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Conserved domains on  [gi|32967283|ref|NP_861515|]
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ubiquitin-conjugating enzyme E2 C isoform 2 [Homo sapiens]

Protein Classification

ubiquitin-conjugating enzyme family protein( domain architecture ID 439)

ubiquitin-conjugating enzyme family protein similar to ubiquitin-conjugating enzyme E2 that catalyzes the covalent attachment of ubiquitin to other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBCc_UEV super family cl49610
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; ...
 33-153 1.51e-37

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; The family includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain and ubiquitin (Ub) E2 variant (UEV) domain. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin, and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s. Several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) contains the UEV domain, which lacks the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways.


The actual alignment was detected with superfamily member cd23791:

Pssm-ID: 483950  Cd Length: 140  Bit Score: 125.37  E-value: 1.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTAVGSIR------------------------------TSST 82
Cdd:cd23791   2 KRLQSELMTLMMSGDPGISAFPDGDNLFKWIGTITGPEGTVYEGLKyklslefpsnypykaptvkfetpcfhpnvdQHGN 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32967283  83 VCLlsgpretqDSSKPlVWGLGWDMRlllelTLQLFLQ--MPEPNIDSPLNTHAAELWKNPTAFKKYLQETYS 153
Cdd:cd23791  82 ICL--------DILKE-KWSALYDVR-----TILLSIQslLGEPNNDSPLNGQAAELWDNQEEYKKVLLKKYE 140
 
Name Accession Description Interval E-value
UBCc_UBE2C cd23791
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C ...
 33-153 1.51e-37

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C and related proteins; The E2C family includes mammalian ubiquitin-conjugating enzyme E2 C (UBE2C/UBCH10), yeast E2 ubiquitin-conjugating enzyme 11 (UBC11), plant ubiquitin-conjugating enzyme E2 19 (UBC19) and 20 (UBC20). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2C, also known as (E3-independent) E2 ubiquitin-conjugating enzyme C (EC 2.3.2.24), E2 ubiquitin-conjugating enzyme C, ubiquitin carrier protein C, or ubiquitin-protein ligase C, catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination in vitro. It is a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe. In Saccharomyces cerevisiae, UBC11 is not essential for mitotic cyclin destruction. Arabidopsis thaliana UBC19 is part of the anaphase-promoting complex (APC). It may have a key function during cell cycle and be involved in cyclin B1 degradation.


Pssm-ID: 467411  Cd Length: 140  Bit Score: 125.37  E-value: 1.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTAVGSIR------------------------------TSST 82
Cdd:cd23791   2 KRLQSELMTLMMSGDPGISAFPDGDNLFKWIGTITGPEGTVYEGLKyklslefpsnypykaptvkfetpcfhpnvdQHGN 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32967283  83 VCLlsgpretqDSSKPlVWGLGWDMRlllelTLQLFLQ--MPEPNIDSPLNTHAAELWKNPTAFKKYLQETYS 153
Cdd:cd23791  82 ICL--------DILKE-KWSALYDVR-----TILLSIQslLGEPNNDSPLNGQAAELWDNQEEYKKVLLKKYE 140
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 34-152 1.10e-12

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 61.44  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283    34 RLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT--AVGSIR----------------------------TSSTV 83
Cdd:pfam00179   1 RLQKELKELLKDPPPGISAGPVDDNLFEWKVTIIGPDGTpyEGGVFKlsvefpedypfkppkvkfttkiyhpnvdSSGEV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32967283    84 CLlsgpretqDSSKPLVWGLGWDMRllleltlqlflQ--------MPEPNIDSPLNTHAAELWK-NPTAFKKYLQETY 152
Cdd:pfam00179  81 CL--------DILKDERWSPALTLE-----------QvllsiqslLSEPNPEDPLNAEAAKLYRkNREEFEKKVREYV 139
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 34-154 1.47e-11

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 58.46  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283     34 RLQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGT--AVGSIR----------------------------TSST 82
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYPVDDeNLLEWTGTIVGPPGTpyEGGVFKltiefpedypfkppkvkfitkiyhpnvdSSGE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32967283     83 VCLlsgpretqDSSKPLVWGLGWDMRLLLELTLQLflqMPEPNIDSPLNTHAAELWK-NPTAFKKYLQETYSK 154
Cdd:smart00212  81 ICL--------DILKQEKWSPALTLETVLLSLQSL---LSEPNPDSPLNADAAELYKkNREEFKKKAREWTKK 142
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 33-68 1.54e-03

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 37.04  E-value: 1.54e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 32967283   33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHG 68
Cdd:PLN00172   4 KRIQKEHKDLLKDPPSNCSAGPSDENLFRWTASIIG 39
 
Name Accession Description Interval E-value
UBCc_UBE2C cd23791
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C ...
 33-153 1.51e-37

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C and related proteins; The E2C family includes mammalian ubiquitin-conjugating enzyme E2 C (UBE2C/UBCH10), yeast E2 ubiquitin-conjugating enzyme 11 (UBC11), plant ubiquitin-conjugating enzyme E2 19 (UBC19) and 20 (UBC20). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2C, also known as (E3-independent) E2 ubiquitin-conjugating enzyme C (EC 2.3.2.24), E2 ubiquitin-conjugating enzyme C, ubiquitin carrier protein C, or ubiquitin-protein ligase C, catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination in vitro. It is a ubiquitin carrier protein required for the destruction of mitotic cyclins and proteins that maintain sister chromatid cohesion in animal cells and in Schizosaccharomyces pombe. In Saccharomyces cerevisiae, UBC11 is not essential for mitotic cyclin destruction. Arabidopsis thaliana UBC19 is part of the anaphase-promoting complex (APC). It may have a key function during cell cycle and be involved in cyclin B1 degradation.


Pssm-ID: 467411  Cd Length: 140  Bit Score: 125.37  E-value: 1.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTAVGSIR------------------------------TSST 82
Cdd:cd23791   2 KRLQSELMTLMMSGDPGISAFPDGDNLFKWIGTITGPEGTVYEGLKyklslefpsnypykaptvkfetpcfhpnvdQHGN 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32967283  83 VCLlsgpretqDSSKPlVWGLGWDMRlllelTLQLFLQ--MPEPNIDSPLNTHAAELWKNPTAFKKYLQETYS 153
Cdd:cd23791  82 ICL--------DILKE-KWSALYDVR-----TILLSIQslLGEPNNDSPLNGQAAELWDNQEEYKKVLLKKYE 140
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 34-152 1.10e-12

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 61.44  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283    34 RLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT--AVGSIR----------------------------TSSTV 83
Cdd:pfam00179   1 RLQKELKELLKDPPPGISAGPVDDNLFEWKVTIIGPDGTpyEGGVFKlsvefpedypfkppkvkfttkiyhpnvdSSGEV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32967283    84 CLlsgpretqDSSKPLVWGLGWDMRllleltlqlflQ--------MPEPNIDSPLNTHAAELWK-NPTAFKKYLQETY 152
Cdd:pfam00179  81 CL--------DILKDERWSPALTLE-----------QvllsiqslLSEPNPEDPLNAEAAKLYRkNREEFEKKVREYV 139
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 34-154 1.47e-11

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 58.46  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32967283     34 RLQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGT--AVGSIR----------------------------TSST 82
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYPVDDeNLLEWTGTIVGPPGTpyEGGVFKltiefpedypfkppkvkfitkiyhpnvdSSGE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32967283     83 VCLlsgpretqDSSKPLVWGLGWDMRLLLELTLQLflqMPEPNIDSPLNTHAAELWK-NPTAFKKYLQETYSK 154
Cdd:smart00212  81 ICL--------DILKQEKWSPALTLETVLLSLQSL---LSEPNPDSPLNADAAELYKkNREEFKKKAREWTKK 142
UBCc_SpUBC14-like cd23815
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 ...
 33-72 3.20e-07

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 and related proteins; Schizosaccharomyces pombe UBC14 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2 14, E2 ubiquitin-conjugating enzyme 14, ubiquitin carrier protein 14, or ubiquitin-protein ligase 14, acts as a ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. It mediates the selective degradation of short-lived and abnormal proteins.


