BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770   153 FDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTeFPSDRT 232
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK-LISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 32564770   233 AEKILEMADRFMVQSAIDHVEYHLLHNS 260
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770   153 FDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTeFPSDRT 232
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK-LISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 32564770   233 AEKILEMADRFMVQSAIDHVEYHLLHNS 260
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18186   3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770   153 FDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTeFPSDRT 232
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK-LISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 32564770   233 AEKILEMADRFMVQSAIDHVEYHLLHNS 260
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18186   3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 155 EMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIY-PKTEFPSDRTA 233
Cdd:cd18286  10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYgGVLDLPDDVNL 89

                        90       100
                ....*....|....*....|....*.
gi 32564770 234 EKILEMADRFMVQSAIDHVEYHLLHN 259
Cdd:cd18286  90 GELLSLADMYGLDGLKDVVAYTLRRD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18257  20 DVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLL 99

                ....*.
gi 32564770 244 MVQSAI 249
Cdd:cd18257 100 QIKLVL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYpktefpsdrTAEKILEMADRF 243
Cdd:cd18255  20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAY---------TSELTLDLDCIQ 90

                        90
                ....*....|
gi 32564770 244 MVQSAIDHVE 253
Cdd:cd18255  91 DVLGAAVHLQ 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18265  25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLL 104

                ..
gi 32564770 244 MV 245
Cdd:cd18265 105 QV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMA 240
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAA 108

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 150 QFSFDEMFLSSKKN---DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKE-----DKQDEIELKDVVYEDFGLLMTTI 221
Cdd:cd18296   2 VDLDELPFPPEQELsfpDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYI 81

                        90       100
                ....*....|....*....|.
gi 32564770 222 YP-KTEFPSDrTAEKILEMAD 241
Cdd:cd18296  82 YTdDTDLPPE-NAYDVLYVAD 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 153 FDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRT 232
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAEN 87

                        90       100
                ....*....|....*....|....*...
gi 32564770 233 AEKILEMADRF----MVQSAIDHVEYHL 256
Cdd:cd18240  88 VEELLPAADQFnimgIVKACCDFLEDQL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDV 209
Cdd:cd18238  17 DVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI 62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18250  23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 32564770 169 IGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIEL 206
Cdd:cd18320   8 VEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRL 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVY-EDFGLLMTTIYPKTEFPSDRTAEKILEMADR 242
Cdd:cd18267  42 DVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDSIHpEVLELLLDYAYSSRVIINEENAESLLEAGDM 121

                        90       100
                ....*....|....*....|..
gi 32564770 243 FMVQSAIDHVEYHLLHNSRITN 264
Cdd:cd18267 122 LEFQDIRDACAEFLEKNLHPTN 143

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564770 150 QFSFDEMFLSSKKN---DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIY 222
Cdd:cd18235   6 QKAFDVMNELRKQNllcDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIY 222
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAY 73

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18352  15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQY 94

                        90
                ....*....|.
gi 32564770 244 MVQSAIDHVEY 254
Cdd:cd18352  95 LLEGLKRLCEY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 149 LQFSFDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFP 228
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLI 90

                        90       100
                ....*....|....*....|....*...
gi 32564770 229 SDRTAEKILEMADRFMVQSAIDHVEYHL 256
Cdd:cd18236  91 TKQNVQRVLEAASLFQFLRMVDACASFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18237  23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQY 102

                ...
gi 32564770 244 MVQ 246
Cdd:cd18237 103 QIE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 155 EMFLSSKK-NDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTA 233
Cdd:cd18336  11 ENYLQHKQlCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTI 90

                        90
                ....*....|....*..
gi 32564770 234 EKILEMADRFMVQSAID 250
Cdd:cd18336  91 ESLLAAACLLQLSQVID 107

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKT---EFPSDRTAEKILEMA 240
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTgrlDLFSVENVHEVLELA 80

                ...
gi 32564770 241 DRF 243
Cdd:cd18190  81 SKF 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQD--EIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMAD 241
Cdd:cd18245  16 DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAAD 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVY-EDFGLLMTTIYPKTEFPSDRTAEKILEMADr 242
Cdd:cd18254  24 DVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHpEVLELLLDFAYSSRIIINEENAESLLEAGD- 102

                ....
gi 32564770 243 fMVQ 246
Cdd:cd18254 103 -MLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDV 209
Cdd:cd18337  25 DVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGV 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 147 NPLQF--SFDEMFLSSKKNDAVLVIGERKL-HVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYP 223
Cdd:cd18252   4 HPADFldAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYT 83

                        90
                ....*....|....*...
gi 32564770 224 KTEFPSDRTAEKILEMAD 241
Cdd:cd18252  84 SQICITERNVQSLLEAAD 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 32564770 161 KKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDV 209
Cdd:cd18259  31 KLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDV 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18264  30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYL 109

                        90
                ....*....|....*.
gi 32564770 244 MVQSAIDHVEYHLLHN 259
Cdd:cd18264 110 QVTEAIGLCSQYLINN 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIYPKTEFPSDRTAEKILEMADRF 243
Cdd:cd18253  20 DVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSLF 99

                ....*..
gi 32564770 244 MVQSAID 250
Cdd:cd18253 100 QISPLRD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564770 152 SFDEMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIY 222
Cdd:cd18353  10 SLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLY 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32564770 150 QFSFDEMFLSSKKNDAVLVIGERKLHVNKAFLSyHSDYFRALFSSNFKEDKQDEIEL 206
Cdd:cd18305   3 KYIYQTLFLNGENSDITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINL 58

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 155 EMFLSSKKNDAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKDVVYEDFGLLMTTIY--PKTEFPSDRT 232
Cdd:cd18344  16 ELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYtgKAPHLHSHSM 95

                        90
                ....*....|.
gi 32564770 233 AEKILEMADRF 243
Cdd:cd18344  96 ACDVLAAADKY 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSsnfkedkQDEIELKDVVYEDFGLLMTTIYP-KTEFPSDRTAE-----KIL 237
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLS-------RDILKVKGLSYATLRLLVDYVYSgRMAVSKDNVVEvvagaRFL 78

                        90       100
                ....*....|....*....|...
gi 32564770 238 EMAdrFMVQSAIDHVEYHL-LHN 259
Cdd:cd18275  79 QMP--CAAQCAVDAVRAQLcLGN 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564770 164 DAVLVIGERKLHVNKAFLSYHSDYFRALFSSNFKEDKQDEIELKD--VVYEDFGLLMTTIYPKTEFPSDRTAEKILEMAD 241
Cdd:cd18196  23 DCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVLLAAS 102

                        90
                ....*....|....*
gi 32564770 242 RFMVQSAIDHVEYHL 256
Cdd:cd18196 103 HLHLNSVVKACKHYL 117