGVCFNQLMVDIAKYTIGRQRPHFMDVCRPD-IGYQtcsqpDLYITDFKCTTtDTKKIHEAQLSFYSGHSAF 188
Cdd:PLN02250  98 HAILGLLF-SVLITGVITDAIKDAVGRPRPDFFWRCFPDgKGVF-----HPVTTDVLCTG-AKSVIKEGHKSFPSGHTSW 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  189 SFYAAWFTSLYL--QARLF--RPLFSRLLLPVIQFLLfggAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFVAL-FVAE 263
Cdd:PLN02250 171 SFAGLGFLSLYLsgKIRVFdrRGHVAKLCIVFLPLLV---AALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLqFFPP 247

                        170       180       190
                 ....*....|....*....|....*....|...
gi 32565028  264 VFkrrEIPSCGPSNEFGLIRMDRPDGVSNANGN 296
Cdd:PLN02250 248 PY---DIDGWGPHAYFQMLAESRNGAQSSNGIN 277
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 114-257 3.29e-14

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 68.13  E-value: 3.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 114 GYFFVGVCFNQLMVDIAKYTIGRQRPhfmdvcrpdigyqtcsqpDLYITDFkctttdtkkiheaqLSFYSGHSAFSFYAA 193
Cdd:cd03394   6 LILAEAAALTAAVTEGLKFAVGRARP------------------DGSNNGY--------------RSFPSGHTASAFAAA 53

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32565028 194 WFtslyLQARLFRPLFSrllLPviqflLFGGAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVFV 257
Cdd:cd03394  54 TF----LQYRYGWRWYG---IP-----AYALASLVGASRVVANRHWLSDVLAGAAIGILVGYLV 105
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 120-250 1.45e-11

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 65.05  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  120 VCFNQLMVDIAKYTIGRQRPHFMDVCRPDigyqtcsQPDLY--ITDFKCTTtDTKKIHEAQLSFYSGHSAFSFYAAWFTS 197
Cdd:PLN02731 126 VLVTAVLTDAIKNAVGRPRPDFFWRCFPD-------GKALYdsLGDVICHG-DKSVIREGHKSFPSGHTSWSFSGLGFLS 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 32565028  198 LYLQARL----FRPLFSRLLLpVIQFLLFggAAYVSLTRVSDYKHHWSDVLVGAIMG 250
Cdd:PLN02731 198 LYLSGKIqafdGKGHVAKLCI-VILPLLF--AALVGISRVDDYWHHWQDVFAGGLLG 251
PLN02715 PLN02715
lipid phosphate phosphatase
 16-256 5.04e-11

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 63.15  E-value: 5.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028   16 FLVLTLIAIPLYVFHEFIPPVRRGFYCDdesIRYPFRDSKVTRQMLIVVGLLIPILLILATELFRTLAWEkkcetefkty 95
Cdd:PLN02715  54 LVILIAIEIGLNLISPFYRYVGKDMMTD---LKYPFKDNTVPIWSVPVYAVLLPIILFVCFYLKRRCVYD---------- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028   96 hvRNHSVhrlvvrlycfIGYFFvGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDigyqtcsQPDLY--ITDFKCTTTdTKK 173
Cdd:PLN02715 121 --LHHSI----------LGLLF-AVLITGVITDSIKVATGRPRPNFYWRCFPD-------GKELYdaLGGVICHGK-AAE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028  174 IHEAQLSFYSGHSAFSFYAAWFTSLYLQARL----FRPLFSRLLLPVIQFLlfgGAAYVSLTRVSDYKHHWSDVLVGAIM 249
Cdd:PLN02715 180 VKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIkafnGEGHVAKLCLVIFPLL---AACLVGISRVDDYWHHWQDVFAGALI 256


                 ....*..
gi 32565028  250 GSAIGVF 256
Cdd:PLN02715 257 GILVAAF 263
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 114-265 2.22e-08

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 53.48  E-value: 2.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 114 GYFFVGVCFNQLMVDIAKYTIGRQRPHFMdvcrpdigyqtcSQPDLYITDFKctttdtkKIHEAQLSFYSGHSAFSFyaA 193
Cdd:cd03389  72 LFLFATVALSGILVNLLKFIIGRARPKLL------------FDDGLYGFDPF-------HADYAFTSFPSGHSATAG--A 130

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32565028 194 WFTSLYLQARLFRPLFsrlllpviqfllFGGAAYVSLTRVSDYKHHWSDVlvgaIMGSAIGVFVALFVAEVF 265
Cdd:cd03389 131 AAAALALLFPRYRWAF------------ILLALLIAFSRVIVGAHYPSDV----IAGSLLGAVTALALYQRF 186
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 183-256 9.34e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 45.34  E-value: 9.34e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32565028 183 SGHSAF-SFYAAWFT-SLYLQARLFRPLFSRLLLPVIQFLLfggAAYVSLTRVSDYKHHWSDVLVGAIMGSAIGVF 256
Cdd:cd03382  85 SSHSQFmGFFAVYLLlFIYLRLGRLNSLVSRFLLSLGLLLL---ALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 130-257 3.73e-03

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 38.18  E-value: 3.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 130 AKYTIGRQRPHFMdvcrpdigYQTCSQPdlyitdfKCTTTDTKKIHEaqlSFYSGHSAFSFyaAWFTSLylqARLFRPLF 209
Cdd:cd03380 112 AKYHYNRPRPFVA--------IRLQWLP-------ICTPEEGTPKHP---SYPSGHATFGG--AAALVL---AELFPERA 168

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32565028 210 SRLLlpviqfllfggaayvslTRVSDYKH-------HW-SDVLVGAIMGSAIGVFV 257
Cdd:cd03380 169 AELL-----------------ARAAEAGNsrvvagvHWpSDVEAGRILGEAIAAAL 207
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 116-261 6.73e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 36.91  E-value: 6.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565028 116 FFVGVCFNQLMVDIAKYTIGRQRPHFMDVCRPDigyqtCSQPDLYitdfkctttdtkkiheaqlSFYSGHSAFSFY-AAW 194
Cdd:cd03391  52 LLLGLLLDIITVAILKALVRRRRPAYNSPDMLD-----YVAVDKY-------------------SFPSGHASRAAFvARF 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32565028 195 FTSLYLQARLFRPLfsrlllpviqflLFGGAAYVSLTRVSDYKHHWSDVLVGAimgsAIGVFVALFV 261
Cdd:cd03391 108 LLNHLVLAVPLRVL------------LVLWATVVGISRVLLGRHHVLDVLAGA----FLGYLEALLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH