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Conserved domains on  [gi|32306524|ref|NP_861417|]
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G-protein coupled receptor 135 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
89-361 1.35e-125

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15212:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 285  Bit Score: 366.02  E-value: 1.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPG-DSGPWrsFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15212  17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGwLFGDR--LCLANGFFNACFGIVSTLTMTL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVGLVVA 247
Cdd:cd15212  95 ISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSSVLIVL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 248 CYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQgqaTQA 327
Cdd:cd15212 175 CYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG---YQF 251
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 328 PSLLNVAAVWLTWANGAINPVIYAIRNPNISMLL 361
Cdd:cd15212 252 PPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
 
Name Accession Description Interval E-value
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
89-361 1.35e-125

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 366.02  E-value: 1.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPG-DSGPWrsFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15212  17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGwLFGDR--LCLANGFFNACFGIVSTLTMTL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVGLVVA 247
Cdd:cd15212  95 ISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSSVLIVL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 248 CYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQgqaTQA 327
Cdd:cd15212 175 CYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG---YQF 251
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 328 PSLLNVAAVWLTWANGAINPVIYAIRNPNISMLL 361
Cdd:cd15212 252 PPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
89-350 2.84e-27

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 109.69  E-value: 2.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524    89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFG-SALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524   169 SLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLLRAPREPPaPQSFHRCLYRTsPDPAQLGVAYSVGLVV 246
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRtpRRAKVLILVIWVLALLLSLPPLLFGWTLTVP-EGNVTVCFIDF-PEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524   247 ACYLLPFLLMCFCRYHICKTVRLSDVRVRpmttyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA-TRQGQAT 325
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQK------SSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSlALDCELS 231
                         250       260
                  ....*....|....*....|....*
gi 32306524   326 QAPSLLNVAAVWLTWANGAINPVIY 350
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
89-361 1.35e-125

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 366.02  E-value: 1.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPG-DSGPWrsFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15212  17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGwLFGDR--LCLANGFFNACFGIVSTLTMTL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVGLVVA 247
Cdd:cd15212  95 ISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYSSVLIVL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 248 CYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQgqaTQA 327
Cdd:cd15212 175 CYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAGG---YQF 251
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 328 PSLLNVAAVWLTWANGAINPVIYAIRNPNISMLL 361
Cdd:cd15212 252 PPLMDTVAIWMAWANGAINPLIYAIRNPNISMLL 285
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
89-354 1.80e-38

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 140.50  E-value: 1.80e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWrsFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd00637  15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDA--LCKLLGFLQSVSLLASILTLTAI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPpapqsFHRCLYRTSPDPAQLGVAYSVGLVV 246
Cdd:cd00637  93 SVDRYLAIVHPlrYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-----GGYCCCCLCWPDLTLSKAYTIFLFV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 247 ACYLLPFLLMCFCRYHICKTVRLSDVRVR-PMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQGQaT 325
Cdd:cd00637 168 LLFLLPLLVIIVCYVRIFRKLRRHRRRIRsSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDP-S 246
                       250       260
                ....*....|....*....|....*....
gi 32306524 326 QAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd00637 247 PLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
89-350 2.84e-27

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 109.69  E-value: 2.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524    89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFG-SALCKIVGALFVVNGYASILLLTAI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524   169 SLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLLRAPREPPaPQSFHRCLYRTsPDPAQLGVAYSVGLVV 246
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRtpRRAKVLILVIWVLALLLSLPPLLFGWTLTVP-EGNVTVCFIDF-PEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524   247 ACYLLPFLLMCFCRYHICKTVRLSDVRVRpmttyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA-TRQGQAT 325
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQK------SSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSlALDCELS 231
                         250       260
                  ....*....|....*....|....*
gi 32306524   326 QAPSLLNVAAVWLTWANGAINPVIY 350
Cdd:pfam00001 232 RLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
89-357 3.51e-25

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 103.80  E-value: 3.51e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd14967  16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTL-----LGYWpfgPVLCRFWIALDVLCCTASILNL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPP--RDKLGRRRALQLLAGAWLAALGFS-LPWDLLRAPREPPAPQsfhrCLYRTSPDPaqlgvAYSV 242
Cdd:cd14967  91 CAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISlPPLVGWRDETQPSVVD----CECEFTPNK-----IYVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMCFCryhicktvrlsdvrvrpmttYARVLRFFS-EVRTA-TTVLIMIIFVmCCWGPYCFLVLLAATR 320
Cdd:cd14967 162 VSSVISFFIPLLIMIVL--------------------YARIFRVARrELKAAkTLAIIVGAFL-LCWLPFFIIYLVSAFC 220
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 321 QGQATqaPSLLNVAAVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd14967 221 PPDCV--PPILYAVFFWLGYLNSALNPIIYALFNRDF 255
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
89-354 4.77e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 98.43  E-value: 4.77e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd14969  17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNL-----SGRWsfgDPGCVIYGFAVTFLGLVSISTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPR-DKLGRRRALQLLAGAWLAALGFSLP----WDllRAPREPpapqSFHRC---LYRTSPDpaqlG 237
Cdd:cd14969  92 AALAFERYLVIVRPLKaFRLSKRRALILIAFIWLYGLFWALPplfgWS--SYVPEG----GGTSCsvdWYSKDPN----S 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLR-FFSEVRTATTVLIMIIFVMCCWGPYCFLVLL 316
Cdd:cd14969 162 LSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32306524 317 AATRQG-----QATQAPSLL-NVAAVWltwangaiNPVIYAIRN 354
Cdd:cd14969 242 VSFGGEstippLLATIPALFaKSSTIY--------NPIIYVFMN 277
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
89-356 2.30e-22

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 96.90  E-value: 2.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPpgdsgPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd14993  17 GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR-----PWVfgeVLCKAVPYLQGVSVSASVLTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPW----DLLRAPREPPAPQSFHRClyRTSPDPAQLGVA 239
Cdd:cd14993  92 VAISIDRYLAICYPlkARRVSTKRRARIIIVAIWVIAIIIMLPLlvvyELEEIISSEPGTITIYIC--TEDWPSPELRKA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTV----RLSDVRVRPMTTYARVLRffSEVRTATTVLIMIIFVMCCWGPYcFLVL 315
Cdd:cd14993 170 YNVALFVVLYVLPLLIISVAYSLIGRRLwrrkPPGDRGSANSTSSRRILR--SKKKVARMLIVVVVLFALSWLPY-YVLS 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32306524 316 LAATRQGQATQAPSLLNVA----AVWLTWANGAINPVIYAIRNPN 356
Cdd:cd14993 247 ILLDFGPLSSEESDENFLLilpfAQLLGYSNSAINPIIYCFMSKK 291
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
89-353 1.16e-20

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 91.27  E-value: 1.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15213  17 GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTII-----TGRWifgDIFCRISAMLYWFFVLEGVAIL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRpPRDKLGRRRALQLLAGAWLAALGFSLP----WDLLRAPrePPAPQsfhrCLYRTSPDPAQLgvAYS 241
Cdd:cd15213  92 LIISVDRYLIIVQ-RQDKLNPHRAKILIAVSWVLSFCVSFPplvgWGKYEFP--PRAPQ----CVLGYTESPADR--IYV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRlsdvrvrpmttyarvlRFfsEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQ 321
Cdd:cd15213 163 VLLLVAVFFIPFLIMLYSYFCILNTVR----------------SF--KTRAFTTILILFIGFSVCWLPYTVYSLLSVFSR 224
                       250       260       270
                ....*....|....*....|....*....|..
gi 32306524 322 GQATQAPslLNVAAVWLTWANGAINPVIYAIR 353
Cdd:cd15213 225 YSSSFYV--ISTCLLWLSYLKSAFNPVIYCWR 254
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
89-356 4.17e-18

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 84.48  E-value: 4.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15202  17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFG--LFMCHFSNFAQYCSVHVSAYTLTAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTS-PDPAQLG-VAYSVGLVV 246
Cdd:cd15202  95 AVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDwPERADLFwKYYDLALFI 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 247 ACYLLPFLLMCFCRYHICKTVRLSDvrvrpMTTYARVLRFFSEVRTATTVLIMIIFVMC----CWGPYCFLVLLAATRQG 322
Cdd:cd15202 175 LQYFLPLLVISFAYARVGIKLWASN-----MPGDATTERYFALRRKKKKVIKMLMVVVVlfalCWLPFNIYVLLLSSKPD 249
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 323 QATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15202 250 YLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNER 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
89-351 2.29e-16

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 79.05  E-value: 2.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWrsFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd14971  17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDF--MCKFVHYFQQVSMHASIFTLVAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLLRAPREP-PAPQSFhrCLYRTSPDPAQLgvAYSVGLV 245
Cdd:cd14971  95 SLDRFLAVVYPLRSLHIRtpRNALAASGCIWVVSLAVAAPVLALHRLRNYtPGNRTV--CSEAWPSRAHRR--AFALCTF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRffsevRTATTVLIMIIFVMCCWGPYCFLVLLAATRQGQAT 325
Cdd:cd14971 171 LFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKR-----KVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLT 245
                       250       260
                ....*....|....*....|....*.
gi 32306524 326 QAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd14971 246 YATYALRIWAHCLAYSNSAVNPVLYA 271
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
89-357 2.59e-16

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 79.19  E-value: 2.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCaasRFFSSCFGI---VST 162
Cdd:cd15203  17 GNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTL-----TKNWpfgSILC---KLVPSLQGVsifVST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPW----DLLRAPREPPaPQSFHRCLYRTSPDPAQLgv 238
Cdd:cd15203  89 LTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLaifqELSDVPIEIL-PYCGYFCTESWPSSSSRL-- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTV--RLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFV-MCCWGPycfLVL 315
Cdd:cd15203 166 IYTISVLVLQFVIPLLIISFCYFRISLKLrkRVKKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVfAVCWLP---LNL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32306524 316 LAATR-----QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd15203 243 FNLLRdfeplPQIDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNF 289
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
89-350 9.66e-16

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 77.33  E-value: 9.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL------------FAPPGDsgpW---RSFCAASRFF 153
Cdd:cd15390  17 GNLIVIWIVLAHKRMRTVTNYFL--------------VNLAVADLlisafntvfnftYLLYND---WpfgLFYCKFSNFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 154 SSCFGIVSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHR--CLYRTSP 231
Cdd:cd15390  80 AITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERtvCFIAWPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 232 DP-AQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVR-------LSDVRVRPMTTYARVLRFFsevrtattVLIMIIFV 303
Cdd:cd15390 160 GPnSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWgsktigeNTPRQLESVRAKRKVVKMM--------IVVVVIFA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32306524 304 McCWGPYCFLVLLAATRQgQATQAPSLLNV--AAVWLTWANGAINPVIY 350
Cdd:cd15390 232 I-CWLPYHLYFILTYLYP-DINSWKYIQQIylAIYWLAMSNSMYNPIIY 278
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
89-357 1.10e-15

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 77.28  E-value: 1.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD-LFA--PPGDsgpwrSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15207  17 GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDnILTgwPFGD-----VMCKLSPLVQGVSVAASVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAP--QSFHRClyrTSPDPAQLG-VAYSV 242
Cdd:cd15207  92 VAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFrgQTVHIC---VEFWPSDEYrKAYTT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMCFCRYHICKTVRLsdvRVRPMTTYARVLRFFSEVRTATTVLIMIIFV----MCCWGPYCFLVLLAA 318
Cdd:cd15207 169 SLFVLCYVAPLLIIAVLYVRIGYRLWF---KPVPGGGSASREAQAAVSKKKVRVIKMLIVVvvlfALSWLPLHTVTMLDD 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 32306524 319 TRQGQATQAPSLLNVA---AVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd15207 246 FGNLSPNQREVLYVYIypiAHWLAYFNSCVNPIVYGYFNRNF 287
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
89-355 2.11e-14

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 73.51  E-value: 2.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLS-DLLTALLCLP----AAFLDLFappgdsgPWRS-FCAASRFFSSCFGIVST 162
Cdd:cd15337  17 GNLLVIYLFSKTKSLRTPSNMFIINLAISdFGFSAVNGFPlktiSSFNKKW-------IWGKvACELYGFAGGIFGFMSI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPPR--DKLGRRRALQLLagawlaalGFSLPWDLLRAPrePP-------APQSFH-RCLYR-TSP 231
Cdd:cd15337  90 TTLAAISIDRYLVIAKPLEamKKMTFKRAFIMI--------IIIWLWSLLWSI--PPffgwgryVPEGFQtSCTFDyLSR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 232 DPAQLgvAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMT-------TYARVLRFFSEVRTATTVLIMIIFVM 304
Cdd:cd15337 160 DLNNR--LFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKEMTQTAksgmgkdTEKNDARKKAEIRIAKVAIILISLFL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32306524 305 CCWGPYCFLVLLAATRQGQ-----ATQAPSLL-NVAAVWltwangaiNPVIYAIRNP 355
Cdd:cd15337 238 LSWTPYAVVALLGQFGPAYwitpyVSELPVMFaKASAIY--------NPIIYALSHP 286
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
89-351 2.59e-14

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 73.22  E-value: 2.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHR--QLRTVTNAFILSLSLSDLLTALLC---------LPAAFLDLFappgdsgpwrsFCAASRFFSSCF 157
Cdd:cd15098  17 GNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCvpfqatiysLPEWVFGAF-----------MCKFVHYFFTVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 158 GIVSTFSVALISLDRYCAIVRPPRDKLGRRRalqllagaWLAALGFSLPWDLLRAPREPPApqsFHRCLYRTS------- 230
Cdd:cd15098  86 MLVSIFTLVAMSVDRYIAVVHSRTSSSLRTR--------RNALLGVLVIWVLSLAMASPVA---VHQDLVHHWtasnqtf 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 231 -----PDPAQLGVaYSVGLVVACYLLPFLLMCFCR----YHICKTvrlsdvrVRPMTTYARVlrffSEVRTATTVLIMII 301
Cdd:cd15098 155 cwenwPEKQQKPV-YVVCTFVFGYLLPLLLITFCYakvlNHLHKK-------LKNMSKKSER----SKKKTAQTVLVVVV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 32306524 302 FVMCCWGPYCFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15098 223 VFGISWLPHHIIHLWVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYA 272
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
89-354 4.75e-13

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 69.31  E-value: 4.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFA----PPGDsgpwrSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15392  17 GNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLIlqywPFGE-----FMCPVVNYLQAVSVFVSAFT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQ-SFHRCLYRTSPDpaQLGVAYSVG 243
Cdd:cd15392  92 LVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNAScGQYICTESWPSD--TNRYIYSLV 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHIckTVRLSDVRVRPMTTYARVLRfFSEVRTAT---TVLIMIIFVmCCWGPYCFLVLLAATR 320
Cdd:cd15392 170 LMILQYFVPLAVLVFTYTRI--GIVVWAKRTPGEAENNRDQR-MAESKRKLvkmMITVVAIFA-LCWLPLNILNLVGDHD 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 321 QGQATQAP-SLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15392 246 ESIYSWPYiPYLWLAAHWLAMSHCCYNPFIYCWMN 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
89-355 4.91e-13

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 69.28  E-value: 4.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15083  17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSF-----SGRWifgKTGCDMYGFSGGLFGIMSINTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLP----WDLLRaPREPPAPQSFHrclYrTSPDPAQLgvA 239
Cdd:cd15083  92 AAIAVDRYLVITRPmkASVRISHRRALIVIAVVWLYSLLWVLPplfgWSRYV-LEGLLTSCSFD---Y-LSRDDANR--S 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTY-------ARVLRFFSEVRTATTVLIMIIFVMCCWGPYCF 312
Cdd:cd15083 165 YVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRfskselsSPKARRQAEVKTAKIALLLVLLFCLAWTPYAV 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 32306524 313 LVLLA-----ATRQGQATQAPSLLNVAAVwltwangAINPVIYAIRNP 355
Cdd:cd15083 245 VALIGqfgylEVLTPLATAIPAAFAKTSA-------IYNPVIYAFSHP 285
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
89-355 1.03e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 68.37  E-value: 1.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLF----APP----GDSGPW---RSFCAASRFFSSCF 157
Cdd:cd15079  17 GNGLVIYIFSTTKSLRTPSNMLV--------------VNLAISDFLmmikMPIfiynSFYEGWalgPLGCQIYAFLGSLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 158 GIVSTFSVALISLDRYCAIVRP-PRDKLGRRRALQLLAGAWLaalgFSLPWDLLraprepPAPQSFHR---------C-- 225
Cdd:cd15079  83 GIGSIWTNAAIAYDRYNVIVKPlNGNPLTRGKALLLILFIWL----YALPWALL------PLLFGWGRyvpegfltsCsf 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 226 --LYRTSpdpaqLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFS---------EVRTAT 294
Cdd:cd15079 153 dyLTRDW-----NTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAKKMNVVSLRSnadankqsaEIRIAK 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32306524 295 TVLIMIIFVMCCWGPYCFLVLLAATRQGQ-----ATQAPSLL-NVAAVwltwangaINPVIYAIRNP 355
Cdd:cd15079 228 VALTNVFLWFIAWTPYAVVALIGAFGNQSlltplVSMIPALFaKTAAC--------YNPIVYAISHP 286
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
89-356 1.24e-12

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 68.20  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP----AAFLDLFAPPgdsgpwRSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15393  17 GNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPfqfqAALLQRWVLP------RFMCPFCPFVQVLSVNVSVFT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDL-LRAPREPPAPQSFHR--CLYrTSPDPaQLGVAYS 241
Cdd:cd15393  91 LTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALaLRVEELTDKTNNGVKpfCLP-VGPSD-DWWKIYN 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLrffseVRTATTVLIMIIFVMC----CWGPYCFLVLLA 317
Cdd:cd15393 169 LYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDVRDDEI-----LKNKKKVIKMLIIVVAlfalCWLPLQTYNLLN 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32306524 318 ATRqgqatqaPSLLNVAAV--------WLTWANGAINPVIYAIRNPN 356
Cdd:cd15393 244 EIK-------PEINKYKYIniiwfcshWLAMSNSCYNPFIYGLYNEK 283
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
89-352 1.55e-12

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 67.69  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP--AAfldLFAPPGdsgpW---RSFCAASRFF------SSCf 157
Cdd:cd15095  17 GNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPftAA---LYATPS----WvfgDFMCKFVNYMmqvtvqATC- 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 158 givstFSVALISLDRYCAIVRPPRDKlgRRRALQLLAGAWLAALGFSLpwdLLRAP---------REPPAPQsfHRCLYR 228
Cdd:cd15095  89 -----LTLTALSVDRYYAIVHPIRSL--RFRTPRVAVVVSACIWIVSF---LLSIPvaiyyrleeGYWYGPQ--TYCREV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 229 TSPDPAQlgVAYSVGLVVACYLLPFLLMCFCR----YHICKTVRLSDVRVRPMTTYARVLRFfsevRTATTVLIMIIFVM 304
Cdd:cd15095 157 WPSKAFQ--KAYMIYTVLLTYVIPLAIIAVCYglilRRLWRRSVDGNNQSEQLSERALRQKR----KVTRMVIVVVVLFA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32306524 305 CCWGP-YCFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15095 231 ICWLPnHVLNLWQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAF 279
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
89-359 2.48e-12

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 67.30  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAfLDLFAPpgDSGPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15204  17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFE-MDYYVV--RQRSWThgdVLCAVVNYLRTVSLYVSTNAL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLL-RAPREPPAPQSF--------HRCLYRtspdpaql 236
Cdd:cd15204  94 LVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYsKTTPYANQGKIFcgqiwpvdQQAYYK-------- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 237 gvAYSVGLVVACYLLPFLLMCFCryHICKTVRLSDVRVRPMTT--YARVLRffseVRTATTVLIMIIFVM--CCWGPY-- 310
Cdd:cd15204 166 --AYYLFLFVLEFVLPVLIMTLC--YLRIVRKVWFRRVPGQQTeqIRRRLR----RRRRKVRLLVVILTAfvLCWAPYyg 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 32306524 311 ------CFLVLLAATRqgqatqapslLNVAAVW----LTWANGAINPVIYAIRNPNISM 359
Cdd:cd15204 238 yaivrdFFPTLLSKEK----------LNTTIFYiveaLAMSNSMINTVVYVAFNNNIRK 286
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
89-350 3.46e-12

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 67.03  E-value: 3.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFL-DLfappgdSGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15208  17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLvDV------TETWffgQVLCKIIPYLQTVSVSVSVLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLP----WDLLRAPREPPAPQSFHRCLYRTSPDPAQlgVAY 240
Cdd:cd15208  91 LSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPqaivMECSRVVPLANKTILLTVCDERWSDSIYQ--KVY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHI-----CKTVRLSDVRVRPMTTYARVLRFFSEV------RTATTVLIMIIFVMC-CWG 308
Cdd:cd15208 169 HICFFLVTYLLPLCLMILAYFQIfrklwCRQIPGTSSVVQRKWNKPRKSAVAAEEkqlrsrRKTAKMLIVVVIMFAiCYL 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32306524 309 PYCFLVLL-----AATRQGQATQAPSLLnvaAVWLTWANGAINPVIY 350
Cdd:cd15208 249 PVHLLNILryvfgLFTVDRETIYAWFLF---SHWLVYANSAINPIIY 292
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
89-351 9.51e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 65.53  E-value: 9.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLR-TVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgDSGPWRSFCaasRFFSSCFGIVSTFSV-- 165
Cdd:cd15057  17 GNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVA---GYWPFGSFC---DVWVSFDIMCSTASIln 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 -ALISLDRYCAIVRPPRDKlgRRRALQLLAGAWLAALGFSLPWDLLraprepPAPQSFHR--------CLYRTSPD-PAQ 235
Cdd:cd15057  91 lCVISVDRYWAISSPFRYE--RRMTRRRAFIMIAVAWTLSALISFI------PVQLGWHRaddtsealALYADPCQcDSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 236 LGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRlsdVRVRPMTTYARVL------------RFFSEVRTATTV-LIMIIF 302
Cdd:cd15057 163 LNRTYAISSSLISFYIPVAIMIVTYTRIYRIAR---RQIRRIAALERAAqestnpdsslrsSLRRETKALKTLsIIMGVF 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 32306524 303 VmCCWGPycFLVL-----LAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15057 240 V-CCWLP--FFILncvlpFCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYA 290
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
89-355 1.27e-11

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 65.02  E-value: 1.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldLFAPPGDSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15048  17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMP-----FYIPYTLTGKWpfgKVFCKAWLVVDYTLCTASALTI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPP--RDKLGRRRALQLLAGAWLAALGFSLP----WDLLRAPREPPAPQ---SFHRCLYrtspdpaql 236
Cdd:cd15048  92 VLISLDRYLSVTKAVkyRAKQTKRRTVLLMALVWILAFLLYGPaiigWDLWTGYSIVPTGDcevEFFDHFY--------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 237 gvaYSVGLVVACYLLPFLLMCF-----------------CRYHICKTVRLSDVRVRPMTTYARVLRffsEVRTATTVLIM 299
Cdd:cd15048 163 ---FTFITSVLEFFIPFISVSFfnlliylnirkrsrrrpLRSVPILPASQNPSRARSQREQVKLRR---DRKAAKSLAIL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32306524 300 IIFVMCCWGPYCFLVLLAAtrQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15048 237 VLVFLICWAPYTILTIIRS--FCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHP 290
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
89-351 2.53e-11

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 63.91  E-value: 2.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15067  16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMT-----GGYWlfgRDWCDVWHSFDVLASTASILN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPP--RDKLGRRRALQLLAGAWLAALGFSLP----WdllRAPREPPAPQsfHRCLYRTSpdpaqlgV 238
Cdd:cd15067  91 LCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFPaiawW---RAVDPGPSPP--NQCLFTDD-------S 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFcryhicktvrlsdvrvrpmtTYARVLRFFS-EVRTATTV-LIMIIFVMcCWGPYCFLVLL 316
Cdd:cd15067 159 GYLIFSSCVSFYIPLVVMLF--------------------TYYRIYRAAAkEQKAAKTLgIVMGVFIL-CWLPFFVTNIL 217
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 317 AATRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15067 218 IGFCPSNCVSNPDILFPLVTWLGYINSGMNPIIYA 252
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
152-354 3.33e-11

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 63.60  E-value: 3.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 152 FFSSCFGIVSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAalgFSLPWDL-------LRAPREPPAPQSFHR 224
Cdd:cd15086  78 FANSLFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWL---YSLLWTLppllgwsSYGPEGPGTTCSVQW 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 225 CLYRTSpdpaqlGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDvRVRPMTTYARvlrffsEVRTATTVLIMIIFVM 304
Cdd:cd15086 155 TSRSAN------SISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVG-KINKSTARKR------EQHVLLMVVTMVICYL 221
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306524 305 CCWGPYCFLVLLAA-TRQGQATQAPSLlnVAAVwLTWANGAINPVIYAIRN 354
Cdd:cd15086 222 LCWLPYGVMALLATfGKPGLVTPVASI--VPSI-LAKSSTVVNPIIYVFMN 269
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
160-352 3.35e-11

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 63.64  E-value: 3.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALG--FSLPWDLLRAPREPPAPQSFhRCLYRTSPDPAQlg 237
Cdd:cd15189  86 TSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGllLSIPTFLLRKIKAIPDLNIT-ACVLLYPHEAWH-- 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAYSVGLVVACYLLPFLLMCFCRYHIcktvrLSDVRVRPMTTYARVLrffSEVRTATTVLIMIIFVMCCWGPYCFLVLL- 316
Cdd:cd15189 163 FAHIVLLNIVGFLLPLLVITFCNYNI-----LQALRTREESTRCEDR---NDSKATALVLAVTLLFLVCWGPYHFFTFLd 234
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306524 317 -----AATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15189 235 flfdvGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVF 275
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
89-354 3.97e-11

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 63.41  E-value: 3.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTallclpAAFLDL----FAPPGDSGPWRSFCAASRFFSSCFGIVSTFS 164
Cdd:cd16003  17 GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASM------AAFNTLinfiYALHSEWYFGEAYCRFHNFFPITSVFASIYS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPapqsfHRCL-YRTSPDPAQLGVAYSVG 243
Cdd:cd16003  91 MTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMP-----GRTLcFVAWPGGPDQHFTYHII 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVrtattVLIMIIFVMC---CWGPY-CFLVLLAAT 319
Cdd:cd16003 166 VIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKV-----VKMMIIVVLTfaiCWLPYhIYFIVTGLY 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 320 RQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd16003 241 QQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN 275
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
89-355 1.23e-10

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 62.04  E-value: 1.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD------LFappGDSGpwrsfCAASRFFSSCFGIVST 162
Cdd:cd15336  17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNslhkrwIF---GEKG-----CELYAFCGALFGITSM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLaalgFSLPWDLlraprePP-------APQSFhrclyRTS--- 230
Cdd:cd15336  89 ITLLAISLDRYLVITKPLAsiRWVSKKRAMIIILLVWL----YSLAWSL------PPlfgwsayVPEGL-----LTSctw 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 231 ----PDPAQLgvAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPM------TTYARVLRFFSEVRTATTVLIMI 300
Cdd:cd15336 154 dymtFTPSVR--AYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLgsqdrkEKAKQYQRMKNEWKMAKIAFVVI 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32306524 301 IFVMCCWGPYCfLVLLAATRQGQATQAPSLLNVAAVwLTWANGAINPVIYAIRNP 355
Cdd:cd15336 232 LLFVLSWSPYA-CVALIAWAGYAHLLTPYMKSVPAV-IAKASAIYNPIIYAITHP 284
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
89-354 2.89e-10

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 60.45  E-value: 2.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgdsGPW---RSFCaasRFFSScFGIV----S 161
Cdd:cd15061  16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL-----GYWplgSHLC---DFWIS-LDVLlctaS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 162 TFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF---SLPWDLLRaprePPAPQSFHRCLYRTSPdpaqlgv 238
Cdd:cd15061  87 ILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLlitSPPLVGPS----WHGRRGLGSCYYTYDK------- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFcryhicktvrlsdvrvrpmtTYARVLRFF-SEVRTATTVLIMIIFVMCCWGPYCFLVLLA 317
Cdd:cd15061 156 GYRIYSSMGSFFLPLLLMLF--------------------VYLRIFRVIaKERKTAKTLAIVVGCFIVCWLPFFIMYLIE 215
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 318 ATrqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15061 216 PF---CDCQFSEALSTAFTWLGYFNSVINPFIYAFYN 249
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
89-355 3.04e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 60.91  E-value: 3.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLslsdlltallclpaAFLDLfappGDSGPWRSFCAASRFFSS-------C----- 156
Cdd:cd15073  17 SNGIVLVTFVKFRELRTPTNALIINL--------------AVTDL----GVSIIGYPFSAASDLHGSwkfgyagCqwyaf 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 157 ----FGIVSTFSVALISLDRYCAIVRPprdKLGRRRALQLLAGAWLAALGFSLPWDLLraPREPPApqsfhrclyRTSPD 232
Cdd:cd15073  79 lnifFGMASIGLLTVVAVDRYLTICRP---DLGRKMTTNTYTVMILLAWTNAFFWAAM--PLVGWA---------SYALD 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 233 PA------------QLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRlsdvRVRPMTTYARVLRFFSEVRTATTV-LIM 299
Cdd:cd15073 145 PTgatctinwrkndSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVK----KVLASDCLESVNIDWTDQNDVTKMsVIM 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32306524 300 IIFVMCCWGPYCFLVLLAATrqGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15073 221 IVMFLVAWSPYSIVCLWASF--GEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANK 274
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
156-358 3.66e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 60.85  E-value: 3.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 156 CFGIV-STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREppAPQSFHRClYRTSPDPA 234
Cdd:cd14986  81 VVGLFaSTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERE--LGDGVHQC-WSSFYTPW 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 235 QLGVaYSVGLVVACYLLPFLLMCFCRYHICKTV--RLSDVRVRPMTTYARVLRFFS------------EVRTATTVLIMI 300
Cdd:cd14986 158 QRKV-YITWLATYVFVIPLIILSYCYGRILRTIwiRSRQKTDRPIAPTAMSCRSVScvssrvslisraKIKTIKMTLVII 236
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32306524 301 IFVMCCWGPYCFLVLLAATrqGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPNIS 358
Cdd:cd14986 237 LAFILCWTPYFIVQLLDVY--AGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
161-351 3.70e-10

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 60.69  E-value: 3.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRdkLGRRRALQLLAGAWLAALGFSLpwdLLRAP----REPPAPQSFHRCLYRTSPDPAQL 236
Cdd:cd14984  85 GILFLACISIDRYLAIVHAVS--ALRARTLLHGKLTCLGVWALAL---LLSLPefifSQVSEENGSSICSYDYPEDTATT 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 237 G-VAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRpmttyARVLRFfsevrtatTVLIMIIFVMcCWGPYCFLVL 315
Cdd:cd14984 160 WkTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKK-----HRALRV--------IFAVVVVFFL-CWLPYNIVLL 225
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 32306524 316 LAATRQGQAT-QAPSLLNVAAVWLTWANG------AINPVIYA 351
Cdd:cd14984 226 LDTLQLLGIIsRSCELSKSLDYALQVTESlafshcCLNPVLYA 268
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
89-355 5.63e-10

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 59.96  E-value: 5.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltalLCLPAAflDL--------FAPPGDSGPWRSF--CaasrFFSSCFG 158
Cdd:cd14968  17 GNVLVIWAVKLNRALRTVTNYFI------------VSLAVA--DIlvgalaipLAILISLGLPTNFhgC----LFMACLV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 159 IV----STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF------SLPWDLLrAPREPPAPQSFHRCLYR 228
Cdd:cd14968  79 LVltqsSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFlvgltpMFGWNNG-APLESGCGEGGIQCLFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 229 TSPDpaqlgVAYSVG-LVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFS-EVRTATTVLIMIIFVMCC 306
Cdd:cd14968 158 EVIP-----MDYMVYfNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRSTLQkEVKAAKSLAIILFLFALC 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 32306524 307 WGPYCflVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd14968 233 WLPLH--IINCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIR 279
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
89-353 1.32e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 59.09  E-value: 1.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15403  17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTII-----TVDWHfgaHFCRISAMLYWFFVLEGVAIL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRpPRDKLGRRRALQLLAGAWLAALGFSLP----WDLLRAPREppAPQsfhrCLYRTSPDPAQLgvAYS 241
Cdd:cd15403  92 LIISVDRFLIIVQ-RQDKLNPHRAKVMIAISWVLSFCISFPsvvgWTLVEVPAR--APQ----CVLGYTESPADR--VYA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTyARVLRFFSEV-------------------RTATTVLIMIIF 302
Cdd:cd15403 163 VLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHAD-SLCLSQVSKLglmglqrphqmnvdmsfktRAFTTILILFVG 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32306524 303 VMCCWGPYCFLVLLAA-TRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIR 353
Cdd:cd15403 242 FSLCWLPHTVFSLLSVfSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWR 293
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
89-356 2.42e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 58.21  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLClPAAFL--DLFappgDSGPWRSF-CAASRFFSSCFGIVSTFSV 165
Cdd:cd15000  16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVC-PWMFLvhDFF----QNYVLGSVgCKLEGFLEGSLLLASVLAL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREppapQSFHRCLYRTSPDPAQLGVAYSVGLV 245
Cdd:cd15000  91 CAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRE----RQWKNFLETYCAENTQVLPIYWHVII 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLLMCFCRYHI-CKTVRLSDVRVRpmTTYARVLRFFSEVrtATTVLIMIIFVMCCWGPYCFLVLLAATRQG-- 322
Cdd:cd15000 167 TVLVWLPLGIMLICYSAIfWKLDKYERRVLR--REHPSVVRYKKKA--AKTLFIVLITFVVCRIPFTALIFYRYKLVPnd 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 323 ----QATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15000 243 ntqnSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNEN 280
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
89-356 3.84e-09