Pssm-ID: 467435  Cd Length: 143  Bit Score: 46.90  E-value: 3.20e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd23815   1 RRIQKELADLQKNPIAGISAGPVEDNLFEWKGTILGPVGS 40
UBCc_UEV cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; ...
 33-72 4.42e-07

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; The family includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain and ubiquitin (Ub) E2 variant (UEV) domain. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin, and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s. Several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) contains the UEV domain, which lacks the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways.


Pssm-ID: 467407 [Multi-domain]  Cd Length: 112  Bit Score: 46.13  E-value: 4.42e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd00195   1 KRLQKELKELQKNPPPGISVEPVDDDLFHWKATIKGPEGT 40
UBCc_UBE2W cd23808
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 W ...
 33-72 9.33e-06

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 W and related enzymes; The E2W subfamily includes mammalian ubiquitin-conjugating enzymes E2 W (UBE2W/UBC16), plant ubiquitin-conjugating enzyme E2 15-18 (UBC15-18), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2W, also called FLJ11011, E2 ubiquitin-conjugating enzyme W, N-terminal E2 ubiquitin-conjugating enzyme (EC 2.3.2.25), N-terminus-conjugating E2, ubiquitin carrier protein W, ubiquitin-conjugating enzyme 16 (UBC-16), or ubiquitin-protein ligase W, specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. In vitro, UBE2W catalyzes 'Lys-11'-linked polyubiquitination. UBE2W is an important protein for early postnatal survival and for the normal functioning of multiple organ systems.


Pssm-ID: 467428 [Multi-domain]  Cd Length: 119  Bit Score: 42.51  E-value: 9.33e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd23808   2 KRLQKELKELQKNPPPGITLDVADNNLTEWIVTIEGAPGT 41
UBCc_UBE2A_2B cd23790
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, ...
 33-73 1.27e-05

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, E2B and related proteins; The E2A/2B subfamily includes mammalian ubiquitin-conjugating enzymes UBE2A/RAD6A and UBE2B/RAD6B, yeast ubiquitin-conjugating enzyme E2 2 (UBC2/RAD6), plant ubiquitin-conjugating enzyme E2 1-3 (UBC1-3), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. Both UBE2A/RAD6A and UBE2B/RAD6B are required for post-replication repair of UV-damaged DNA. In vitro, they catalyze 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. UBE2B might also catalyze 'Lys-63'-linked polyubiquitination. Saccharomyces cerevisiae UBC2 is required for DNA repair, damage-induced mutagenesis, and sporulation.


Pssm-ID: 467410  Cd Length: 143  Bit Score: 42.50  E-value: 1.27e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTA 73
Cdd:cd23790   5 RRLMRDFKRLQKDPPEGISAAPVEDNIMVWNAVIFGPEDTP 45
UBCc_UBE2J cd23799
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 J1, ...
 33-72 2.74e-05

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 J1, J2 and related proteins; The E2J subfamily includes mammalian ubiquitin-conjugating enzymes E2 J1 (UBE2J1/HSPC153/HSPC205/NCUBE1) and J2 (UBE2J2/NCUBE1), yeast ubiquitin-conjugating enzyme E2 6 (UBC6/DOA2), and plant ubiquitin-conjugating enzyme E2 32-34 (UBC32-34). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2J1 and UBE2J2 are non-canonical ubiquitin-conjugating enzyme (NCUBE), which function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Saccharomyces cerevisiae UBC6 functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. It is a cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.


Pssm-ID: 467419  Cd Length: 134  Bit Score: 41.69  E-value: 2.74e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd23799   1 KRLLKELRELQKDPPPYIVAAPLEDNILEWHFTIRGPPDT 40
UBCc_UBE2E cd23793
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 ...
 33-72 3.88e-05

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 E1-E3 and related proteins; The E2E subfamily includes mammalian ubiquitin-conjugating enzyme E2 E1-3 (UBE2E1/UBCH6, UBE2E2/UBCH8, UBE2E3/UBCH9) and similar proteins. UBE2E, also known as (E3-independent) E2 ubiquitin-conjugating enzyme E, or E2 ubiquitin-conjugating enzyme E, accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. UBE2E1 (EC 2.3.2.23 and EC 2.3.2.24) catalyzes the covalent attachment of ISG15 to other proteins. It mediates the selective degradation of short-lived and abnormal proteins. In vitro, it also catalyzes 'Lys-48'-linked polyubiquitination. In vitro, both UBE2E2 (EC 2.3.2.23) and UBE2E3 (EC 2.3.2.23) catalyze 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. UBE2E2 catalyzes the ISGylation of influenza A virus NS1 protein. UBE2E3 participates in the regulation of trans-epithelial sodium transport in renal cells. It may be involved in cell growth arrest.


