BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203   1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203  81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 32469509 333 IKCTKCPEVFQGVEKLVFHMRAQHFifMCPRCGKQFNHSSNLNRH-MNVHR 382
Cdd:cd20908   2 PWCYYCDREFDDEKILIQHQKAKHF--KCHICHKKLYTAGGLAVHcLQVHK 50

FOG: Zn-finger [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509 361 CPRCGKQFNHSSNLN---RHMNVHRG-VKSHSCGICGKCFTQKSTLHDHLN--LHSG--ARPYRC--SYCDVRFAHKPAI 430
Cdd:COG5048 260 SPRSSLPTASSQSSSpneSDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDAL 339

                        90
                ....*....|....*...
gi 32469509 431 RRHLKEQHGKTTAENVLE 448
Cdd:COG5048 340 KRHILLHTSISPAKEKLL 357

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203   1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203  81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509     34 DVTIVADSLKFRGHKVILAACSPFLRDQFLLNP--SSELQVSLMH-SARIVADLLLSCYTGALEFAVRDIVNYLTAASYL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDvSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 32469509    111 QMEHVVEKCRNALSQFI 127
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 32469509   359 FMCPRCGKQFNHSSNLNRHMNVH 381
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 32469509   373 NLNRHMNVHRGVKSHSCGICGKCFTQ 398
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509 328 NPLKNIKC--TKCPEVFQGVEKLVFHMRAQHFIFMCPRCG---KQFNH------SSNLNRHMNV---HRGVKSHS-CGIC 392
Cdd:COG5236 147 EDLLSFKCpkSKCHRRCGSLKELKKHYKAQHGFVLCSECIgnkKDFWNeirlfrSSTLRDHKNGgleEEGFKGHPlCIFC 226

                        90       100
                ....*....|....*....|....*....
gi 32469509 393 GKCFTQKSTLHDHLNLhsgaRPYRCSYCD 421
Cdd:COG5236 227 KIYFYDDDELRRHCRL----RHEACHICD 251

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 32469509   415 YRCSYCDVRFAHKPAIRRHLKEQHG 439
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18203   1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSRVVADLLLS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18203  81 CYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18197   1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18197  81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18227   1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18227  81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   8 LRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLLLS 87
Cdd:cd18220   1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18220  81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQF---------LLNPSSELQVSLMH-SARIVADL 84
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvLVSPAGKCVLDLHHvTVTGFAPL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 32469509  85 LLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCrnalSQFIEPKI 131
Cdd:cd18228  82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC----SEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFL--LNPSSELQVSLMH-SARIVADLLLSCYTG 91
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTggMRESSQDEIELKGvSAKGLKHILDFAYTS 80

                        90       100
                ....*....|....*....|....*...
gi 32469509  92 ALEFAVRDIVNYLTAASYLQMEHVVEKC 119
Cdd:cd18255  81 ELTLDLDCIQDVLGAAVHLQMLPVVELC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHS---ARIVADLLLSCYTG 91
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSgleARGFQLLLDFMYTS 81

                        90       100
                ....*....|....*....|....*....
gi 32469509  92 ALEFAVRDIVNYLTAASYLQMEHVVEKCR 120
Cdd:cd18332  82 RLPLTPRTVPAVLAAATYLQMEHVVETCR 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  20 LRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLlnpsSELQVSLMHSARI-------VADLLLSCYTGA 92
Cdd:cd18238   3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFT----SEMAESKQDSITIkdideeaVELLVDFAYTGK 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  93 LEFAVRDIVNYLTAASYLQMEHVVEKCrnalSQFIE 128
Cdd:cd18238  79 LTLTVDNVQSLLYAASLLQVEEVAKAC----CEFMK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQF--LLNPSSELQVSLMH-SARIVADLLLSCYTG 91
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFssDSDGESILTVKLDGlDPDAVEVLVNYAYTS 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 32469509  92 ALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEPK 130
Cdd:cd18306  81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   6 EVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLL 85
Cdd:cd18289   3 QMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQIL 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 32469509  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEK 118
Cdd:cd18289  83 SFCYTGKLTMAASEQLVVMYTAGFLQIQHIVER 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  14 GHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFL--LNPSSELQVSLMH-SARIVADLLLSCYT 90
Cdd:cd18242   3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTseMSEKGKSEVELQGlTASTMEILLDFVYT 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 32469509  91 GALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18242  83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFL--LNPSSELQVSLMH-SARIVADLLLSCY 89
Cdd:cd18339   2 PAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTgdMSESKAKKIEIKDvDGQTLSKLIDYIY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 32469509  90 TGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18339  82 TAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSLMHSARI-------VADLL 85
Cdd:cd18338   2 PRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMF----TGEMSESRAKRVRIkevdgwtLKMLI 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 32469509  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEP 129
Cdd:cd18338  78 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  18 ATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNpSSELQVSLMHSARIVADLLLSCYTGALEFAV 97
Cdd:cd18208  11 SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLG-YSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQ 89

                        90       100
                ....*....|....*....|....*...
gi 32469509  98 RDIVNYLTAASYLQMEHVVEKCRNALSQ 125
Cdd:cd18208  90 SEALQILTAASILQIKTVIDECTRIVSQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509   6 EVLRFQLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIVADLL 85
Cdd:cd18290   1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQIL 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 32469509  86 LSCYTGALEFAVRDIVNYLTAASYLQMEHVVEK 118
Cdd:cd18290  81 SFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  13 PGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFllnpSSELQVSlmHSARIV-------ADLL 85
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF----TGDLSES--RANRVTlqdvdgkALLL 75

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  86 L--SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKC 119
Cdd:cd18235  76 LidYVYTAEIQVTEENVQVLLPAANLLQLTDVRDAC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  12 LPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLlnpsseLQVSLMH----SARIVADLLLS 87
Cdd:cd18206   2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHldisNAAGLGQVLEF 75

                        90       100       110
                ....*....|....*....|....*....|..
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKC 119
Cdd:cd18206  76 MYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSP----FLRDQFLLNPSSELQVSLMhSARIVADLLL 86
Cdd:cd18325   2 EFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMyfhlFYRDQLDKRDIVHLNSDIV-TAPAFSLLLE 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 32469509  87 SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18325  81 FMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKL 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  32 FCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMH--SARIVADLLLSCYTGALEFAVRDIVNYLTAASY 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPdvPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ..
gi 32469509 110 LQ 111
Cdd:cd18315  81 LQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSP----FLRDQFLLNPSSELQVSLMhSARIVADLLL 86
Cdd:cd18324   2 EFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMyfhlFYKDQLDKRDIVHLNSDIV-TAPAFALLLE 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 32469509  87 SCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQ 125
Cdd:cd18324  81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  14 GHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLN---PSSELQVSLM-HSARIVADLLLSCY 89
Cdd:cd18202   1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgavSSHEAVVDLSgFCKSSFLPLLEFAY 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 32469509  90 TGALEFAVRDIVNYLTAASYLQMEHVVEKCRN 121
Cdd:cd18202  81 TSELTFDFCSMAEVAMLARHLFMNEVLEICES 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  20 LRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNP----SSELQVSLMH-SARIVADLLLSCYTGAL- 93
Cdd:cd18245   2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPpkddGSTYKIELEGiSVEVMEEILDYIYTGQIk 81

                        90       100
                ....*....|....*....|....*...
gi 32469509  94 --EFAVRDIVNyltAASYLQMEHVVEKC 119
Cdd:cd18245  82 lsEDNIQDIVQ---AADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32469509  11 QLPGHEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSL---MHSARIVADLLLS 87
Cdd:cd18194   2 EFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLnsdIVTAPAFGLLLDF 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 32469509  88 CYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNAL 123
Cdd:cd18194  82 MYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRL 117