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 57.87  E-value: 3.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWrsFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15205  17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAF--MCKMVPFVQSTAVVTSILTMTCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFSLP-WDLLRAP-REPPAPQSFHRCLYRTSPDPAQlGVAYSVGL 244
Cdd:cd15205  95 AVERHQGIVHPLKMKwqYTNRRAFTMLGLVWIVSVIVGSPmLFVQQLEvKYDFLYEKRHVCCLERWYSPTQ-QKIYTTFI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 245 VVACYLLPFLLMCF----------CRYHICKTVRLSDVRVRPMTTYARVLRffsevRTATTVLIMIIFVMCCWGPYCFLV 314
Cdd:cd15205 174 LVILFLLPLTTMLFlysrigyelwIKKRVGDASVLQTIHGIEMSKISRKKK-----RAVKMMVTVVLLFAVCWAPFHVVH 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32306524 315 LLA--ATRQGQATQAPSLLNVAAVWLT-WANGAINPVIYAIRNPN 356
Cdd:cd15205 249 MMIeySNLENKYDGVTIKLIFAIVQLIgFSNSFNNPIVYAFMNEN 293
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
161-356 5.06e-09

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 57.09  E-value: 5.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTsPDPAQlgvAY 240
Cdd:cd15093  86 SIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQW-PEPAA---AW 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLL----PFLLMCFCRYHICKTVRLSDVRVrpmttyARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLL 316
Cdd:cd15093 162 SAGFIIYTFVLgfllPLLIICLCYLLIVIKVKSAGLRA------GWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLV 235
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 32306524 317 AATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15093 236 NVFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDN 275
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
89-354 5.23e-09

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 57.14  E-value: 5.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15391  17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIM-----LGHWvfpAPMCPIVLYVQLVSVTASVLTN 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGA-WLAALGFSLPWDLLRAPREPPAPQSFHRClYRTSPDPAQLGVAYSVGL 244
Cdd:cd15391  92 TAIGIDRFFAVIFPLRSRHTKSRTKCIIASIwAISFSLSSVQLFAGRTQRYGQYSEGRVLC-GESWPGPDTSRSAYTVFV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 245 VVACYLLPFLLMCFCRYHICKTVRLsdvrvRPMTTYARVLRFFSEVRTATTVLIMIIFVMC----CWGP-YCFLVLLAAT 319
Cdd:cd15391 171 MLLTYIIPLLILTSTYGYVGFRLWN-----RTAPGNADKGRDDMQIKSKRKVIKMLVFVVLmfgiCWLPlHLFNLVQDFS 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 320 R--QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15391 246 TvfRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMN 282
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
89-356 9.54e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 56.32  E-value: 9.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRsfCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15209  17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLH--CQASGFIMGLSVIGSIFNITAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR-DKLGRRRALQLLagawlaalgFSLPWDLLRAPREPPA--------PQSFhRCLYRTSPDPaqlgvA 239
Cdd:cd15209  95 AINRYCYICHSLQyDRLYSLRNTCCY---------LCLTWLLTVLAVLPNFfigslqydPRIY-SCTFAQTVST-----V 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTtyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15209 160 YTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQ---RPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGLAVAI 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 320 R-QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15209 237 NpKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQN 274
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
89-351 1.01e-08

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 56.15  E-value: 1.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFappGDSGPWRSF-CAASRFFSSCFGIVSTFSVAL 167
Cdd:cd14970  17 GNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYL---LGYWPFGEVmCKIVLSVDAYNMFTSIFCLTV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTsPDPAQLG----VAYSvg 243
Cdd:cd14970  93 MSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQW-PDPPDYWgrvfTIYT-- 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVAcYLLPFLLMCFCRYHIckTVRLSDVRVRPMTTYARVLRffSEVRTATTVLIMII-FVMcCWGPY--CFLVLLAATR 320
Cdd:cd14970 170 FVLG-FAVPLLVITVCYSLI--IRRLRSSRNLSTSGAREKRR--ARRKVTRLVLVVVAvFVV-CWLPFhvFQIVRLLIDP 243
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 321 QgqatQAPSLLNVA--AVWLTWANGAINPVIYA 351
Cdd:cd14970 244 P----ETLTVVGVFlfCIALSYANSCLNPILYA 272
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
89-357 1.05e-08

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 55.92  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVtnAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15220  16 GNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSVCLVSASILTISAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLgvAYSVGLVV 246
Cdd:cd15220  94 SVERYYYIVHPMRyeVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSHSGHRG--VFVVLFAL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 247 ACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPY-CFLVLLAATRQgqaT 325
Cdd:cd15220 172 VCFLLPLLLI--------------------LVVYCGVFKVFGGGKAALTLAAIVGQFLCCWLPYfAFHLYSALAAS---P 228
                       250       260       270
                ....*....|....*....|....*....|..
gi 32306524 326 QAPSLLNVAAVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd15220 229 VSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQI 260
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
89-356 1.07e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 56.07  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15401  17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLG--NIHCQISGFLMGLSVIGSVFNITAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR-DKLGRRRALQLLagawlaalgFSLPWDLLRAPREPP--------APQSFHRCLYRTspdpaqLGVA 239
Cdd:cd15401  95 AINRYCYICHSLRyDKLYNMKKTCCY---------VCLTWVLTLAAIVPNffvgslqyDPRIYSCTFAQT------VSSS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRpmTTYARVLRfFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15401 160 YTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRVR--QDSKQKLK-ANDIRNFLTMFVVFVLFAVCWGPLNFIGLAVAI 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 320 RQGQ-ATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15401 237 NPLKvAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQN 274
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
89-352 1.10e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 56.13  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCfgIVSTFSVALI 168
Cdd:cd15001  16 GNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSF--ICSVLTLTAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDK----LGRRRALQLLAGAWLAAlgFSLP------WDLLRAPREPPAPQSFHRClyrtsPDPAqLGV 238
Cdd:cd15001  94 SIERYYVILHPMKAKsfctIGRARKVALLIWILSAI--LASPvlfgqgLVRYESENGVTVYHCQKAW-----PSTL-YSR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCryhicktvrlsdvrvrpmttYARVLRFfsevRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd15001 166 LYVVYLAIVIFFIPLIVMTFA--------------------YARDTRK----QVIKMLISVVVLFAVCWGPLLIDNLLVS 221
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 319 TRQGQA--TQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15001 222 FDVISTlhTQALKYMRIAFHLLSYANSCINPIIYAF 257
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
89-356 2.00e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 55.42  E-value: 2.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP---AAFLdlfappgdSGPW---RSFCAASRFFSSCFGIVST 162
Cdd:cd15389  17 GNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPftlVRFV--------NSTWvfgKIMCHLSRFAQYCSVYVST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTS-PDPAQLGVAY- 240
Cdd:cd15389  89 LTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSfPEPSDLFWKYl 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVrVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPY-CFLVLLAAt 319
Cdd:cd15389 169 DLATFILQYVLPLLIIGVAYTRVAKKLWLRNA-IGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWLPLnCYHVLLSS- 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 320 rqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15389 247 ---HPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDS 280
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
157-350 2.59e-08

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 55.01  E-value: 2.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 157 FGI-VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCL-YRTSPDPA 234
Cdd:cd15382  83 FGLyLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVESHPCVTWFSQCVtFNFFPSHD 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 235 QLgVAYSVGLVVACYLLPFLLMCFCR----YHICKTVRLSDVRVRPMTTYARVLR----FFSEVRTAT---TVLIMIIFV 303
Cdd:cd15382 163 HE-LAYNIFNMITMYALPLIIIVFCYslilCEISRKSKEKKEDVSEKSSSVRLRRssvgLLERARSRTlkmTIVIVLVFI 241
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 32306524 304 McCWGPYCFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd15382 242 I-CWTPYFIMSLWYWFDRESASKVDPRIQKGLFLFAVSNSCMNPIVY 287
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
89-354 3.68e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 54.21  E-value: 3.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFAppgdsGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15310  17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPwVVYLEVTG-----GVWnfsRICCDVFVTLDVMMCTASILN 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLG-----RRRALQLLAGAWLAALGFSLPwdLLRApreppapqsfhrclYRTSPDPAQLGVA 239
Cdd:cd15310  92 LCAISIDRYTAVVMPVHYQHGtgqssCRRVSLMITAVWVLAFAVSCP--LLFG--------------FNTTGDPTVCSIS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLV---VACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFFSEVRTATTVLIMIIFV-MCCWGPYCFLVL 315
Cdd:cd15310 156 NPDFVIyssVVSFYLPFGVT--------------------LLVYVRIYVVLLREKKATQMLAIVLGAfIVCWLPFFLTHI 215
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306524 316 LAAtrQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15310 216 LNT--HCQACHVPPELYSATTWLGYVNSALNPVIYTTFN 252
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
89-354 5.33e-08

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 54.08  E-value: 5.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALlcLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd16004  17 GNATVIWIILAHRRMRTVTNYFIVNLALADLSMAA--FNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFslpwdllrapreppaPQSFHRCLYRTSPD-------PAQLG-- 237
Cdd:cd16004  95 AADRYMAIIHPfkPRLSAGSTKVVIAGIWLVALALAF---------------PQCFYSTVTMDQGRtkcivawPGDSGgk 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 --VAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMT-TYARVLRFFSEVrTATTVLIMIIFVMCcWGPYCFLV 314
Cdd:cd16004 160 hqLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHgAYHRQLQAKKKF-VKTMVVVVVTFAIC-WLPYHLYF 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 32306524 315 LLAATRQGQATQA-PSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd16004 238 ILGSFNEDIYCQKyIQQVYLAIFWLAMSSTMYNPIIYCCLN 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
89-356 5.80e-08

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 53.98  E-value: 5.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgDSGPWRSF-CAASRFFSSCFGIVSTFSVAL 167
Cdd:cd14992  17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVS---LSWEYGHFlCKIVNYLRTVSVYASSLTLTA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQS---FHRCLYRTSPDPAQLGV-AYSVG 243
Cdd:cd14992  94 IAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVknqEKIFCCQIPPVDNKTYEkVYFLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHIckTVRLSDVRVRPMTTYARVLRffsEVRTATTVLIMIIFVMC----CWGPYCFLVLLAAT 319
Cdd:cd14992 174 IFVVIFVLPLIVMTLAYARI--SRELWFRKVPGFSIKEVERK---RLKCKRRVIKMLVCVVVlfviCWLPFHLFFLLRDF 248
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 320 RQGQATQAPSLLNVAAV-WLTWANGAINPVIYAIRNPN 356
Cdd:cd14992 249 FPLIMKEKHTLQVYYFLhWIAMSNSMYNPIIYVTLNNN 286
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
160-356 6.30e-08

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 53.48  E-value: 6.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 VSTFSVALISLDRYCAIVRPP--RDKLGRRRALQLLAGA-WLAALGFSLP---WDLLRAPREPPAPQsfhrCLYRTSPDP 233
Cdd:cd15049  86 ASVMNLLLISFDRYFSVTRPLtyRAKRTPKRAILMIALAwVISFVLWAPAilgWQYFVGERTVPDGQ----CYIQFLDDP 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 234 aqlgvAYSVGLVVACYLLPFLLMCFCRYHICKTVrlsdVRVRpmttyaRVLRffsevrtaTTVLIMIIFVMcCWGPYCFL 313
Cdd:cd15049 162 -----AITFGTAIAAFYLPVLVMTILYWRIYRET----ARER------KAAR--------TLSAILLAFII-TWTPYNIL 217
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 32306524 314 VLLAATrqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15049 218 VLVSTF---CAKCIPDTLWSFGYWLCYINSTINPFCYALCNKT 257
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
89-355 6.69e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 53.71  E-value: 6.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLFA-----PP------------GDSgpwrsFCAASR 151
Cdd:cd15055  17 GNLLVIISISHFKQLHTPTNLLL--------------LSLAVADFLVgllvmPFsmirsietcwyfGDT-----FCKLHS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 152 FFSSCFGIVSTFSVALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPwdLLRAPREPPAPQSFHRClyrt 229
Cdd:cd15055  78 SLDYILTSASIFNLVLIAIDRYVAVCDPLLypTKITIRRVKICICLCWFVSALYSSV--LLYDNLNQPGLIRYNSC---- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 230 sPDPAQLGVAYSVGLV--VACYLLPFLLMCFCRYHICKTVRlSDVRV-RPMTTYA------RVLRFFSEVRTATTV-LIM 299
Cdd:cd15055 152 -YGECVVVVNFIWGVVdlVLTFILPCTVMIVLYMRIFVVAR-SQARAiRSHTAQVslegssKKVSKKSERKAAKTLgIVV 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32306524 300 IIFVMCcWGPYcFLVLLAatrqGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15055 230 GVFLLC-WLPY-YIVSLV----DPYISTPSSVFDVLIWLGYFNSCLNPLIYALFYP 279
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
89-352 6.71e-08

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 53.83  E-value: 6.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPgdsgPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd14997  17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWARE----PWllgEFMCKLVPFVELTVAHASVLTI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFSLPW----DLLRAPREPPAPqsFHRCLyrtSPDPAQLGVA 239
Cdd:cd14997  93 LAISFERYYAICHPLQAKyvCTKRRALVIIALIWLLALLTSSPVlfitEFKEEDFNDGTP--VAVCR---TPADTFWKVA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKtvRLsdVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMC----CWGPYCFL-- 313
Cdd:cd14997 168 YILSTIVVFFVVPLAILSGLYSVICR--RL--VGHPALESRRADAANRHTLRSRRQVVYMLITVVVlffvCLLPFRVVtl 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 32306524 314 -VLLAATRQGQATQAPSLLNVAAV--WLTWANGAINPVIYAI 352
Cdd:cd14997 244 wIIFAPDEDLQALGLEGYLNLLVFcrVMVYLNSALNPILYNL 285
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
90-357 6.74e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.84  E-value: 6.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  90 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSgPWRSFCAASRFFSScfGIVSTFSVALIS 169
Cdd:cd14972  16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPS-PATWLLRKGSLVLS--LLASAYSLLAIA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 170 LDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLpwdllrapreppAPQSFHRCLYRTSPDPAQLGVAYSVGLVVA 247
Cdd:cd14972  93 VDRYISIVHGLTyvNNVTNKRVKVLIALVWVWSVLLAL------------LPVLGWNCVLCDQESCSPLGPGLPKSYLVL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 248 C---YLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTA-TTVLIMIIFVMcCWGPYCFLVLL--AATRQ 321
Cdd:cd14972 161 IlvfFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPSTSRKLAkTVVIVLGVFLV-CWLPLLILLVLdvLCPSV 239
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 322 GQATQAPSLLNVAAVWltwaNGAINPVIYAIRNPNI 357
Cdd:cd14972 240 CDIQAVFYYFLVLALL----NSAINPIIYAFRLKEM 271
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
89-354 7.26e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 53.88  E-value: 7.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWrsFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15051  17 GNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPV--FCNIYISLDVMLCTASILNLFAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFS-LP----W---DLLRAPREPPapqsfHRCLYRTSPdpaqlgv 238
Cdd:cd15051  95 SLDRYLAITAPLRypSRVTPRRVAIALAAIWVVSLAVSfLPihlgWntpDGRVQNGDTP-----NQCRFELNP------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTY----ARVLRFFSEVRTATTVL--IMIIFVMcCWGPYCF 312
Cdd:cd15051 163 PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPAstanSSKSAATAREHKATVTLaaVLGAFII-CWFPYFT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 32306524 313 LVLLAATRQgqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15051 242 YFTYRGLCG---DNINETALSVVLWLGYANSALNPILYAFLN 280
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
89-349 1.03e-07