Pssm-ID: 467413  Cd Length: 141  Bit Score: 41.21  E-value: 3.88e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd23793   1 KRIQKELAEITLDPPPNCSAGPKGDNLYEWVSTILGPPGS 40
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 33-63 8.36e-04

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


Pssm-ID: 467422  Cd Length: 157  Bit Score: 37.61  E-value: 8.36e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 32967283  33 KRLQQELMTLMMS--GDKGISAFPESDNLFKWV 63
Cdd:cd23802   1 KRLMKELKDLMKSqsKKLGFSVDPVDDNLYHWE 33
UBCc_invertebrate cd23955
ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating ...
 33-77 1.23e-03

ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domains mostly found in non-vertebrate eukaryotes. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s.


Pssm-ID: 467440 [Multi-domain]  Cd Length: 120  Bit Score: 36.85  E-value: 1.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTAVGSI 77
Cdd:cd23955   1 RRLLRDLKELQEEPLPGVSAEPLENDLFEWHVNIRGPDGPYSGVI 45
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 33-68 1.54e-03

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 37.04  E-value: 1.54e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 32967283   33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHG 68
Cdd:PLN00172   4 KRIQKEHKDLLKDPPSNCSAGPSDENLFRWTASIIG 39
UBCc_UBE2G1 cd23795
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 G1 ...
 123-146 4.15e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 G1 and related proteins; The subfamily includes mammalian ubiquitin-conjugating enzymes E2 G1 (UBE2G1/UBC7/E217K), fission yeast ubiquitin-conjugating enzyme E2 15 (UBC15), plant ubiquitin-conjugating enzymes E2 7 (UBC7), E2 13 (UBC13) and E2 14 (UBC14). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. In vitro, UBE2G1 catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. It may be involved in the degradation of muscle-specific proteins and may mediate polyubiquitination of CYP3A4. Schizosaccharomyces pombe UBC15 has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors. Arabidopsis thaliana UBC7, UBC13 and UBC14 are involved in the formation of multiubiquitin chains. They signal the protein for selective degradation.


Pssm-ID: 467415  Cd Length: 155  Bit Score: 35.61  E-value: 4.15e-03
                        10        20
                ....*....|....*....|....*
gi 32967283 123 EPNIDSPLNTHAAELWK-NPTAFKK 146
Cdd:cd23795 126 DPNDESPANVDAAKEWReDPDEFKK 150
UBCc_UBE2U cd23806
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 U ...
 35-73 4.40e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 U and related proteins; The E2U subfamily includes mammalian ubiquitin-conjugating enzymes E2 U (UBE2U/, EC 2.3.2.23) and similar proteins. They are ubiquitin-conjugating enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins.


Pssm-ID: 467426  Cd Length: 141  Bit Score: 35.67  E-value: 4.40e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  35 LQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGTA 73
Cdd:cd23806   3 LERELLELQENPLWGIEAKPVSDdNLFEWTAKIKGLKDTI 42
UBCc_UBE2T cd23805
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 T ...
 33-72 6.67e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 T and related enzymes; The E2T subfamily includes mammalian ubiquitin-conjugating enzymes E2 T (UBE2T/HSPC150/PIG50), plant ubiquitin-conjugating enzyme E2 37 (UBC37), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2T, also called cell proliferation-inducing gene 50 protein, catalyzes monoubiquitination. It is involved in mitomycin-C (MMC)-induced DNA repair. It acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. UBE2T also mediates monoubiquitination of FANCL and FANCI. It may contribute to ubiquitination and degradation of BRCA1. In vitro, UBE2T can promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.


Pssm-ID: 467425  Cd Length: 146  Bit Score: 35.20  E-value: 6.67e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 32967283  33 KRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT 72
Cdd:cd23805   1 ARLKRELQLLQKDPPPGISCWPKDDSLDELEAQIQGPEGT 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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