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 53.19  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPP---GDSGpwrsfCAASRFFSSCFGIVSTFSV 165
Cdd:cd14977  17 GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDwlfGDVM-----CKLVPFIQVTSLGVTVFSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSL------PWDLLRAPrePPAPQSFHRCLYRTSPDPAQLGVA 239
Cdd:cd14977  92 CALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLavpeavLSTVARES--SLDNSSLTVCIMKPSTPFAETYPK 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACY-LLPFLLMCFCRYHICKTVRLSDvrvRPMTTYARvLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd14977 170 ARSWWLFGCYfCLPLAFTAVCYLLMARTLIRAA---KEYTRGTK-KHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRA 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 319 TRQGQATQAPS----LLNVAAVWLTWANGAINPVI 349
Cdd:cd14977 246 TLYNEVLIDTRstldILDLIGQFLSFFNSCVNPIA 280
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
89-356 1.09e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 53.26  E-value: 1.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15056  17 GNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELV-----NNRWIygeTFCLVRTSLDVLLTTASIMHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPP-RDKLGRRRALQLLAGAWLAALGFS-LP----W-----DLLRAPREPPAPQSfhrCLYrtspdpa 234
Cdd:cd15056  92 CCIALDRYYAICCQPlVYKMTPLRVAVMLGGCWVIPTFISfLPimqgWnhigiEDLIAFNCASGSTS---CVF------- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 235 QLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYA---------RVLRFFSEVRTATTVLIMIIFVMC 305
Cdd:cd15056 162 MVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQRAGssnheadqhRNSRMRTETKAAKTLGIIMGCFCV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306524 306 CWGPYcFLVLLAATRQGqaTQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15056 242 CWAPF-FVTNIVDPFIG--YRVPYLLWTAFLWLGYINSGLNPFLYAFFNKS 289
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
89-356 1.23e-07

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 52.95  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFAppgdsGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15092  17 GNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFL-----GFWpfgNALCKTVIAIDYYNMFTSTFTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSfhrCLYRTSPDPAQLGVAYSVG 243
Cdd:cd15092  91 TAMSVDRYVAICHPIKalDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIE---CLVEIPTPQDYWDPVFGIC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHICKtvRLSDVRVRPMTTYA-RVLRffsevRTATTVLIMIIFVMCCWGPYCFLVLLaatrQG 322
Cdd:cd15092 168 VFLFSFIIPVLIISVCYSLMIR--RLRGVRLLSGSKEKdRNLR-----RITRLVLVVVAVFVGCWTPIQIFVLA----QG 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 323 QATQAPSLLNVA----AVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15092 237 LGVQPSSETAVAilrfCTALGYVNSSLNPVLYAFLDEN 274
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
89-348 1.39e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 53.04  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgDSGPWRSF-CAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15927  17 GNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTL---DSWPFGEFlCKLSEFLKDTSIGVSVFTLTA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDKLG--RRRALQLLAGAWLAALGFSLPWDLLR--APREPPAPQSFHRClyrtSPDPAQLGVAYSVG 243
Cdd:cd15927  94 LSADRYFAIVNPMRKHRSqaTRRTLVTAASIWIVSILLAIPEAIFShvVTFTLTDNQTIQIC----YPYPQELGPNYPKI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVAC----YLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVL---L 316
Cdd:cd15927 170 MVLLRflvyYLIPLLIIGVFYVLMARHLIRSTRNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLwfhF 249
                       250       260       270
                ....*....|....*....|....*....|..
gi 32306524 317 AATRQGQATQAPSLLNVAAVWLTWANGAINPV 348
Cdd:cd15927 250 APNGLVDYNAFWHVLKIVGFCLSFINSCVNPV 281
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
89-358 1.75e-07

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 52.40  E-value: 1.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSlslsdlltallcLPAA--FLDLFAPPGD-----SGPWRSFCAASRF--FSSCFGI 159
Cdd:cd15195  17 GNLTVLIQLFRRRRAKSHIQILIMH------------LALAdlMVTFFNMPMDavwnyTVEWLAGDLMCRVmmFLKQFGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 -VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRA--PREPPAPQsFHRCL-YRTSPDPAQ 235
Cdd:cd15195  85 yLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSvlRKMPEQPG-FHQCVdFGSAPTKKQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 236 LgVAYSVGLVVACYLLPFLLM--CFCR--YHICKTVRLSdvRVRPMTTYARV-LRFFSEVRTAT---TVLIMIIFVMcCW 307
Cdd:cd15195 164 E-RLYYFFTMILSFVIPLIITvtCYLLilFEISKMAKRA--RDTPISNRRRSrTNSLERARMRTlrmTALIVLTFIV-CW 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306524 308 GPYCFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPNIS 358
Cdd:cd15195 240 GPYYVLGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
89-354 1.99e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 52.01  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD------LFAPpgdsgpwrSFCAASRFFSSCFGIVST 162
Cdd:cd15206  17 GNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGqllrnfIFGE--------VMCKLIPYFQAVSVSVST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF--SLPWdLLRAPREPPAPQSFHRCLYRTSPDPAQLgvAY 240
Cdd:cd15206  89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFliMSPI-LVFSNLIPMSRPGGHKCREVWPNEIAEQ--AW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMtTYARVLRFFsevrtattVLIMIIFVMCCWgpYCFLVLLAATR 320
Cdd:cd15206 166 YVFLDLMLLVIPGLVMSVAYGLISWTLLEAKKRVIRM-LFVIVVEFF--------ICWTPLYVINTW--KAFDPPSAARY 234
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 321 QGQATQAPSLLnvaavwLTWANGAINPVIYAIRN 354
Cdd:cd15206 235 VSSTTISLIQL------LAYISSCVNPITYCFMN 262
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
86-353 2.64e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 51.76  E-value: 2.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  86 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15404  14 SFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFG--DAFCRVSAMFFWLFVMEGVAIL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRpPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPP--APQsfhrCLYRTSPDPAQLgvAYSVG 243
Cdd:cd15404  92 LIISIDRFLIIVQ-KQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPsrAPQ----CVFGYTTNPGYQ--AYVIL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHICKTVRlsdvrvrpmttyarvlrfFSEVRTATTVLIMIIFVMCCWGPYCFLVLLaATRQGQ 323
Cdd:cd15404 165 IMLIFFFIPFMVMLYSFMGILNTVR------------------SFKTRAFTTILILFIVFTVCWAPFTTYSLV-ATFNSH 225
                       250       260       270
                ....*....|....*....|....*....|..
gi 32306524 324 ATQAPSLLNVAA--VWLTWANGAINPVIYAIR 353
Cdd:cd15404 226 FYHKHNFFEISTwlLWLCYLKSALNPLIYYWR 257
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
89-356 2.78e-07

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 51.50  E-value: 2.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15210  17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFL-----HQAWIhgeTLCRVFPLLRYGLVAVSLLTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPR-DKLGRRRALQLLAGAW-LAALGFSLPWDLLRAPREPPAPQ----SFHRCLYRTSPDPAqlgva 239
Cdd:cd15210  92 VLITLNRYILIAHPSLyPRIYTRRGLALMIAGTwIFSFGSFLPLWLGIWGRFGLDPKvcscSILRDKKGRSPKTF----- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 ysvgLVVACYLLPFLLMCFCrYhicktVRLSDVRVrpmttyarvlrffsevrTATTVLIMIIFVMcCWGPYcFLVLLAat 319
Cdd:cd15210 167 ----LFVFGFVLPCLVIIIC-Y-----ARREDRRL-----------------TRMMLVIFLCFLV-CYLPI-TLVNVF-- 215
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 320 rqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15210 216 ---DDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQ 249
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
89-356 3.55e-07

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 51.44  E-value: 3.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRsfCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15402  17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLH--CQISGFLMGLSVIGSIFNITGI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR-DKLGRRRALQLLAGawlaalgfsLPWDLLRAPREP-------PAPQSFHRCLYRTSpdpaqLGVAY 240
Cdd:cd15402  95 AINRYCYICHSLKyDKLYSDKNSLCYVL---------LIWVLTVAAIVPnlfvgslQYDPRIYSCTFAQS-----VSSAY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTtyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVL-LAAT 319
Cdd:cd15402 161 TIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDN---KPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLaVAVD 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 320 RQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15402 238 PETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQN 274
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
86-353 4.06e-07

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 51.48  E-value: 4.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  86 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldlFAPPGDSGpwrsFCAASR--FFSSCFGIV--- 160
Cdd:cd15068  14 AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP------FAITISTG----FCAACHgcLFIACFVLVltq 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 -STFSVALISLDRYCAIVRPPRDK---LGRR-RALQLLAGAWLAALGFS--LPWDLLRAPREPPA-----PQSFHRCLYR 228
Cdd:cd15068  84 sSIFSLLAIAIDRYIAIRIPLRYNglvTGTRaKGIIAICWVLSFAIGLTpmLGWNNCGQPKEGKNhsqgcGEGQVACLFE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 229 TSPdPAQLGVAYSvglVVACYLLPFLLM--CFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCC 306
Cdd:cd15068 164 DVV-PMNYMVYFN---FFACVLVPLLLMlgVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 32306524 307 WGPY----CFLVLLAAtrqgqATQAPSLLNVAAVWLTWANGAINPVIYAIR 353
Cdd:cd15068 240 WLPLhiinCFTFFCPD-----CSHAPLWLMYLAIVLSHTNSVVNPFIYAYR 285
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
89-354 4.48e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 51.20  E-value: 4.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFappgdsGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15065  16 GNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTfAVVNDLL------GYWlfgETFCNIWISFDVMCSTASILN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFS-LPWDL-LRAPREPPAPQSFHrclyRTSPDPA---QLG 237
Cdd:cd15065  90 LCAISLDRYIHIKKPLKYErwMTTRRALVVIASVWILSALISfLPIHLgWHRLSQDEIKGLNH----ASNPKPScalDLN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFF--------------SEVRTATTV-LIMIIF 302
Cdd:cd15065 166 PTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFqvpslsskhnnqgvSDHKAAVTLgIIMGVF 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 32306524 303 vMCCWGPYCFLVLLAATrqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15065 246 -LICWLPFFIINIIAAF---CKTCIPPKCFKILTWLGYFNSCLNPIIYSIFN 293
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
144-354 4.74e-07

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 51.32  E-value: 4.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 144 RSFCAASRFFSSCFGIVSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAalgFSLPWDL----------LRAP 213
Cdd:cd15075  70 RVGCVLEGFAVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASSWL---WSLIWNTpplfgwgsyqLEGV 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 214 REPPAPQSFHRclyrtspDPAQlgVAYSVGLVVACYLLPFLLMCFCRYHICKTVRlsdvRVRPMTTYARVLRFFSEVRTA 293
Cdd:cd15075 147 MTSCAPDWYSR-------DPVN--VSYILCYFSFCFAIPFAIILVSYGYLLWTLR----QVAKLGVAEGGSTAKAEVQVA 213
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32306524 294 TTVLIMIIFVMCCWGPYCFLVLLAATRQGqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15075 214 RMVVVMVMAFLLCWLPYAAFALTVVSKPD--VYINPLIATVPMYLAKSSTVYNPIIYIFMN 272
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
89-354 4.83e-07

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 51.13  E-value: 4.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgdsGPWRSFCAASRFFSSCFGIVSTFSV--- 165
Cdd:cd15330  17 GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL-----NKWTLGQVTCDLFIALDVLCCTSSIlhl 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPWDL-LRAPREPPAPQSfhrClyRTSPDPaqlgvAYSV 242
Cdd:cd15330  92 CAIALDRYWAITDPIDyvNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPDA---C--TISKDP-----GYTI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFFS-EVRTATTV-LIMIIFVMcCWGPYcFLVLLAATR 320
Cdd:cd15330 162 YSTFGAFYIPLILM--------------------LVLYGRIFKAAArERKTVKTLgIIMGTFIL-CWLPF-FIVALVLPF 219
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 321 QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15330 220 CESTCHMPELLGAIINWLGYSNSLLNPIIYAYFN 253
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
86-356 5.07e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 51.12  E-value: 5.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  86 SSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgdSGPWRSFCAASRFFSSC---FGIVST 162
Cdd:cd15074  14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAF-----AHRWLFGDIGCVFYGFCgflFGCCSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 163 FSVALISLDRYCAIVRPP-RDKLGRRRALQLLAGAWLAALGFSLPwDLLRAPREPPAPQSFHRCL--YRTSPDPAqlGVA 239
Cdd:cd15074  89 NTLTAISIYRYLKICHPPyGPKLSRRHVCIVIVAIWLYALFWAVA-PLVGWGSYGPEPFGTSCSIdwTGASASVG--GMS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRV-RPMTTYARVLRFfsEVRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd15074 166 YIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVaGFDSRSKRQHKI--ERKVTKVAVLICAGFLIAWTPYAVVSMWSA 243
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 319 TrqGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15074 244 F--GSPDSVPILASILPALFAKSSCMYNPIIYLLFSSK 279
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
89-357 6.63e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 50.83  E-value: 6.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLR-TVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFF--SSCfgIVSTFSV 165
Cdd:cd15104  16 GNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQ--KVLCLLRMCFviTSC--AASVLSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREP----PAPQSFHRCLYRTspdpaqlgvaYS 241
Cdd:cd15104  92 AAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQqtsyKGKCSFFAAFHPR----------VL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVR----PMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLA 317
Cdd:cd15104 162 LVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYkvehALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQ 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32306524 318 ATRQGQAtqapsLLNVAAVWLtW----ANGAINPVIYAIRNPNI 357
Cdd:cd15104 242 ALCDECK-----LYDVLEDYL-WllglCNSLLNPWIYAFWQKEV 279
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
89-351 7.15e-07

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 50.73  E-value: 7.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRT-VTNAFILSLSLSDLLTALLCLPaafLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15319  17 GNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMP---WKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPR--DKLGRRRALQLlagawlaalgFSLPWDLLRAPREPPAPQSFHRCL---------YRTSPDPAQ- 235
Cdd:cd15319  94 ISVDRYWAISSPFRyeRKMTQRVALVM----------ISVAWTLSVLISFIPVQLNWHKDSgddwvglhnSSISRQVEEn 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 236 ----LGVAYSVGLVVACYLLPFLLMCFCRYHIcktVRLSDVRVRPMTTYARVLRFFSEVRTA------------------ 293
Cdd:cd15319 164 cdssLNRTYAISSSLISFYIPVAIMIVTYTRI---YRIAQIQIRRISSLERAAEHAQSCRSNridchhhtslrtsikket 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32306524 294 ----TTVLIMIIFVmCCWGPYCFLVLLAATRQGQATQAPSLLNVAA-------VWLTWANGAINPVIYA 351
Cdd:cd15319 241 kvlkTLSVIMGVFV-CCWLPFFILNCMVPFCDRPPADPDAGLPCVSettfdvfVWFGWANSSLNPIIYA 308
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
147-352 7.74e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 50.50  E-value: 7.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 147 CAASRFFSSCFGIVSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPwdLLRAPREPPAPQSFHRCl 226
Cdd:cd15197  73 CKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIP--MLIIFEKTGLSNGEVQC- 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 227 YRTSPDPAQLGVaYSVGLVVACYLLPFLLMCFCRYHICKTV-----------RLSDVRVRPMTTYARVLRFFSEVRTATT 295
Cdd:cd15197 150 WILWPEPWYWKV-YMTIVAFLVFFIPATIISICYIIIVRTIwkkskiqvtinKAGLHDGSSRRSSSRGIIPRAKIKTIKM 228
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32306524 296 VLIMIIFVMCCWGPYCFLVLLAATRQGQATQ-----APSLLNVAAVwltwaNGAINPVIYAI 352
Cdd:cd15197 229 TFVIVTVFIICWSPYFVFDLLDVFGLLPRSKtkiaaATFIQSLAPL-----NSAINPLIYCL 285
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
89-354 7.89e-07

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 50.42  E-value: 7.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgdsGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15059  17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELM-----GYWyfgSVWCEIWLALDVLFCTASIVNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPwDLLRAPREPPAPQSFHRCLYRTSPdpaqlgvAYSVG 243
Cdd:cd15059  92 CAISLDRYWSVTQAVEYNLKRtpRRAKAMIAAVWIISAVISLP-PLFGWKDEQPWHGAEPQCELSDDP-------GYVLF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFF-SEVRTATTVL--IMIIFVMcCWGPYCFLVLLAATr 320
Cdd:cd15059 164 SSIGSFYIPLLIM--------------------IIVYARIYRAAkRKERRFTLVLgvVMGAFVL-CWLPFFFTYPLVVV- 221
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 321 qGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15059 222 -CKTCGVPELLFKFFFWLGYCNSALNPVIYTIFN 254
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
89-354 8.58e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 50.19  E-value: 8.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFAPPGDSGPWrsfCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15063  17 GNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPfSAVNEVLDVWIFGHTW---CQIWLAVDVWMCTASILNLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFSLP----WDLLRAPREPPAPQSFHRClyRTSPDPAQLGVAYS 241
Cdd:cd15063  94 ISLDRYLAITRPIRYPslMSTKRAKCLIAGVWVLSFVICFPplvgWNDGKDGIMDYSGSSSLPC--TCELTNGRGYVIYS 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VglvVACYLLPFLLMCFCRYHICKTVRLsdvrvrpmttyarvlrffsEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQ 321
Cdd:cd15063 172 A---LGSFYIPMLVMLFFYFRIYRAARM-------------------ETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCE 229
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 322 gqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15063 230 ---DCIPPLLFSVFFWLGYCNSALNPCIYALFS 259
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
89-352 1.02e-06

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 50.07  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLP----AAFLDLFAPPGDsgpwrSFCAASRFFSSCFGIVSTFS 164
Cdd:cd14985  17 GNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLT-LPlwatYTANQYDWPFGA-----FLCKVSSYVISVNMFASIFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALG--FSLPWDLLRAPREPPAPQSfHRCLYRTSPDPAQLGVaySV 242
Cdd:cd14985  91 LTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVAclLSLPTFLLRSLQAIENLNK-TACIMLYPHEAWHFGL--SL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMCFCRYHICKTVRlsdvrvrpmttyARVLRFFSEVRTATTVLIMI----IFVMCCWGPYCFLVLLAA 318
Cdd:cd14985 168 ELNILGFVLPLLIILTCYFHIARSLR------------KRYERTGKNGRKRRKSLKIIfalvVAFLVCWLPFHFFKFLDF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32306524 319 TRQGQATQAPSLLNVA------AVWLTWANGAINPVIYAI 352
Cdd:cd14985 236 LAQLGAIRPCFWELFLdlglpiATCLAFTNSCLNPFIYVF 275
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
89-356 1.05e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 50.02  E-value: 1.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLfappgdSGPWRSFCAASRFFSSCFGIVSTFS--- 164
Cdd:cd15064  17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPlSAVYEL------TGRWILGQVLCDIWISLDVTCCTASilh 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPprDKLGRRRALQLLAGAWLAALGFSLPWDLlrapreppAPQSFHRCLYRTSPDPAQLG--VAYSV 242
Cdd:cd15064  91 LCVIALDRYWAITDA--VEYAHKRTPKRAAVMIALVWTLSICISL--------PPLFGWRTPDSEDPSECLISqdIGYTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFFSEVRTATTVLIMII--FVMcCWGPYcFLVLLAATR 320
Cdd:cd15064 161 FSTFGAFYIPLLLM--------------------LILYWKIYRAAARERKAAKTLGIILgaFIV-CWLPF-FLVALIVPL 218
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 321 QGQATQAPSLLNVAAvWLTWANGAINPVIYAIRNPN 356
Cdd:cd15064 219 CSHCWIPLALKSFFL-WLGYFNSLINPLIYTFFNKD 253
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
89-352 1.24e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 49.80  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDlLTALLCLPAAFLDLFAPpgdsGPWR---SFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15928  17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSD-LLIFLVLPLDLYRLWRY----RPWRfgdLLCRLMYFFSETCTYASILHI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVg 243
Cdd:cd15928  92 TALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSGLLSVMLW- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCRYHICKTVRLsdvRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPY------CFLVLLA 317
Cdd:cd15928 171 VSTSFFFVPMVCLSLLYGLIGRALWD---RRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFhvgrviFNHSRAS 247
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 318 ATRQGQATQApslLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15928 248 TKHLHYVSQY---FNLVSFVLFYLSAAINPILYNL 279
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
89-356 1.32e-06

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 49.85  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15400  17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALG--EMHCKVSGFVMGLSVIGSIFNITGI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRP-PRDKLGRRRALQLLagawlaalgFSLPWDLLRAPREPP--------APQSFHRCLYRTSPDpaqlgvA 239
Cdd:cd15400  95 AINRYCYICHSfAYDKLYSRWNTLLY---------VCLIWALTVVAIVPNffvgsleyDPRIYSCTFVQTASS------S 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTtyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15400 160 YTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSES---KPRLKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAVAI 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 32306524 320 R-QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15400 237 NpQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQN 274
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
89-351 1.47e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 50.00  E-value: 1.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRT-VTNAFILSLSLSDLLTALLCLPAAFLDLFAppgDSGPWRSFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15320  18 GNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIA---GFWPFGSFCNIWVAFDIMCSTASILNLCV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFS-LPWDLLRAPREPPAPQSFHRCLYRTSPD--PAQLGVAYSV 242
Cdd:cd15320  95 ISVDRYWAISSPFRyeRKMTPKVAFIMISVAWTLSVLISfIPVQLNWHKAKPTSFLDLNASLRDLTMDncDSSLNRTYAI 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPFLLMCFCRYHIcktVRLSDVRVRPMTTYARV---------------------------LRFFSEVRTATT 295
Cdd:cd15320 175 SSSLISFYIPVAIMIVTYTRI---YRIAQKQIRRISALERAavhakncqnstgnrgsgdcqqpessfkMSFKRETKVLKT 251
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32306524 296 V-LIMIIFVmCCWGPY----CFLVLLAATRQGQATQAPSLLNVaAVWLTWANGAINPVIYA 351
Cdd:cd15320 252 LsVIMGVFV-CCWLPFfilnCMVPFCKPTSTEPFCISSTTFDV-FVWFGWANSSLNPIIYA 310
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
89-354 2.04e-06

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 48.91  E-value: 2.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLD----LFAPPGD-----SGPW---RSFCAASRFFSSC 156
Cdd:cd15066  16 GNLLVIISVMRHRKLRVITNYFV--------------VSLAMADmlvaLCAMTFNasveiTGRWmfgYFMCDVWNSLDVY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 157 FGIVSTFSVALISLDRYCAIVRP---PRdKLGRRRALQLLAGAwlaalgfslpWDLlraprepPAPQSF----------- 222
Cdd:cd15066  82 FSTASILHLCCISVDRYYAIVQPleyPS-KMTKRRVAIMLANV----------WIS-------PALISFlpiflgwytte 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 223 -HRCLYRTSPDPAQLGV--AYSVGLVVACYLLPFLLMCFCRYHIcktvrlsdvrvrpmttYARVLRffsEVRTATTV-LI 298
Cdd:cd15066 144 eHLQYRKTHPDQCEFVVnkIYALISSSVSFWIPCIVMIFTYYRI----------------YLEAKR---EHKAAKTLgII 204
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 32306524 299 MIIFVMcCWGPYcFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15066 205 MGAFIL-CWLPF-FLWYVTTTLCGDACPYPPILVSILFWIGYFNSTLNPLIYAYFN 258
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
146-350 2.71e-06

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 48.85  E-value: 2.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 146 FCAASRFFSSCFGIVSTFSVALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSfh 223
Cdd:cd15168  72 MCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPlrSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTT-- 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 224 rCLYRTSPDPAQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRffsevrtaTTVLIMIIFV 303
Cdd:cd15168 150 -CYDTTSPEELNDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKSIR--------LVIIVLALFA 220
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 32306524 304 McCWGPYCFL-VLLAATRQGQATQAPSLLNVAAVW------LTWANGAINPVIY 350
Cdd:cd15168 221 V-CFLPFHVTrTINLAARLLSGTASCATLNGIYVAykvtrpLASLNSCLNPLLY 273
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
89-350 3.40e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 48.35  E-value: 3.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFappgdsGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15326  17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfSATLEIL------GYWvfgRIFCDIWAAVDVLCCTASILS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLpwDLLRAPREPPAPQSFhRCLYRTSPdpaqlgvAYSV 242
Cdd:cd15326  91 LCAISIDRYIGVRHSLQypTIVTRKRAILALLGVWVLSTVISI--GPLLGWKEPAPPDDK-VCEITEEP-------FYAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPF--LLMCFCRYHICktvrlsdvrvrpmttyarVLRFFSEVRTATTVLIMIIFVMCCWGPycFLVLLAATR 320
Cdd:cd15326 161 FSSLGSFYIPLivILVMYCRVYIV------------------ALKFSREKKAAKTLGIVVGMFILCWLP--FFIALPLGS 220
                       250       260       270
                ....*....|....*....|....*....|
gi 32306524 321 QGQATQAPSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd15326 221 LFSHLKPPETLFKIIFWLGYFNSCLNPIIY 250
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
89-355 3.73e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 48.35  E-value: 3.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15325  17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCII 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPR------DKLGRRRALQLLAGAWLAALGFSLPWdllraprEPPAPQSFHRCLYRTSPdpaqlgvAYSV 242
Cdd:cd15325  95 SIDRYIGVSYPLRypsimtERRGLLALLCVWVLSLVISIGPLFGW-------KEPAPEDETICQITEEP-------GYAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 243 GLVVACYLLPF--LLMCFCRyhicktvrlsdvrvrpmtTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYcFLVLLAATR 320
Cdd:cd15325 161 FSALGSFYLPLaiILVMYCR------------------VYVVALKFSREKKAAKTLGIVVGCFVLCWLPF-FLVMPIGSI 221
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 321 QGQATQAPSLLNVaAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15325 222 FPAYKPSDTVFKI-TFWLGYFNSCINPIIYPCSSQ 255
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
89-350 3.90e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 48.26  E-value: 3.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15054  17 GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALY--GRWVLARDFCPIWYAFDVMCCSASILNLCVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLaalgfslpWDLLRAPREPPAPQSFHRC-LYRTSPDPAQLGVAYSVGLVVA 247
Cdd:cd15054  95 SLDRYLLIISPLRYKLRMTPPRALALILAA--------WTLAALASFLPIELGWHELgHERTLPNLTSGTVEGQCRLLVS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 248 cylLPFLLMCFCRYHICKTVRLSdvrvrpmTTYARVLRFFSEVRTATTVL-IMIIFVMCCWGPYcflvLLAATRQGQATQ 326
Cdd:cd15054 167 ---LPYALVASCLTFFLPSGAIC-------FTYCRILLAARKALKASLTLgILLGMFFVTWLPF----FVANVVQAVCDC 232
                       250       260
                ....*....|....*....|....
gi 32306524 327 APSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd15054 233 VSPGLFDVLTWLGYCNSTMNPIIY 256
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
90-274 4.54e-06

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 48.31  E-value: 4.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  90 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSScfgIVSTFSVALIS 169
Cdd:cd15211  17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRLFREGLLFLGL---TVSLLSHSLIA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 170 LDRYCAIVRPP---RDKLGRRRALQLLAGAWLAALGFSLPWdllrAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVGLVV 246
Cdd:cd15211  94 LNRYVLITKLPavyQALYQKRNTEWMIALSWALALGLLLPW----LTSFRYPTKSCHDSADGSFAVVSVLSSRYPALLLA 169
                       170       180
                ....*....|....*....|....*...
gi 32306524 247 ACYLLPFLLMCFCRYHICKTVRLSDVRV 274
Cdd:cd15211 170 FTVLGQTALVLHCYFGIFRRVQISVKRV 197
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
157-350 4.96e-06

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 48.20  E-value: 4.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 157 FGI-VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCL---YRTSPD 232
Cdd:cd15384  82 FGLyLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQCVtygFYTAEW 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 233 PAQLgvaYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVL-----RFFSEVRTAT---TVLIMIIFVM 304
Cdd:cd15384 162 QEQL---YNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNRgpnrqRLFHKAKVKSlrmSAVIVTAFIL 238
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 32306524 305 cCWGPYCFLVLLAATRQGQATQapSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd15384 239 -CWTPYYVIMIWFLFFNPYPLN--DILFDVIFFFGMSNSCVNPLIY 281
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
89-355 5.85e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 47.73  E-value: 5.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFappgDSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15053  17 GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEV----NGGKWylgPILCDIYIAMDVMCSTASIFNL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLLRAPREPPAPqsfHRCLYRTSPdpaqlgvaYSVG 243
Cdd:cd15053  93 CAISIDRYIAVTQPIKYARQKnsKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDP---EECRFYNPD--------FIIY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFcryhicktvrlsdvrvrpmtTYARVLRFFSEVRTATTVLIMIIFV-MCCWGPYCFLVLLAA---T 319
Cdd:cd15053 162 SSISSFYIPCIVMLL--------------------LYYRIFRALRREKKATKTLAIVLGVfLFCWLPFFTLNILNAicpK 221
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 320 RQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15053 222 LQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNI 257
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
125-318 5.98e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 48.01  E-value: 5.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 125 CLPAAFLDLFAP---PGDSGPWRSFCAASRFFSSCFGIVSTFSVALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLA 199
Cdd:cd14978  52 ALPLFLLPYIADyssSFLSYFYAYFLPYIYPLANTFQTASVWLTVALTVERYIAVCHPlkARTWCTPRRARRVILIIIIF 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 200 ALGFSLPWDLLRAPRE---PPAPQSFHRCLYRTSPDPAQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRP 276
Cdd:cd14978 132 SLLLNLPRFFEYEVVEcenCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRL 211
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 32306524 277 MT-TYARVLRFFSEVRTATTVLIMIIFV-MCCWGPYCFLVLLAA 318
Cdd:cd14978 212 LRrRRRLLSRSQRRERRTTIMLIAVVIVfLICNLPAGILNILEA 255
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
89-354 1.15e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 46.85  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSlslsdlltallcLPAA--FLDLFAPPGDSGPWRSFCA--ASRFFSSCFGIV---- 160
Cdd:cd15069  17 GNVLVCAAVGTNSTLQTPTNYFLVS------------LAAAdvAVGLFAIPFAITISLGFCTdfHSCLFLACFVLVltqs 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKL----GRRRALQLLAGAWLAALGFS--LPWDLLRA-------PREPPAPQS--FHRC 225
Cdd:cd15069  85 SIFSLLAVAVDRYLAIKVPLRYKSlvtgKRARGVIAVLWVLAFGIGLTpfLGWNKAMSatnnstnPADHGTNHSccLISC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 226 LYRTSpdpaqLGVAYSVGL-VVACYLLPFLLMCFCRYHI----CKTVRLSDVRVRPMTTYARvlrffsEVRTATTVLIMI 300
Cdd:cd15069 165 LFENV-----VPMSYMVYFnFFGCVLPPLLIMLVIYIKIflvaCRQLQRTELMDHSRTTLQR------EIHAAKSLAIIV 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 32306524 301 IFVMCCWGPYCFLVLLAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15069 234 GIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRN 287
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
89-206 1.90e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 46.39  E-value: 1.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAP-PGDSGPWRSFCAASRFFSSCFGivSTFSVAL 167
Cdd:cd15357  17 GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNyPFLFGPVGCYFKTALFETVCFA--SILSVTT 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 32306524 168 ISLDRYCAIVRPPRDKLG--RRRALQLLAGAWLAALGFSLP 206
Cdd:cd15357  95 VSVERYVAILHPFRAKLNstRERALKIIVVLWVLSVLFSIP 135
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
161-313 2.02e-05

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 46.21  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTS-PDPAQlGVA 239
Cdd:cd15383  88 SAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQCATHGSfPAHWQ-ETL 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHI----CKTVRLSDVRVRPMTTYARVLRFFSEVRTAT---TVLIMIIFVMcCWGPYCF 312
Cdd:cd15383 167 YNMFTFFCLFLLPLLIMIFCYTRIlleiSRRMKEKKDSAKNEVALRSSSDNIPKARMRTlkmTIVIVSSFIV-CWTPYYL 245

                .
gi 32306524 313 L 313
Cdd:cd15383 246 L 246
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
90-354 2.08e-05

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 46.33  E-value: 2.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  90 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRsfCAASRFFSSCFGIVSTFSVALIS 169
Cdd:cd15082  31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWA--CVLEGFAVTFFGIVALWSLAVLA 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 170 LDRYCAIVRPprdkLGRRRALQLLAGAWLAAL-GFSLPWDLlraprePPAP--QSFHRCLYRTSPDPAQLGVAYS----- 241
Cdd:cd15082 109 FERFFVICRP----LGNIRLQGKHAALGLLFVwTFSFIWTI------PPVLgwSSYTVSKIGTTCEPNWYSGNMHdhtyi 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVR-LSDVRVRPMTTYArvlrffSEVRTATTVLIMIIFVMCCWGPYCFLVLLaatr 320
Cdd:cd15082 179 ITFFTTCFILPLGVIFVSYGKLLQKLRkVSNTQGRLGNARK------PERQVTRMVVVMIVAFMVCWTPYAAFSIL---- 248
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306524 321 qgqATQAPSL-----LNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15082 249 ---VTAHPTIhldprLAAIPAFFSKTAAVYNPIIYVFMN 284
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
89-350 2.14e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 46.10  E-value: 2.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSlSDLLTALLCLPA-AFLDLfappgdSGPWRSFCAASRFFSSCFGIVSTFS--- 164
Cdd:cd14982  17 GNILALWVFLRKMKKRSPTTIYMINLA-LADLLFVLTLPFrIYYYL------NGGWWPFGDFLCRLTGLLFYINMYGsil 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 -VALISLDRYCAIVRPPRDKLGRRRALQLLAGAW--LAALGFSLPWDLLRAprePPAPQSFHRCLYRTSPDPAQLGVAYS 241
Cdd:cd14982  90 fLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGvwILVLVASVPLLLLRS---TIAKENNSTTCFEFLSEWLASAAPIV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFsevrtattVLIMIIFVMcCWGPY---CFLVLLAA 318
Cdd:cd14982 167 LIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMI--------LIVLAVFLV-CFLPYhvtRILYLLVR 237
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 319 TRQGQATQAPSLLNVA---AVWLTWANGAINPVIY 350
Cdd:cd14982 238 LSFIADCSARNSLYKAyriTLCLASLNSCLDPLIY 272
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
89-351 2.52e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 45.75  E-value: 2.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWrsFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15096  17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDV--WCKIVQYLVYVTAYASVYTLVLM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLL---RAPREPPAPQSFhrCLYRTSPDPAqlGVAYSVG 243
Cdd:cd15096  95 SLDRYLAVVHPITSMSIRteRNTLIAIVGIWIVILVANIPVLFLhgvVSYGFSSEAYSY--CTFLTEVGTA--AQTFFTS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFcrYHICKTVRL-----SDVRVRPMTTYARvlrffsevRTAT--TVLIMIIFVMcCWGPYCFLVLL 316
Cdd:cd15096 171 FFLFSYLIPLTLICV--LYMLMLRRLrrqksPGGRRSAESQRGK--------RRVTrlVVVVVVVFAI-CWLPIHIILLL 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 317 AATRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15096 240 KYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYA 274
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
89-356 2.67e-05

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 45.96  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15395  17 GNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFG--EAMCKLNSMVQCISITVSIFSLVLI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPP---APQSFHR------CLYRTSPDPAQLgvA 239
Cdd:cd15395  95 AIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTDEPfknVNVSLDAykgkyvCLDQFPSDTIRL--S 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLP--FLLMCFCRYHIcKTVRLSDVRVRPMTTYARVlrffSEVRTATTVLIMIIFVMC-CWGPY-CFLVL 315
Cdd:cd15395 173 YTTCLLVLQYFGPlcFIFICYLKIYI-RLKRRNNMMDKMRDNKYRS----SETKRINIMLISIVVAFAvCWLPLnIFNAV 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 32306524 316 LAATRQGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15395 248 FDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKN 288
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
147-351 3.02e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 45.59  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 147 CAASRFFSSCFGIVSTFSVALISLDRYCAIVRpprdklGRRRALQLLAGAWLAALGFSLPWD---LLRAPREPPAPQSFH 223
Cdd:cd15078  73 CVWDGFSNSLFGIVSIMTLTVLAYERYIRVVH------AKVVNFSWSWRAITYIWLYSLAWTgapLLGWNRYTLEVHGLG 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 224 RCLYRTSPDPAQlgVAYSVGLVVACYLLPFLLMCFCRYHICKTVR-LSDVRVRPMTTYARVLRFfsEVRTATTVLIMIIF 302
Cdd:cd15078 147 CSFDWKSKDPND--TSFVLLFFLGCLVVPLGIMAYCYGHILYEIRmLRSVEDLQTFQVIKILKY--EKKVAKMCLLMIST 222
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 32306524 303 VMCCWGPYCFLVLLAATrqGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15078 223 FLICWMPYAVVSLLVTS--GYSKLVTPTIAIIPSLFAKSSTAYNPVIYI 269
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
89-351 3.12e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 45.50  E-value: 3.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGdsgpW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15394  17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRG----WvfgRFMCYFVFLMQPVTVYVSVFTL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPaPQSFHRCL-YRTSPDPAQLgvAYSVGL 244
Cdd:cd15394  93 TAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFK-GLDFSICEeFWFGQEKQRL--AYACST 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 245 VVACYLLPFLLMCFCryHICKTVRLSDvRVRPMTTYARVLRFFSEVRTATTVLIMIIFVM--CCWGP-YCFLVLLAATRQ 321
Cdd:cd15394 170 LLITYVLPLLAISLS--YLRISVKLRN-RVVPGSMTQSQAEWDRARRRKTFRLLVVVVVAfaICWLPlHIFNVIRDIDID 246
                       250       260       270
                ....*....|....*....|....*....|
gi 32306524 322 GQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15394 247 LIDKQYFNLIQLLCHWLAMSSACYNPFLYA 276
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
161-352 3.72e-05

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 45.37  E-value: 3.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQS-FHRCLYRTSPDPAQLG 237
Cdd:cd14974  86 SVFLLTAISLDRCLLVLHPvwAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRScNLTCVEDYDLRRSRHK 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAYSVGLVVAcYLLPFLLMCFCryHICKTVRLSDVRVRPMTTYARVLrffsevrtatTVLIMIIFVmcCWGPYCFLVLLa 317
Cdd:cd14974 166 ALTVIRFLCG-FLLPLLIIAIC--YSVIAVKLRRKRLAKSSKPLRVL----------LAVVVAFFL--CWLPYHVFALL- 229
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306524 318 atrqgQATQAPSLLNVAAVW------LTWANGAINPVIYAI 352
Cdd:cd14974 230 -----ELVAAAGLPEVVLLGlplatgLAYFNSCLNPILYVF 265
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
89-359 3.75e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 45.25  E-value: 3.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15978  17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFG--SAVCKTATYFMGISVSVSTFNLVAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFS--LPWDLLR--APREPPAPQSFHRCLYRTSPDPAQLgvAYSVGL 244
Cdd:cd15978  95 SLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTimLPYPIYSnlVPFTRINNSTGNMCRLLWPNDVTQQ--SWYIFL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 245 VVACYLLPFLLMCFCRYHIcktvrlsdvrvrPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPycfLVLLAATRQGQA 324
Cdd:cd15978 173 LLILFLIPGIVMMTAYGLI------------SLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTP---IFSANAWRAFDT 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306524 325 TQAPSLLNVAAV----WLTWANGAINPVIYAIRNPNISM 359
Cdd:cd15978 238 RSADRLLSGAPIsfihLLSYTSACVNPIIYCFMNKRFRM 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
89-356 3.77e-05

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 45.22  E-value: 3.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFAPPGDSGPwrSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15971  17 GNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLG-LPFLAIQVALVHWPFGK--AICRVVMTVDGINQFTSIFCLTVM 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPrdKLGRRRALQLLAGAWLAALGFSLPWDL---LRAPREPPAPQSFHRCLYrtsPDPAQlgvAYSVGLV 245
Cdd:cd15971  94 SIDRYLAVVHPI--KSAKWRKPRTAKMINMAVWGVSLLVILpimIYAGVQTKHGRSSCTIIW---PGESS---AWYTGFI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLL----MCFCRYHICKTVRLSDVRVrpmttyARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQ 321
Cdd:cd15971 166 IYTFILGFFVpltiICLCYLFIIIKVKSSGIRV------GSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVS 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 322 GQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15971 240 ISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDN 274
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
282-350 3.93e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 45.17  E-value: 3.93e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32306524 282 RVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATRQGQATqaPSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd15296 194 RRFRLSRDKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCV--PDYWYETSFWLLWVNSAINPVLY 260
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
146-357 4.07e-05

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 45.31  E-value: 4.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 146 FCAASRFFSSCFGIVSTFSVALISLDRYCAIVRP-PRDKLGRRRALQLLAGAWLAALGFSLpwdllrAPREPPAPQSFHR 224
Cdd:cd14980  80 PCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPfSNKRLSYKSAKIILILGWLFSIIFAA------IPILYSINQPGDN 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 225 CLYRTSP--------DPAQLG--VAYsVGLVVACyllpFLLMCFCRYHICKTVRLSDVRVrpmttyaRVLRFFSEVRTAT 294
Cdd:cd14980 154 RLYGYSSicmpsnvsNPYYRGwlIAY-LLLTFIA----WIIICILYILIFISVRKSRKSA-------RRSSSKRDKRIAI 221
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32306524 295 TVLIMIIFVMCCWGPYCFLVLLAATRQGQATqaPSLLNVAAVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd14980 222 RLALILITDLICWLPYYIVIFSGLLTSTEID--IHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
89-354 4.20e-05

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 45.24  E-value: 4.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLdlFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd16002  17 GNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFT--YAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGrrRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFhrCLYRTSPDPAQL--GVAYSVGLVV 246
Cdd:cd16002  95 ALDRYMAIIHPLQPRLS--ATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRV--VCYVEWPEHEERkyETVYHVCVTV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 247 ACYLLPFLLMCfCRYHICKtvrlsdvrvrpMTTYARVL------RFFSEVRTATTVLIMIIFVMC----CWGPYCFLVLL 316
Cdd:cd16002 171 LIYFLPLLVIG-CAYTVVG-----------ITLWASEIpgdssdRYHEQVSAKRKVVKMMIVVVCtfaiCWLPYHIYFLL 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306524 317 AATRQGQATQA-PSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd16002 239 QYFHPELYEQKfIQQVYLAIMWLAMSSTMYNPIIYCCLN 277
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
141-352 6.97e-05

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 44.39  E-value: 6.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 141 GPWRSFCAASRFFSSCFGI---VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPP 217
Cdd:cd15151  63 GPWQLRAFVCRFSAVVFYItmyISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPA 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 218 APQSFHRCLYRTSPdpaqLGVAYSVGLVVACYLL---PFLLMCFCRYHICKTVRLSDVRVRPMTTYARvlrffseVRTAT 294
Cdd:cd15151 143 TPISVKKCASLKSP----LGLKWHEVVNYICQFIfwgVFALMVLFYTIISKKVYESYKKSRSKDNKAS-------KKTKA 211
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32306524 295 TVLIMIIFVMCCWGPYCFLVL---LAATRQGQATQAPSLLNVA---AVWLTWANGAINPVIYAI 352
Cdd:cd15151 212 KVFIIVAVFFVCFAPFHFVRVpytLSQTGKITDCQLQNLLYIAkeiTLWLAATNVCLDPLIYIF 275
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
89-355 7.51e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 44.23  E-value: 7.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppGDSGPWR-SFCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15052  17 GNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELF--GGVWPLPlVLCLLWVTLDVLFCTASIMHLCT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHrCLYrtsPDPaqlgvAYSVGLV 245
Cdd:cd15052  95 ISLDRYMAIRYPlrTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGT-CVL---FNP-----NFVIYGS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLLMcfcryhicktvrlsdvrvrpMTTYARVLRFFSEVRTATTVL--IMIIFVMcCWGPYCFLVLLAATRQGQ 323
Cdd:cd15052 166 IVAFFIPLLIM--------------------VVTYALTIRLLSNEQKASKVLgiVFAVFVI-CWCPFFITNILTGLCEEC 224
                       250       260       270
                ....*....|....*....|....*....|..
gi 32306524 324 ATQAPSLLNVAAVWLTWANGAINPVIYAIRNP 355
Cdd:cd15052 225 NCRISPWLLSVFVWLGYVSSTINPIIYTIFNK 256
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
160-355 8.35e-05

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 44.11  E-value: 8.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 VSTFSVALISLDRYCAIVRPPRD-KLGRRRALQLLAGAWLAALGFS----LPWDLLRapreppapqSFHR----C--LYR 228
Cdd:cd15137  93 VSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLLAvlplLPWDYFG---------NFYGrsgvClpLHI 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 229 TSPDPAqlGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPmttyarvlRFFSEVRTATTVLIMIIFV-MCCW 307
Cdd:cd15137 164 TDERPA--GWEYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAAS--------RKSKRDMAVAKRFFLIVLTdFLCW 233
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32306524 308 GPYCFLVLLAatrqgqatqapsLLNVA---------AVWLTWANGAINPVIYAIRNP 355
Cdd:cd15137 234 IPIIVIGILA------------LSGVPipgevyawvAVFVLPINSALNPILYTLSTP 278
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
90-354 8.70e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 44.47  E-value: 8.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  90 NCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALIS 169
Cdd:cd15084  28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFG--KTMCEFEGFMVSLTGIVGLWSLAILA 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 170 LDRYCAIVRPPRDKLGRRRALQLLAGawlaalgFSLPWDLLRApreppAPQSFHRCLY-----RTSPDP-----AQLGVA 239
Cdd:cd15084 106 FERYLVICKPMGDFRFQQRHAVSGCA-------FTWGWSLLWT-----SPPLFGWSSYvpeglRTSCGPnwytgGTNNNS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARvlrffSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15084 174 YILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETTQR-----AEKEVTRMVIAMVMAFLICWLPYATFAMVVAT 248
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 320 RQGQATQaPSLLNVAAVWLTWANgAINPVIYAIRN 354
Cdd:cd15084 249 NKDVVIQ-PTLASLPSYFSKTAT-VYNPIIYVFMN 281
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
89-188 9.27e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 44.03  E-value: 9.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPwrSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15979  17 GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGE--VICKAVAYLMGVSVSVSTFSLVAI 94
                        90       100
                ....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRR 188
Cdd:cd15979  95 AIERYSAICNPLQSRVWQTR 114
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
89-310 9.32e-05

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 44.04  E-value: 9.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaaFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15399  17 GNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLP--FTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFH--RCLYRTSPDPAQLGVAYSVGLVV 246
Cdd:cd15399  95 ALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKiqACSEKWPNGTLNDGTIYSVSMLL 174
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32306524 247 ACYLLPFLLMCFCryHICKTVRLSDvRVRPMttyARVLRFFSEVRTATTVLIMIIFVMC-CWGPY 310
Cdd:cd15399 175 IQYVLPLAIISYA--YIRIWTKLKN-HVSPG---GGNDHYHQRRRKTTKMLVCVVVVFAvSWLPF 233
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
89-350 1.05e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 43.75  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLP-AAFLDLFappgdsGPW---RSFCAASRFFSSCFGIVSTFS 164
Cdd:cd15327  17 GNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfSATLEVL------GFWafgRVFCDIWAAVDVLCCTASILS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAI---VRPPRDKLGRRRALQLL---AGAWLAALGFSLPWdllrapREPPAPQSfHRCLYRTSPdpaqlgv 238
Cdd:cd15327  91 LCVISVDRYVGVkhsLKYPTIMTERKAGVILVllwVSSMVISIGPLLGW------KEPPPPDE-SICSITEEP------- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFL--LMCFCRyhicktvrlsdvrvrpmtTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYcFLVLL 316
Cdd:cd15327 157 GYALFSSLFSFYLPLMviLVMYFR------------------VYVVALKFSREKKAAKTLAIVVGVFILCWFPF-FFVLP 217
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 317 AATRQGQATQAPSLLNVaAVWLTWANGAINPVIY 350
Cdd:cd15327 218 LGSFFPALKPSEMVFKV-IFWLGYFNSCVNPIIY 250
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
89-354 1.79e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 43.40  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAppgDSGPWRS-FCAASRFFSSCFGIVSTFSVAL 167
Cdd:cd15307  17 GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVK---GHFPLSSeHCLTWICLDVLFCTASIMHLCT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPWDLLRApREPPAPQSFHRClyrTSPDPaqlgVAYSVGLV 245
Cdd:cd15307  94 ISVDRYLSLRYPMRfgRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYS-KDHASVLVNGTC---QIPDP----VYKLVGSI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VaCYLLPFLLMCFCryhICKTVRLsdvRVRPMTTYARVLRFfseVRTATTVLIMIIFV-MCCWGPYCFL-VLLAATRQGQ 323
Cdd:cd15307 166 V-CFYIPLGVMLLT---YCLTVRL---LARQRSRHGRIIRL---EQKATKVLGVVFFTfVILWSPFFVLnLLPTVCAECE 235
                       250       260       270
                ....*....|....*....|....*....|.
gi 32306524 324 ATQAPSLLNVaAVWLTWANGAINPVIYAIRN 354
Cdd:cd15307 236 ERISHWVFDV-VTWLGYASSMVNPIFYTIFN 265
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
89-354 1.96e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 43.03  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVA-- 166
Cdd:cd17790  17 GNLLVLISFKVNSELKTVNNYFL-----LSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMnl 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 167 -LISLDRYCAIVRPP--RDKLGRRRALQLLAGAWLAALGFSLP----WDLLRAPREPPAPQSFHRCLyrTSPdpaqlgvA 239
Cdd:cd17790  92 lIISFDRYFSITRPLtyRAKRTPRRAAIMIGLAWLISFVLWAPailfWQYLVGERTVLAGQCYIQFL--SQP-------I 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCfcryhicktvrlsdvrvrpmTTYARVLR-FFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd17790 163 ITFGTAIAAFYLPVTIMI--------------------ILYWRIYReTIKEKKAARTLSAILLAFILTWTPYNIMVLVST 222
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 319 TRQgqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd17790 223 FCK---DCVPKTLWELGYWLCYVNSTVNPMCYALCN 255
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
239-354 1.98e-04

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 42.97  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARvlrffSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd15081 177 SYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKESESTQK-----AEKEVSRMVVVMIFAYCFCWGPYTFFACFAA 251
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 32306524 319 TRQGQATQAPSllnvAAVWLTWANGAI--NPVIYAIRN 354
Cdd:cd15081 252 ANPGYAFHPLA----AALPAYFAKSATiyNPIIYVFMN 285
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
89-354 2.07e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 43.08  E-value: 2.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVA-- 166
Cdd:cd15298  17 GNILVMLSIKVNRQLQTVNNYFL-----FSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMnl 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 167 -LISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSL--P----WDLLRAPREPPAPQSFHRCLyrTSPdpaqlgvA 239
Cdd:cd15298  92 lIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLwaPailfWQFVVGKRTVPDNQCFIQFL--SNP-------A 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHIcktvRLSDVRVRPMTtyarvlrffsevRTATTVLIMIIFVmccWGPYCFLVLLAAT 319
Cdd:cd15298 163 VTFGTAIAAFYLPVVIMTVLYIHI----SLASARERKVT------------RTIFAILLAFILT---WTPYNVMVLVNTF 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 320 RQgqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15298 224 CQ---SCIPDTVWSIGYWLCYVNSTINPACYALCN 255
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
161-356 2.40e-04

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 42.87  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF--SLPWDLLRAPREppapqSFHRClYRTSPDPAQL-G 237
Cdd:cd15974  86 SIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFlvVLPVIIFSDVQP-----DLNTC-NISWPEPVSVwS 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVrpmttyARVLRFFSEVRTATTVLIMIIFVMCCWGPycFLVLLA 317
Cdd:cd15974 160 TAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRV------GSTKRRKSERKVTRMVVIIVVVFVFCWLP--FYMLNI 231
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 32306524 318 ATRQGQATQAPSLLNV--AAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15974 232 VNLIVILPEEPAFVGVyfFVVVLSYANSCANPILYGFLSDN 272
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
161-356 3.37e-04

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 42.21  E-value: 3.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTsPDPAQlgvAY 240
Cdd:cd15970  86 SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQM-PEPSQ---RW 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLL----MCFCRYHICKTVRLSDVRVrpmttyARVLRFFSEVRTATTVLIMIIFVMCCWGPYcFLVLL 316
Cdd:cd15970 162 LAVFVVYTFLMGFLLpviaICLCYILIIVKMRVVALKA------GWQQRKRSERKITLMVMMVVTVFVICWMPF-YVVQL 234
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 32306524 317 AATRQGQATQAPSLLNVAavwLTWANGAINPVIYAIRNPN 356
Cdd:cd15970 235 VSVFVGQHDATVSQLSVI---LGYANSCANPILYGFLSDN 271
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
89-352 3.56e-04

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 42.12  E-value: 3.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQL-RTVTNAFILSLSLSDLLTALLCLP--AAFLDLfappgDSGPWRSF-CAASRFFSSCFGIVSTFS 164
Cdd:cd15097  17 GNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPfqATIYSL-----EGWVFGSFlCKAVHFFIYLTMYASSFT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 165 VALISLDRYCAIVRPPRDKlgRRRALQLLAGAWLAALGFSLpwdLLRAPREPPAPQSFHRCLYRTSPD-PAQLGVAYSVG 243
Cdd:cd15097  92 LAAVSVDRYLAIRYPLRSR--ELRTPRNAVAAIALIWGLSL---LFAGPYLSYYDLIDYANSTVCMPGwEEARRKAMDTC 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCryhICKTVRLSDVRVRPMTTYARVLRffsEVRTATTVLIMIIFVMC-CWGPYCFLVLLAATRQG 322
Cdd:cd15097 167 TFAFGYLIPVLVVSLS---YTRTIKYLWTAVDPLEAMSESKR---AKRKVTKMIIIVTALFClCWLPHHVVILCYLYGDF 240
                       250       260       270
                ....*....|....*....|....*....|
gi 32306524 323 QATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15097 241 PFNQATYAFRLLSHCMAYANSCLNPIVYAL 270
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
280-357 4.36e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 41.87  E-value: 4.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 280 YARVLRFFSEVRTATTVL--IMIIFVMCcWGPYCFLVLLAATRQGQATQA-PSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15329 177 YYKIYRAAKSERKAIKTLgiIMGAFTLC-WLPFFILALLRPFLKPIKCSCiPLWLSRLFLWLGYANSFLNPIIYAKFNRE 255

                .
gi 32306524 357 I 357
Cdd:cd15329 256 F 256
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
89-350 5.39e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 41.64  E-value: 5.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSlSDLLTALLCLPAAFLDLFAPPGDSGPwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd14964  15 GNLLVLLSLVRLRKRPRSTRLLLASLA-ACDLLASLVVLVLFFLLGLTEASSRP-QALCYLIYLLWYGANLASIWTTLVL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAW--LAALGFSLPWDLlrapreppAPQSFHRCLYRTSPDP-AQLGVAYSVGLV 245
Cdd:cd14964  93 TYHRYFALCGPLKYTRLSSPGKTRVIILGcwGVSLLLSIPPLV--------GKGAIPRYNTLTGSCYlICTTIYLTWGFL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLLMCFCRYhicKTVRLSDVRVRPMTTYARvLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAtrQGQAT 325
Cdd:cd14964 165 LVSFLLPLVAFLVIFS---RIVLRLRRRVRAIRSAAS-LNTDKNLKATKSLLILVITFLLCWLPFSIVFILHA--LVAAG 238
                       250       260
                ....*....|....*....|....*
gi 32306524 326 QAPSLLNVAAVWLTWANGAINPVIY 350
Cdd:cd14964 239 QGLNLLSILANLLAVLASTLNPFIY 263
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
241-357 5.84e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 41.55  E-value: 5.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAATr 320
Cdd:cd15961 154 NAAILSVSFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY- 232
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 32306524 321 qgqatQAPSLLNVAAVWLTWANGAINPVIYAIRNPNI 357
Cdd:cd15961 233 -----TYPSIYTYATLLPATYNSIINPVIYAFRNQEI 264
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
89-351 6.08e-04

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 41.71  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLltallcLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGI---VSTFSV 165
Cdd:cd15972  17 GNTLVIYVVLRYSASESVTNIYILNLALADE------LFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAInqfTSIFCL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHrclyRTSPDPAQL-GVAYSVGL 244
Cdd:cd15972  91 TVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCH----IAWPEPAQVwRAGFIIYT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 245 VVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVlrffSEVRTATTVLIMIIFVMCCWGPycFLVLLAATRQGQA 324
Cdd:cd15972 167 ATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRG----SERKVTRMVVIVVAAFVLCWLP--FYALNIVNLVCPL 240
                       250       260
                ....*....|....*....|....*....
gi 32306524 325 TQAPSLLNVA--AVWLTWANGAINPVIYA 351
Cdd:cd15972 241 PEEPSLFGLYffVVVLSYANSCANPIIYG 269
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
86-351 6.14e-04

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 41.66  E-value: 6.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  86 SSLGNCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDL-------FAPPGDSGPW---RSFC----AASR 151
Cdd:cd15181  14 GVVGNGLVLTILLRRRRSRRTTENYL--------------LHLALADLlllltfpFSVVESIAGWvfgTFLCklvgAIHK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 152 FFSSCfgivSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF--SLPwDLLRAPREPPAPQSFHRCLYrt 229
Cdd:cd15181  80 LNFYC----SSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFllSLP-NLVFLEVETSTNANRTSCSF-- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 230 spdpAQLGVAYSVGLV-------VACYLLPFLLMCFCRYHICKTVRLSDVRVrpmttyarvlrffsEVRTATTVLIMIIF 302
Cdd:cd15181 153 ----HQYGIHESNWWLtsrflyhVVGFFLPLLIMGYCYATIVVTLCQSSRRL--------------QKQKAIRVAILVTL 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32306524 303 VMC-CWGPYCFLVLLAATRQGQATQAPSLLNV---AAVWLTWANG----AINPVIYA 351
Cdd:cd15181 215 VFClCWLPYNIVIFLDTLDDLKAVVKNCKLNDlldAAITVTESLGfshcCLNPILYA 271
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
89-352 6.18e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 41.67  E-value: 6.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFAPP------GDSGPW---RSFCAASRFFSSCFGI 159
Cdd:cd15088  17 GNGIVLYVLVRCSKLRTAPDIFIFNLAV-----------ADLLFMLGMPflihqfAIDGQWyfgEVMCKIITALDANNQF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAqlGVA 239
Cdd:cd15088  86 TSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDD--LYW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFfsevrTATTVLIMIIFVMcCWGPYcFLVLLAAT 319
Cdd:cd15088 164 FTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRV-----TKMVILIVVVFIV-CWLPF-HVVQLVNL 236
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 320 RQGQATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15088 237 AMNRPTLAFEVAYFLSICLGYANSCLNPFVYIL 269
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
89-357 6.88e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 41.46  E-value: 6.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSG-PWRSFCAASRFFSSCfgiVSTFSVAL 167
Cdd:cd15214  16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGvVWCNFSALLYLLISS---ASMLTLGA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 168 ISLDRYCAIVRP---PRDKLGRRRALQLLAGAWLAALGFSLP---WDLLRAPR-EPPAPQSFHRclyrtspdpaqlGVAY 240
Cdd:cd15214  93 IAIDRYYAVLYPmvyPMKITGNRAVLALVYIWLHSLIGCLPPlfgWSSLEFDRfKWMCVAAWHK------------EAGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLsdvrvrpmttyarvlrffSEVRTATTVLIMIIFVMCCWGPYcFLVLLAATR 320
Cdd:cd15214 161 TAFWQVWCALLPFVVMLVCYGFIFRVARA------------------NQCKAFITILVVLGAFVTTWGPY-MVVISTEAL 221
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 32306524 321 QGQATQAPSLLNVAAvWLTWANGAINPVIYAIRNPNI 357
Cdd:cd15214 222 WGKNSVSPQLETLAT-WLSFTSAVCHPLIYGLWNKTV 257
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
89-356 7.99e-04

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 41.09  E-value: 7.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLP---AAFLDLFAPPGDsgpwrSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15091  17 GNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPfqsTVYLMNSWPFGD-----VLCKIVISIDYYNMFTSIFTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPR--DKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYSVG 243
Cdd:cd15091  91 TMMSVDRYIAVCHPVKalDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYSWWDTFMKIC 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 244 LVVACYLLPFLLMCFCryHICKTVRLSDVRVRPMTTYA-RVLRffsevRTATTVLIMIIFVMCCWGPYCFLVLLAATRQG 322
Cdd:cd15091 171 VFIFAFVIPVLIIIVC--YTLMILRLKSVRLLSGSREKdRNLR-----RITRLVLVVVAVFVVCWTPIHIFILVEALGSV 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 32306524 323 QATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15091 244 SHSTAAVSSYYFCIALGYTNSSLNPILYAFLDEN 277
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
161-351 9.52e-04

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 40.91  E-value: 9.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF--SLPWDLLrapREPPAPQSFHRCLYRTSpdpaqlgV 238
Cdd:cd15115  86 SVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALllCLPVFIY---RTTVTDGNHTRCGYDFL-------V 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRvrpmttyarvlrfFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAA 318
Cdd:cd15115 156 AITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA-------------KSQSKTFRVIIAVVVAFFVCWAPYHIIGILSL 222
                       170       180       190
                ....*....|....*....|....*....|...
gi 32306524 319 TRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15115 223 YGDPPLSKVLMSWDHLSIALAYANSCLNPVLYV 255
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
89-356 9.68e-04

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 40.96  E-value: 9.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLD--LFAPPGDSgpwrSFCAASRFFSSCFGIVSTFSVA 166
Cdd:cd15981  17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDnlITGWPFDN----AMCKMSGLVQGMSVSASVFTLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 167 LISLDRYCAIVRPPRDKLGRRRALQLlagawlaalgFSLPWDLLRAPREPPA------PQSFH-------------RClY 227
Cdd:cd15981  93 AIAVERFRCIVHPFRQKLTLRKAIVT----------IVIIWVLALIIMCPSAvtltvtREEHHfmvddynnsyplySC-W 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 228 RTSPDPaQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARVLRFFSE--VRTATTVLIMIIFVMC 305
Cdd:cd15981 162 EAWPDT-EMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGRRVSKrkIKVINMLIIVALFFTL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32306524 306 CWGPYCFLVLLAATRQGQATQapslLNVAAV-------WLTWANGAINPVIYAIRNPN 356
Cdd:cd15981 241 SWLPLWTLMLLTDYGHLSEDQ----LNLVTVyvfpfahWLAFFNSSVNPIIYGYFNEN 294
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
89-354 1.26e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 40.33  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLtallcLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVA-- 166
Cdd:cd15297  17 GNILVMVSIKVNRHLQTVNNYFLFSLACADLI-----IGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMnl 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 167 -LISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSL--P----WDLLRAPREPPAPQsfhrCLYRTSPDPaqlgvA 239
Cdd:cd15297  92 lIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILwaPailfWQFIVGGRTVPEGE----CYIQFFSNA-----A 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRlsdvrvrpmttyarvlrffSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15297 163 VTFGTAIAAFYLPVIIMTVLYWQISRASS-------------------REKKVTRTILAILLAFIITWTPYNVMVLINTF 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 320 rqgQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15297 224 ---CASCIPNTVWTIGYWLCYINSTINPACYALCN 255
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
89-347 1.28e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 40.68  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15123  17 GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFG--RIGCKLLSFIQLTSVGVSVFTLTVL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRP----PRDKLgrRRALQLLAGAWLAALGFSLP---WDLLRAPREPPAPQSFHRClyrtSPDPAQ---LGV 238
Cdd:cd15123  95 SADRYRAIVKPlelqTSDAV--LKTCCKAGCVWIVSMLFAIPeavFSDLYSFRDPEKNTTFEAC----APYPVSekiLQE 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVrPMTTYARVLRFF-SEVRTATTVLIMIIFVMCCWGPYCFLVLLA 317
Cdd:cd15123 169 IHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNM-PAEEHSHARKQIeSRKRVAKTVLVLVALFAFCWLPNHILYLYR 247
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 318 ATRQGQATQAPSLLNVAAVW---LTWANGAINP 347
Cdd:cd15123 248 SFTYHTSVDSSAFHLIATIFsrvLAFSNSCVNP 280
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
89-352 1.38e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 40.42  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafLDLFA-------PPGDSGpwrsfCAASRFFSSCFGIVS 161
Cdd:cd14979  17 GNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP---VELYNfwwqypwAFGDGG-----CKLYYFLFEACTYAT 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 162 TFSVALISLDRYCAIVRPPRDK--LGRRRALQLLAGAWLAALGFSLPWDLL---RAPREPP--APQSFHRClyRTSPDPA 234
Cdd:cd14979  89 VLTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIWLVSILCAIPILFLmgiQYLNGPLpgPVPDSAVC--TLVVDRS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 235 QLGVAYSVGLVVAcYLLPFLLMCFCRYHI---CKTVRLSDVRVRPMTTYARVLRFFSEVRTATT---VLIMIIFVMcCWG 308
Cdd:cd14979 167 TFKYVFQVSTFIF-FVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSLSQQARRQVVkmlGAVVIAFFV-CWL 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 32306524 309 PYCFLVLLAATRQGQAT---QAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd14979 245 PFHAQRLMFSYASKEDTflfDFYQYLYPISGILFYLSSAINPILYNL 291
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
161-318 1.99e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 39.91  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 161 STFSVALISLDRYCAIVRPPRD-KLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQsfHRCLYRTSPDPAQlgVA 239
Cdd:cd15196  87 SSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGV--YDCWATFEPPWGL--RA 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRvrpmttyarvlrffsevrtatTVLIMIIFVMC---CWGPYCFLVLL 316
Cdd:cd15196 163 YITWFTVAVFVVPLIILAFCYGRICYVVWRAKIK---------------------TVKLTLVVVACyivCWTPFFVVQMW 221

                ..
gi 32306524 317 AA 318
Cdd:cd15196 222 AA 223
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
89-351 1.99e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 40.06  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLltallcLPAAFLDLFAPPGDSGpWRSFCAASRFFSSCFGI---VSTFSV 165
Cdd:cd15180  17 GNGLVLAVLLQKRRNLSVTDTFILHLALADI------LLLVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKInfyCGIFLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPrdKLGRRRALQLLAGAWLAALGFSL-----PWDLLRAPREPpaPQSFHRCLYRTSPDPAQLGVAY 240
Cdd:cd15180  90 ACISFDRYLSIVHAV--QMYSRKKPMLVHLSCLIVWLFCLllsipDFIFLEATKDP--RQNKTECVHNFPQSDTYWWLAL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDvrvrpmttyarvlRFFSEVRTATTVLIMIIFVMCCWGPYCfLVLLAAT- 319
Cdd:cd15180 166 RLLYHIVGFLLPLAVMVYCYTSILLRLLRSS-------------QGFQKQRAIRVIVAVVVVFFLCWTPYN-IALLVDTl 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32306524 320 --------RQGQATQAPSLLNVAAVwLTWANGAINPVIYA 351
Cdd:cd15180 232 idlsvldrNCGTESRLDIALSVTSS-LGYFHCCLNPLLYA 270
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
90-354 2.17e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  90 NCAVMGVIVKHRQLRTVTNAFIlslslsdlltallcLPAAFLDLFAPPGDS---------GPW---RSFCAASRFFSSCF 157
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFI--------------LNLSFSDLMMALCGTtivtvtnyeGYFylgDAFCIFQGFAVNYF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 158 GIVSTFSVALISLDRYCAIVRPPRD-KLGRRRALQLLAGAWLaalgFSLPWDLlrAPR---EPPAPQSFHRCLYRTSPDP 233
Cdd:cd15085  84 GIVSLWSLTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWL----FCLFWAV--APLfgwSSYGPEGVQTSCSIGWEER 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 234 AQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPM--TTYARvlrffSEVRTATTVLIMIIFVMCCWGPYC 311
Cdd:cd15085 158 SWSNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQggKNCPE-----EEERAVIMVLAMVIAFLICWLPYT 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 32306524 312 FLVLLAATrqGQATQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15085 233 VFALIVVV--NPELSISPLAATMPTYFAKTSPVYNPIIYIFLN 273
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
292-351 2.36e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 39.92  E-value: 2.36e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 292 TATTVLIMIIFvMCCWGPYcFLVLLAATRQGQATqaPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15314 217 TKTLAIVMGVF-LLCWTPF-FLCNIIDPFINYSI--PPVLIEVLNWLGYSNSTLNPFIYA 272
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
160-350 3.07e-03

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 39.35  E-value: 3.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 160 VSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGF--SLPWDLLRapREPPAPQSFHRCLYRTSPdpaqLG 237
Cdd:cd15924  85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFllSLPNMILT--NQQPREKNVKKCSFLKSE----LG 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 VAY---SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRPMTTYARvlrffseVRTATTVLIMIIFVMCCWGPYCFLV 314
Cdd:cd15924 159 LKWheiVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSRR-------KKSNVKIFIIVAVFFVCFVPYHFAR 231
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 32306524 315 L---LAATRQGQATQAPSLLNV---AAVWLTWANGAINPVIY 350
Cdd:cd15924 232 IpytLSQTRDVFDCTAENILFYvkeATLFLSALNVCLDPIIY 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
89-356 3.22e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 39.42  E-value: 3.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPaafldLFAPPGDSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15301  17 GNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMP-----LFTVYTALGYWplgYEVCDTWLAIDYLASNASVLNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKlgRRRALQLLAGAWLAALGFSL--------PWDLLRAPREPPAPQSFHRCLyRTSPdpaqlg 237
Cdd:cd15301  92 LIISFDRYFSVTRPLTYR--ARRTTKKAAVMIASAWIISLllwppwiySWPYIEGKRTVPAGTCYIQFL-ETNP------ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 238 vAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRvrpmttyarvlrffSEVRTATTVLIMIIFVMCCWGPYCFLVLLA 317
Cdd:cd15301 163 -YVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKK--------------QESKAAKTLSAILLAFIVTWTPYNVLVLIK 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 32306524 318 ATRQGQATqAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15301 228 AFFPCSDT-IPTELWDFSYYLCYINSTINPLCYALCNAA 265
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
89-352 3.49e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 39.32  E-value: 3.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIV--KHRQLRTVTNAFILSLSLSDLLTALLCLP---AAFLDLFAPPGDsgpwrSFCAASRFFSSCFGIVSTF 163
Cdd:cd15002  16 GNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPfraAAYSKGSWPLGW-----FVCKTADWFGHACMAAKSF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 164 SVALISLDRYCAIVRPPRD-KLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCL-YRTSPDPAQLGVAYS 241
Cdd:cd15002  91 TIAVLAKACYMYVVNPTKQvTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIpPLAHEFMSAFVKLYP 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 vgLVVACYLLPFLLMCFCR-YHICKtvrlsdvRVRPMTTYARVLRFFSEVrTATTVLIMIIFVMcCWGP-YCFLVLLAAT 319
Cdd:cd15002 171 --LFVFCLPLTFALFYFWRaYGQCQ-------RRGTKTQNLRNQIRSRKL-THMLLSVVLAFTI-LWLPeWVAWLWLIHI 239
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 320 RQgQATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15002 240 KS-SGSSPPQLFNVLAQLLAFSISSVNPIIFLL 271
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
89-351 4.20e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 4.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPAAFLDLFAPPGDSGPwrSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd14975  17 GNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLT-LPVWIYFLATGTWDFGL--AACKGCVYVCAVSMYASVFLITLM 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLrAPREPPAPQSFHRCLYRTSPDpAQLGVAYSVGLVVAc 248
Cdd:cd14975  94 SLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVI-AFRHVEETVENGMCKYRHYSD-GQLVFHLLLETVVG- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 249 YLLPFLLMCFCryHICKTVRLsdvrvrpmttyaRVLRFFSEVRTATTVLIMIIFVMCCWGPYCFLVLL--AATRQGQATQ 326
Cdd:cd14975 171 FAVPFTAVVLC--YSCLLRRL------------RRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLevVSELIGGSKM 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 32306524 327 APSLLNVA------AVWLTWANGAINPVIYA 351
Cdd:cd14975 237 AGTLGKVAeagrpiAGALAFLSSSINPLLYA 267
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
151-361 4.24e-03

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 38.99  E-value: 4.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 151 RFFSSCFGI---VSTFSVALISLDRYCAIVRPPRDKLGR--RRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRC 225
Cdd:cd15120  73 KVLNSTLSVgmfTSVFLLTAISLDRYLLTLHPVWSRQHRtnRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQN 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 226 LYRTSPD---------PAQLGVAYSVGLVVACYLLPFLLMCFCRYHIckTVRLSDVRVRPMTTYARVLrffsevrtattv 296
Cdd:cd15120 153 NYALSTNwesaevqasRQWIHVAMFVFRFLLGFLLPFLIITFCYVRM--ALKMKERGLARSSKPFKVM------------ 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32306524 297 LIMIIFVMCCWGPYCFLVLLAATRQGQATQAPSLLnVAAVWLTWANGAINPVIYAIRNPNISMLL 361
Cdd:cd15120 219 FTAVVSFFVCWLPYHLHSGLVLTRGRPPSLTDITL-LLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
134-313 4.78e-03

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 38.91  E-value: 4.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 134 FAPPGDsgpWR---SFCAASRFFSSCFGIVSTFSVALISLDRYCAIVRP--PRDKLGRRRALQLLAGAWLAALGFSLPWD 208
Cdd:cd15376  61 YYPPKN---WRfgeAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPffTRSHVRPKHAKLVSLAVWLLVAALSAPVL 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 209 LLRAPREPPAPQSfhRCLYRTSPDPAQLGVAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSdvrvrPMTTYARVLrffs 288
Cdd:cd15376 138 SFSHLEVERHNKT--ECLGTAVDSRLPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLRS-----PGITTLEKR---- 206
                       170       180
                ....*....|....*....|....*
gi 32306524 289 evRTATTVLIMIIFVMCCWGPYCFL 313
Cdd:cd15376 207 --KVAALVAVVVALYAVSFVPYHIL 229
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
89-356 4.95e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 38.66  E-value: 4.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLfappgDSGPW---RSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15008  16 GNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQF-----TSGRWtlgSAMCKLVRYFQYLTPGVQIYVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFhrclyrtsPDPAQLGVAYSVGLV 245
Cdd:cd15008  91 LSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSNWGPHCNFF--------LPDSWDGAAYAIIHL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 246 VACYLLPFLLMCFCRYHICKTV-RLS----DVRvRPMTTYARvlrffSEVRTATTVLIMIIFVMCCWGPycFLVLLAATR 320
Cdd:cd15008 163 LVGFLVPSILIILFYQKVIKYIwRIGtdgrTVR-RTMNIVPR-----TKVKTIKMFLMLNSMFLLSWLP--FYVVQLWHP 234
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 32306524 321 QGQATQAPSLLNVAAVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15008 235 RESDYRQSSLVFLAVTWISFSSSASKPTLYSVYNAN 270
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
89-356 6.18e-03

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 38.71  E-value: 6.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGpwRSFCAASRFFSSCFGIVSTFSVALI 168
Cdd:cd15980  17 GNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFG--STVCKMSGMVQGISVSASVFTLVAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 169 SLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTSP--------DPAQLGVAY 240
Cdd:cd15980  95 AVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPvywcredwPNQEMRKIY 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCFCRYHICKTVRLSDVrvrPMTTYARVLRFFSEVRTATTVLIMIIFV----MCCWGPYCFLVLL 316
Cdd:cd15980 175 TTVLFANIYLAPLSLIVIMYARIGITLFKTAM---PHTGKHNQEQRHVVSRKKQKVIKMLLIVallfILSWLPLWTLMML 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32306524 317 AATRQGQATQApSLLNVA----AVWLTWANGAINPVIYAIRNPN 356
Cdd:cd15980 252 SDYANLSPNQL-QIINIYiypfAHWLAFFNSSVNPIIYGFFNEN 294
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
159-352 8.02e-03

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 38.25  E-value: 8.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 159 IVSTFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREPPAPQSFHRCLYRTsPDPAQLGV 238
Cdd:cd15338  88 ITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLL-PNPETDTY 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 239 AYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVrvrpmTTYARVLRFFSEVRTATTVLIMIIFVMcCWGPYCFLVLLAA 318
Cdd:cd15338 167 WFTLYQFFLAFALPLVVICVVYFKILQNMASTVA-----PLPQRSLRVRTKKVTRMAVAICLAFFI-CWAPFYILQLAHL 240
                       170       180       190
                ....*....|....*....|....*....|....
gi 32306524 319 TRQgQATQAPSLLNVAAVWLTWANGAINPVIYAI 352
Cdd:cd15338 241 SID-RPSLAFLYAYNVAISMGYANSCINPFLYIM 273
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
89-351 8.16e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 38.19  E-value: 8.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLC-LPAAFLDLFA--PPGdsgpwRSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15012  16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCvLQNLSIYLIPswPFG-----EVLCRMYQFVHSLSYTASIGIL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDK----LGRRRALQLLAGAWLAALGFslPWDLLRAPREPPAPQSFHRCLYRTSPDPAQLGVAYS 241
Cdd:cd15012  91 VVISVERYIAILHPLRCKqlltAARLRVTIVTVWLTSAVYNT--PYFVFSQTVEILVTQDGQEEEICVLDREMFNSKLYD 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDvRVRPMTTYARVLrffsevrtattVLIMIIFVMCCWGPYCFLVLLAATRQ 321
Cdd:cd15012 169 TINFIVWYLIPLLIMTVLYSKISIVLWKSS-SIEARRKVVRLL-----------VAVVVSFALCNLPYHARKMWQYWSEP 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 32306524 322 GQA-TQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15012 237 YRCdSNWNALLTPLTFLVLYFNSAVNPLLYA 267
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
89-273 8.25e-03

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 38.19  E-value: 8.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLsdlltallclpAAFLDLFAPP----GDSGPWRSFCAASRFFSSCFGI---VS 161
Cdd:cd15176  17 GNSLVVAIYAYYKKLKTKTDVYILNLAV-----------ADLLLLFTLPfwaaDAVNGWVLGTAMCKITSALYTMnfsCG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 162 TFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWDLLRAPREppaPQSFHRCLyrtSPDPAQLGVAYS 241
Cdd:cd15176  86 MQFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRE---NSDRYRCL---PVFPPSLVTSAK 159
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 32306524 242 VGL----VVACYLLPFLLMCFCRYHICKTV-RLSDVR 273
Cdd:cd15176 160 ATIqileVLLGFVLPFLVMVFCYSRVARALsRTPNVK 196
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
89-351 8.74e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 37.80  E-value: 8.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLP---AAFLDLFAPPGDsgpwrSFCAASRFFSSCFGIVSTFSV 165
Cdd:cd15087  17 GNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPiniAEHLLQQWPFGE-----LLCKLILSIDHYNIFSSIYFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFS----LPWDLLRAPREPpaPQSFHRCLYrTSPDPAQLGV-AY 240
Cdd:cd15087  91 TVMSVDRYLVVLATVRSRRMPYRTYRAAKIVSLCVWLLVtiivLPFTVFAGVYSN--ELGRKSCVL-SFPSPESLWFkAS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 241 SVGLVVACYLLPFLLMCfcryhICKTVRLSDVRVRPMTTYARVLrffSEVRTATTVLIMIIFVMC--CWGPYCFLVLLAA 318
Cdd:cd15087 168 RIYTLVLGFAIPVSTIC-----ILYTMMLYKLRNMRLNSNAKAL---DKAKKKVTLMVLVVLAVClfCWTPFHLSTVVAL 239
                       250       260       270
                ....*....|....*....|....*....|...
gi 32306524 319 TRQGQATQAPSLLNVAAVWLTWANGAINPVIYA 351
Cdd:cd15087 240 TTDLPQTPLVIGISYFITSLSYANSCLNPFLYA 272
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
87-352 8.86e-03

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 37.82  E-value: 8.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  87 SLGNCAVMGVIVKHRQLRTVTNAFIlSLSLSDLLTALLCLPaaFLDLFAPPGDSGPWRSF-CAASRFFSSCFGIVSTFSV 165
Cdd:cd15381  15 TIENAFVLIVFCLHKSSCTVAEIYL-GNLAAADLLLVCCLP--FWAINISNGFNWPFGEFlCKSVNAVIYMNLYSSIYFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 166 ALISLDRYCAIVRPPrdKLGRRRALQLLAGAWLAALGF----SLPWDLLRAPREPPApQSFHRCLYRtSPDPAqLGVAYS 241
Cdd:cd15381  92 MMVSIDRYLALVKTM--SSGRMRRPACAKLNCLIIWMFgllmSTPMIVFRTVMYFPE-YNITACVLD-YPSEG-WHVALN 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 242 VGLVVACYLLPFLLMCFCRYHICKTVRLSDvrvrpmttyarvLRFFSEVRTAT--TVLIMIIFVM--CCWGPYCFLVLLA 317
Cdd:cd15381 167 ILLNVVGFLIPLSIITFCSTQIIQVLRNNK------------MQKFKEIQTERkaTVLVLAVLLMffICWLPFHIFTFLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 32306524 318 ATRQG---QATQAPSLLNVA---AVWLTWANGAINPVIYAI 352
Cdd:cd15381 235 TLHKLgliSGCRWEDILDIGtqiATFLAYSNSCLNPLLYVI 275
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
89-354 8.88e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 38.01  E-value: 8.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524  89 GNCAVMGVIVKHRQLRTVTNAFIlslslSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIVSTFSVA-- 166
Cdd:cd15299  20 GNILVIVSFKVNKQLKTVNNYFL-----LSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMnl 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 167 -LISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSL--P----WDLLRAPREPPAPQSFHRCLyrTSPdpaqlgvA 239
Cdd:cd15299  95 lVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLwaPailfWQYFVGKRTVPPDECFIQFL--SEP-------I 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32306524 240 YSVGLVVACYLLPFLLMCFCRYHICKTVrlsdvrvrpmttyarvlrfFSEVRTATTVLIMIIFVMCCWGPYCFLVLLAAT 319
Cdd:cd15299 166 ITFGTAIAAFYLPVTIMTILYWRIYKET-------------------IKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 32306524 320 RQgqaTQAPSLLNVAAVWLTWANGAINPVIYAIRN 354
Cdd:cd15299 227 CD---SCIPKTYWNLGYWLCYINSTVNPVCYALCN 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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